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The map label for this gene is panB

Identifier: 119716273

GI number: 119716273

Start: 2185754

End: 2186641

Strand: Reverse

Name: panB

Synonym: Noca_2042

Alternate gene names: 119716273

Gene position: 2186641-2185754 (Counterclockwise)

Preceding gene: 119716281

Following gene: 119716272

Centisome position: 43.86

GC content: 71.4

Gene sequence:

>888_bases
ATGACGTCAGGGAGAGCCATGAGCCCCGAGGAGACGGCGCCGTACGGCACCGGTCCGGCCCGTGCGGAGAGCGCGCCGGA
CGCACCCGCACCGATCAAGCGGATCCGCACCCACCACCTGCGCGAGATGAAGCAGCGCGGCGAGAAGTTCGCGATGCTCA
CCGCCTACGAGCAGTACGCCGCGCAGACCTTCGACGAGGCCGGCATCGAGGTGCTGCTGGTCGGCGACAGCGCGTCGAAC
AACGTGTTCGCGAACGAGACGTCGCTGCCGGTGACCGTCGACGAGCTGATCCCGCTGGCGCGGGCCGTCAGCCGGTCGGT
ACGCCGGGCACTGGTGGTCGCCGACCTGCCGTTCGGCTCCTACCAGGCCTCCCCGGAGCAGGCCTACCTGACCGCCGTGC
GGTTCATGAAGGAGGCGAACGCGCACGCGGTCAAGCTCGAGGGCGGGATCGAGATGGCCCCCCAGGTCCGCAAGCTCACC
GAGGGCGGCATCCCGGTGATGGCCCACATCGGCTTCACCCCCCAGTCCGAGCACAACCTGGGTGGCTACCGGGTCCAGGG
CCGCGGCGAGGCGGCGGCCCGGGTCGTCGCGGAGGCGGTGGCGATGGAGCAGGCCGGTGCCTTCGCCGTCGTGATGGAGA
TGGTCCCCGGCGACGTCGCCGCGGAGGTGACCAAGTCGGTGTCGATCCCCACGATCGGGATCGGCGCCGGGCTCGACTGC
GACGGGCAGGTGCTGGTCTGGCAGGACGCCTTCGGCCTGCGCACCGGCCGGATGCCGCGCTTCGTCAAGCAGTACGCCGA
CCTGCACGGCGTACTCCTCCAGGCCGCCCGCGACTACGCCGCCGACGTCAAGGCCGGCACCTTCCCCGGCCCCGAGCACA
CCTTCTGA

Upstream 100 bases:

>100_bases
CCCCCTGAGTGATCCTGGGTGACCATCGACACAGGCGTGAACCCGCCGGTACCGGGCTAGCCTGACGAACGGTCCGTGGA
CTCCACCAGGGAGCTGCGAG

Downstream 100 bases:

>100_bases
CCCCGCCCGGACCCGTCGACAGGTGGTGATCGGGGCGCCGACCGGGAAGGGTGGGCGCATGCGCATGCTCGTTCTCGGAC
TGACCGCGATGCTCGGCCTG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTSGRAMSPEETAPYGTGPARAESAPDAPAPIKRIRTHHLREMKQRGEKFAMLTAYEQYAAQTFDEAGIEVLLVGDSASN
NVFANETSLPVTVDELIPLARAVSRSVRRALVVADLPFGSYQASPEQAYLTAVRFMKEANAHAVKLEGGIEMAPQVRKLT
EGGIPVMAHIGFTPQSEHNLGGYRVQGRGEAAARVVAEAVAMEQAGAFAVVMEMVPGDVAAEVTKSVSIPTIGIGAGLDC
DGQVLVWQDAFGLRTGRMPRFVKQYADLHGVLLQAARDYAADVKAGTFPGPEHTF

Sequences:

>Translated_295_residues
MTSGRAMSPEETAPYGTGPARAESAPDAPAPIKRIRTHHLREMKQRGEKFAMLTAYEQYAAQTFDEAGIEVLLVGDSASN
NVFANETSLPVTVDELIPLARAVSRSVRRALVVADLPFGSYQASPEQAYLTAVRFMKEANAHAVKLEGGIEMAPQVRKLT
EGGIPVMAHIGFTPQSEHNLGGYRVQGRGEAAARVVAEAVAMEQAGAFAVVMEMVPGDVAAEVTKSVSIPTIGIGAGLDC
DGQVLVWQDAFGLRTGRMPRFVKQYADLHGVLLQAARDYAADVKAGTFPGPEHTF
>Mature_294_residues
TSGRAMSPEETAPYGTGPARAESAPDAPAPIKRIRTHHLREMKQRGEKFAMLTAYEQYAAQTFDEAGIEVLLVGDSASNN
VFANETSLPVTVDELIPLARAVSRSVRRALVVADLPFGSYQASPEQAYLTAVRFMKEANAHAVKLEGGIEMAPQVRKLTE
GGIPVMAHIGFTPQSEHNLGGYRVQGRGEAAARVVAEAVAMEQAGAFAVVMEMVPGDVAAEVTKSVSIPTIGIGAGLDCD
GQVLVWQDAFGLRTGRMPRFVKQYADLHGVLLQAARDYAADVKAGTFPGPEHTF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=44.3579766536965, Blast_Score=213, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319653, Length=277, Percent_Identity=32.8519855595668, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_NOCSJ (A1SIB6)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_923238.1
- ProteinModelPortal:   A1SIB6
- SMR:   A1SIB6
- STRING:   A1SIB6
- GeneID:   4595796
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_2042
- eggNOG:   COG0413
- HOGENOM:   HBG299908
- OMA:   AKFVRNF
- PhylomeDB:   A1SIB6
- ProtClustDB:   PRK00311
- BioCyc:   NSP35761:NOCA_2042-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 31508; Mature: 31377

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: ACT_SITE 213-213 BINDING 115-115 BINDING 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSGRAMSPEETAPYGTGPARAESAPDAPAPIKRIRTHHLREMKQRGEKFAMLTAYEQYA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHH
AQTFDEAGIEVLLVGDSASNNVFANETSLPVTVDELIPLARAVSRSVRRALVVADLPFGS
HHHHHHCCCEEEEEECCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHEEEEEECCCCC
YQASPEQAYLTAVRFMKEANAHAVKLEGGIEMAPQVRKLTEGGIPVMAHIGFTPQSEHNL
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCC
GGYRVQGRGEAAARVVAEAVAMEQAGAFAVVMEMVPGDVAAEVTKSVSIPTIGIGAGLDC
CCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCC
DGQVLVWQDAFGLRTGRMPRFVKQYADLHGVLLQAARDYAADVKAGTFPGPEHTF
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TSGRAMSPEETAPYGTGPARAESAPDAPAPIKRIRTHHLREMKQRGEKFAMLTAYEQYA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHH
AQTFDEAGIEVLLVGDSASNNVFANETSLPVTVDELIPLARAVSRSVRRALVVADLPFGS
HHHHHHCCCEEEEEECCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHEEEEEECCCCC
YQASPEQAYLTAVRFMKEANAHAVKLEGGIEMAPQVRKLTEGGIPVMAHIGFTPQSEHNL
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCC
GGYRVQGRGEAAARVVAEAVAMEQAGAFAVVMEMVPGDVAAEVTKSVSIPTIGIGAGLDC
CCEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCC
DGQVLVWQDAFGLRTGRMPRFVKQYADLHGVLLQAARDYAADVKAGTFPGPEHTF
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA