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The map label for this gene is maeB [C]

Identifier: 119716265

GI number: 119716265

Start: 2177285

End: 2178670

Strand: Reverse

Name: maeB [C]

Synonym: Noca_2034

Alternate gene names: 119716265

Gene position: 2178670-2177285 (Counterclockwise)

Preceding gene: 119716266

Following gene: 119716263

Centisome position: 43.7

GC content: 70.2

Gene sequence:

>1386_bases
ATGGCAACTCCCAGTCCCGGCTACTCGATCACGGTCCGGATGGAGGTCCCTTCGTCCGCACGGGCCACCGGAGACGTGGT
CGCCGCAGTGACCGGGGCCGGGGGCTCGGTCACCGCTCTCGATGTGGCCGAGTCCCTCGCGGACCGGCTCGTCGTCGACG
TCAGCTGCGACGCCTCCGACCTGGAGCACGCCGACCTGATCACGGAGGCGCTCAACCGCGTGGACGGTGCGACGGTCCGC
AAGGTCAGCGATCGCACCTTCCTGCTGCACCTCGGGGGCAAGCTCGAGGTCGTGCCGAAGGTGCCGCTCAAGCACCGTGA
CGACCTCTCACGCGCCTACACCCCGGGAGTGGCGAGGGTGTGCCTGGCCATCGCGAAGAACCCGGAGGACGCTCGCCGAC
TCACCATCAAGCGCAACACGGTGGCCGTGGTGACCGACGGCTCGGCGGTCCTGGGACTGGGCAACCTGGGCCCTGCGGCG
GCCCTGCCGGTGATGGAGGGCAAGGCGGCACTCTTCAAGCAGTTCGCCGGGGTCGACGCGTGGCCGGTCTGCCTCGACAC
CCAGGACACCGAGGAGATCATCGCGATCGTGAAGGCGATCGCGCCGGTGTACGGCGGCATCAACCTCGAGGACATCGCCG
CGCCACGGTGCTTCGAGATCGAGGCCCGGCTGCGCGCGGAGCTCGACATCCCCGTGTTCCACGACGACCAGCACGGTACG
GCGATCGTGGTGCTCGCCGCTCTCACCAACGCCCTGCGGGTCGTGGGCAAGCAGCTGAGCGAGGTGCGCATCGTCGTCAG
CGGGGTGGGAGCGGCCGGTCACGCGATCATCGAGCTGCTGCACGCCCAGGGCGCGACCGACATCGTGGCCTGTGGCCGGA
GCGGCTCGGTGCACGGCGGACAGGAGAACCTCGACTCGGCGCGACAGTGGATCGCCGACCACACCAACCGCGACCGCTTC
GCCGGCTCGCTCAGGCAGGCGATGGTCGGGGCGGACGTCTTCATCGGCGTATCGGCGCCGAACCTGCTCACCGGCGACGA
CGTCGCGACGATGGCCGACGATGCGATCGTCTTCGCGCTCGCGAACCCCGACCCGGAGGTCGACCCGGTCGCCGCGGGAC
AGCACGCAGCGGTGGTCGCGACCGGTCGCTCCGACTACCCCAACCAGATCAACAACGTGTTGGCCTTCCCGGGGTTCTTC
CGCGGGATGCTCGATGCCGGCACCCACGACATCACCCAGGAGGTCATGCTCGCGGCCGCCTCCGCGATCGCGGACGCCGT
CTCGCCGTCGGAGCTGAACGCCAGCTACATCGTGCCCTCGGTCTTCGACCCCCGTGTCGCAACCGCGGTGGCCGATGCCG
TGCGCGAGGCCGCCACGCCGGCCTGA

Upstream 100 bases:

>100_bases
CGCAGCGGGCGGCGCTACGCTCGGCCGGCACCCGTATGAGCCCAGACCGGCACGTCGGTCCTGAGGCCCTACCTCCAGCT
ACCCGACAAAAGGGGCGTCC

Downstream 100 bases:

>100_bases
GACTGCCCGCCAGGCACTGTGAGCCCGTTGTCTATACCTTGCTCGCCACCACCATGTAGTTCTCGGCCTCAGGGTTGAAC
GTGCTCATTTCCGTCCGGAG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MATPSPGYSITVRMEVPSSARATGDVVAAVTGAGGSVTALDVAESLADRLVVDVSCDASDLEHADLITEALNRVDGATVR
KVSDRTFLLHLGGKLEVVPKVPLKHRDDLSRAYTPGVARVCLAIAKNPEDARRLTIKRNTVAVVTDGSAVLGLGNLGPAA
ALPVMEGKAALFKQFAGVDAWPVCLDTQDTEEIIAIVKAIAPVYGGINLEDIAAPRCFEIEARLRAELDIPVFHDDQHGT
AIVVLAALTNALRVVGKQLSEVRIVVSGVGAAGHAIIELLHAQGATDIVACGRSGSVHGGQENLDSARQWIADHTNRDRF
AGSLRQAMVGADVFIGVSAPNLLTGDDVATMADDAIVFALANPDPEVDPVAAGQHAAVVATGRSDYPNQINNVLAFPGFF
RGMLDAGTHDITQEVMLAAASAIADAVSPSELNASYIVPSVFDPRVATAVADAVREAATPA

Sequences:

>Translated_461_residues
MATPSPGYSITVRMEVPSSARATGDVVAAVTGAGGSVTALDVAESLADRLVVDVSCDASDLEHADLITEALNRVDGATVR
KVSDRTFLLHLGGKLEVVPKVPLKHRDDLSRAYTPGVARVCLAIAKNPEDARRLTIKRNTVAVVTDGSAVLGLGNLGPAA
ALPVMEGKAALFKQFAGVDAWPVCLDTQDTEEIIAIVKAIAPVYGGINLEDIAAPRCFEIEARLRAELDIPVFHDDQHGT
AIVVLAALTNALRVVGKQLSEVRIVVSGVGAAGHAIIELLHAQGATDIVACGRSGSVHGGQENLDSARQWIADHTNRDRF
AGSLRQAMVGADVFIGVSAPNLLTGDDVATMADDAIVFALANPDPEVDPVAAGQHAAVVATGRSDYPNQINNVLAFPGFF
RGMLDAGTHDITQEVMLAAASAIADAVSPSELNASYIVPSVFDPRVATAVADAVREAATPA
>Mature_460_residues
ATPSPGYSITVRMEVPSSARATGDVVAAVTGAGGSVTALDVAESLADRLVVDVSCDASDLEHADLITEALNRVDGATVRK
VSDRTFLLHLGGKLEVVPKVPLKHRDDLSRAYTPGVARVCLAIAKNPEDARRLTIKRNTVAVVTDGSAVLGLGNLGPAAA
LPVMEGKAALFKQFAGVDAWPVCLDTQDTEEIIAIVKAIAPVYGGINLEDIAAPRCFEIEARLRAELDIPVFHDDQHGTA
IVVLAALTNALRVVGKQLSEVRIVVSGVGAAGHAIIELLHAQGATDIVACGRSGSVHGGQENLDSARQWIADHTNRDRFA
GSLRQAMVGADVFIGVSAPNLLTGDDVATMADDAIVFALANPDPEVDPVAAGQHAAVVATGRSDYPNQINNVLAFPGFFR
GMLDAGTHDITQEVMLAAASAIADAVSPSELNASYIVPSVFDPRVATAVADAVREAATPA

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=375, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI62420882, Length=361, Percent_Identity=26.3157894736842, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI62420880, Length=361, Percent_Identity=26.3157894736842, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI239049447, Length=361, Percent_Identity=26.3157894736842, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1788806, Length=385, Percent_Identity=47.5324675324675, Blast_Score=328, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17537199, Length=417, Percent_Identity=27.0983213429257, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646388, Length=368, Percent_Identity=26.9021739130435, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646386, Length=368, Percent_Identity=26.9021739130435, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78707242, Length=367, Percent_Identity=24.7956403269755, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI78707238, Length=367, Percent_Identity=24.7956403269755, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI78707240, Length=367, Percent_Identity=25.0681198910082, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 47881; Mature: 47750

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPSPGYSITVRMEVPSSARATGDVVAAVTGAGGSVTALDVAESLADRLVVDVSCDASD
CCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHEEEEECCCCCC
LEHADLITEALNRVDGATVRKVSDRTFLLHLGGKLEVVPKVPLKHRDDLSRAYTPGVARV
CHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCEEEEECCCCCCCCHHHHHHCCCHHHHH
CLAIAKNPEDARRLTIKRNTVAVVTDGSAVLGLGNLGPAAALPVMEGKAALFKQFAGVDA
HHHHHCCCCHHHEEEEECCEEEEEECCCEEEEECCCCCHHCCCCCCCHHHHHHHHHCCCC
WPVCLDTQDTEEIIAIVKAIAPVYGGINLEDIAAPRCFEIEARLRAELDIPVFHDDQHGT
CEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEHHHEEECCCEEECCCCCC
AIVVLAALTNALRVVGKQLSEVRIVVSGVGAAGHAIIELLHAQGATDIVACGRSGSVHGG
EEHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QENLDSARQWIADHTNRDRFAGSLRQAMVGADVFIGVSAPNLLTGDDVATMADDAIVFAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHCCCCEEEEEE
ANPDPEVDPVAAGQHAAVVATGRSDYPNQINNVLAFPGFFRGMLDAGTHDITQEVMLAAA
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHEECCHHHHHHHHCCCHHHHHHHHHHHH
SAIADAVSPSELNASYIVPSVFDPRVATAVADAVREAATPA
HHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATPSPGYSITVRMEVPSSARATGDVVAAVTGAGGSVTALDVAESLADRLVVDVSCDASD
CCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHEEEEECCCCCC
LEHADLITEALNRVDGATVRKVSDRTFLLHLGGKLEVVPKVPLKHRDDLSRAYTPGVARV
CHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCEEEEECCCCCCCCHHHHHHCCCHHHHH
CLAIAKNPEDARRLTIKRNTVAVVTDGSAVLGLGNLGPAAALPVMEGKAALFKQFAGVDA
HHHHHCCCCHHHEEEEECCEEEEEECCCEEEEECCCCCHHCCCCCCCHHHHHHHHHCCCC
WPVCLDTQDTEEIIAIVKAIAPVYGGINLEDIAAPRCFEIEARLRAELDIPVFHDDQHGT
CEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEHHHEEECCCEEECCCCCC
AIVVLAALTNALRVVGKQLSEVRIVVSGVGAAGHAIIELLHAQGATDIVACGRSGSVHGG
EEHHHHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QENLDSARQWIADHTNRDRFAGSLRQAMVGADVFIGVSAPNLLTGDDVATMADDAIVFAL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHCCCCEEEEEE
ANPDPEVDPVAAGQHAAVVATGRSDYPNQINNVLAFPGFFRGMLDAGTHDITQEVMLAAA
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHEECCHHHHHHHHCCCHHHHHHHHHHHH
SAIADAVSPSELNASYIVPSVFDPRVATAVADAVREAATPA
HHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]