Click here to switch to the map view.

The map label for this gene is aceE [H]

Identifier: 119716225

GI number: 119716225

Start: 2130565

End: 2133363

Strand: Reverse

Name: aceE [H]

Synonym: Noca_1993

Alternate gene names: 119716225

Gene position: 2133363-2130565 (Counterclockwise)

Preceding gene: 119716234

Following gene: 119716223

Centisome position: 42.79

GC content: 69.6

Gene sequence:

>2799_bases
GTGACCGAAGACCCAACCCCTGCTTCTGGCCCCACCCCTGGCACGGACACCAAGCGGAGCGGCGCGATCCCGACCGTCAT
CCACGAAGGACTGCCGACCCAGCTGCCCGACACCGACCCGGACGAGACCACCGACTGGATCGACTCCTTCGACTCACTCG
TCGGGGAACGCGGCCGCGAACGTGCCCGCTACGTCATGCTGCGCCTCCTCGAACGTGCGCGGGAGATGCAGGTGGGCGTG
CCCGCCCTGCGGAGCACCGACTACATCAACACCATCCCGCCCGAGCGTGAGCCGTGGTTCCCCGGGGACGAGGAGACCGA
GCGTCGGATCCGCGCGTTCATCCGCTGGAACGCCGCGGTCATGGTGTCGAGCGCCAACCGCAAGGGCCTCGAGGTCGGTG
GTCACATCGCCACCTACCAGTCCTCCGCGAGCCTCTACGAGGTCGGCTTCAACCACTTCTTCCGCGGCAAGGACCACCCC
GGTGGCGGCGACCAGGTCTTCATCCAGGGCCACGCCTCCCCCGGCATCTACGCTCGCGCGTTCCTCGAGGGCCGGCTGAC
CGAGACCCAGCTCTCCCGGTTCCGCCAGGAGGTCCAGCACGGCCCGCACGCCGGCCTCTCGTCGTACCCCCACCCGCGCC
TGATGCCGGAGTTCTGGGAGTTCCCGACGGTGTCGATGGGGCTGACCTCGCTCAACTCGATCTACCAGGCACGGTTCAAC
CGCTACCTGCACAACCGCGGCATCAAGGACACCGCCCAGCAGCGCGTGTGGGCGTTCCTCGGCGACGGCGAGATGGGCGA
GCCGGAGTCGCTCGGCGCGATCCGGGTCGCCGCCCGCGAGGAGCTGGACAACCTGGTCTGGGTCGTGAACTGCAACCTGC
AGCAGCTCGACGGACCGGTGACCGGCAACGGCAAGATCATCCAGGAGCTCGAGGCCAACTTCCGGGGCGCCGGCTGGAAC
GTGATCAAGGTCGTGTGGGGCCGCGAGTGGGACCAGCTGCTGGCCCGCGACGTCGACGGCGTCCTGGTCAACCGGATGAA
CTCCACGCCGGACGGCGCGTTCCAGACCTACTCGGTCGAGTCCGGCGAGTACGTCCGCGAGAGCTTCTTCGGGGCCGACC
CGCGGCTGCGCAAGATGGTCGAGCACATGAGCGACGACCAGATCCGCAAGCTGCCGCGCGGTGGCCACGACTACCGCAAG
GTGTACGCCGCCTTCGACGCGGCCACCAAGCACGTCGGCCAGCCGACCGTGATCCTGGCCAAGACCGTCAAGGGCTGGAC
GATCGACGCGCTGGAGGGCCGCAACGCGACCCACCAGATGAAGAAGCTGACCCAGGACGACCTGAAGAAGTTCCGGGACC
GGCTCTACCTCCCGATCTCCGACCGCGACCTGGAGCGCACCTACGAGGAGACCGGCGCCGCACCGTTCTTCCACCCCGGC
ATGGAGTCCCCCGAGATCGAGTACATGCTCGAGCGTCGCCGCCAGCTCGGCGGGTCGATCCCCCAGCGGGTCCAGCGCGC
CAAGCCGCTCCAGCTGCCGGGCGACGCGATGTACGCCGACCTCAAGCAGGGCTCGGGCAAGCACGCCATCGCCTCCACGA
TGGCGCTGGTGCGGCTGCTCAAGGACTGGATGAAGGACCCCGAGATCGGCAAGCGGATCGTGCCGATCGCCCCGGACGAG
TACCGCACGTTCGGCATGGACTCGATGTTCCCGAGCGCGAAGGTGTACAACCCGGGCGGCCAGCAGTACGAGTCGGTCGA
CCGGAAACTGTTGCTCTCCTACAAGGAGTCCGCCCAGGGGCAGCTGCTCCACGAGGGCATCTCGGAGGCCGGTGGCGTCG
CGTCCGCGACCGCCGCGGGCTCGGCGTACTCCACGCACGGCGAGCACATGATCCCGTTCTTCATCTTCTACTCGATGTTC
GGGTTCCAGCGCACCGGCGACTCGATCTGGGCGATGAGCGACCAGCTCGCCCGCGGCTTCCTGATCGGCGCCACCGCCGG
CCGGACCACGCTGACCGGCGAGGGCCTGCAGCACGCCGACGGCCACTCGCCGCTGCTCGCGGCGTCCAACCCGGCGGTCG
TGCACTACGACCCGGCGTTCGCCTACGAGATCAGCCACGTGATGCGCTCCGGCCTGGAGCGGATGTACGGCCCGGACGCC
GAGGACGTGATCTTCTACATCACCGTCTACAACGAGCCGGTGCAGCAGCCGGCCGAGCCCGAGGACGTCGACGTCGAGGG
CATCCTCAAGGGCATCCACCACGTCTCCTCCGCGGACGGCGAGGGACCGCGGGCACAGCTGCTCGCCTCCGGTGTCGGGT
TCCCGTGGATCAAGGAGGCCCAGCAGATCCTGGCCGACGAGTGGGGCGTGCGCGCCGACACCTGGTCGGTCACCTCGTGG
AACGAGCTGGCCCGGGACGGGGCGGCCGCCGAGGAGTGGAACCTGCTGCACCCGGGCGAGACCCCGCGCACGGCGTACGT
CACGGACAAGCTGGCCGGCGCGTCCGGTCCGGTCGTGGCGGTCTCGGACTACATGCGCGCGGTGCCGCTGCAGATCGCCC
GCTGGGTCCCGGCCGACTACCGCGTGCTCGGCGCCGACGGCTACGGCTTCGCCGACACCCGGCCCGCCGCCCGCCGGTTC
TTCCACATCGACGCCCAGTCGGTGGTCGTGCAGACCCTGCAGGCCCTCGCCGACGCCGGCCAGATCGACCGCTCGAAGGT
CGAGGAGGCGTTCGCGAAGTACCGCATCGACGACCCCACCGCGGTCGCCGGCGTCAAGCAGGAAGGTGGCGACGCCTGA

Upstream 100 bases:

>100_bases
CGCAACCCGTCCCGCTCGAACCGCCCCCTACGACGGACCGCACCGTGGGTCTACCGGTGGGTAAATTCGCCGCCTCCCGG
GCGCGTGCGACGATGGGCCC

Downstream 100 bases:

>100_bases
TCGCTCCGCGTTGGCGGTTTCCCCGGTTCACCGGGGAAGTTGGAACTTCTGGCCCGAAACTTCGGCCCAACAGTTCCGGT
TTCCCCGGGTAACCGGGGAA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 932; Mature: 931

Protein sequence:

>932_residues
MTEDPTPASGPTPGTDTKRSGAIPTVIHEGLPTQLPDTDPDETTDWIDSFDSLVGERGRERARYVMLRLLERAREMQVGV
PALRSTDYINTIPPEREPWFPGDEETERRIRAFIRWNAAVMVSSANRKGLEVGGHIATYQSSASLYEVGFNHFFRGKDHP
GGGDQVFIQGHASPGIYARAFLEGRLTETQLSRFRQEVQHGPHAGLSSYPHPRLMPEFWEFPTVSMGLTSLNSIYQARFN
RYLHNRGIKDTAQQRVWAFLGDGEMGEPESLGAIRVAAREELDNLVWVVNCNLQQLDGPVTGNGKIIQELEANFRGAGWN
VIKVVWGREWDQLLARDVDGVLVNRMNSTPDGAFQTYSVESGEYVRESFFGADPRLRKMVEHMSDDQIRKLPRGGHDYRK
VYAAFDAATKHVGQPTVILAKTVKGWTIDALEGRNATHQMKKLTQDDLKKFRDRLYLPISDRDLERTYEETGAAPFFHPG
MESPEIEYMLERRRQLGGSIPQRVQRAKPLQLPGDAMYADLKQGSGKHAIASTMALVRLLKDWMKDPEIGKRIVPIAPDE
YRTFGMDSMFPSAKVYNPGGQQYESVDRKLLLSYKESAQGQLLHEGISEAGGVASATAAGSAYSTHGEHMIPFFIFYSMF
GFQRTGDSIWAMSDQLARGFLIGATAGRTTLTGEGLQHADGHSPLLAASNPAVVHYDPAFAYEISHVMRSGLERMYGPDA
EDVIFYITVYNEPVQQPAEPEDVDVEGILKGIHHVSSADGEGPRAQLLASGVGFPWIKEAQQILADEWGVRADTWSVTSW
NELARDGAAAEEWNLLHPGETPRTAYVTDKLAGASGPVVAVSDYMRAVPLQIARWVPADYRVLGADGYGFADTRPAARRF
FHIDAQSVVVQTLQALADAGQIDRSKVEEAFAKYRIDDPTAVAGVKQEGGDA

Sequences:

>Translated_932_residues
MTEDPTPASGPTPGTDTKRSGAIPTVIHEGLPTQLPDTDPDETTDWIDSFDSLVGERGRERARYVMLRLLERAREMQVGV
PALRSTDYINTIPPEREPWFPGDEETERRIRAFIRWNAAVMVSSANRKGLEVGGHIATYQSSASLYEVGFNHFFRGKDHP
GGGDQVFIQGHASPGIYARAFLEGRLTETQLSRFRQEVQHGPHAGLSSYPHPRLMPEFWEFPTVSMGLTSLNSIYQARFN
RYLHNRGIKDTAQQRVWAFLGDGEMGEPESLGAIRVAAREELDNLVWVVNCNLQQLDGPVTGNGKIIQELEANFRGAGWN
VIKVVWGREWDQLLARDVDGVLVNRMNSTPDGAFQTYSVESGEYVRESFFGADPRLRKMVEHMSDDQIRKLPRGGHDYRK
VYAAFDAATKHVGQPTVILAKTVKGWTIDALEGRNATHQMKKLTQDDLKKFRDRLYLPISDRDLERTYEETGAAPFFHPG
MESPEIEYMLERRRQLGGSIPQRVQRAKPLQLPGDAMYADLKQGSGKHAIASTMALVRLLKDWMKDPEIGKRIVPIAPDE
YRTFGMDSMFPSAKVYNPGGQQYESVDRKLLLSYKESAQGQLLHEGISEAGGVASATAAGSAYSTHGEHMIPFFIFYSMF
GFQRTGDSIWAMSDQLARGFLIGATAGRTTLTGEGLQHADGHSPLLAASNPAVVHYDPAFAYEISHVMRSGLERMYGPDA
EDVIFYITVYNEPVQQPAEPEDVDVEGILKGIHHVSSADGEGPRAQLLASGVGFPWIKEAQQILADEWGVRADTWSVTSW
NELARDGAAAEEWNLLHPGETPRTAYVTDKLAGASGPVVAVSDYMRAVPLQIARWVPADYRVLGADGYGFADTRPAARRF
FHIDAQSVVVQTLQALADAGQIDRSKVEEAFAKYRIDDPTAVAGVKQEGGDA
>Mature_931_residues
TEDPTPASGPTPGTDTKRSGAIPTVIHEGLPTQLPDTDPDETTDWIDSFDSLVGERGRERARYVMLRLLERAREMQVGVP
ALRSTDYINTIPPEREPWFPGDEETERRIRAFIRWNAAVMVSSANRKGLEVGGHIATYQSSASLYEVGFNHFFRGKDHPG
GGDQVFIQGHASPGIYARAFLEGRLTETQLSRFRQEVQHGPHAGLSSYPHPRLMPEFWEFPTVSMGLTSLNSIYQARFNR
YLHNRGIKDTAQQRVWAFLGDGEMGEPESLGAIRVAAREELDNLVWVVNCNLQQLDGPVTGNGKIIQELEANFRGAGWNV
IKVVWGREWDQLLARDVDGVLVNRMNSTPDGAFQTYSVESGEYVRESFFGADPRLRKMVEHMSDDQIRKLPRGGHDYRKV
YAAFDAATKHVGQPTVILAKTVKGWTIDALEGRNATHQMKKLTQDDLKKFRDRLYLPISDRDLERTYEETGAAPFFHPGM
ESPEIEYMLERRRQLGGSIPQRVQRAKPLQLPGDAMYADLKQGSGKHAIASTMALVRLLKDWMKDPEIGKRIVPIAPDEY
RTFGMDSMFPSAKVYNPGGQQYESVDRKLLLSYKESAQGQLLHEGISEAGGVASATAAGSAYSTHGEHMIPFFIFYSMFG
FQRTGDSIWAMSDQLARGFLIGATAGRTTLTGEGLQHADGHSPLLAASNPAVVHYDPAFAYEISHVMRSGLERMYGPDAE
DVIFYITVYNEPVQQPAEPEDVDVEGILKGIHHVSSADGEGPRAQLLASGVGFPWIKEAQQILADEWGVRADTWSVTSWN
ELARDGAAAEEWNLLHPGETPRTAYVTDKLAGASGPVVAVSDYMRAVPLQIARWVPADYRVLGADGYGFADTRPAARRFF
HIDAQSVVVQTLQALADAGQIDRSKVEEAFAKYRIDDPTAVAGVKQEGGDA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=885, Percent_Identity=52.090395480226, Blast_Score=905, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 103398; Mature: 103267

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDPTPASGPTPGTDTKRSGAIPTVIHEGLPTQLPDTDPDETTDWIDSFDSLVGERGRE
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RARYVMLRLLERAREMQVGVPALRSTDYINTIPPEREPWFPGDEETERRIRAFIRWNAAV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
MVSSANRKGLEVGGHIATYQSSASLYEVGFNHFFRGKDHPGGGDQVFIQGHASPGIYARA
EEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHH
FLEGRLTETQLSRFRQEVQHGPHAGLSSYPHPRLMPEFWEFPTVSMGLTSLNSIYQARFN
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
RYLHNRGIKDTAQQRVWAFLGDGEMGEPESLGAIRVAAREELDNLVWVVNCNLQQLDGPV
HHHHHCCCHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCHHHCCCCC
TGNGKIIQELEANFRGAGWNVIKVVWGREWDQLLARDVDGVLVNRMNSTPDGAFQTYSVE
CCCCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHCCCCCCCCCEEEEECC
SGEYVRESFFGADPRLRKMVEHMSDDQIRKLPRGGHDYRKVYAAFDAATKHVGQPTVILA
CCHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
KTVKGWTIDALEGRNATHQMKKLTQDDLKKFRDRLYLPISDRDLERTYEETGAAPFFHPG
ECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCCCC
MESPEIEYMLERRRQLGGSIPQRVQRAKPLQLPGDAMYADLKQGSGKHAIASTMALVRLL
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
KDWMKDPEIGKRIVPIAPDEYRTFGMDSMFPSAKVYNPGGQQYESVDRKLLLSYKESAQG
HHHCCCHHHCCEEECCCCCHHHHCCCHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCH
QLLHEGISEAGGVASATAAGSAYSTHGEHMIPFFIFYSMFGFQRTGDSIWAMSDQLARGF
HHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCE
LIGATAGRTTLTGEGLQHADGHSPLLAASNPAVVHYDPAFAYEISHVMRSGLERMYGPDA
EEECCCCCCEECCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCC
EDVIFYITVYNEPVQQPAEPEDVDVEGILKGIHHVSSADGEGPRAQLLASGVGFPWIKEA
CCEEEEEEEECCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHH
QQILADEWGVRADTWSVTSWNELARDGAAAEEWNLLHPGETPRTAYVTDKLAGASGPVVA
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHCCCCCCCCCCCEEEEEHHHCCCCCCEEE
VSDYMRAVPLQIARWVPADYRVLGADGYGFADTRPAARRFFHIDAQSVVVQTLQALADAG
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHEEECCHHHHHHHHHHHHHHCC
QIDRSKVEEAFAKYRIDDPTAVAGVKQEGGDA
CCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
TEDPTPASGPTPGTDTKRSGAIPTVIHEGLPTQLPDTDPDETTDWIDSFDSLVGERGRE
CCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RARYVMLRLLERAREMQVGVPALRSTDYINTIPPEREPWFPGDEETERRIRAFIRWNAAV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
MVSSANRKGLEVGGHIATYQSSASLYEVGFNHFFRGKDHPGGGDQVFIQGHASPGIYARA
EEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHH
FLEGRLTETQLSRFRQEVQHGPHAGLSSYPHPRLMPEFWEFPTVSMGLTSLNSIYQARFN
HHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
RYLHNRGIKDTAQQRVWAFLGDGEMGEPESLGAIRVAAREELDNLVWVVNCNLQQLDGPV
HHHHHCCCHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCHHHCCCCC
TGNGKIIQELEANFRGAGWNVIKVVWGREWDQLLARDVDGVLVNRMNSTPDGAFQTYSVE
CCCCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHCCCHHHHHCCCCCCCCCEEEEECC
SGEYVRESFFGADPRLRKMVEHMSDDQIRKLPRGGHDYRKVYAAFDAATKHVGQPTVILA
CCHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEE
KTVKGWTIDALEGRNATHQMKKLTQDDLKKFRDRLYLPISDRDLERTYEETGAAPFFHPG
ECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCCCCC
MESPEIEYMLERRRQLGGSIPQRVQRAKPLQLPGDAMYADLKQGSGKHAIASTMALVRLL
CCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
KDWMKDPEIGKRIVPIAPDEYRTFGMDSMFPSAKVYNPGGQQYESVDRKLLLSYKESAQG
HHHCCCHHHCCEEECCCCCHHHHCCCHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCH
QLLHEGISEAGGVASATAAGSAYSTHGEHMIPFFIFYSMFGFQRTGDSIWAMSDQLARGF
HHHHHHHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCE
LIGATAGRTTLTGEGLQHADGHSPLLAASNPAVVHYDPAFAYEISHVMRSGLERMYGPDA
EEECCCCCCEECCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCC
EDVIFYITVYNEPVQQPAEPEDVDVEGILKGIHHVSSADGEGPRAQLLASGVGFPWIKEA
CCEEEEEEEECCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHH
QQILADEWGVRADTWSVTSWNELARDGAAAEEWNLLHPGETPRTAYVTDKLAGASGPVVA
HHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHCCCCCCCCCCCEEEEEHHHCCCCCCEEE
VSDYMRAVPLQIARWVPADYRVLGADGYGFADTRPAARRFFHIDAQSVVVQTLQALADAG
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHEEECCHHHHHHHHHHHHHHCC
QIDRSKVEEAFAKYRIDDPTAVAGVKQEGGDA
CCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA