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The map label for this gene is ccdA [H]

Identifier: 119716183

GI number: 119716183

Start: 2082948

End: 2083661

Strand: Reverse

Name: ccdA [H]

Synonym: Noca_1951

Alternate gene names: 119716183

Gene position: 2083661-2082948 (Counterclockwise)

Preceding gene: 119716195

Following gene: 119716182

Centisome position: 41.79

GC content: 75.07

Gene sequence:

>714_bases
ATGACCGCAGAGATCGCGCTCGTGTTCGCCGCCGGCGTGATCTCCTTCGCCTCGCCCTGCGTGCTCCCCCTCGTGCCGGT
CTACCTGTCGGTGGCGACCGGCCTGGGGGTGGCCGACCTCCAGCAGCGGCGCAGCCTGGGCCGGGTGCTGGCCGGCACCT
CGGCCTTCGCCGCGGGGTTCGGCATCGTGTTCGTGCTGCTCGGGCTCTCCGCCACCGCGCTGGGCGGCGCCCTGACCCGC
GAACAGGTCTCGATCACCCGGATCGGCGGCGCGATCGTGCTGACGCTGGCGCTGGTGATGTTCGCCGGCACCCTCGACCT
GCCGTTCGCGCGAGGGCGGGAGCTCCGCTTCCACCCACGACCCGGCGCCGGCGCCACCTGGGCCGCCCCGGTCATGGGAG
CGGCGTTCGCGTTCGGCTGGACTCCCTGCATCGGGCCGGTGCTGGGCTCGGTGCTCACCGTCGCCGCCGGCCAGGACGGG
GCGGCCCGCGGCGGCCTGCTGCTGGCCTGCTACGCCGCCGGGCTGACCCTCCCCCTCCTCGTCACCGCGGTGTTCCTCGG
CCGGCTGGGACCGACGCTGCGCTGGGTGCGCGCCCGAGGGCTGCTGCTCTCCCGGGCCTCGGCCGTGGTGCTGTTCGGCT
ACGGGCTGATGCTGGTCACCGACCAGCTCTCGTGGCTGACCCGGGTGCTGCAGGGGGGTGTGCCCGCCCTCTAG

Upstream 100 bases:

>100_bases
CGGTAGGTGGCTCGGCGCCCCGCGTCAACGGTGCTCTCGTCCACCCTTGCCGACCTCGCTTCTAACGGTCATACTTTTGC
ACCTTAGACCGGGAGGGACG

Downstream 100 bases:

>100_bases
GTGGGAACCATGCCAGTGCACGGTTCTCCGGAAGGGAGCACGCGATGCTCAGCAGGCTCGCCACCGTCACCGCCGCACTC
ACCCTGGCCGGCGGGTTGTC

Product: cytochrome c biogenesis protein, transmembrane region

Products: DsbDoxidized; DsbGreduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTAEIALVFAAGVISFASPCVLPLVPVYLSVATGLGVADLQQRRSLGRVLAGTSAFAAGFGIVFVLLGLSATALGGALTR
EQVSITRIGGAIVLTLALVMFAGTLDLPFARGRELRFHPRPGAGATWAAPVMGAAFAFGWTPCIGPVLGSVLTVAAGQDG
AARGGLLLACYAAGLTLPLLVTAVFLGRLGPTLRWVRARGLLLSRASAVVLFGYGLMLVTDQLSWLTRVLQGGVPAL

Sequences:

>Translated_237_residues
MTAEIALVFAAGVISFASPCVLPLVPVYLSVATGLGVADLQQRRSLGRVLAGTSAFAAGFGIVFVLLGLSATALGGALTR
EQVSITRIGGAIVLTLALVMFAGTLDLPFARGRELRFHPRPGAGATWAAPVMGAAFAFGWTPCIGPVLGSVLTVAAGQDG
AARGGLLLACYAAGLTLPLLVTAVFLGRLGPTLRWVRARGLLLSRASAVVLFGYGLMLVTDQLSWLTRVLQGGVPAL
>Mature_236_residues
TAEIALVFAAGVISFASPCVLPLVPVYLSVATGLGVADLQQRRSLGRVLAGTSAFAAGFGIVFVLLGLSATALGGALTRE
QVSITRIGGAIVLTLALVMFAGTLDLPFARGRELRFHPRPGAGATWAAPVMGAAFAFGWTPCIGPVLGSVLTVAAGQDGA
ARGGLLLACYAAGLTLPLLVTAVFLGRLGPTLRWVRARGLLLSRASAVVLFGYGLMLVTDQLSWLTRVLQGGVPAL

Specific function: Cytochrome c oxidase activity is partially restored by mutations in bdbC or bdbD that are defective in the synthesis of disulfide bond containing proteins. The same mutations abrogate the need for CcdA in sporulation [H]

COG id: COG0785

COG function: function code O; Cytochrome c biogenesis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DsbD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834 [H]

Pfam domain/function: PF02683 DsbD [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 24212; Mature: 24081

Theoretical pI: Translated: 11.67; Mature: 11.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEIALVFAAGVISFASPCVLPLVPVYLSVATGLGVADLQQRRSLGRVLAGTSAFAAGF
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHH
GIVFVLLGLSATALGGALTREQVSITRIGGAIVLTLALVMFAGTLDLPFARGRELRFHPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
PGAGATWAAPVMGAAFAFGWTPCIGPVLGSVLTVAAGQDGAARGGLLLACYAAGLTLPLL
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHH
VTAVFLGRLGPTLRWVRARGLLLSRASAVVLFGYGLMLVTDQLSWLTRVLQGGVPAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TAEIALVFAAGVISFASPCVLPLVPVYLSVATGLGVADLQQRRSLGRVLAGTSAFAAGF
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHH
GIVFVLLGLSATALGGALTREQVSITRIGGAIVLTLALVMFAGTLDLPFARGRELRFHPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
PGAGATWAAPVMGAAFAFGWTPCIGPVLGSVLTVAAGQDGAARGGLLLACYAAGLTLPLL
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHH
VTAVFLGRLGPTLRWVRARGLLLSRASAVVLFGYGLMLVTDQLSWLTRVLQGGVPAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DsbGoxidized; DsbDreduced/thiol:disulfide reductase [C]

Specific reaction: DsbDreduced/thiol:disulfide reductase + DsbCoxidized = DsbDoxidized + DsbCreduced DsbGoxidized + DsbDreduced/thiol:disulfide reductase = DsbGreduced + DsbDoxidized [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969507; 9068642; 9384377; 10781554; 11844773 [H]