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The map label for this gene is wecA [H]

Identifier: 119715989

GI number: 119715989

Start: 1865093

End: 1866277

Strand: Direct

Name: wecA [H]

Synonym: Noca_1754

Alternate gene names: 119715989

Gene position: 1865093-1866277 (Clockwise)

Preceding gene: 119715988

Following gene: 119715990

Centisome position: 37.41

GC content: 70.89

Gene sequence:

>1185_bases
GTGCGGGAGTACCTCCTCGTCTTCCTCGTCGCGGCCGCGACGACGTACCTCCTCACGGTCATCGCGCGCGAGATCGCCCT
CCGCACCGGCGCGGTCGCGAAGGTCCGGGACCGCGACGTGCACGCCGTGCCGATCCCGTACCTCGGCGGGCTCGCGATGC
TGGGTGGCCTGGTGGCGGCGTACCTCGTGGCGCGGCAGCTGCCGTTCCTCTCCAAGAGCGGAGCGTTCGTCTTCCACGAT
GCCGGCATCGTGCTGATCGCGGGCGCGCTCATCTGTGCAGTGGGCGTGCTCGACGACCTCTTCGAGCTCGACGCCCTGAC
CAAGCTCGGCGGCCAGGTGCTCGCCGCGGGCTTCCTCATCGCGTTCGGGATCCAGTACATCTTCTTCCCGGGTGGCGACG
GGGTACAGGTCAGCATCGACCAGAGCCAGGGCGCGCTGCTGACCGGGTTCATCGTCGTCGCGACCGTGAACGCGGTGAAC
TTCGTCGACGGCCTGGACGGCCTGGCCACCGGTGTGGTCGGGATGGGGGCGCTCGCGTTCTTCGTCTACTGCTACCAGCT
CGCGAACATCAACAACGTGACGCTGGCGACGACCGGGGCGCTGCTGAGCGCCTCGCTCGCCGGCGCGTGCGCCGGCTTCC
TGCCCCACAACTTCCACCCGGCGCGGCTGTTCATGGGGGACAGCGGCTCGATGTTGCTCGGTCTGGTGCTCTCCGCGAGC
GCGGTCACCCTGACCGGGCAGTTCGACCCCGAGCAGATCAGCGCGGGTGCGGCGGGCTCGCGGGCCAGCTTCGTGCCGAC
GCTGCTGCCCCTGCTGCTGCCCGTCTCGCTCCTGGTCGTGCCGATGCTCGACCTGGTGCTCGCCGTCGTCCGCCGCACCC
GCGCCGGCCGGTCGCCGTTCGCCCCGGACAAGCAGCACCTGCACCACCGGCTGCTCGAGATCGGGCACTCGCACCGGCGC
GCGGTCCTGATCATGTGGATGTGGGCCGCGCTGGTGGCCTTCGGCACCGTCTTGATCAGCCTCTACAGCGCCGACGCGTG
GATGTGGTCGTCGGTCTCGGCGATGGCGGCGCTGACGGTCGGGGTGACCTTCGTGCTGCCCAAGCTGCGCCGGACCCAGC
TCGTCACCGACGCCGGGGTCGCCGACGCCGGGCACACCGAAGGTGGGGCCGCCGACGCGTCCTAG

Upstream 100 bases:

>100_bases
GCCGGGTCCTGCGTCGTGGAGCGCTCTCGCTCGAGCGGCTCAACGAGGTGCTCGAGCCGCTCGGCGCGACGCTGACCGTC
GAGGGCTGAGGGCGGGGCCG

Downstream 100 bases:

>100_bases
GGCATGTCTCTCAAGTCTCGGCGACGCGCAGCAGGCCATGGACTTGGGAGACACGCCCTAGCCCCGGCGCTTGCCGCCGG
CGGCTATTGGAACGTTCCGT

Product: glycosyl transferase family protein

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MREYLLVFLVAAATTYLLTVIAREIALRTGAVAKVRDRDVHAVPIPYLGGLAMLGGLVAAYLVARQLPFLSKSGAFVFHD
AGIVLIAGALICAVGVLDDLFELDALTKLGGQVLAAGFLIAFGIQYIFFPGGDGVQVSIDQSQGALLTGFIVVATVNAVN
FVDGLDGLATGVVGMGALAFFVYCYQLANINNVTLATTGALLSASLAGACAGFLPHNFHPARLFMGDSGSMLLGLVLSAS
AVTLTGQFDPEQISAGAAGSRASFVPTLLPLLLPVSLLVVPMLDLVLAVVRRTRAGRSPFAPDKQHLHHRLLEIGHSHRR
AVLIMWMWAALVAFGTVLISLYSADAWMWSSVSAMAALTVGVTFVLPKLRRTQLVTDAGVADAGHTEGGAADAS

Sequences:

>Translated_394_residues
MREYLLVFLVAAATTYLLTVIAREIALRTGAVAKVRDRDVHAVPIPYLGGLAMLGGLVAAYLVARQLPFLSKSGAFVFHD
AGIVLIAGALICAVGVLDDLFELDALTKLGGQVLAAGFLIAFGIQYIFFPGGDGVQVSIDQSQGALLTGFIVVATVNAVN
FVDGLDGLATGVVGMGALAFFVYCYQLANINNVTLATTGALLSASLAGACAGFLPHNFHPARLFMGDSGSMLLGLVLSAS
AVTLTGQFDPEQISAGAAGSRASFVPTLLPLLLPVSLLVVPMLDLVLAVVRRTRAGRSPFAPDKQHLHHRLLEIGHSHRR
AVLIMWMWAALVAFGTVLISLYSADAWMWSSVSAMAALTVGVTFVLPKLRRTQLVTDAGVADAGHTEGGAADAS
>Mature_394_residues
MREYLLVFLVAAATTYLLTVIAREIALRTGAVAKVRDRDVHAVPIPYLGGLAMLGGLVAAYLVARQLPFLSKSGAFVFHD
AGIVLIAGALICAVGVLDDLFELDALTKLGGQVLAAGFLIAFGIQYIFFPGGDGVQVSIDQSQGALLTGFIVVATVNAVN
FVDGLDGLATGVVGMGALAFFVYCYQLANINNVTLATTGALLSASLAGACAGFLPHNFHPARLFMGDSGSMLLGLVLSAS
AVTLTGQFDPEQISAGAAGSRASFVPTLLPLLLPVSLLVVPMLDLVLAVVRRTRAGRSPFAPDKQHLHHRLLEIGHSHRR
AVLIMWMWAALVAFGTVLISLYSADAWMWSSVSAMAALTVGVTFVLPKLRRTQLVTDAGVADAGHTEGGAADAS

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=331, Percent_Identity=27.4924471299094, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 41126; Mature: 41126

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREYLLVFLVAAATTYLLTVIAREIALRTGAVAKVRDRDVHAVPIPYLGGLAMLGGLVAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEECCHHHHHHHHHHHHHHH
YLVARQLPFLSKSGAFVFHDAGIVLIAGALICAVGVLDDLFELDALTKLGGQVLAAGFLI
HHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGIQYIFFPGGDGVQVSIDQSQGALLTGFIVVATVNAVNFVDGLDGLATGVVGMGALAF
HHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVYCYQLANINNVTLATTGALLSASLAGACAGFLPHNFHPARLFMGDSGSMLLGLVLSAS
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCC
AVTLTGQFDPEQISAGAAGSRASFVPTLLPLLLPVSLLVVPMLDLVLAVVRRTRAGRSPF
EEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APDKQHLHHRLLEIGHSHRRAVLIMWMWAALVAFGTVLISLYSADAWMWSSVSAMAALTV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVTFVLPKLRRTQLVTDAGVADAGHTEGGAADAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MREYLLVFLVAAATTYLLTVIAREIALRTGAVAKVRDRDVHAVPIPYLGGLAMLGGLVAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEECCHHHHHHHHHHHHHHH
YLVARQLPFLSKSGAFVFHDAGIVLIAGALICAVGVLDDLFELDALTKLGGQVLAAGFLI
HHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGIQYIFFPGGDGVQVSIDQSQGALLTGFIVVATVNAVNFVDGLDGLATGVVGMGALAF
HHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVYCYQLANINNVTLATTGALLSASLAGACAGFLPHNFHPARLFMGDSGSMLLGLVLSAS
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCC
AVTLTGQFDPEQISAGAAGSRASFVPTLLPLLLPVSLLVVPMLDLVLAVVRRTRAGRSPF
EEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APDKQHLHHRLLEIGHSHRRAVLIMWMWAALVAFGTVLISLYSADAWMWSSVSAMAALTV
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVTFVLPKLRRTQLVTDAGVADAGHTEGGAADAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]