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The map label for this gene is thrB [H]

Identifier: 119715981

GI number: 119715981

Start: 1856450

End: 1857352

Strand: Direct

Name: thrB [H]

Synonym: Noca_1746

Alternate gene names: 119715981

Gene position: 1856450-1857352 (Clockwise)

Preceding gene: 119715980

Following gene: 119715982

Centisome position: 37.23

GC content: 76.08

Gene sequence:

>903_bases
GTGGTCACCTTCGTCGACGGGCCGGTCCGGGTGTCGGTCCCGGCCACCTCCGCGAACCTCGGGCCGGGCTTCGACTCGCT
CGGCCTGGCCCTGTCGATGCGCGACGAGATCGAGGCCGAGGTGCTCGGCGCGGGTCTCGAGGTCCGGGTGTCGGGCTCGG
GGTCCGACGAGGTGCCGCTCGACGAGACGCACCTGGTCGTGCGCTCGATGCACGCGGCCTTCGACCTGCTCGGCCGGCGC
CCACCGGGGCTGCGGTTGACGTGCCGCAACGCGATCCCGCACGGCCGCGGCCTCGGGTCGTCCTCGGCGGCGATCGTGGG
CGGTGTGGTCCTGGCCCGCGCCCTGGTCGCCGGGGGAGCCCTGCTGGTCGACGACGCGACCCTGTTCCGGATGGCCGCGC
GGATCGAGGGCCATCCCGACAACGTCGCGCCCGCGTTCCACGGCGGGTTCGTGATCGCCGGCCGGGACGAGGGCACCGAC
TTCTACGCCGTGTCCTCCCCGGTGGACCCGCGCATCGAGACCGTCGTCTTCGTGCCGCCGACCCCGGTCGCCACCGAGGT
CGCCCGCGGCCTGCTGCCGGCGGCGGTGCCGCATGCCGACGCGGCCGCTGACGCCGGGCGTACGGCGCTGCTGGTCGCGG
CGCTCGCCGGCCAGCCCGAGCACCTGTGGCTGGCCACCCGCGACTACCTCCACCAGGACTACCGCCGCCCCGCGATGCCG
GAGTCACTGGCCCTGGTCGACGCGCTGCGGGCCGACGGCGTGCCGGCGACCGTGTCCGGCGCCGGTCCGACGGTGCTCGC
GTTCACCGACGCCTCGGCGGCCGGTGCGCTGGCGGACCGTTGCCCCGCGGGCTGGGTGGCGCACCACCTCACCGTCGATC
GCGACGGTGCCCGGTCCACCTGA

Upstream 100 bases:

>100_bases
CGAGGGCTTCACCGAGAGCGGGAACAGCATCGTCGACACCGTGATCGACGCCGAGGTGACCGCCGCGGCGCAGGCCGCCG
GTCTCGCGTAACGGGCCGGC

Downstream 100 bases:

>100_bases
GGCTGCCTCGGCCGGCCGGCTCTCCTGACACTTCCGTGGGTACGGCGGGGTGTCCTGGCCACCGAACCGGCCCCGGGAAC
GGTTGCTCACGCACCGCCGG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MVTFVDGPVRVSVPATSANLGPGFDSLGLALSMRDEIEAEVLGAGLEVRVSGSGSDEVPLDETHLVVRSMHAAFDLLGRR
PPGLRLTCRNAIPHGRGLGSSSAAIVGGVVLARALVAGGALLVDDATLFRMAARIEGHPDNVAPAFHGGFVIAGRDEGTD
FYAVSSPVDPRIETVVFVPPTPVATEVARGLLPAAVPHADAAADAGRTALLVAALAGQPEHLWLATRDYLHQDYRRPAMP
ESLALVDALRADGVPATVSGAGPTVLAFTDASAAGALADRCPAGWVAHHLTVDRDGARST

Sequences:

>Translated_300_residues
MVTFVDGPVRVSVPATSANLGPGFDSLGLALSMRDEIEAEVLGAGLEVRVSGSGSDEVPLDETHLVVRSMHAAFDLLGRR
PPGLRLTCRNAIPHGRGLGSSSAAIVGGVVLARALVAGGALLVDDATLFRMAARIEGHPDNVAPAFHGGFVIAGRDEGTD
FYAVSSPVDPRIETVVFVPPTPVATEVARGLLPAAVPHADAAADAGRTALLVAALAGQPEHLWLATRDYLHQDYRRPAMP
ESLALVDALRADGVPATVSGAGPTVLAFTDASAAGALADRCPAGWVAHHLTVDRDGARST
>Mature_300_residues
MVTFVDGPVRVSVPATSANLGPGFDSLGLALSMRDEIEAEVLGAGLEVRVSGSGSDEVPLDETHLVVRSMHAAFDLLGRR
PPGLRLTCRNAIPHGRGLGSSSAAIVGGVVLARALVAGGALLVDDATLFRMAARIEGHPDNVAPAFHGGFVIAGRDEGTD
FYAVSSPVDPRIETVVFVPPTPVATEVARGLLPAAVPHADAAADAGRTALLVAALAGQPEHLWLATRDYLHQDYRRPAMP
ESLALVDALRADGVPATVSGAGPTVLAFTDASAAGALADRCPAGWVAHHLTVDRDGARST

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=306, Percent_Identity=27.7777777777778, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321814, Length=315, Percent_Identity=28.8888888888889, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 30839; Mature: 30839

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFVDGPVRVSVPATSANLGPGFDSLGLALSMRDEIEAEVLGAGLEVRVSGSGSDEVPL
CEEEECCCEEEEECCCCCCCCCCCHHHCEEEEEHHHHHHHHCCCCEEEEECCCCCCCCCC
DETHLVVRSMHAAFDLLGRRPPGLRLTCRNAIPHGRGLGSSSAAIVGGVVLARALVAGGA
CHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCE
LLVDDATLFRMAARIEGHPDNVAPAFHGGFVIAGRDEGTDFYAVSSPVDPRIETVVFVPP
EEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEECC
TPVATEVARGLLPAAVPHADAAADAGRTALLVAALAGQPEHLWLATRDYLHQDYRRPAMP
CCHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCCCC
ESLALVDALRADGVPATVSGAGPTVLAFTDASAAGALADRCPAGWVAHHLTVDRDGARST
HHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MVTFVDGPVRVSVPATSANLGPGFDSLGLALSMRDEIEAEVLGAGLEVRVSGSGSDEVPL
CEEEECCCEEEEECCCCCCCCCCCHHHCEEEEEHHHHHHHHCCCCEEEEECCCCCCCCCC
DETHLVVRSMHAAFDLLGRRPPGLRLTCRNAIPHGRGLGSSSAAIVGGVVLARALVAGGA
CHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCE
LLVDDATLFRMAARIEGHPDNVAPAFHGGFVIAGRDEGTDFYAVSSPVDPRIETVVFVPP
EEECCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEECC
TPVATEVARGLLPAAVPHADAAADAGRTALLVAALAGQPEHLWLATRDYLHQDYRRPAMP
CCHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHCCCCCC
ESLALVDALRADGVPATVSGAGPTVLAFTDASAAGALADRCPAGWVAHHLTVDRDGARST
HHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]