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The map label for this gene is merR1 [H]

Identifier: 119715881

GI number: 119715881

Start: 1749234

End: 1749635

Strand: Reverse

Name: merR1 [H]

Synonym: Noca_1646

Alternate gene names: 119715881

Gene position: 1749635-1749234 (Counterclockwise)

Preceding gene: 119715884

Following gene: 119715879

Centisome position: 35.09

GC content: 71.14

Gene sequence:

>402_bases
ATGTTGATCGGACAGTTGGCCGATGCGGCAGGCGTGACCGCGCAGACGATCAGGTTCTACGAGCGCGACGGCCTGTTGCC
GAGGCCACCGCGGGAGGCCAACGGCTACCGCGTCTACGGCGGTGACACACTGGGCCGGCTCAGGTTCATCCGGAGCGCTC
AGGCATCGGGCCTCACCCTCGCCGAGATCCGCGGCATCGTCGACCTGCGAGACGCAGGCACCGTGCCGTGCACCCACGTC
ACCACCCTGCTGGCGGCCAGACTCGACGAGGTTCACGCGCGGGTGCGCGAGCTCGAGGCACTCGCCGGCGAGCTCGAGCG
CCTCCTCACGCGCGGCGACCGCCTCGACCCCGCCGACTGCGGGGACGCCGCCGTCTGCCACATCCTGGTCGGGGACTCGT
GA

Upstream 100 bases:

>100_bases
TCTTCCAGTTCGGGCAGCCGTCGAAGTAGAGCAGCGTGACGTCCATGGCGCCGAACCTAGACCTTGATCCGCACTACAAG
GTCAAGGCTAGGCTGCGACC

Downstream 100 bases:

>100_bases
CCCGGCTGCGTCCCCTTCGCCAGCTCCTCGGGCCGGCCCGGCGTCGCCCCTGAGCCGCCGCATCGTCCGAGGCGGTCACC
GCAGCCGGTCGGCGAGCTCC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MLIGQLADAAGVTAQTIRFYERDGLLPRPPREANGYRVYGGDTLGRLRFIRSAQASGLTLAEIRGIVDLRDAGTVPCTHV
TTLLAARLDEVHARVRELEALAGELERLLTRGDRLDPADCGDAAVCHILVGDS

Sequences:

>Translated_133_residues
MLIGQLADAAGVTAQTIRFYERDGLLPRPPREANGYRVYGGDTLGRLRFIRSAQASGLTLAEIRGIVDLRDAGTVPCTHV
TTLLAARLDEVHARVRELEALAGELERLLTRGDRLDPADCGDAAVCHILVGDS
>Mature_133_residues
MLIGQLADAAGVTAQTIRFYERDGLLPRPPREANGYRVYGGDTLGRLRFIRSAQASGLTLAEIRGIVDLRDAGTVPCTHV
TTLLAARLDEVHARVRELEALAGELERLLTRGDRLDPADCGDAAVCHILVGDS

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=131, Percent_Identity=36.6412213740458, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1786695, Length=120, Percent_Identity=31.6666666666667, Blast_Score=63, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14336; Mature: 14336

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGQLADAAGVTAQTIRFYERDGLLPRPPREANGYRVYGGDTLGRLRFIRSAQASGLTL
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCH
AEIRGIVDLRDAGTVPCTHVTTLLAARLDEVHARVRELEALAGELERLLTRGDRLDPADC
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GDAAVCHILVGDS
CCCEEEEEEECCC
>Mature Secondary Structure
MLIGQLADAAGVTAQTIRFYERDGLLPRPPREANGYRVYGGDTLGRLRFIRSAQASGLTL
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCH
AEIRGIVDLRDAGTVPCTHVTTLLAARLDEVHARVRELEALAGELERLLTRGDRLDPADC
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GDAAVCHILVGDS
CCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]