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The map label for this gene is ahcY [H]

Identifier: 119715668

GI number: 119715668

Start: 1516415

End: 1517845

Strand: Direct

Name: ahcY [H]

Synonym: Noca_1432

Alternate gene names: 119715668

Gene position: 1516415-1517845 (Clockwise)

Preceding gene: 119715667

Following gene: 119715669

Centisome position: 30.41

GC content: 67.65

Gene sequence:

>1431_bases
ATGGACTACAAGGTCGCCGACCTCTCCCTGGCCGACTTCGGCCGCACGGAGATCCAGCTCGCCGAGCACGAGATGCCCGG
CCTGATGGCGATGCGCGAGCGCTACGCCGCAGAGCAGCCGCTCGCCGGGGCCCGGATCGCCGGCTCGCTGCACATGACCA
TCCAGACAGCGGTCCTGATCGAGACGCTCGTCGCGCTCGGCGCCGAGGTCCGCTGGGCCTCCTGCAACATCTTCTCCACC
CAGGACCACGCCGCTGCCGCGATCGCGGTCGGTCCGAACGGCACCGCCGACGACCCCCAGGGCGTGCCGGTCTTCGCCTG
GAAGGGCGAGACCCTGGAGGAGTACTGGTGGTGCACCCAGCAGATCCTCGACTGGCCCGGCGGCACGATGCCGAACATGA
TCCTCGACGACGGCGGCGACGCCACGCTCCTCGTCCACCTCGGCGTCCAGGCCGAGAAGACCGGGCAGGCGCCGGACCCG
GCGAGCGCCACCAGCAACGAGCAGCGGATCATCTTCGAGGCCCTGGGTGAGGTCCTCGCGAAGAACCCCAACCACTGGAC
GCCGATCGCCAACTCGATCAAGGGCGTCACCGAGGAGACCACCACCGGCGTGCACCGTCTCTACGAGATGATGCGCGAGG
GCTCGCTGCTGTTCCCGGCCATCAACGTCAACGACTCGGTGACGAAGTCGAAGTTCGACAACAAGTACGGCTGCCGGCAC
TCGCTGATCGACGGGATCAACCGCGCGACCGACGTCCTGATCGGCGGCAAGGTCGCGGTCGTCTGCGGCTACGGCGACGT
CGGCAAGGGCTGCGCGGAGTCGCTGCGCGGCCAGGGCGCACGCGTGATCGTCACCGAGATCGACCCGATCTGCGCGCTGC
AGGCGTCGATGGACGGCTACCAGGTCACCACGCTCGAGGACGCCCTGCCGATCGCGGACATCATCATCACCGCCACCGGC
AACAAGGACGTCGTGACCGTCGACCACATGCGATCGATGAAGCACAACGCGATCGTCGGCAACATCGGCCACTTCGACAA
CGAGATCGACATGGCCGGCCTGGAGGCGCCGGGCGTGGCCGAGCGCAAGAACGTCAAGCCGCAGGTCGACGTGTGGACCT
TCGCCAACGGCAGGTCCGTGGTCGTGCTGTCCGAGGGCCGGCTGATGAACCTGGGCAACGCGACCGGCCATCCGTCGTTC
GTGATGTCGAACTCCTTCACCAACCAGGTGCTCGCCCAGATCGAGATCTTCACCAAGACCGAGGAGTACCCGGTCGGCGT
CTACGTGCTGCCCAAGCACCTCGACGAGGAGGTGGCGCGCCTGCACCTCGACGCGCTCGGGGTGAAGCTCACCCGCCTCA
CCGACGAGCAGGCCACCTACCTCGGCGTCGATGCCGCGGGACCGTACAAGCCGGACCAGTACCGGTACTAG

Upstream 100 bases:

>100_bases
GGTCGCGGGTGGGAGGCCGAGGATTCTTCGGAACCCCCGGCCGCGATCTAACCTCGGATTCCAGGCAGCACCGATCGTCG
CCGGACCCGCAGGAGCAGAC

Downstream 100 bases:

>100_bases
TGATCCTTGGTCGCTAGGTGCGCTGAGCCTGCGACGGCCGGGGCCCAGCAGCCGGGTCGAGAAGCACGGCTCCGGCAACG
AGAAGATGCCCGCTCCACAC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MDYKVADLSLADFGRTEIQLAEHEMPGLMAMRERYAAEQPLAGARIAGSLHMTIQTAVLIETLVALGAEVRWASCNIFST
QDHAAAAIAVGPNGTADDPQGVPVFAWKGETLEEYWWCTQQILDWPGGTMPNMILDDGGDATLLVHLGVQAEKTGQAPDP
ASATSNEQRIIFEALGEVLAKNPNHWTPIANSIKGVTEETTTGVHRLYEMMREGSLLFPAINVNDSVTKSKFDNKYGCRH
SLIDGINRATDVLIGGKVAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQASMDGYQVTTLEDALPIADIIITATG
NKDVVTVDHMRSMKHNAIVGNIGHFDNEIDMAGLEAPGVAERKNVKPQVDVWTFANGRSVVVLSEGRLMNLGNATGHPSF
VMSNSFTNQVLAQIEIFTKTEEYPVGVYVLPKHLDEEVARLHLDALGVKLTRLTDEQATYLGVDAAGPYKPDQYRY

Sequences:

>Translated_476_residues
MDYKVADLSLADFGRTEIQLAEHEMPGLMAMRERYAAEQPLAGARIAGSLHMTIQTAVLIETLVALGAEVRWASCNIFST
QDHAAAAIAVGPNGTADDPQGVPVFAWKGETLEEYWWCTQQILDWPGGTMPNMILDDGGDATLLVHLGVQAEKTGQAPDP
ASATSNEQRIIFEALGEVLAKNPNHWTPIANSIKGVTEETTTGVHRLYEMMREGSLLFPAINVNDSVTKSKFDNKYGCRH
SLIDGINRATDVLIGGKVAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQASMDGYQVTTLEDALPIADIIITATG
NKDVVTVDHMRSMKHNAIVGNIGHFDNEIDMAGLEAPGVAERKNVKPQVDVWTFANGRSVVVLSEGRLMNLGNATGHPSF
VMSNSFTNQVLAQIEIFTKTEEYPVGVYVLPKHLDEEVARLHLDALGVKLTRLTDEQATYLGVDAAGPYKPDQYRY
>Mature_476_residues
MDYKVADLSLADFGRTEIQLAEHEMPGLMAMRERYAAEQPLAGARIAGSLHMTIQTAVLIETLVALGAEVRWASCNIFST
QDHAAAAIAVGPNGTADDPQGVPVFAWKGETLEEYWWCTQQILDWPGGTMPNMILDDGGDATLLVHLGVQAEKTGQAPDP
ASATSNEQRIIFEALGEVLAKNPNHWTPIANSIKGVTEETTTGVHRLYEMMREGSLLFPAINVNDSVTKSKFDNKYGCRH
SLIDGINRATDVLIGGKVAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQASMDGYQVTTLEDALPIADIIITATG
NKDVVTVDHMRSMKHNAIVGNIGHFDNEIDMAGLEAPGVAERKNVKPQVDVWTFANGRSVVVLSEGRLMNLGNATGHPSF
VMSNSFTNQVLAQIEIFTKTEEYPVGVYVLPKHLDEEVARLHLDALGVKLTRLTDEQATYLGVDAAGPYKPDQYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=476, Percent_Identity=59.2436974789916, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI239937451, Length=452, Percent_Identity=59.7345132743363, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI298286489, Length=476, Percent_Identity=48.3193277310924, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI24308043, Length=476, Percent_Identity=48.3193277310924, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI195539337, Length=476, Percent_Identity=48.3193277310924, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=476, Percent_Identity=48.3193277310924, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI21361647, Length=476, Percent_Identity=47.2689075630252, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17506425, Length=477, Percent_Identity=62.0545073375262, Blast_Score=565, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6320882, Length=490, Percent_Identity=57.5510204081633, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=474, Percent_Identity=60.7594936708861, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24656245, Length=468, Percent_Identity=48.7179487179487, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553387, Length=475, Percent_Identity=48, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553385, Length=474, Percent_Identity=47.8902953586498, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51548; Mature: 51548

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKVADLSLADFGRTEIQLAEHEMPGLMAMRERYAAEQPLAGARIAGSLHMTIQTAVLI
CCEEEEECCHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECEEEEHHHHHHHH
ETLVALGAEVRWASCNIFSTQDHAAAAIAVGPNGTADDPQGVPVFAWKGETLEEYWWCTQ
HHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHH
QILDWPGGTMPNMILDDGGDATLLVHLGVQAEKTGQAPDPASATSNEQRIIFEALGEVLA
HHHHCCCCCCCCEEEECCCCEEEEEEECCCHHCCCCCCCCCCCCCCCCEEHHHHHHHHHH
KNPNHWTPIANSIKGVTEETTTGVHRLYEMMREGSLLFPAINVNDSVTKSKFDNKYGCRH
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCCHH
SLIDGINRATDVLIGGKVAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQASMDGY
HHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCEEEEECCCCCE
QVTTLEDALPIADIIITATGNKDVVTVDHMRSMKHNAIVGNIGHFDNEIDMAGLEAPGVA
EEEEHHHCCCEEEEEEEECCCCCEEEHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCC
ERKNVKPQVDVWTFANGRSVVVLSEGRLMNLGNATGHPSFVMSNSFTNQVLAQIEIFTKT
HHCCCCCCEEEEEECCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHEEEEEEECC
EEYPVGVYVLPKHLDEEVARLHLDALGVKLTRLTDEQATYLGVDAAGPYKPDQYRY
CCCCEEEEECCCHHHHHHHHHHHHHHCEEEEEECCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MDYKVADLSLADFGRTEIQLAEHEMPGLMAMRERYAAEQPLAGARIAGSLHMTIQTAVLI
CCEEEEECCHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECEEEEHHHHHHHH
ETLVALGAEVRWASCNIFSTQDHAAAAIAVGPNGTADDPQGVPVFAWKGETLEEYWWCTQ
HHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHH
QILDWPGGTMPNMILDDGGDATLLVHLGVQAEKTGQAPDPASATSNEQRIIFEALGEVLA
HHHHCCCCCCCCEEEECCCCEEEEEEECCCHHCCCCCCCCCCCCCCCCEEHHHHHHHHHH
KNPNHWTPIANSIKGVTEETTTGVHRLYEMMREGSLLFPAINVNDSVTKSKFDNKYGCRH
CCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCCHH
SLIDGINRATDVLIGGKVAVVCGYGDVGKGCAESLRGQGARVIVTEIDPICALQASMDGY
HHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCEEEEECCCCCE
QVTTLEDALPIADIIITATGNKDVVTVDHMRSMKHNAIVGNIGHFDNEIDMAGLEAPGVA
EEEEHHHCCCEEEEEEEECCCCCEEEHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCC
ERKNVKPQVDVWTFANGRSVVVLSEGRLMNLGNATGHPSFVMSNSFTNQVLAQIEIFTKT
HHCCCCCCEEEEEECCCCEEEEEECCCEEECCCCCCCCCEEEECCHHHHHHEEEEEEECC
EEYPVGVYVLPKHLDEEVARLHLDALGVKLTRLTDEQATYLGVDAAGPYKPDQYRY
CCCCEEEEECCCHHHHHHHHHHHHHHCEEEEEECCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]