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The map label for this gene is manB [H]

Identifier: 119715661

GI number: 119715661

Start: 1508756

End: 1510165

Strand: Direct

Name: manB [H]

Synonym: Noca_1425

Alternate gene names: 119715661

Gene position: 1508756-1510165 (Clockwise)

Preceding gene: 119715660

Following gene: 119715662

Centisome position: 30.26

GC content: 71.21

Gene sequence:

>1410_bases
ATGGCGGACTCCACCCTCGACCCGGCGAACGTCCGCTCGGTGTTCAAAGCCTACGACGTGCGCGGCCTCGTCCCGGACCA
GGTCGACGACGTGCTCGCCCGGGCGACCGGCCGCGCGTTCGTCCGGGTGGTGGGCGCGAGCACGGTGGTCGTCGGACACG
ACATGCGCCCGAGCTCTCCCGGGATGGCTGGCGCGTTCGCCGAGGGCGCGAGTGCCGCGGGCGCCGACGTGGTGATGATC
GGGCTCGCCTCCACCGACCAGCTCTACTTCGCCTCCGGTCACCTCGGCCATCCCGGCGCGATGTTCACCGCCAGTCACAA
CCCTTCGCAGTACAACGGCATCAAGATGTGCCGCAAGCTGGCTCAGCCGGTCGGGATGGAGACCGGCCTCGCCGAGATCC
GCGACCTCGTCCTGAGCGAACCGACCGGCTCGGGACGACCTTCGGCCGGCTCGACGGTCGGGGACATCTCCGAGCACGAC
GTGCTCGAGGCGTACGCCGCCCACCTGCTCGCCCTCGCACCGGTGTCCGGCCGACGGCTCAAGGTGGTGGTCGATGCGGG
CAACGGGATGGCCGGCCACACGGCACCGGCGGTGTTCGCTCGCCTGGGCGCCGCCGTCGAGCTGGTGCCGATGTACTTCG
AGCTCGACGGCACCTTCCCGAACCACGAGGCGAACCCGATCGACCCCGCCAACCTGGTCGACCTCGAACGCCGGGTCCGC
GCCGAGCACGCCGACCTCGGGCTGGCCTTCGACGGTGATGCCGACCGCTGCTTCGTCGTCGACGAGCGGGGCCGGGCCGT
GTCGCCCTCGACGCTCACCGCGCTGATCGCGGCTCGCGAGCTCGCCAAGGAGCCGGGCGCCACGGTGATCCACAACCTGA
TCACCAGCCGCGCCGTCCCCGAGATCGTCCGTGAGCTCGGCGGCACCCCGGTCCGCACCCGGGTCGGGCACTCGTTCATC
AAGGCGACGATGGCCGAGACCGGTGCGATCTTCGGCGGCGAGCACAGCGGGCACTTCTACTTCCGCGACTTCTGGCGCGC
GGACTCCGGCATGCTCGCCGCCCTGCACACGATGGCAGCGCTGGCCGAGACGAAGCAGCCGCTCTCGAGGCTCCTGGCGC
AGTACGAGCGGTACGTCGTCAGCGGCGAGATCAACAGCGAGGCCGCCGAGCCGGCCACGGTGCTGGCGGACATCGAGGCG
GCGTACGCCGGCTCGGACGGTGTCGGCATCGACCACCTCGACGGACTGACGGTCAGCCACGCCGACTGGTCGTTCAACGT
CCGGCCGTCCAACACCGAGCCCCTGCTCCGGCTGAACGCCGAGGGCCGAGACGATGCCACCATGGCCGAGGTGCGCGACC
GCGTGCTCGAGCAGATCCGGGCTGACCACCCGAGCCCCGAGGAGGAGTGA

Upstream 100 bases:

>100_bases
CACGGGTGGCCCCGGCCGCCGAGACCGGCCGCGAGACCGCCCGGCGTGGACACCTGCGGGTGCTGAGCAGCGACTGACGC
TCGCCGATAGGCTGCCAGTC

Downstream 100 bases:

>100_bases
CGTGAACGCCGTGAACATCGATCCCGAGCTGCTGGAGATCATCGTCTGCCCGGCCTGCCGGTCCGAGCTGGACCTGGTCG
AGGCGGAGCTGGTGTGCCGC

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MADSTLDPANVRSVFKAYDVRGLVPDQVDDVLARATGRAFVRVVGASTVVVGHDMRPSSPGMAGAFAEGASAAGADVVMI
GLASTDQLYFASGHLGHPGAMFTASHNPSQYNGIKMCRKLAQPVGMETGLAEIRDLVLSEPTGSGRPSAGSTVGDISEHD
VLEAYAAHLLALAPVSGRRLKVVVDAGNGMAGHTAPAVFARLGAAVELVPMYFELDGTFPNHEANPIDPANLVDLERRVR
AEHADLGLAFDGDADRCFVVDERGRAVSPSTLTALIAARELAKEPGATVIHNLITSRAVPEIVRELGGTPVRTRVGHSFI
KATMAETGAIFGGEHSGHFYFRDFWRADSGMLAALHTMAALAETKQPLSRLLAQYERYVVSGEINSEAAEPATVLADIEA
AYAGSDGVGIDHLDGLTVSHADWSFNVRPSNTEPLLRLNAEGRDDATMAEVRDRVLEQIRADHPSPEEE

Sequences:

>Translated_469_residues
MADSTLDPANVRSVFKAYDVRGLVPDQVDDVLARATGRAFVRVVGASTVVVGHDMRPSSPGMAGAFAEGASAAGADVVMI
GLASTDQLYFASGHLGHPGAMFTASHNPSQYNGIKMCRKLAQPVGMETGLAEIRDLVLSEPTGSGRPSAGSTVGDISEHD
VLEAYAAHLLALAPVSGRRLKVVVDAGNGMAGHTAPAVFARLGAAVELVPMYFELDGTFPNHEANPIDPANLVDLERRVR
AEHADLGLAFDGDADRCFVVDERGRAVSPSTLTALIAARELAKEPGATVIHNLITSRAVPEIVRELGGTPVRTRVGHSFI
KATMAETGAIFGGEHSGHFYFRDFWRADSGMLAALHTMAALAETKQPLSRLLAQYERYVVSGEINSEAAEPATVLADIEA
AYAGSDGVGIDHLDGLTVSHADWSFNVRPSNTEPLLRLNAEGRDDATMAEVRDRVLEQIRADHPSPEEE
>Mature_468_residues
ADSTLDPANVRSVFKAYDVRGLVPDQVDDVLARATGRAFVRVVGASTVVVGHDMRPSSPGMAGAFAEGASAAGADVVMIG
LASTDQLYFASGHLGHPGAMFTASHNPSQYNGIKMCRKLAQPVGMETGLAEIRDLVLSEPTGSGRPSAGSTVGDISEHDV
LEAYAAHLLALAPVSGRRLKVVVDAGNGMAGHTAPAVFARLGAAVELVPMYFELDGTFPNHEANPIDPANLVDLERRVRA
EHADLGLAFDGDADRCFVVDERGRAVSPSTLTALIAARELAKEPGATVIHNLITSRAVPEIVRELGGTPVRTRVGHSFIK
ATMAETGAIFGGEHSGHFYFRDFWRADSGMLAALHTMAALAETKQPLSRLLAQYERYVVSGEINSEAAEPATVLADIEAA
YAGSDGVGIDHLDGLTVSHADWSFNVRPSNTEPLLRLNAEGRDDATMAEVRDRVLEQIRADHPSPEEE

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=450, Percent_Identity=38.6666666666667, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1789566, Length=473, Percent_Identity=28.3298097251586, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 49700; Mature: 49569

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSTLDPANVRSVFKAYDVRGLVPDQVDDVLARATGRAFVRVVGASTVVVGHDMRPSSP
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCC
GMAGAFAEGASAAGADVVMIGLASTDQLYFASGHLGHPGAMFTASHNPSQYNGIKMCRKL
CCCCHHHCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHH
AQPVGMETGLAEIRDLVLSEPTGSGRPSAGSTVGDISEHDVLEAYAAHLLALAPVSGRRL
HHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEE
KVVVDAGNGMAGHTAPAVFARLGAAVELVPMYFELDGTFPNHEANPIDPANLVDLERRVR
EEEEECCCCCCCCHHHHHHHHHCCHHEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
AEHADLGLAFDGDADRCFVVDERGRAVSPSTLTALIAARELAKEPGATVIHNLITSRAVP
HHHCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EIVRELGGTPVRTRVGHSFIKATMAETGAIFGGEHSGHFYFRDFWRADSGMLAALHTMAA
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCEEEHHHHCCCCCHHHHHHHHHH
LAETKQPLSRLLAQYERYVVSGEINSEAAEPATVLADIEAAYAGSDGVGIDHLDGLTVSH
HHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEC
ADWSFNVRPSNTEPLLRLNAEGRDDATMAEVRDRVLEQIRADHPSPEEE
CCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADSTLDPANVRSVFKAYDVRGLVPDQVDDVLARATGRAFVRVVGASTVVVGHDMRPSSP
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCC
GMAGAFAEGASAAGADVVMIGLASTDQLYFASGHLGHPGAMFTASHNPSQYNGIKMCRKL
CCCCHHHCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHH
AQPVGMETGLAEIRDLVLSEPTGSGRPSAGSTVGDISEHDVLEAYAAHLLALAPVSGRRL
HHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEE
KVVVDAGNGMAGHTAPAVFARLGAAVELVPMYFELDGTFPNHEANPIDPANLVDLERRVR
EEEEECCCCCCCCHHHHHHHHHCCHHEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
AEHADLGLAFDGDADRCFVVDERGRAVSPSTLTALIAARELAKEPGATVIHNLITSRAVP
HHHCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EIVRELGGTPVRTRVGHSFIKATMAETGAIFGGEHSGHFYFRDFWRADSGMLAALHTMAA
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCEEEHHHHCCCCCHHHHHHHHHH
LAETKQPLSRLLAQYERYVVSGEINSEAAEPATVLADIEAAYAGSDGVGIDHLDGLTVSH
HHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEC
ADWSFNVRPSNTEPLLRLNAEGRDDATMAEVRDRVLEQIRADHPSPEEE
CCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]