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The map label for this gene is ykuT [H]

Identifier: 119715614

GI number: 119715614

Start: 1454752

End: 1455780

Strand: Reverse

Name: ykuT [H]

Synonym: Noca_1378

Alternate gene names: 119715614

Gene position: 1455780-1454752 (Counterclockwise)

Preceding gene: 119715617

Following gene: 119715612

Centisome position: 29.2

GC content: 69.0

Gene sequence:

>1029_bases
ATGGGGCCCATGTTCGGCTTCGGAGACAGCGACTGCGACACGGGCCACGACCTGTGTGAGTGGACCTTCAAGATGACCGA
CAACCAGGGCGTGGCGAACGCGGTGGATGTGCTGATCGGCAAGCCGCTCTCGATCGCCGGTCTGCTGCTCCTGATGATGG
TCGTCCGGTGGCTGCTGCACCGGCTCGTGGACCGCTTGGTGGTGAGCGCCGAGGACGGCGTGCTGCCCGACCGGGTGAGC
CGGTTCGGCCTGCGCGGCAAGGCCGCGCAGCAGGCGACCGCCCAGGACCTCGCGGCGTCGACCCGCCGGGTGCAGCGCGC
CAAGACCATGGGCGACCTGCTCAAGAGCGTGATCACCGGCCTGCTGATCGCGGTCTTCGGCACCATGATCCTCAGCGAGA
TCGGCGTCAACATCGCCCCGATCATCGCCAGCGCCGGCATCATCGGCATCGCGCTCGGCTTCGGCGCCCAGTCGCTGGTC
AAGGACTTCCTGTCGGGGATCTTCATGATCTTCGAGGACCAGTACGGCGTCGGCGACGTGGTCGACGTCGGCGAGGCGAG
CGGCACGGTCGAGGCGGTGAGCCTGCGCGTCACCCGCCTGCGCGACCTGAACGGGACGGTCTGGTACGTGCCGAACGGCG
AGATCCTGCGGGTCGGGAACATGAGCCAGAACTGGTCGCGGGCGGTGGTCGACGTCAGCGTCGCGTATGGCGAGGACGTC
GCCCGCGTCACCCGCGTCCTCAAGGAGCTGGCGCACGACCTGTGGGAGGACGACGACTTCCACGGCATCATCATCGAGGA
GCCCGAGGTGACCGGGGTCGAGGTCCTCGGCCCCGAGTCGCTGACGCTGCGCGTGCTGCTCAAGACCGCGCCGATGGAGC
AGTGGGGCATCGCCCGCGAGCTGCGCCAACGGATCAAGGCCCGCTTCGACCACGAGGGCATCGAGATCCCGCTCCCCCAG
CGGGTCATCTGGCACCGAGAGCAGCAGACGGGCCCCGCTCCCGAGGAAGCGGAGCCCGTCGAGGGCTGA

Upstream 100 bases:

>100_bases
GCTGAGGACGCTGCGGAGGACGGGGTGCGCGAGCTTCGTGGTCACGCCGCCAGCCTATCGGCTCGGTGGGGTCGAGGAGC
CTAGGCCCGGTGCGGTAGAC

Downstream 100 bases:

>100_bases
TCGGAGGGTCAGGCCAGGGACGCCTCCAGCGTGATCGTGGTGCCGGCGAGCGCCTGGCTGACCGGGCAGCCCTCCTTGGC
GGCCTGGGCGGCCGCGACGA

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MGPMFGFGDSDCDTGHDLCEWTFKMTDNQGVANAVDVLIGKPLSIAGLLLLMMVVRWLLHRLVDRLVVSAEDGVLPDRVS
RFGLRGKAAQQATAQDLAASTRRVQRAKTMGDLLKSVITGLLIAVFGTMILSEIGVNIAPIIASAGIIGIALGFGAQSLV
KDFLSGIFMIFEDQYGVGDVVDVGEASGTVEAVSLRVTRLRDLNGTVWYVPNGEILRVGNMSQNWSRAVVDVSVAYGEDV
ARVTRVLKELAHDLWEDDDFHGIIIEEPEVTGVEVLGPESLTLRVLLKTAPMEQWGIARELRQRIKARFDHEGIEIPLPQ
RVIWHREQQTGPAPEEAEPVEG

Sequences:

>Translated_342_residues
MGPMFGFGDSDCDTGHDLCEWTFKMTDNQGVANAVDVLIGKPLSIAGLLLLMMVVRWLLHRLVDRLVVSAEDGVLPDRVS
RFGLRGKAAQQATAQDLAASTRRVQRAKTMGDLLKSVITGLLIAVFGTMILSEIGVNIAPIIASAGIIGIALGFGAQSLV
KDFLSGIFMIFEDQYGVGDVVDVGEASGTVEAVSLRVTRLRDLNGTVWYVPNGEILRVGNMSQNWSRAVVDVSVAYGEDV
ARVTRVLKELAHDLWEDDDFHGIIIEEPEVTGVEVLGPESLTLRVLLKTAPMEQWGIARELRQRIKARFDHEGIEIPLPQ
RVIWHREQQTGPAPEEAEPVEG
>Mature_341_residues
GPMFGFGDSDCDTGHDLCEWTFKMTDNQGVANAVDVLIGKPLSIAGLLLLMMVVRWLLHRLVDRLVVSAEDGVLPDRVSR
FGLRGKAAQQATAQDLAASTRRVQRAKTMGDLLKSVITGLLIAVFGTMILSEIGVNIAPIIASAGIIGIALGFGAQSLVK
DFLSGIFMIFEDQYGVGDVVDVGEASGTVEAVSLRVTRLRDLNGTVWYVPNGEILRVGNMSQNWSRAVVDVSVAYGEDVA
RVTRVLKELAHDLWEDDDFHGIIIEEPEVTGVEVLGPESLTLRVLLKTAPMEQWGIARELRQRIKARFDHEGIEIPLPQR
VIWHREQQTGPAPEEAEPVEG

Specific function: May play a role in resistance to osmotic downshock [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI87081787, Length=249, Percent_Identity=32.9317269076305, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789291, Length=218, Percent_Identity=28.8990825688073, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786670, Length=161, Percent_Identity=29.1925465838509, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI2367355, Length=215, Percent_Identity=26.5116279069767, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR011014 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 37375; Mature: 37243

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPMFGFGDSDCDTGHDLCEWTFKMTDNQGVANAVDVLIGKPLSIAGLLLLMMVVRWLLH
CCCCCCCCCCCCCCCHHHHHHHEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RLVDRLVVSAEDGVLPDRVSRFGLRGKAAQQATAQDLAASTRRVQRAKTMGDLLKSVITG
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLIAVFGTMILSEIGVNIAPIIASAGIIGIALGFGAQSLVKDFLSGIFMIFEDQYGVGDV
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCH
VDVGEASGTVEAVSLRVTRLRDLNGTVWYVPNGEILRVGNMSQNWSRAVVDVSVAYGEDV
HCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCHHEEEEEHHHCCHH
ARVTRVLKELAHDLWEDDDFHGIIIEEPEVTGVEVLGPESLTLRVLLKTAPMEQWGIARE
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCEEEEEHHHHCCCHHHHHHHH
LRQRIKARFDHEGIEIPLPQRVIWHREQQTGPAPEEAEPVEG
HHHHHHHHCCCCCCCCCCCHHHHHHCHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
GPMFGFGDSDCDTGHDLCEWTFKMTDNQGVANAVDVLIGKPLSIAGLLLLMMVVRWLLH
CCCCCCCCCCCCCCHHHHHHHEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RLVDRLVVSAEDGVLPDRVSRFGLRGKAAQQATAQDLAASTRRVQRAKTMGDLLKSVITG
HHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLIAVFGTMILSEIGVNIAPIIASAGIIGIALGFGAQSLVKDFLSGIFMIFEDQYGVGDV
HHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCH
VDVGEASGTVEAVSLRVTRLRDLNGTVWYVPNGEILRVGNMSQNWSRAVVDVSVAYGEDV
HCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCHHEEEEEHHHCCHH
ARVTRVLKELAHDLWEDDDFHGIIIEEPEVTGVEVLGPESLTLRVLLKTAPMEQWGIARE
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCEEEEEHHHHCCCHHHHHHHH
LRQRIKARFDHEGIEIPLPQRVIWHREQQTGPAPEEAEPVEG
HHHHHHHHCCCCCCCCCCCHHHHHHCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]