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The map label for this gene is accD [C]

Identifier: 119715484

GI number: 119715484

Start: 1323588

End: 1325156

Strand: Direct

Name: accD [C]

Synonym: Noca_1248

Alternate gene names: 119715484

Gene position: 1323588-1325156 (Clockwise)

Preceding gene: 119715483

Following gene: 119715485

Centisome position: 26.55

GC content: 70.3

Gene sequence:

>1569_bases
GTGAGCAAGCACAAGCAGCACCAGGCCTCCATGGAGGAGCGCACCTCCGAGCTCGCGGAGCGGCGCCACAAGGTCGAGCT
CGGCGGCGGCGAGTCCCGCCAGCAGAAGCAGCACGACCAGGGCAAGCTGACCGCCCGCGAGCGGATCGAGGCGCTGATCG
ACCCCGGCACGTTCCAGGAGACGGGGATGTTCGCCCGGCACCAGTCGACGTACTTCGGGCTCGACAAGGCCGACTACCCG
GCCGACGGCGTGGTCACCGGCGAGGGCGCCGTCCTCGGCCGTCCGATCCACGTAGCCAGCCAGGACTTCACGGTCGCCGG
CGGCTCCGCGGGCGAGGTGCACAGCGACAAGGTCGTCGCGATGATGCAGGCGAGCCTGACCACCGGCACGCCGTTCGTGT
TCATCAACGACTCCGGCGGCGCCCGCGTCCAGGAGGGCATCGGCTCCCTGGCCGGCTACGGCCGGGTGTTCTACAGCAAC
GTGCTGCTCTCCGGTGTGGTCCCGCAGATCGCGATCATCGCGGGGCCGTGCGCGGGCGGCGCGGCGTACTCCCCGGCGCT
GACCGACTTCATCATCCAGACCCGCAAGGCCCACATGTTCATCACCGGGCCCAACGTGATCGCCCAGGTCACCGGCGAGC
AGGTCTCCTCCGACGCGCTCGGCGGCGCGGACGCGCACATGGCGCGCTCCGGCGTCACCCACTTCGTGGCCGACGACGAC
GAGCAGGCGGTGCTGATCACCAAGAAGCTGCTCAGCTTCCTGCCGCAGAACAACACCGAGGACCCGCCGATCGTCGACCC
CGACGACACCATCGAGCCGGACCTGGAGCTGCCGAAGGTGGTGCCGGTCTCGGACAAGAAGGGGTACGACGTGCGCGAGG
TGATCGCGCGGATCGTCGACCGCGCGGACTTCCTCGAGGTGCAGGCGGGCTACGCCCAGAACATCGTGATCGGCTTCGGC
CGGATCACCGGGCGCACGGTCGGCATCGTCGCCAACCAGCCCAGCGTGATCTCCGGCGTGCTCGACATCAACGCCTCCGA
CAAGGGCTCGTGGTTCGTGCGGTTCTGCAACGCGTTCAACATCCCGCTGGTGACCCTGGTCGACGTGCCGGGCTTCCTGC
CGGGCGTCGCGCAGGAGCACGGCGGCATCATCCGCCACGGCGCGAAGCTGCTCTACGCCTACTCCGCGGCGACGGTCCCG
AAGATCACCGTGGTGCTGCGCAAGGCCTACGGCGGCGCGTACGTCGCGATGTGCTCGAAGGACCTGGGCGCCGACAAGGT
GTTCGCCTGGCCGACGGCCGAGATCGCGGTGATGGGCGCCGAGGGCGCGGCCGAGATCGTGTTCCGGCGCGAGATCGCCG
ACGCCGAGGACCCCGACACCCGGCGCGCGGAGCTGGTCGACGAGTACCGCTCGACGTTCTCCACGCCGTACGTCGCGGCC
GGCCGGGGCCTGGTCGACGACATCATCGACCCGTGCTGCACCCGGGCGCACATCTCGCGGGCGCTGGAGATGCTGGCCAG
CAAGCGCGAGCTGCGGCCCGCCAAGAAGCACGGGCTGGGCCCGACGTGA

Upstream 100 bases:

>100_bases
GCGCCCGGCACCGGCCCGGTCACGGGCCCCATCCACTACGCCGTCTCGATGAACGGCCGCAAGCACGACGTCACCGTCGA
GCGAGCCTGAAGGGAATCCG

Downstream 100 bases:

>100_bases
GCGGCAGCGACATGCAGGAGCTGCTCGCGGCGGTCCGCGAGCTCACCGAGCGGGTCGCGGCCCTCGAGGCCGAGGTCGCC
GCCGTACGGACGCGGCAGGA

Product: carboxyl transferase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSKHKQHQASMEERTSELAERRHKVELGGGESRQQKQHDQGKLTARERIEALIDPGTFQETGMFARHQSTYFGLDKADYP
ADGVVTGEGAVLGRPIHVASQDFTVAGGSAGEVHSDKVVAMMQASLTTGTPFVFINDSGGARVQEGIGSLAGYGRVFYSN
VLLSGVVPQIAIIAGPCAGGAAYSPALTDFIIQTRKAHMFITGPNVIAQVTGEQVSSDALGGADAHMARSGVTHFVADDD
EQAVLITKKLLSFLPQNNTEDPPIVDPDDTIEPDLELPKVVPVSDKKGYDVREVIARIVDRADFLEVQAGYAQNIVIGFG
RITGRTVGIVANQPSVISGVLDINASDKGSWFVRFCNAFNIPLVTLVDVPGFLPGVAQEHGGIIRHGAKLLYAYSAATVP
KITVVLRKAYGGAYVAMCSKDLGADKVFAWPTAEIAVMGAEGAAEIVFRREIADAEDPDTRRAELVDEYRSTFSTPYVAA
GRGLVDDIIDPCCTRAHISRALEMLASKRELRPAKKHGLGPT

Sequences:

>Translated_522_residues
MSKHKQHQASMEERTSELAERRHKVELGGGESRQQKQHDQGKLTARERIEALIDPGTFQETGMFARHQSTYFGLDKADYP
ADGVVTGEGAVLGRPIHVASQDFTVAGGSAGEVHSDKVVAMMQASLTTGTPFVFINDSGGARVQEGIGSLAGYGRVFYSN
VLLSGVVPQIAIIAGPCAGGAAYSPALTDFIIQTRKAHMFITGPNVIAQVTGEQVSSDALGGADAHMARSGVTHFVADDD
EQAVLITKKLLSFLPQNNTEDPPIVDPDDTIEPDLELPKVVPVSDKKGYDVREVIARIVDRADFLEVQAGYAQNIVIGFG
RITGRTVGIVANQPSVISGVLDINASDKGSWFVRFCNAFNIPLVTLVDVPGFLPGVAQEHGGIIRHGAKLLYAYSAATVP
KITVVLRKAYGGAYVAMCSKDLGADKVFAWPTAEIAVMGAEGAAEIVFRREIADAEDPDTRRAELVDEYRSTFSTPYVAA
GRGLVDDIIDPCCTRAHISRALEMLASKRELRPAKKHGLGPT
>Mature_521_residues
SKHKQHQASMEERTSELAERRHKVELGGGESRQQKQHDQGKLTARERIEALIDPGTFQETGMFARHQSTYFGLDKADYPA
DGVVTGEGAVLGRPIHVASQDFTVAGGSAGEVHSDKVVAMMQASLTTGTPFVFINDSGGARVQEGIGSLAGYGRVFYSNV
LLSGVVPQIAIIAGPCAGGAAYSPALTDFIIQTRKAHMFITGPNVIAQVTGEQVSSDALGGADAHMARSGVTHFVADDDE
QAVLITKKLLSFLPQNNTEDPPIVDPDDTIEPDLELPKVVPVSDKKGYDVREVIARIVDRADFLEVQAGYAQNIVIGFGR
ITGRTVGIVANQPSVISGVLDINASDKGSWFVRFCNAFNIPLVTLVDVPGFLPGVAQEHGGIIRHGAKLLYAYSAATVPK
ITVVLRKAYGGAYVAMCSKDLGADKVFAWPTAEIAVMGAEGAAEIVFRREIADAEDPDTRRAELVDEYRSTFSTPYVAAG
RGLVDDIIDPCCTRAHISRALEMLASKRELRPAKKHGLGPT

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=518, Percent_Identity=51.5444015444015, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI295821216, Length=538, Percent_Identity=49.6282527881041, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI11545863, Length=506, Percent_Identity=35.5731225296443, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI134142062, Length=396, Percent_Identity=23.2323232323232, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI38679960, Length=349, Percent_Identity=24.3553008595989, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38679977, Length=349, Percent_Identity=24.3553008595989, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38679967, Length=349, Percent_Identity=24.3553008595989, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38679971, Length=349, Percent_Identity=24.3553008595989, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38679974, Length=349, Percent_Identity=24.3553008595989, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1788655, Length=188, Percent_Identity=28.1914893617021, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=52.8487229862475, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=52.8487229862475, Blast_Score=536, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17552936, Length=519, Percent_Identity=35.2601156069364, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71997163, Length=317, Percent_Identity=25.8675078864353, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI133931226, Length=268, Percent_Identity=23.5074626865672, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324343, Length=384, Percent_Identity=23.4375, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323863, Length=352, Percent_Identity=20.7386363636364, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24586065, Length=534, Percent_Identity=33.1460674157303, Blast_Score=261, Evalue=7e-70,
Organism=Drosophila melanogaster, GI161076407, Length=321, Percent_Identity=23.3644859813084, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586460, Length=321, Percent_Identity=23.3644859813084, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586458, Length=369, Percent_Identity=23.5772357723577, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076409, Length=321, Percent_Identity=23.3644859813084, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 55853; Mature: 55722

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKHKQHQASMEERTSELAERRHKVELGGGESRQQKQHDQGKLTARERIEALIDPGTFQE
CCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHH
TGMFARHQSTYFGLDKADYPADGVVTGEGAVLGRPIHVASQDFTVAGGSAGEVHSDKVVA
HCCHHHCCCCEECCCCCCCCCCCEEECCCCEECCCEEECCCCEEEECCCCCCCCCCHHHH
MMQASLTTGTPFVFINDSGGARVQEGIGSLAGYGRVFYSNVLLSGVVPQIAIIAGPCAGG
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
AAYSPALTDFIIQTRKAHMFITGPNVIAQVTGEQVSSDALGGADAHMARSGVTHFVADDD
CCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCHHCCCCCCCCHHHHHHCCCEEEEECCC
EQAVLITKKLLSFLPQNNTEDPPIVDPDDTIEPDLELPKVVPVSDKKGYDVREVIARIVD
CCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHC
RADFLEVQAGYAQNIVIGFGRITGRTVGIVANQPSVISGVLDINASDKGSWFVRFCNAFN
CHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCC
IPLVTLVDVPGFLPGVAQEHGGIIRHGAKLLYAYSAATVPKITVVLRKAYGGAYVAMCSK
CCEEEEECCCCCCCCHHHHCCCHHHHCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECC
DLGADKVFAWPTAEIAVMGAEGAAEIVFRREIADAEDPDTRRAELVDEYRSTFSTPYVAA
CCCCCCEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHC
GRGLVDDIIDPCCTRAHISRALEMLASKRELRPAKKHGLGPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
SKHKQHQASMEERTSELAERRHKVELGGGESRQQKQHDQGKLTARERIEALIDPGTFQE
CCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHH
TGMFARHQSTYFGLDKADYPADGVVTGEGAVLGRPIHVASQDFTVAGGSAGEVHSDKVVA
HCCHHHCCCCEECCCCCCCCCCCEEECCCCEECCCEEECCCCEEEECCCCCCCCCCHHHH
MMQASLTTGTPFVFINDSGGARVQEGIGSLAGYGRVFYSNVLLSGVVPQIAIIAGPCAGG
HHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCC
AAYSPALTDFIIQTRKAHMFITGPNVIAQVTGEQVSSDALGGADAHMARSGVTHFVADDD
CCCCHHHHHHHHHHCCCEEEEECCCEEEEECCCHHCCCCCCCCHHHHHHCCCEEEEECCC
EQAVLITKKLLSFLPQNNTEDPPIVDPDDTIEPDLELPKVVPVSDKKGYDVREVIARIVD
CCEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHC
RADFLEVQAGYAQNIVIGFGRITGRTVGIVANQPSVISGVLDINASDKGSWFVRFCNAFN
CHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCC
IPLVTLVDVPGFLPGVAQEHGGIIRHGAKLLYAYSAATVPKITVVLRKAYGGAYVAMCSK
CCEEEEECCCCCCCCHHHHCCCHHHHCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECC
DLGADKVFAWPTAEIAVMGAEGAAEIVFRREIADAEDPDTRRAELVDEYRSTFSTPYVAA
CCCCCCEEECCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHC
GRGLVDDIIDPCCTRAHISRALEMLASKRELRPAKKHGLGPT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]