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The map label for this gene is paaX [H]

Identifier: 119715442

GI number: 119715442

Start: 1279978

End: 1280754

Strand: Reverse

Name: paaX [H]

Synonym: Noca_1206

Alternate gene names: 119715442

Gene position: 1280754-1279978 (Counterclockwise)

Preceding gene: 119715445

Following gene: 119715441

Centisome position: 25.69

GC content: 77.61

Gene sequence:

>777_bases
ATGCAGGCCCGCTCGGCGCTCTTCGACGTGTACGGCGACCACCTGCGCGCGCGCGGCAGCGAGGCCCCGGTGGCCGCGTT
GGTGCGGCTCCTGGACCCGGTCGGCATCGCGGCCCCGGCCGTGCGCACGGCGATCTCCCGGATGGTGATGCAGGGCTGGC
TCGAGCCGGTCCAGCTCGACGGCGGCCGCGGCTACCGCACCACCACGCGGGCGGACCGGCGTCTCGACGAGACCGGGCGT
CGCGTCTACCGCCGCGACGCACCCGCCTGGGACGGCCACTGGCACCTGGCGTTCGTCAGCCCGCCGCCGGGCCGGGCCGC
CCGGGCCCGGCTGCGCGCCGGGCTCACCTTCATCGGGTACGCCGAGCTCGCCGACCACGTGTGGGTCACCCCGTTCGAGC
GGACCGAGCTCGGCTCGGTGCTGGACCGCGAGCGCGCCAGCGCCACGACCGCGCGGGCCGACCGCTTCGACCCCCCGCCG
ACCGGCGCCTGGGACCTGGCCGCCCTGCGGCTGGCCTACGAGGGGTGGCTGCAGGCCGCCGACGACCTGGTCGAACAGCA
CCTCGCCGCCCACGAGGACCCCGACGAGGCCGCGTTCGCGGCCCGGTTCCACCTCGTCCACGAGTGGCGCAAGTTCCTCT
TCACCGACCCCGGGCTGCCCGACGCCCTGCTGCCGCGCGACTGGCCGGGCCACGCCGCGGCCGAGCTGTTCGCGGGCGCG
GCCGGCCGGCTCAAGCCGGGGGCCGACCGGTTCGTGGCCCGCTGCCTGGGCGACTGA

Upstream 100 bases:

>100_bases
ACCCGGCTGCGCCGTACGCACGGACCATTATCCCCTATCCGACGGTGACGCGGAGCACAGCCCGCCCGGAGCCCGGCCGG
GCTACTGGCACACTCCTGAC

Downstream 100 bases:

>100_bases
CACCGCCGTACCCGCCGGCCCCCGGCCCTCGGCCCGACCTGACAGGATGCCCGCATGACCGAGCCCTCCGTCCTCCTCGA
CGTCACCGACGGCGTCGGGA

Product: PaaX domain-containing protein, C- domain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MQARSALFDVYGDHLRARGSEAPVAALVRLLDPVGIAAPAVRTAISRMVMQGWLEPVQLDGGRGYRTTTRADRRLDETGR
RVYRRDAPAWDGHWHLAFVSPPPGRAARARLRAGLTFIGYAELADHVWVTPFERTELGSVLDRERASATTARADRFDPPP
TGAWDLAALRLAYEGWLQAADDLVEQHLAAHEDPDEAAFAARFHLVHEWRKFLFTDPGLPDALLPRDWPGHAAAELFAGA
AGRLKPGADRFVARCLGD

Sequences:

>Translated_258_residues
MQARSALFDVYGDHLRARGSEAPVAALVRLLDPVGIAAPAVRTAISRMVMQGWLEPVQLDGGRGYRTTTRADRRLDETGR
RVYRRDAPAWDGHWHLAFVSPPPGRAARARLRAGLTFIGYAELADHVWVTPFERTELGSVLDRERASATTARADRFDPPP
TGAWDLAALRLAYEGWLQAADDLVEQHLAAHEDPDEAAFAARFHLVHEWRKFLFTDPGLPDALLPRDWPGHAAAELFAGA
AGRLKPGADRFVARCLGD
>Mature_258_residues
MQARSALFDVYGDHLRARGSEAPVAALVRLLDPVGIAAPAVRTAISRMVMQGWLEPVQLDGGRGYRTTTRADRRLDETGR
RVYRRDAPAWDGHWHLAFVSPPPGRAARARLRAGLTFIGYAELADHVWVTPFERTELGSVLDRERASATTARADRFDPPP
TGAWDLAALRLAYEGWLQAADDLVEQHLAAHEDPDEAAFAARFHLVHEWRKFLFTDPGLPDALLPRDWPGHAAAELFAGA
AGRLKPGADRFVARCLGD

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=261, Percent_Identity=28.735632183908, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 28498; Mature: 28498

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQARSALFDVYGDHLRARGSEAPVAALVRLLDPVGIAAPAVRTAISRMVMQGWLEPVQLD
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEC
GGRGYRTTTRADRRLDETGRRVYRRDAPAWDGHWHLAFVSPPPGRAARARLRAGLTFIGY
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHEEH
AELADHVWVTPFERTELGSVLDRERASATTARADRFDPPPTGAWDLAALRLAYEGWLQAA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DDLVEQHLAAHEDPDEAAFAARFHLVHEWRKFLFTDPGLPDALLPRDWPGHAAAELFAGA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCC
AGRLKPGADRFVARCLGD
CCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MQARSALFDVYGDHLRARGSEAPVAALVRLLDPVGIAAPAVRTAISRMVMQGWLEPVQLD
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEC
GGRGYRTTTRADRRLDETGRRVYRRDAPAWDGHWHLAFVSPPPGRAARARLRAGLTFIGY
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHEEH
AELADHVWVTPFERTELGSVLDRERASATTARADRFDPPPTGAWDLAALRLAYEGWLQAA
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DDLVEQHLAAHEDPDEAAFAARFHLVHEWRKFLFTDPGLPDALLPRDWPGHAAAELFAGA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCC
AGRLKPGADRFVARCLGD
CCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]