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The map label for this gene is moaE2 [H]

Identifier: 119715038

GI number: 119715038

Start: 835115

End: 836356

Strand: Direct

Name: moaE2 [H]

Synonym: Noca_0791

Alternate gene names: 119715038

Gene position: 835115-836356 (Clockwise)

Preceding gene: 119715037

Following gene: 119715039

Centisome position: 16.75

GC content: 74.64

Gene sequence:

>1242_bases
ATGGCTGAGGTCCTGATCTCGGTCGACGACCACCTCGCCCGGATCCTCGCGGAGATCGAGCCGCTGCCGGACTTCCCCCA
GCCACTGATGGACGCGCTGGGCCTGGCCGTGGCCGAGGACGTGGTCGCGCCGATCGGGCTGCCGTCGTTCGACAACTCCG
CGATGGACGGGTACGCCGTGCGCCACGCGGACGTCGTGACCGCCACCGAGGAGTCCCCGGTGCACCTGCCGGTGGTCGGC
GAGATCGGGGCCGGCCAGGCGCAGCTGCTCGCGATGTCGCCCGGCACGGCGGTGAAGATCATGACCGGCGCCCCGGTGCC
GGCCGGCGCCGACAGCGTGGTGCCCTACGAGTGGACCGACCGGGGCGTCGCCCAGGTCCGCATCGAGCGCGCGCCCTCCC
TCGGCCAGCACGTGCGACCCGCCGGCGAGGACGTCGCCGCCGGGGACCTGGTCGTCTCCCGCGGCACCGTGCTCGGCCCT
CGCCACCTCGGCCTGCTCGCCTCCGTCGGCCGCGCCGCGGTCCGGTCCCGGCCGCGCCCGCGGGTCGTGGTCATCTCGAC
CGGCTCGGAGCTGCGCGAGCCCGGTGCCGAGCTCGGGCACGACTCGATCTACGACGGCAACTCCTTCCTCCTCGCGGCCG
CCGCCCGGGCCGCGGGCGCGATCACCTACCGGGTCGGCATCGTCCCGGACGAGCCGCGCGCGTTCCTCGCCGCCGTGCAC
GACCAGCTGGTCCGCGCCGACCTGGTCGTCACCAGCGGCGGCGTCTCGCAGGGCGACTACGACGTGGTCAAGGAGGCGCT
CCGCCCGCTGGGGACCGTGTGGTTCGGCGGGGTGGCGATGCAGCCCGGCAAGCCGCAGGGCTTCGGCCACGTCGGCGAGG
ACCGGACCCCGATCTTCACGCTGCCGGGCAACCCGGTCTCGTCGTACATCTCCTTCCAGCAGTTCGTGCTGCCGGCGCTG
CGCAAGCTGATGGGGCGCACGCCGTACGCCCGTCCGACGACGCCCGCGCGGCTCACGCACGCCATCCGCTCCCCGGAGGG
CAAGCGGCAGTTCGTGCGCGCGGAGTACGCCGTCGACCCGGCCGGCCGCGCCGGCCCGTCGGTGACCCCGGTCGGCGGCC
ACGGTTCCCACCTGATCGGCGATCTGGCATCCTCCGACGCGCTGGTCGTCGTGCCGGCGGACGTCACCTCCGTCGAGGCC
GGCGAGCAGGTCCAGGTCCTGAGGCTCGACGAGGAGTTCTGA

Upstream 100 bases:

>100_bases
GAGGGCGACTGGACCTTCGCGCACGGGGTGCAGGTCGTGGGCGATGTGAACCTGGAGGCGAGCTCCGCGCAGCGCGTCGA
CGCCGACACCGTCCTCTCCG

Downstream 100 bases:

>100_bases
CGATGTCCGATTCGCCCCGGCGGCTCACCCACGTCGACGAGTCCGGGGCGGCCCGGATGGTCGACGTCTCCGGCAAGGAC
GTCACCGCCCGCACGGCGAC

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase 2 [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MAEVLISVDDHLARILAEIEPLPDFPQPLMDALGLAVAEDVVAPIGLPSFDNSAMDGYAVRHADVVTATEESPVHLPVVG
EIGAGQAQLLAMSPGTAVKIMTGAPVPAGADSVVPYEWTDRGVAQVRIERAPSLGQHVRPAGEDVAAGDLVVSRGTVLGP
RHLGLLASVGRAAVRSRPRPRVVVISTGSELREPGAELGHDSIYDGNSFLLAAAARAAGAITYRVGIVPDEPRAFLAAVH
DQLVRADLVVTSGGVSQGDYDVVKEALRPLGTVWFGGVAMQPGKPQGFGHVGEDRTPIFTLPGNPVSSYISFQQFVLPAL
RKLMGRTPYARPTTPARLTHAIRSPEGKRQFVRAEYAVDPAGRAGPSVTPVGGHGSHLIGDLASSDALVVVPADVTSVEA
GEQVQVLRLDEEF

Sequences:

>Translated_413_residues
MAEVLISVDDHLARILAEIEPLPDFPQPLMDALGLAVAEDVVAPIGLPSFDNSAMDGYAVRHADVVTATEESPVHLPVVG
EIGAGQAQLLAMSPGTAVKIMTGAPVPAGADSVVPYEWTDRGVAQVRIERAPSLGQHVRPAGEDVAAGDLVVSRGTVLGP
RHLGLLASVGRAAVRSRPRPRVVVISTGSELREPGAELGHDSIYDGNSFLLAAAARAAGAITYRVGIVPDEPRAFLAAVH
DQLVRADLVVTSGGVSQGDYDVVKEALRPLGTVWFGGVAMQPGKPQGFGHVGEDRTPIFTLPGNPVSSYISFQQFVLPAL
RKLMGRTPYARPTTPARLTHAIRSPEGKRQFVRAEYAVDPAGRAGPSVTPVGGHGSHLIGDLASSDALVVVPADVTSVEA
GEQVQVLRLDEEF
>Mature_412_residues
AEVLISVDDHLARILAEIEPLPDFPQPLMDALGLAVAEDVVAPIGLPSFDNSAMDGYAVRHADVVTATEESPVHLPVVGE
IGAGQAQLLAMSPGTAVKIMTGAPVPAGADSVVPYEWTDRGVAQVRIERAPSLGQHVRPAGEDVAAGDLVVSRGTVLGPR
HLGLLASVGRAAVRSRPRPRVVVISTGSELREPGAELGHDSIYDGNSFLLAAAARAAGAITYRVGIVPDEPRAFLAAVHD
QLVRADLVVTSGGVSQGDYDVVKEALRPLGTVWFGGVAMQPGKPQGFGHVGEDRTPIFTLPGNPVSSYISFQQFVLPALR
KLMGRTPYARPTTPARLTHAIRSPEGKRQFVRAEYAVDPAGRAGPSVTPVGGHGSHLIGDLASSDALVVVPADVTSVEAG
EQVQVLRLDEEF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=396, Percent_Identity=36.6161616161616, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI66932975, Length=396, Percent_Identity=36.6161616161616, Blast_Score=198, Evalue=1e-50,
Organism=Escherichia coli, GI1787049, Length=392, Percent_Identity=37.5, Blast_Score=224, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI25147659, Length=359, Percent_Identity=30.9192200557103, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=382, Percent_Identity=25.9162303664921, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136978, Length=387, Percent_Identity=32.0413436692506, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24638841, Length=387, Percent_Identity=32.0413436692506, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43238; Mature: 43106

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVLISVDDHLARILAEIEPLPDFPQPLMDALGLAVAEDVVAPIGLPSFDNSAMDGYAV
CCEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
RHADVVTATEESPVHLPVVGEIGAGQAQLLAMSPGTAVKIMTGAPVPAGADSVVPYEWTD
EECEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCC
RGVAQVRIERAPSLGQHVRPAGEDVAAGDLVVSRGTVLGPRHLGLLASVGRAAVRSRPRP
CCEEEEEEECCCCCCHHCCCCCCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHCCCCC
RVVVISTGSELREPGAELGHDSIYDGNSFLLAAAARAAGAITYRVGIVPDEPRAFLAAVH
EEEEEECCHHHHCCCHHCCCCCEECCCCEEEEEHHHHCCEEEEEEECCCCCHHHHHHHHH
DQLVRADLVVTSGGVSQGDYDVVKEALRPLGTVWFGGVAMQPGKPQGFGHVGEDRTPIFT
HHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEE
LPGNPVSSYISFQQFVLPALRKLMGRTPYARPTTPARLTHAIRSPEGKRQFVRAEYAVDP
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHEEHHEEECC
AGRAGPSVTPVGGHGSHLIGDLASSDALVVVPADVTSVEAGEQVQVLRLDEEF
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure 
AEVLISVDDHLARILAEIEPLPDFPQPLMDALGLAVAEDVVAPIGLPSFDNSAMDGYAV
CEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
RHADVVTATEESPVHLPVVGEIGAGQAQLLAMSPGTAVKIMTGAPVPAGADSVVPYEWTD
EECEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCC
RGVAQVRIERAPSLGQHVRPAGEDVAAGDLVVSRGTVLGPRHLGLLASVGRAAVRSRPRP
CCEEEEEEECCCCCCHHCCCCCCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHCCCCC
RVVVISTGSELREPGAELGHDSIYDGNSFLLAAAARAAGAITYRVGIVPDEPRAFLAAVH
EEEEEECCHHHHCCCHHCCCCCEECCCCEEEEEHHHHCCEEEEEEECCCCCHHHHHHHHH
DQLVRADLVVTSGGVSQGDYDVVKEALRPLGTVWFGGVAMQPGKPQGFGHVGEDRTPIFT
HHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEE
LPGNPVSSYISFQQFVLPALRKLMGRTPYARPTTPARLTHAIRSPEGKRQFVRAEYAVDP
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHEEHHEEECC
AGRAGPSVTPVGGHGSHLIGDLASSDALVVVPADVTSVEAGEQVQVLRLDEEF
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]