Click here to switch to the map view.

The map label for this gene is emrB [C]

Identifier: 119715020

GI number: 119715020

Start: 816194

End: 817750

Strand: Direct

Name: emrB [C]

Synonym: Noca_0773

Alternate gene names: 119715020

Gene position: 816194-817750 (Clockwise)

Preceding gene: 119715019

Following gene: 119715021

Centisome position: 16.37

GC content: 69.81

Gene sequence:

>1557_bases
ATGTCACACCGCGAGATCCTCGAGGCCCTCAGCGGCCTGCTCCTCGCCATGTTCGTCGCGATGCTGTCCAGCACGGTCGT
CACCAACGCCTTGCCGCGGATGGTCGCGGACCTGCACGGCAGCCAGACCGGCTACACCTGGGTCGTGGTCGCCACCATGC
TGGCGATGACCGCGACCACGCCGATCTGGGGCAAGCTCTCGGACCTGTTCAGCAAGAAGATGCTGGTCCAGCTCGCCCTG
GTCATCTACATCGTCGGGTCGCTCATCGCGGCCTTCGCGCCCAGCATGGAGGTGCTGATCGGCGCGCGGGCCGTGCAGGG
GCTCGGCGTCGGCGGTCTCACGGCCCTGGTCCAGGTCGTGATCGCGACGATGATCTCGCCGCGCGAGCGCGGGCGGTACT
CCGGCTACCTGGGCGCAGTCTTCGCGCTCGCGACCGTGAGCGGACCACTGATCGGCGGCGTGATCGTGGACTCCGCCCTC
GGCTGGCGGGGCTGCTTCTTCGTCGGCCTGCCGATCGCGGTGGCGGCGTTCTTCCTGCTCCAGAAGACCCTGCACCTGCC
GGTCGTGAAGCGGCCCGTGCACATCGACTACCTCGGCGCCACGCTCCTCGTCGGCGGCGTCTCCACCCTGCTCGTGTGGA
TCAGCCTCGCCGGCAATCAGTTCGCGTGGGCGTCCAGCACCACCGCCGTGCTCGTCGTGGCCGGGGTGCTGATGCTGGTC
GCCGCGGTGTACGTCGAGGCCAGGGTCGCGGTCGAGCCGGTGATCCCACTGCGCCTGTTCCGTGACCGCACCACCACGCT
GGCCACGATCGCCTCGGTGATGATCGGCGTCGCGATGTTCGGCTCCACCGTCTACCTGAGCCAGTACTTCCAGACCGCCC
GCGGCATGAGCCCCACCGAGGCCGGCCTGATGTCGATCGCGATGGTCGGCGGCCTGTTCGTCTCCAGCGTCGTGAGCGGC
CGGATCATCAGTGACACCGGCATCTGGAAGCGCTGGCTGGTCGGCGGGATGCTGCTCGTCGTCGTCGGCCTGGCGCTGCT
CGGCACCATCGACGAGACCACCAGCCTGGTCGTGATCGGCGGGTTCATGGCGATCCTCGGCGTCGGCCTCGGCGCGACCA
TGCAGAACCTGGTGCTCTCGGTCCAGAACAACGTCACCCTCGCCGACATGGGCGCGGCAAGCTCCGTGGTCGCGTTCTTC
CGGTCGATGGGCGGCTCGATCGGCGTCTCCGCGCTGGGCGCGCTGCTGAGCCACCAGGTCGCCGCGCAGGTGACGGAGGG
GTACGTCGCCGCGCAGCGACCGCCGACGTTCCCGGCCGGCAGCCACGCCGTGCCGGACGTCACGACCCTGCCGGGCTGGG
AGCAGAGCATCTGGGAGCACGCGTTCGGCTCGTCCTTCGGACACCTCTTCTTCGTGGCGACGCCGTTCGCGCTGGTCGCC
CTGCTCTGCGTGCTGCTCGTCCGGGAGGTGCCGCTGCGCACGTCCAACCTCGAGGCCGAGGCCGCGGCCTCCCCGGAGGT
CGCGGCGGAGCTGCACCGTGCGATCGTGAGGAAGTGA

Upstream 100 bases:

>100_bases
TGTCCGCGACAACCTTCTACTCGCCGTGAATCGAGCTTCCGTGTCCCAGGTCCCACCCGCCCCGTCTCGTGCCGGATCCT
CGGCCGCGGAGTCCGGGCAG

Downstream 100 bases:

>100_bases
GGTGACCGTGGCGAGCGTGACCAGTCCGCGCACCGACCTGCTCCGCGGGCTCGAGCAGGAGGTCGGCGTGATGGTCCGCC
GGATCCGGCGGGTGATCCGG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSHREILEALSGLLLAMFVAMLSSTVVTNALPRMVADLHGSQTGYTWVVVATMLAMTATTPIWGKLSDLFSKKMLVQLAL
VIYIVGSLIAAFAPSMEVLIGARAVQGLGVGGLTALVQVVIATMISPRERGRYSGYLGAVFALATVSGPLIGGVIVDSAL
GWRGCFFVGLPIAVAAFFLLQKTLHLPVVKRPVHIDYLGATLLVGGVSTLLVWISLAGNQFAWASSTTAVLVVAGVLMLV
AAVYVEARVAVEPVIPLRLFRDRTTTLATIASVMIGVAMFGSTVYLSQYFQTARGMSPTEAGLMSIAMVGGLFVSSVVSG
RIISDTGIWKRWLVGGMLLVVVGLALLGTIDETTSLVVIGGFMAILGVGLGATMQNLVLSVQNNVTLADMGAASSVVAFF
RSMGGSIGVSALGALLSHQVAAQVTEGYVAAQRPPTFPAGSHAVPDVTTLPGWEQSIWEHAFGSSFGHLFFVATPFALVA
LLCVLLVREVPLRTSNLEAEAAASPEVAAELHRAIVRK

Sequences:

>Translated_518_residues
MSHREILEALSGLLLAMFVAMLSSTVVTNALPRMVADLHGSQTGYTWVVVATMLAMTATTPIWGKLSDLFSKKMLVQLAL
VIYIVGSLIAAFAPSMEVLIGARAVQGLGVGGLTALVQVVIATMISPRERGRYSGYLGAVFALATVSGPLIGGVIVDSAL
GWRGCFFVGLPIAVAAFFLLQKTLHLPVVKRPVHIDYLGATLLVGGVSTLLVWISLAGNQFAWASSTTAVLVVAGVLMLV
AAVYVEARVAVEPVIPLRLFRDRTTTLATIASVMIGVAMFGSTVYLSQYFQTARGMSPTEAGLMSIAMVGGLFVSSVVSG
RIISDTGIWKRWLVGGMLLVVVGLALLGTIDETTSLVVIGGFMAILGVGLGATMQNLVLSVQNNVTLADMGAASSVVAFF
RSMGGSIGVSALGALLSHQVAAQVTEGYVAAQRPPTFPAGSHAVPDVTTLPGWEQSIWEHAFGSSFGHLFFVATPFALVA
LLCVLLVREVPLRTSNLEAEAAASPEVAAELHRAIVRK
>Mature_517_residues
SHREILEALSGLLLAMFVAMLSSTVVTNALPRMVADLHGSQTGYTWVVVATMLAMTATTPIWGKLSDLFSKKMLVQLALV
IYIVGSLIAAFAPSMEVLIGARAVQGLGVGGLTALVQVVIATMISPRERGRYSGYLGAVFALATVSGPLIGGVIVDSALG
WRGCFFVGLPIAVAAFFLLQKTLHLPVVKRPVHIDYLGATLLVGGVSTLLVWISLAGNQFAWASSTTAVLVVAGVLMLVA
AVYVEARVAVEPVIPLRLFRDRTTTLATIASVMIGVAMFGSTVYLSQYFQTARGMSPTEAGLMSIAMVGGLFVSSVVSGR
IISDTGIWKRWLVGGMLLVVVGLALLGTIDETTSLVVIGGFMAILGVGLGATMQNLVLSVQNNVTLADMGAASSVVAFFR
SMGGSIGVSALGALLSHQVAAQVTEGYVAAQRPPTFPAGSHAVPDVTTLPGWEQSIWEHAFGSSFGHLFFVATPFALVAL
LCVLLVREVPLRTSNLEAEAAASPEVAAELHRAIVRK

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=420, Percent_Identity=25.2380952380952, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788710, Length=415, Percent_Identity=28.1927710843373, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081983, Length=287, Percent_Identity=26.1324041811847, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790195, Length=415, Percent_Identity=23.1325301204819, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788392, Length=421, Percent_Identity=27.790973871734, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=449, Percent_Identity=26.0579064587973, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323735, Length=330, Percent_Identity=29.0909090909091, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6325455, Length=427, Percent_Identity=23.8875878220141, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319770, Length=382, Percent_Identity=25.3926701570681, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321663, Length=457, Percent_Identity=25.601750547046, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319783, Length=362, Percent_Identity=24.8618784530387, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324954, Length=341, Percent_Identity=27.5659824046921, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54196; Mature: 54065

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHREILEALSGLLLAMFVAMLSSTVVTNALPRMVADLHGSQTGYTWVVVATMLAMTATT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC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HHHHHHHHHCCCCCCCCCCHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]