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The map label for this gene is mdh [H]

Identifier: 119714971

GI number: 119714971

Start: 770344

End: 771600

Strand: Direct

Name: mdh [H]

Synonym: Noca_0724

Alternate gene names: 119714971

Gene position: 770344-771600 (Clockwise)

Preceding gene: 119714962

Following gene: 119714972

Centisome position: 15.45

GC content: 74.3

Gene sequence:

>1257_bases
ATGAGCGAGACCGTCTTCACCTACGCCGCACCCGCGCTGAAGTTCGGGACGGGCGCCTCCGCCGAGGTCGGGCACGACCT
CGCGTCGTACGGCGCCCGCCGCGTGCTGCTGGTCACCGATCCGGGGGTCGCGGCCACCGGGCACCCCGAGCGGATCGCCG
CGCAGGTCACGGCTCGTGGCATCGAGGTGACGACGTACGACCGGGTCCACGTCGAGCCGACCGATGAGTCCCTGGCCGAG
GCGATCGACTTCGCCCGGGACGCGGGGCCGTTCGACGCGATCCTGGCCGTCGGGGGCGGCTCGTCGATCGACACCGCCAA
GGCGGTCAACCTGCTCACCACCAACCCGGGTGAGCTGATGGACTACGTCAACGCCCCGGTCGGCCGGGCGCAGGCGCCCC
AGCACCCGCTGCTGCCGCTGGTGGCGATCCCCACCACGACCGGAACCGGCGCCGAGAGCACCACGATCTGCGTGCTCGAC
GTGCTGGCGCTGAAGGTCAAGACCGGGATCAGCCACCCCCGGCTGCGGCCGACCCTGGCGGTCGTCGACCCGGCGCTGAC
GATCAGCCAGCCCGCCGTGGTCACCGCGGCCGCGGGCCTGGACATCGTCTGCCACGCCCTCGAGAGCTACACCGCCCGGT
GGTACGCCGAGTTCGACGCCAAGCAGCCCGAGCAGCGGGTGCCCTACTGCGGGGCGAACCCGATCTCCGACCTGTGGTCG
GAGCGGGCGCTGTCGCTGCTGGCCGGCTCGTTCCGGGCGGCGGTCCGGGACGGGTCCGACCGCGCCGCGCGGGAGCAGAT
GGCGATGGCGGCGACCTTCGCCGGCCTGGGCTTCGGCAACGCCGGCGTGCACATCCCGCACGCGAACGCCTACCCGATCG
CCGGCCGGGTCCGCGACTACCGGCCCGACGGCTACCCCGACGAGCCGATCGTCCCGCACGGCATGGCGGTCTCGCTGACG
GCGCCCGCCGCGTTCCGGTTCACCTTCGACGCCGCCCCCGACCGGCACGTCCGCGCGGCCCAGCTGCTCGACCCCGGCGT
CGCGCCTGGCCCGGACGCCCTGCCCGCGGCGCTGCGCAGCCTGATGCGCGACGTGGGCATCCCGAACGGCCTCGCGGCGG
TGGGGTACGCCGATGCCGATGTCGACGACCTGGTCGCGGGGGCGCTCCAGCAGCAGCGGCTGCTCGCGACCGCGCCGAGG
CGTCCCACGGAGGAGGACCTGGCGTCGGTGTTCCGGGCCTCGATGGAACACTGGTGA

Upstream 100 bases:

>100_bases
GCACGATCCAGCGTGCCTGGTGCCGCGCGTGCAGCCGCATGGAAGCCCCCCTCTCCACGGGACCAATCGTACGGTCCGGA
GCGGCCGTTATGTTGGCCGA

Downstream 100 bases:

>100_bases
CGTGTCGCAACCGCCCTCTGCACTCGTCGCGGAACTGCGCCGGCGGGACGTCTCGGACGTCGACGACTCCACGCTGACCC
GGGCGCTGTACTCCTCGGAC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSETVFTYAAPALKFGTGASAEVGHDLASYGARRVLLVTDPGVAATGHPERIAAQVTARGIEVTTYDRVHVEPTDESLAE
AIDFARDAGPFDAILAVGGGSSIDTAKAVNLLTTNPGELMDYVNAPVGRAQAPQHPLLPLVAIPTTTGTGAESTTICVLD
VLALKVKTGISHPRLRPTLAVVDPALTISQPAVVTAAAGLDIVCHALESYTARWYAEFDAKQPEQRVPYCGANPISDLWS
ERALSLLAGSFRAAVRDGSDRAAREQMAMAATFAGLGFGNAGVHIPHANAYPIAGRVRDYRPDGYPDEPIVPHGMAVSLT
APAAFRFTFDAAPDRHVRAAQLLDPGVAPGPDALPAALRSLMRDVGIPNGLAAVGYADADVDDLVAGALQQQRLLATAPR
RPTEEDLASVFRASMEHW

Sequences:

>Translated_418_residues
MSETVFTYAAPALKFGTGASAEVGHDLASYGARRVLLVTDPGVAATGHPERIAAQVTARGIEVTTYDRVHVEPTDESLAE
AIDFARDAGPFDAILAVGGGSSIDTAKAVNLLTTNPGELMDYVNAPVGRAQAPQHPLLPLVAIPTTTGTGAESTTICVLD
VLALKVKTGISHPRLRPTLAVVDPALTISQPAVVTAAAGLDIVCHALESYTARWYAEFDAKQPEQRVPYCGANPISDLWS
ERALSLLAGSFRAAVRDGSDRAAREQMAMAATFAGLGFGNAGVHIPHANAYPIAGRVRDYRPDGYPDEPIVPHGMAVSLT
APAAFRFTFDAAPDRHVRAAQLLDPGVAPGPDALPAALRSLMRDVGIPNGLAAVGYADADVDDLVAGALQQQRLLATAPR
RPTEEDLASVFRASMEHW
>Mature_417_residues
SETVFTYAAPALKFGTGASAEVGHDLASYGARRVLLVTDPGVAATGHPERIAAQVTARGIEVTTYDRVHVEPTDESLAEA
IDFARDAGPFDAILAVGGGSSIDTAKAVNLLTTNPGELMDYVNAPVGRAQAPQHPLLPLVAIPTTTGTGAESTTICVLDV
LALKVKTGISHPRLRPTLAVVDPALTISQPAVVTAAAGLDIVCHALESYTARWYAEFDAKQPEQRVPYCGANPISDLWSE
RALSLLAGSFRAAVRDGSDRAAREQMAMAATFAGLGFGNAGVHIPHANAYPIAGRVRDYRPDGYPDEPIVPHGMAVSLTA
PAAFRFTFDAAPDRHVRAAQLLDPGVAPGPDALPAALRSLMRDVGIPNGLAAVGYADADVDDLVAGALQQQRLLATAPRR
PTEEDLASVFRASMEHW

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=426, Percent_Identity=44.131455399061, Blast_Score=330, Evalue=1e-90,
Organism=Escherichia coli, GI48994951, Length=389, Percent_Identity=31.8766066838046, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082107, Length=413, Percent_Identity=29.2978208232446, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1789163, Length=406, Percent_Identity=27.5862068965517, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787493, Length=418, Percent_Identity=27.2727272727273, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17537053, Length=427, Percent_Identity=39.1100702576112, Blast_Score=314, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6321181, Length=417, Percent_Identity=29.2565947242206, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24657991, Length=425, Percent_Identity=46.1176470588235, Blast_Score=348, Evalue=6e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 43874; Mature: 43743

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETVFTYAAPALKFGTGASAEVGHDLASYGARRVLLVTDPGVAATGHPERIAAQVTARG
CCCCEEEEECCHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
IEVTTYDRVHVEPTDESLAEAIDFARDAGPFDAILAVGGGSSIDTAKAVNLLTTNPGELM
EEEEEECEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHEEEEECCHHHHH
DYVNAPVGRAQAPQHPLLPLVAIPTTTGTGAESTTICVLDVLALKVKTGISHPRLRPTLA
HHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
VVDPALTISQPAVVTAAAGLDIVCHALESYTARWYAEFDAKQPEQRVPYCGANPISDLWS
EECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHEEEECCCCCCHHCCCCCCCCHHHHHHH
ERALSLLAGSFRAAVRDGSDRAAREQMAMAATFAGLGFGNAGVHIPHANAYPIAGRVRDY
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCC
RPDGYPDEPIVPHGMAVSLTAPAAFRFTFDAAPDRHVRAAQLLDPGVAPGPDALPAALRS
CCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHH
LMRDVGIPNGLAAVGYADADVDDLVAGALQQQRLLATAPRRPTEEDLASVFRASMEHW
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SETVFTYAAPALKFGTGASAEVGHDLASYGARRVLLVTDPGVAATGHPERIAAQVTARG
CCCEEEEECCHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCC
IEVTTYDRVHVEPTDESLAEAIDFARDAGPFDAILAVGGGSSIDTAKAVNLLTTNPGELM
EEEEEECEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHEEEEECCHHHHH
DYVNAPVGRAQAPQHPLLPLVAIPTTTGTGAESTTICVLDVLALKVKTGISHPRLRPTLA
HHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
VVDPALTISQPAVVTAAAGLDIVCHALESYTARWYAEFDAKQPEQRVPYCGANPISDLWS
EECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHEEEECCCCCCHHCCCCCCCCHHHHHHH
ERALSLLAGSFRAAVRDGSDRAAREQMAMAATFAGLGFGNAGVHIPHANAYPIAGRVRDY
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCC
RPDGYPDEPIVPHGMAVSLTAPAAFRFTFDAAPDRHVRAAQLLDPGVAPGPDALPAALRS
CCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHH
LMRDVGIPNGLAAVGYADADVDDLVAGALQQQRLLATAPRRPTEEDLASVFRASMEHW
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]