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The map label for this gene is mmr [H]

Identifier: 119714877

GI number: 119714877

Start: 663671

End: 664000

Strand: Direct

Name: mmr [H]

Synonym: Noca_0627

Alternate gene names: 119714877

Gene position: 663671-664000 (Clockwise)

Preceding gene: 119714876

Following gene: 119714878

Centisome position: 13.31

GC content: 61.82

Gene sequence:

>330_bases
ATGGTGACGTATCTACTGCTAGGACTCGCAATCGCCGTGGAGGTGATGGCCACCCTGTCCCTGCGAGCATCCGAGGGCTT
CAGCAGACCTCTGCCGAGCCTTATCGTCGTGAGTGGATATGGGTTGTCGTTCTTCCTGCTCTCCGTAGTGCTCCAACGCG
GTCTGAACGTCGCTATCGTGTACGCGTTGTGGTCCGCGACCGGCATCGTCGCCATCGCCGTGATCGGCGCGACCTTCTTA
GGCGAACGCCTCACAAGTGCACAGGTTCTGGGCATGGGCCTCATCGTCAGCGGTGTGCTAGCCCTCGAGTTGGGCGCGCG
CCACGGGTGA

Upstream 100 bases:

>100_bases
TAAACCGGCTGTCAGTTTCCAGCACAAGACCCGCAGACGCTGGTCGCGATGCGTCCTACCGTCGGACCGGAAGGACGGAC
GTGGCGTTGGGCGGAGACAC

Downstream 100 bases:

>100_bases
GCGGATGGGCGCAGCCGTCGGGCGCGGGAACCGGACGACCGGGGGTCAAATATCGCCGAGCAATCGAGAGACACTGTGAT
CACGAGGGTGGAAGCGGCCG

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MVTYLLLGLAIAVEVMATLSLRASEGFSRPLPSLIVVSGYGLSFFLLSVVLQRGLNVAIVYALWSATGIVAIAVIGATFL
GERLTSAQVLGMGLIVSGVLALELGARHG

Sequences:

>Translated_109_residues
MVTYLLLGLAIAVEVMATLSLRASEGFSRPLPSLIVVSGYGLSFFLLSVVLQRGLNVAIVYALWSATGIVAIAVIGATFL
GERLTSAQVLGMGLIVSGVLALELGARHG
>Mature_109_residues
MVTYLLLGLAIAVEVMATLSLRASEGFSRPLPSLIVVSGYGLSFFLLSVVLQRGLNVAIVYALWSATGIVAIAVIGATFL
GERLTSAQVLGMGLIVSGVLALELGARHG

Specific function: Multidrug efflux pump. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. Mmr (TC 2.A.7.1.2) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=107, Percent_Identity=41.1214953271028, Blast_Score=71, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11274; Mature: 11274

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTYLLLGLAIAVEVMATLSLRASEGFSRPLPSLIVVSGYGLSFFLLSVVLQRGLNVAIV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEHH
YALWSATGIVAIAVIGATFLGERLTSAQVLGMGLIVSGVLALELGARHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVTYLLLGLAIAVEVMATLSLRASEGFSRPLPSLIVVSGYGLSFFLLSVVLQRGLNVAIV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEHH
YALWSATGIVAIAVIGATFLGERLTSAQVLGMGLIVSGVLALELGARHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]