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The map label for this gene is mutY [H]

Identifier: 119714731

GI number: 119714731

Start: 498338

End: 499204

Strand: Reverse

Name: mutY [H]

Synonym: Noca_0467

Alternate gene names: 119714731

Gene position: 499204-498338 (Counterclockwise)

Preceding gene: 119714733

Following gene: 119714720

Centisome position: 10.01

GC content: 76.7

Gene sequence:

>867_bases
ATGAACGAGCTCCATGCACCCGTGCTGCAGTGGTACGACGAGCACGCCCGCGACCTGCCCTGGCGACGCGCGGAGGCCGG
TCCGTGGTCGGTGCTGGTCTCGGAGTTCATGCTGCAGCAGACCCCCGTCGCCCGGGTGCTGCCTGTCCACGAGCAGTGGC
TGGCCCGGTGGCCGCAGCCGGCCGACCTCGCGGCCGAGTCCGCCGGCGAGGCGGTGCGCGCCTGGGGTCGCCTGGGCTAC
CCACGCCGAGCGCTGCGCCTGCACGCCGCGGCCACGGCGATCCTCGAGCGGCACGACGGCGCCGTGCCGTCGTCGTACGA
CGACCTGATCGCGCTGCCCGGGGTCGGCGACTACACCGCCGCGGCGATCGCGGTGTTCGCGTACGGGCGGCGGCACGTCG
TGCTCGACACCAACGTGCGGCGGGTGCTCACGCGGACGCTGCAGGGCGTGGAGTTCCCGGCGCCGTCGGTGACCCGCGCC
GAGCGCGAGCTGGCCCTGGCGGTGCTGCCCGCGGACGAGCCGACCGCGGCGACCTGGTCGGTCGCGGTGATGGAGCTCGG
GGCGCTCGTGTGCACGGCGGCCAACCCGCGGTGCGCCGACTGCCCGGTCGCCCGGCTGTGCGCGTGGCGCACGGCCGGCT
ACCCGGCGTACGACGGGCCCAAGCGCCTGGTGCAGACCTGGGCCGGCACCGACCGCCAGTGCCGCGGCCGGCTGCTCGCC
GTGCTCCGCGAGGACGACGGGCCCGTGCACCGCAGCCGGCTCGACGCCGTCTGGTCGGAGGAGGCCCAGCGGGTCCGCTG
CCTCGCCTCGCTGGCGGCCGACGGGCTGGTCGTCCACGTCGGCCCGGACGCCTACGCGCTGCCCTGA

Upstream 100 bases:

>100_bases
GCGCGCGGGCAGCGGGCCACGGGTGAGGGCGGGCATGACGCAACGCTAGTCACGGGGGCGGCGCCGGTGGTGGTGCCACA
CCGGCGACAATGGCCCGGAC

Downstream 100 bases:

>100_bases
GACGCCGAAGTCGGCGCATCCTGCCCGGGCAGGATGCGCCGACTCGGCGTTGGTGCAGGGGTCAGTCGGTGGACTTGGGT
ACGTCGGTGCCGCTGTCGGA

Product: HhH-GPD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNELHAPVLQWYDEHARDLPWRRAEAGPWSVLVSEFMLQQTPVARVLPVHEQWLARWPQPADLAAESAGEAVRAWGRLGY
PRRALRLHAAATAILERHDGAVPSSYDDLIALPGVGDYTAAAIAVFAYGRRHVVLDTNVRRVLTRTLQGVEFPAPSVTRA
ERELALAVLPADEPTAATWSVAVMELGALVCTAANPRCADCPVARLCAWRTAGYPAYDGPKRLVQTWAGTDRQCRGRLLA
VLREDDGPVHRSRLDAVWSEEAQRVRCLASLAADGLVVHVGPDAYALP

Sequences:

>Translated_288_residues
MNELHAPVLQWYDEHARDLPWRRAEAGPWSVLVSEFMLQQTPVARVLPVHEQWLARWPQPADLAAESAGEAVRAWGRLGY
PRRALRLHAAATAILERHDGAVPSSYDDLIALPGVGDYTAAAIAVFAYGRRHVVLDTNVRRVLTRTLQGVEFPAPSVTRA
ERELALAVLPADEPTAATWSVAVMELGALVCTAANPRCADCPVARLCAWRTAGYPAYDGPKRLVQTWAGTDRQCRGRLLA
VLREDDGPVHRSRLDAVWSEEAQRVRCLASLAADGLVVHVGPDAYALP
>Mature_288_residues
MNELHAPVLQWYDEHARDLPWRRAEAGPWSVLVSEFMLQQTPVARVLPVHEQWLARWPQPADLAAESAGEAVRAWGRLGY
PRRALRLHAAATAILERHDGAVPSSYDDLIALPGVGDYTAAAIAVFAYGRRHVVLDTNVRRVLTRTLQGVEFPAPSVTRA
ERELALAVLPADEPTAATWSVAVMELGALVCTAANPRCADCPVARLCAWRTAGYPAYDGPKRLVQTWAGTDRQCRGRLLA
VLREDDGPVHRSRLDAVWSEEAQRVRCLASLAADGLVVHVGPDAYALP

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=217, Percent_Identity=41.0138248847926, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI115298652, Length=217, Percent_Identity=41.0138248847926, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI115298650, Length=217, Percent_Identity=41.0138248847926, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI6912520, Length=214, Percent_Identity=41.1214953271028, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI190358497, Length=214, Percent_Identity=41.1214953271028, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI115298648, Length=214, Percent_Identity=41.1214953271028, Blast_Score=137, Evalue=8e-33,
Organism=Escherichia coli, GI1789331, Length=208, Percent_Identity=38.9423076923077, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1787920, Length=151, Percent_Identity=31.1258278145695, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 31581; Mature: 31581

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELHAPVLQWYDEHARDLPWRRAEAGPWSVLVSEFMLQQTPVARVLPVHEQWLARWPQP
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCC
ADLAAESAGEAVRAWGRLGYPRRALRLHAAATAILERHDGAVPSSYDDLIALPGVGDYTA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHH
AAIAVFAYGRRHVVLDTNVRRVLTRTLQGVEFPAPSVTRAERELALAVLPADEPTAATWS
HHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEEECCCCCCCHHHH
VAVMELGALVCTAANPRCADCPVARLCAWRTAGYPAYDGPKRLVQTWAGTDRQCRGRLLA
HHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHEE
VLREDDGPVHRSRLDAVWSEEAQRVRCLASLAADGLVVHVGPDAYALP
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
>Mature Secondary Structure
MNELHAPVLQWYDEHARDLPWRRAEAGPWSVLVSEFMLQQTPVARVLPVHEQWLARWPQP
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCC
ADLAAESAGEAVRAWGRLGYPRRALRLHAAATAILERHDGAVPSSYDDLIALPGVGDYTA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHH
AAIAVFAYGRRHVVLDTNVRRVLTRTLQGVEFPAPSVTRAERELALAVLPADEPTAATWS
HHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEEECCCCCCCHHHH
VAVMELGALVCTAANPRCADCPVARLCAWRTAGYPAYDGPKRLVQTWAGTDRQCRGRLLA
HHHHHHHHHHEECCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHEE
VLREDDGPVHRSRLDAVWSEEAQRVRCLASLAADGLVVHVGPDAYALP
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]