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The map label for this gene is disA [H]

Identifier: 119714733

GI number: 119714733

Start: 500207

End: 501289

Strand: Reverse

Name: disA [H]

Synonym: Noca_0469

Alternate gene names: 119714733

Gene position: 501289-500207 (Counterclockwise)

Preceding gene: 119714734

Following gene: 119714731

Centisome position: 10.05

GC content: 71.75

Gene sequence:

>1083_bases
GTGGCCACCGATCGCTCGGACGACATCCTGCGCCTGCGCGCGACCCTCGCGACGATCGCCCCGGGCACGCCGCTGCGCGA
CGGCTTGGAGCGGATCCTGCGCGGCCGCACCGGCGCGCTGATCGTGCTCGGCCACGACAAGGTCGTCGAGTCGATCTCCA
CCGGCGGCTTCACCCTCGACGTCCCGTTCACGGCCACCGGGCTGCGCGAGCTGGCGAAGATGGACGGCGCCATCATCGTC
GATCGCGACGTCACCCGGATCCAGCGCGCGGCGGTGCACCTGATGCCGGACCACACCATCCCGTCGGAGGAGACCGGCAC
CCGGCACCGGACCGCCGACCGGGTCGCCCGCCAGACCGGGTTCCCGGTGATCTCGGTGTCCCAGTCGATGCAGATCATCG
CGGCGTACGTCGGAGAGACCCGCCACGTGCTCGAGGACTCCGGTCAGATCCTGTCGCGCGCCAACCAGGCGCTGGCCACC
TTGGAGCGCTACAAGCTGCGCCTCGACGAGGTGTCCAGCACGCTGTCCGCGCTCGAGATCGAGGACCTGGTCACGGTCCG
CGACGTCGCCGTGGTCGCGCAGCGGCTGGAGATGGTCACCCGGATCGCGAGCGAGATCGAGGACTACGTCCTCGAGCTCG
GCACCGACGGGCGCCTGCTGTCGCTCCAGCTCGAGGAGCTGATCACGGGCGTCGACACCGAGCGCGAGCTGGTGATCCGC
GACTACCTGCCGGCCGGCCGGCGGTCGAAGAGCCCCGAGGCGCTGCTGAACCGACTCGAGTCGCTCTCCTCCACCGAGCT
GGTCGATCCCGCGGCCGCTGCCCGGGCGCTCGGCCTCGGCAACGGCGAGCACCTCGACGGCGCCGTCGCCCCTCGCGGCT
TCCGGCTGCTGGCCAAGGTGCCGCGACTGCCCGCGACCGTGGTCGACCGCCTGGTCGACCACTTCGGCACCCTCCAGAAG
CTGCTCTCCGCTGGGGTCGACGACCTCCAGGCCGTCGAGGGCGTCGGTGAGCTGCGGGCCCGCAGCGTGCGCGAGGGCCT
CTCCCGCCTCGCCGAGTCGACGATCCTCGAGAGATACGTGTAG

Upstream 100 bases:

>100_bases
CGTTCGATCGAGGGCCGGTAGCGGTCGAAGGCTGGTAAGAGCCTGCCCTAGACTCGACCCAGCGGCCGACCGGTGCCGCA
CGCACAGGAGGGACCGGCAG

Downstream 100 bases:

>100_bases
TCGTCGTCCGAGCGAAGCGCAGGACGACTGCTACGCGTATCTCTGATGGTGGTCGAGCGAGCCGCGCGACCGAGGAACGA
GGTCGCGACCGGCGTGTCGA

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MATDRSDDILRLRATLATIAPGTPLRDGLERILRGRTGALIVLGHDKVVESISTGGFTLDVPFTATGLRELAKMDGAIIV
DRDVTRIQRAAVHLMPDHTIPSEETGTRHRTADRVARQTGFPVISVSQSMQIIAAYVGETRHVLEDSGQILSRANQALAT
LERYKLRLDEVSSTLSALEIEDLVTVRDVAVVAQRLEMVTRIASEIEDYVLELGTDGRLLSLQLEELITGVDTERELVIR
DYLPAGRRSKSPEALLNRLESLSSTELVDPAAAARALGLGNGEHLDGAVAPRGFRLLAKVPRLPATVVDRLVDHFGTLQK
LLSAGVDDLQAVEGVGELRARSVREGLSRLAESTILERYV

Sequences:

>Translated_360_residues
MATDRSDDILRLRATLATIAPGTPLRDGLERILRGRTGALIVLGHDKVVESISTGGFTLDVPFTATGLRELAKMDGAIIV
DRDVTRIQRAAVHLMPDHTIPSEETGTRHRTADRVARQTGFPVISVSQSMQIIAAYVGETRHVLEDSGQILSRANQALAT
LERYKLRLDEVSSTLSALEIEDLVTVRDVAVVAQRLEMVTRIASEIEDYVLELGTDGRLLSLQLEELITGVDTERELVIR
DYLPAGRRSKSPEALLNRLESLSSTELVDPAAAARALGLGNGEHLDGAVAPRGFRLLAKVPRLPATVVDRLVDHFGTLQK
LLSAGVDDLQAVEGVGELRARSVREGLSRLAESTILERYV
>Mature_359_residues
ATDRSDDILRLRATLATIAPGTPLRDGLERILRGRTGALIVLGHDKVVESISTGGFTLDVPFTATGLRELAKMDGAIIVD
RDVTRIQRAAVHLMPDHTIPSEETGTRHRTADRVARQTGFPVISVSQSMQIIAAYVGETRHVLEDSGQILSRANQALATL
ERYKLRLDEVSSTLSALEIEDLVTVRDVAVVAQRLEMVTRIASEIEDYVLELGTDGRLLSLQLEELITGVDTERELVIRD
YLPAGRRSKSPEALLNRLESLSSTELVDPAAAARALGLGNGEHLDGAVAPRGFRLLAKVPRLPATVVDRLVDHFGTLQKL
LSAGVDDLQAVEGVGELRARSVREGLSRLAESTILERYV

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N [H]

EC number: NA

Molecular weight: Translated: 39196; Mature: 39065

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDRSDDILRLRATLATIAPGTPLRDGLERILRGRTGALIVLGHDKVVESISTGGFTLD
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHCCCCEEEE
VPFTATGLRELAKMDGAIIVDRDVTRIQRAAVHLMPDHTIPSEETGTRHRTADRVARQTG
CCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHC
FPVISVSQSMQIIAAYVGETRHVLEDSGQILSRANQALATLERYKLRLDEVSSTLSALEI
CCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDLVTVRDVAVVAQRLEMVTRIASEIEDYVLELGTDGRLLSLQLEELITGVDTERELVIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHEEHHHHHCCCCCCHHHHHH
DYLPAGRRSKSPEALLNRLESLSSTELVDPAAAARALGLGNGEHLDGAVAPRGFRLLAKV
HCCCCCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHC
PRLPATVVDRLVDHFGTLQKLLSAGVDDLQAVEGVGELRARSVREGLSRLAESTILERYV
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATDRSDDILRLRATLATIAPGTPLRDGLERILRGRTGALIVLGHDKVVESISTGGFTLD
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHCCCCEEEE
VPFTATGLRELAKMDGAIIVDRDVTRIQRAAVHLMPDHTIPSEETGTRHRTADRVARQTG
CCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHC
FPVISVSQSMQIIAAYVGETRHVLEDSGQILSRANQALATLERYKLRLDEVSSTLSALEI
CCEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDLVTVRDVAVVAQRLEMVTRIASEIEDYVLELGTDGRLLSLQLEELITGVDTERELVIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHEEHHHHHCCCCCCHHHHHH
DYLPAGRRSKSPEALLNRLESLSSTELVDPAAAARALGLGNGEHLDGAVAPRGFRLLAKV
HCCCCCCCCCCHHHHHHHHHHCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHC
PRLPATVVDRLVDHFGTLQKLLSAGVDDLQAVEGVGELRARSVREGLSRLAESTILERYV
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA