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The map label for this gene is folP1 [H]

Identifier: 119714710

GI number: 119714710

Start: 477930

End: 478790

Strand: Direct

Name: folP1 [H]

Synonym: Noca_0446

Alternate gene names: 119714710

Gene position: 477930-478790 (Clockwise)

Preceding gene: 119714709

Following gene: 119714711

Centisome position: 9.59

GC content: 75.61

Gene sequence:

>861_bases
ATGGCCGCCCTCGCAGACCTGCTCGCCCCCCGCGCACGGCCGCGGCTGATGGGCGTCGTGAACGTGACCCCGGACTCGTT
CTCGGACGGCGGCCGGTGGCTCGAGCCGCGCGACGCCATCGCGCACGGTCGCGACCTGCTCGCCGACGGCGCCGACATCC
TCGACATCGGCGGGGAGTCCACCCGACCGGGCGCCACCCGCCCCCTGGTGGAGGAGGAGCTGGGCCGGGTCGTCCCGGTG
ATCACGGCGCTGGCGGCGGAGGGTGCCGTCGTCTCGGTCGACACGATGCGCGCCGAGGTCGCCGAGGCCGCGCTGGCGGC
CGGGGCCACCGTCGTCAACGACGTGTCGGGGGGTCTCGCCGACCCGCGGATCCTCGAGGTCGTCGCCGCGAGCGGAGCGG
CGTACGTCGCCATGCACTGGCGCGCGCACGCCGACCACATGCGGGACTTCGCGGTGTACGACGGCCCCGGTGGCGTGGTC
GGGGCCGTCTGCGACGAGCTGACCGCGCGGGTCCGGGCGATGACCGCCGCCGGGATCGCCCGGGAGCAGGTCATCCTCGA
CCCCGGGCTCGGCTTCGCCAAGCGCGCGGAGCACAACTGGGAGCTGCTGCGCCGGATCGACGAGCTGGCCGCCCTCGGCT
ACCCGCTCCTCGTCGGGGCCAGCCGCAAGTCGTTCCTCGGCCGGCTCCTGGTCGACCGGGGCGGCGTCCCCCGCGCCGTC
GACCAGCGCGAGCATGCGAACGCCGCGATCACCCTGCACCTGGCCCGGCATGCGGTGTGGGGCGTACGGGTGCACGACGT
CCGAGCCTCCCGGGACGCGCTCCGCGTCGCCGAGCAGCTGAGCGAGGAGGGTTCCACGTGA

Upstream 100 bases:

>100_bases
GGTGCTCGCACCATCACCTCCGCAGTGCGCGGCACGATGCGGACCAACCCCACGACCCGGGCCGAGGCGATGGCCCTGAT
CCACCGGCGATGAGCCGCTG

Downstream 100 bases:

>100_bases
CCGAACGGCCGACCGACGAGCTGAGCGTCACCGGCATCGCGTGCTACGGGCACCACGGCGTCTTCGACTTCGAGCGACGC
GAGGGGCAGACGTTCGTCGT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MAALADLLAPRARPRLMGVVNVTPDSFSDGGRWLEPRDAIAHGRDLLADGADILDIGGESTRPGATRPLVEEELGRVVPV
ITALAAEGAVVSVDTMRAEVAEAALAAGATVVNDVSGGLADPRILEVVAASGAAYVAMHWRAHADHMRDFAVYDGPGGVV
GAVCDELTARVRAMTAAGIAREQVILDPGLGFAKRAEHNWELLRRIDELAALGYPLLVGASRKSFLGRLLVDRGGVPRAV
DQREHANAAITLHLARHAVWGVRVHDVRASRDALRVAEQLSEEGST

Sequences:

>Translated_286_residues
MAALADLLAPRARPRLMGVVNVTPDSFSDGGRWLEPRDAIAHGRDLLADGADILDIGGESTRPGATRPLVEEELGRVVPV
ITALAAEGAVVSVDTMRAEVAEAALAAGATVVNDVSGGLADPRILEVVAASGAAYVAMHWRAHADHMRDFAVYDGPGGVV
GAVCDELTARVRAMTAAGIAREQVILDPGLGFAKRAEHNWELLRRIDELAALGYPLLVGASRKSFLGRLLVDRGGVPRAV
DQREHANAAITLHLARHAVWGVRVHDVRASRDALRVAEQLSEEGST
>Mature_285_residues
AALADLLAPRARPRLMGVVNVTPDSFSDGGRWLEPRDAIAHGRDLLADGADILDIGGESTRPGATRPLVEEELGRVVPVI
TALAAEGAVVSVDTMRAEVAEAALAAGATVVNDVSGGLADPRILEVVAASGAAYVAMHWRAHADHMRDFAVYDGPGGVVG
AVCDELTARVRAMTAAGIAREQVILDPGLGFAKRAEHNWELLRRIDELAALGYPLLVGASRKSFLGRLLVDRGGVPRAVD
QREHANAAITLHLARHAVWGVRVHDVRASRDALRVAEQLSEEGST

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=268, Percent_Identity=40.6716417910448, Blast_Score=185, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=29.595015576324, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30205; Mature: 30074

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALADLLAPRARPRLMGVVNVTPDSFSDGGRWLEPRDAIAHGRDLLADGADILDIGGES
CCCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCHHHHHCCCCEEECCCCC
TRPGATRPLVEEELGRVVPVITALAAEGAVVSVDTMRAEVAEAALAAGATVVNDVSGGLA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHCCCCCC
DPRILEVVAASGAAYVAMHWRAHADHMRDFAVYDGPGGVVGAVCDELTARVRAMTAAGIA
CHHHHHHHHCCCCEEEEEEHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
REQVILDPGLGFAKRAEHNWELLRRIDELAALGYPLLVGASRKSFLGRLLVDRGGVPRAV
HCEEEECCCCCHHHHCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCHH
DQREHANAAITLHLARHAVWGVRVHDVRASRDALRVAEQLSEEGST
HHHHCCCEEEEEEEHHHHHHCEEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AALADLLAPRARPRLMGVVNVTPDSFSDGGRWLEPRDAIAHGRDLLADGADILDIGGES
CCHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCHHHHHCCCCEEECCCCC
TRPGATRPLVEEELGRVVPVITALAAEGAVVSVDTMRAEVAEAALAAGATVVNDVSGGLA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHCCCCCC
DPRILEVVAASGAAYVAMHWRAHADHMRDFAVYDGPGGVVGAVCDELTARVRAMTAAGIA
CHHHHHHHHCCCCEEEEEEHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
REQVILDPGLGFAKRAEHNWELLRRIDELAALGYPLLVGASRKSFLGRLLVDRGGVPRAV
HCEEEECCCCCHHHHCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCHH
DQREHANAAITLHLARHAVWGVRVHDVRASRDALRVAEQLSEEGST
HHHHCCCEEEEEEEHHHHHHCEEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]