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The map label for this gene is folE [H]

Identifier: 119714709

GI number: 119714709

Start: 477305

End: 477922

Strand: Direct

Name: folE [H]

Synonym: Noca_0445

Alternate gene names: 119714709

Gene position: 477305-477922 (Clockwise)

Preceding gene: 119714708

Following gene: 119714710

Centisome position: 9.57

GC content: 71.36

Gene sequence:

>618_bases
ATGGTCGTCGCCATGAGCGACTCGACGCTGCCGGGCGGACGTCCCGCGCCCGCCTTCGACCTGGCGCGCGCCGAGGCGGC
CGTCCGGGAGCTGCTCATCGCGATCGGTGAGGACCCCGAGCGGGAGGGCCTGCAGGAGACCCCGGCCCGGGTGGCGCGGG
CGTACGCCGAGCTCACGGCCGGGCTGCGGATGGAGCCCGAGGACGTGCTCACCACGACCTTCGACATCGGGCACGACGAG
ATGGTGCTGGTGCGCGACATCGAGCTGTGGTCGATGTGCGAGCACCACCTGGTGCCGTTCACCGGTGTCGCGCACGTCGG
CTACATCCCCGCGACCAGCGGGAAGATCACCGGACTGTCCAAGCTCGCCCGGCTCGTCGACGTCTACGCGAAGCGCCCCC
AGGTCCAGGAGCGGCTCACCACCCAGGTCGCCGACGCCCTGACCCGCCTCCTCGAAGCGCGCGGCGTGATCGTGGTGATC
GAGGCCGAGCACCTGTGCATGACCATGCGGGGGGTCAAGAAGGCGGGTGCTCGCACCATCACCTCCGCAGTGCGCGGCAC
GATGCGGACCAACCCCACGACCCGGGCCGAGGCGATGGCCCTGATCCACCGGCGATGA

Upstream 100 bases:

>100_bases
CGCGCCGGGGCTCGGGTCTCGACACGGCGGTCGCGACCTCGTGCCTCGGTCGCGCGCCTCGCTCGACCACCAACGACGGG
CCCGCTGACGCGTCCCCGCT

Downstream 100 bases:

>100_bases
GCCGCTGATGGCCGCCCTCGCAGACCTGCTCGCCCCCCGCGCACGGCCGCGGCTGATGGGCGTCGTGAACGTGACCCCGG
ACTCGTTCTCGGACGGCGGC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MVVAMSDSTLPGGRPAPAFDLARAEAAVRELLIAIGEDPEREGLQETPARVARAYAELTAGLRMEPEDVLTTTFDIGHDE
MVLVRDIELWSMCEHHLVPFTGVAHVGYIPATSGKITGLSKLARLVDVYAKRPQVQERLTTQVADALTRLLEARGVIVVI
EAEHLCMTMRGVKKAGARTITSAVRGTMRTNPTTRAEAMALIHRR

Sequences:

>Translated_205_residues
MVVAMSDSTLPGGRPAPAFDLARAEAAVRELLIAIGEDPEREGLQETPARVARAYAELTAGLRMEPEDVLTTTFDIGHDE
MVLVRDIELWSMCEHHLVPFTGVAHVGYIPATSGKITGLSKLARLVDVYAKRPQVQERLTTQVADALTRLLEARGVIVVI
EAEHLCMTMRGVKKAGARTITSAVRGTMRTNPTTRAEAMALIHRR
>Mature_205_residues
MVVAMSDSTLPGGRPAPAFDLARAEAAVRELLIAIGEDPEREGLQETPARVARAYAELTAGLRMEPEDVLTTTFDIGHDE
MVLVRDIELWSMCEHHLVPFTGVAHVGYIPATSGKITGLSKLARLVDVYAKRPQVQERLTTQVADALTRLLEARGVIVVI
EAEHLCMTMRGVKKAGARTITSAVRGTMRTNPTTRAEAMALIHRR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=185, Percent_Identity=49.7297297297297, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI4503949, Length=185, Percent_Identity=49.7297297297297, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI66932970, Length=155, Percent_Identity=47.741935483871, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI66932972, Length=145, Percent_Identity=50.3448275862069, Blast_Score=144, Evalue=5e-35,
Organism=Escherichia coli, GI1788476, Length=172, Percent_Identity=41.2790697674419, Blast_Score=114, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=180, Percent_Identity=49.4444444444444, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321706, Length=187, Percent_Identity=49.1978609625668, Blast_Score=181, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24656782, Length=196, Percent_Identity=48.9795918367347, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24656796, Length=196, Percent_Identity=48.9795918367347, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24656791, Length=196, Percent_Identity=48.9795918367347, Blast_Score=177, Evalue=4e-45,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22378; Mature: 22378

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAMSDSTLPGGRPAPAFDLARAEAAVRELLIAIGEDPEREGLQETPARVARAYAELTA
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
GLRMEPEDVLTTTFDIGHDEMVLVRDIELWSMCEHHLVPFTGVAHVGYIPATSGKITGLS
CCCCCHHHHHEEEEECCCCCEEEEECCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHH
KLARLVDVYAKRPQVQERLTTQVADALTRLLEARGVIVVIEAEHLCMTMRGVKKAGARTI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHH
TSAVRGTMRTNPTTRAEAMALIHRR
HHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVVAMSDSTLPGGRPAPAFDLARAEAAVRELLIAIGEDPEREGLQETPARVARAYAELTA
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
GLRMEPEDVLTTTFDIGHDEMVLVRDIELWSMCEHHLVPFTGVAHVGYIPATSGKITGLS
CCCCCHHHHHEEEEECCCCCEEEEECCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCHHHH
KLARLVDVYAKRPQVQERLTTQVADALTRLLEARGVIVVIEAEHLCMTMRGVKKAGARTI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHH
TSAVRGTMRTNPTTRAEAMALIHRR
HHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]