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The map label for this gene is cynR [H]

Identifier: 119714657

GI number: 119714657

Start: 423752

End: 424702

Strand: Reverse

Name: cynR [H]

Synonym: Noca_0392

Alternate gene names: 119714657

Gene position: 424702-423752 (Counterclockwise)

Preceding gene: 119714663

Following gene: 119714656

Centisome position: 8.52

GC content: 72.56

Gene sequence:

>951_bases
ATGCTTTCGTTACATCAGCTCACGTGCTTCCTCGCGACCTACGAGCACGGCTCGCTGACGGCGGCGGCCGAGGAGCTCGG
CTACGCCCAGCCGTCGGTCTCCGAGCAGATCCGGGCCCTGGAGAAGACGCTCGGCGTGCAGCTCTTCCGCCGGGTCGGCC
GGGGCGTGGTCCCCACGACGGTCGCCGACACGCTTCGGCCGCACGCCGAGAAGGTGCTCGCGACGGTCGACGAGGCGGCG
CAGGCCGTGCAGAGCGTGAAGTCGCTCGAGACCGGCACGATCCGCTTCGGCATGTTCGGGATCGCGCGGTTGTACGCCGG
AGCGGGGCTGATCGGCGACGTGCTCTCGCGCTACCCGGGCGTGCGCGTCGAGCTGGTCGGCCAGAACTCCACCGAGGTCG
CGGAGGACCTGCGCCGCGGCCGCCTGGAGGCCGCGATGCTCGCGGTCTCAGGCATCCAGAGCGAGGGGATGACGGTCACC
CCGGTGGCGCGCGAGGAGCTCGTGTACATCAGCGCCGACCCCACCCGCCTGGCCACGCCCGTCACCCCCCACCGGCTCTC
CCAGGCGTCCCTGGTGATGTCGGAGACGACGTACCGCGCCGTCGACTCGACCCGCGCCACGCTGCGGCAGATGCTCCACG
AGACCGGGCACAATCCCGCCACCCGGATCGAGGTCGAGGACATCGAGACGGCCGTGGAGCTGGTGGGGATGGGGTACGCC
GACTCGGTGGTCCCGAAGGGCGCCGCGCTCCAGCTGCTCCCCCGCCTGGCGCCGGAGGCGGGCTGGGTGGCGCTGCGGCC
GCGGCAGTACGACACCTTCGCCGTGGTCCACCGCACCGGCGCCATCCTCTCCCCCGCCGCCCGGTTGATGATCGACCTCG
CCACCGCACGGATCCAGGCGATCGCCGAGCCGGTGACGGCTCGCGCGGCGCGGGCTACCGTCGGAGCATGA

Upstream 100 bases:

>100_bases
ACCTCCTCCGAGGCGCGGGCGAGCGGGAACACCGCCATTCTCGCCGCGCACTACACATAGGGGTAGCCTAGGTATCCTTC
ATCATCCCTAGGATATTCCT

Downstream 100 bases:

>100_bases
CCCCCGAGCAGACCGTCCGTGCCTTCCTCGAGCACCTCTCCCGGGCGGAGAGCGAGGCGGCCCTCGCGCTCCTGGACGCC
GACGTGGAGTGGCGCAACAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MLSLHQLTCFLATYEHGSLTAAAEELGYAQPSVSEQIRALEKTLGVQLFRRVGRGVVPTTVADTLRPHAEKVLATVDEAA
QAVQSVKSLETGTIRFGMFGIARLYAGAGLIGDVLSRYPGVRVELVGQNSTEVAEDLRRGRLEAAMLAVSGIQSEGMTVT
PVAREELVYISADPTRLATPVTPHRLSQASLVMSETTYRAVDSTRATLRQMLHETGHNPATRIEVEDIETAVELVGMGYA
DSVVPKGAALQLLPRLAPEAGWVALRPRQYDTFAVVHRTGAILSPAARLMIDLATARIQAIAEPVTARAARATVGA

Sequences:

>Translated_316_residues
MLSLHQLTCFLATYEHGSLTAAAEELGYAQPSVSEQIRALEKTLGVQLFRRVGRGVVPTTVADTLRPHAEKVLATVDEAA
QAVQSVKSLETGTIRFGMFGIARLYAGAGLIGDVLSRYPGVRVELVGQNSTEVAEDLRRGRLEAAMLAVSGIQSEGMTVT
PVAREELVYISADPTRLATPVTPHRLSQASLVMSETTYRAVDSTRATLRQMLHETGHNPATRIEVEDIETAVELVGMGYA
DSVVPKGAALQLLPRLAPEAGWVALRPRQYDTFAVVHRTGAILSPAARLMIDLATARIQAIAEPVTARAARATVGA
>Mature_316_residues
MLSLHQLTCFLATYEHGSLTAAAEELGYAQPSVSEQIRALEKTLGVQLFRRVGRGVVPTTVADTLRPHAEKVLATVDEAA
QAVQSVKSLETGTIRFGMFGIARLYAGAGLIGDVLSRYPGVRVELVGQNSTEVAEDLRRGRLEAAMLAVSGIQSEGMTVT
PVAREELVYISADPTRLATPVTPHRLSQASLVMSETTYRAVDSTRATLRQMLHETGHNPATRIEVEDIETAVELVGMGYA
DSVVPKGAALQLLPRLAPEAGWVALRPRQYDTFAVVHRTGAILSPAARLMIDLATARIQAIAEPVTARAARATVGA

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=253, Percent_Identity=29.2490118577075, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI145693105, Length=298, Percent_Identity=23.8255033557047, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787806, Length=314, Percent_Identity=27.0700636942675, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788297, Length=272, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=283, Percent_Identity=23.321554770318, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33830; Mature: 33830

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLHQLTCFLATYEHGSLTAAAEELGYAQPSVSEQIRALEKTLGVQLFRRVGRGVVPTT
CCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
VADTLRPHAEKVLATVDEAAQAVQSVKSLETGTIRFGMFGIARLYAGAGLIGDVLSRYPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC
VRVELVGQNSTEVAEDLRRGRLEAAMLAVSGIQSEGMTVTPVAREELVYISADPTRLATP
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCC
VTPHRLSQASLVMSETTYRAVDSTRATLRQMLHETGHNPATRIEVEDIETAVELVGMGYA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCH
DSVVPKGAALQLLPRLAPEAGWVALRPRQYDTFAVVHRTGAILSPAARLMIDLATARIQA
HHHCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IAEPVTARAARATVGA
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSLHQLTCFLATYEHGSLTAAAEELGYAQPSVSEQIRALEKTLGVQLFRRVGRGVVPTT
CCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHH
VADTLRPHAEKVLATVDEAAQAVQSVKSLETGTIRFGMFGIARLYAGAGLIGDVLSRYPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC
VRVELVGQNSTEVAEDLRRGRLEAAMLAVSGIQSEGMTVTPVAREELVYISADPTRLATP
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCC
VTPHRLSQASLVMSETTYRAVDSTRATLRQMLHETGHNPATRIEVEDIETAVELVGMGYA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCH
DSVVPKGAALQLLPRLAPEAGWVALRPRQYDTFAVVHRTGAILSPAARLMIDLATARIQA
HHHCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IAEPVTARAARATVGA
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]