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The map label for this gene is nhaA1

Identifier: 119714611

GI number: 119714611

Start: 365914

End: 367218

Strand: Reverse

Name: nhaA1

Synonym: Noca_0345

Alternate gene names: 119714611

Gene position: 367218-365914 (Counterclockwise)

Preceding gene: 119714612

Following gene: 119714610

Centisome position: 7.37

GC content: 73.95

Gene sequence:

>1305_bases
GTGACCGGCCGCCGCCCGACCCGCCCCCGCCTGTTCTCGCGAGGGTCGTTCCTCGAGAGCTCCCGGGTCGCCGACATCCT
CCGCGCGGAGACCACCGGCGGCCTGCTGCTGATCGCCGCCGCCACGGTGGCGATCGTGTGGGCGAACACCCCCTGGTCGG
CGTCGTACGCCGACCTCCGCGACCTGCGGGTCGGTCCGCAGGCGTGGCACCTCGACCTCACCCTGGGCGCCTGGGCGGCC
GACGGCCTGCTGGCGATCTTCTTCTTCGTGGCCGGCCTGGAGCTCAAGCGGGAGTTCGTGGCCGGCGACCTCCGGGACCC
GCGCCGGGCGGCGCTGCCCGTGGTCGCCGCCATGGGCGGGATGGCGGTGCCCGCGCTCGTCTACGTGCTGTGGAACCTCG
GCGGGGACGGGGCGCTGCAGGGCTGGGCGATCCCCACGGCGACCGACATCGCGTTCGCCGTCGCCATCCTCGCGGTGATC
AGCACCCACCTGCCCACGGGCCTGCGGACGTTCCTGCTGACCCTGGCGGTCGTCGACGACCTGTTGGCCATCACGATCAT
CGCGCTCTTCTACACCGACGAGCTGCACCTGGGCTACCTCGCGGCCGCCGCCGTCCCCCTCCTGGTCTTCGCGCTGCTGG
TGCAGCGACGGATCCACCGCGGCTGGCTGCTGATCCCCCTGGCCGCCACCGCCTGGGTCCTGGTGCACGAGTCGGGCGTG
CACGCGACCGTCGCCGGGGTGCTGCTCGGCTTCGCCGTCCCGGTGCTGCGCTCGGACGGCCAGGAGGGGCCCGGGCTCGC
CGAGCACCTCGAGCACCTGGTCCGGCCGCTCTCGGCCGGCCTCGCCGTACCCGTGTTCGCGTTCTTCGCCGCCGGGGTCA
CCGTCGGGGGGTTCGACGGGCTCGTGGACGCGCTCTCCGACCCGGTCGCGCTCGGCGTCGTCACCGGCCTGGTCGTCGGC
AAGACCGTCGGGATCGCCGGCTCCACGTGGTTGCTCGCGACCTTCACCCGCGCCGACCTCGACGACCAGCTGAGCTGGGT
CGACGTGGTCGGCCTGGCGATGCTCGCCGGCATCGGCTTCACCGTCTCGCTGCTGATCGGCGAGCTCGCGTTCGGCAGCG
GCACCCCCCGGGACGATCACGTGAAGGTGGGCGTGCTCGTCGGCTCGCTGGCCGCCACGGCCCTCGCGACAGGGGTGCTG
CGGATGCGCAACCGCGCCTACCGGCGGCTGGTCGAGATCGAGGAGCAGGACGCCGACGCGGACGGGGTCCCCGACGTCTA
CCAGCGCGACGCCGACGAGGGGTGA

Upstream 100 bases:

>100_bases
ACGCCCGCCCGGCGGGCCGGGTGGGGGTCGACGCGTAGGGTGGGCAGCGGTGAGCCGGGAAGTCTGGTCGGCATGTGGAC
CGCCGACCCCGAGGAGCCCT

Downstream 100 bases:

>100_bases
GGGTTCTGTAGGGTGAGCGACATGGCGAGCAACCAGGTCCAGGCTGCACCTCCGGATGAGGGCGATCCGACCATCGGTCG
TCTGGTCCACGACGCCAGCC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLRDLRVGPQAWHLDLTLGAWAA
DGLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGGMAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVI
STHLPTGLRTFLLTLAVVDDLLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGV
HATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDGLVDALSDPVALGVVTGLVVG
KTVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGFTVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVL
RMRNRAYRRLVEIEEQDADADGVPDVYQRDADEG

Sequences:

>Translated_434_residues
MTGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLRDLRVGPQAWHLDLTLGAWAA
DGLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGGMAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVI
STHLPTGLRTFLLTLAVVDDLLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGV
HATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDGLVDALSDPVALGVVTGLVVG
KTVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGFTVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVL
RMRNRAYRRLVEIEEQDADADGVPDVYQRDADEG
>Mature_433_residues
TGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLRDLRVGPQAWHLDLTLGAWAAD
GLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGGMAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVIS
THLPTGLRTFLLTLAVVDDLLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGVH
ATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDGLVDALSDPVALGVVTGLVVGK
TVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGFTVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVLR
MRNRAYRRLVEIEEQDADADGVPDVYQRDADEG

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=346, Percent_Identity=41.907514450867, Blast_Score=234, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA1_NOCSJ (A1SDK4)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921576.1
- ProteinModelPortal:   A1SDK4
- SMR:   A1SDK4
- STRING:   A1SDK4
- GeneID:   4597982
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0345
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   AFMIPME
- PhylomeDB:   A1SDK4
- BioCyc:   NSP35761:NOCA_0345-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 45692; Mature: 45560

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x125f9ee4)-; HASH(0x15235ebc)-; HASH(0x1444072c)-; HASH(0x1523e658)-; HASH(0x15240e84)-; HASH(0x14019720)-; HASH(0x156433e4)-; HASH(0x14019870)-; HASH(0x15238f90)-; HASH(0x15238f9c)-; HASH(0x148a2508)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLR
CCCCCCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCCCCHHHHH
DLRVGPQAWHLDLTLGAWAADGLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGG
HHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
MAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVISTHLPTGLRTFLLTLAVVDD
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHEEEEEECCCC
HATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHH
LVDALSDPVALGVVTGLVVGKTVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGF
HHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHEEHHCCCCHHHHHHHHHHHHHHHHHHH
TVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVLRMRNRAYRRLVEIEEQDADA
HHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGVPDVYQRDADEG
CCCCHHHHCCCCCH
>Mature Secondary Structure 
TGRRPTRPRLFSRGSFLESSRVADILRAETTGGLLLIAAATVAIVWANTPWSASYADLR
CCCCCCCCCHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCCCCHHHHH
DLRVGPQAWHLDLTLGAWAADGLLAIFFFVAGLELKREFVAGDLRDPRRAALPVVAAMGG
HHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
MAVPALVYVLWNLGGDGALQGWAIPTATDIAFAVAILAVISTHLPTGLRTFLLTLAVVDD
HHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LLAITIIALFYTDELHLGYLAAAAVPLLVFALLVQRRIHRGWLLIPLAATAWVLVHESGV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHEEEEEECCCC
HATVAGVLLGFAVPVLRSDGQEGPGLAEHLEHLVRPLSAGLAVPVFAFFAAGVTVGGFDG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHH
LVDALSDPVALGVVTGLVVGKTVGIAGSTWLLATFTRADLDDQLSWVDVVGLAMLAGIGF
HHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHEEHHCCCCHHHHHHHHHHHHHHHHHHH
TVSLLIGELAFGSGTPRDDHVKVGVLVGSLAATALATGVLRMRNRAYRRLVEIEEQDADA
HHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGVPDVYQRDADEG
CCCCHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA