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The map label for this gene is cobB [H]

Identifier: 119714532

GI number: 119714532

Start: 284215

End: 284913

Strand: Direct

Name: cobB [H]

Synonym: Noca_0265

Alternate gene names: 119714532

Gene position: 284215-284913 (Clockwise)

Preceding gene: 119714531

Following gene: 119714533

Centisome position: 5.7

GC content: 74.11

Gene sequence:

>699_bases
GTGGTCGTGAGGATCGTCGTCCTGACCGGGGCCGGGATCTCCGCCGAGAGCGGGCTCCCGACGTTCCGTGACGCCGACGG
ACTCTGGCACGGCCACCGGGTCGAGGAGGTCGCGACGCCGGAGGCGTTCGAGCGCGTGCCCGCGCTCGTGCACCGGTTCT
ACGACGAGCGCCGCGCGGCCCTGGCCACCGTCCGGCCCAACGCCGCCCACGAGGCGCTCGCCCGGCTCGAGCAGGCGCTC
GGGGACGACCTGCTCGTCGTCACCCAGAACATCGACGACCTCCACGAGCGGAGCGGCTCGCGCCAGGTCCTGCACATGCA
CGGCCGACTGCGCTCGGCGCTGTGCGGGTCCTGTGCCGGGCACTTCGACTGGGTCGGCGACCTGGGCGACGCGCCGCCGT
GCCCGCGGTGCGGTCGGCGCGAGCTGCGTCCCGACGTCGTGTGGTTCGGCGAGGCCCCCTACGACATGGATCGGATCCTC
GGCGCCGTCGGCCGGGCCGACCTGTTCGTGTCCGTCGGCACGTCCGGCGCGGTCTACCCGGCCGCGGGCTTCGTGCAGTA
CGCCGCCGGCCAGGGCGCCCGCACCCTCGAGCTCAACCTGGTCCCGAGCGAGGGCAGCCACCTCTTCGACGAGTCCCGCC
ACGGGCCGGCCTCCCGCCTCGTCCCCGAATGGGTGGCCGAGATCTTCGATACTCCCTGA

Upstream 100 bases:

>100_bases
CTGGACGGTGAGTCGGTGCGCAAGGTCTTCCTCGAGGAGTTCAAGACTCAGGCGGCCCGGCGCAGGGTCGGGCGCCGATG
ACGCGCAGGGACGCGACGGG

Downstream 100 bases:

>100_bases
CGGTTGCGCGCCGTTCCGTGGGCCGGGACCGCGCAATCGTCAGGGACTACCACAGGCGGTCGGTGTGAGACGGCGCGGGT
CGGAGTATCTCCGGGCCGTC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MVVRIVVLTGAGISAESGLPTFRDADGLWHGHRVEEVATPEAFERVPALVHRFYDERRAALATVRPNAAHEALARLEQAL
GDDLLVVTQNIDDLHERSGSRQVLHMHGRLRSALCGSCAGHFDWVGDLGDAPPCPRCGRRELRPDVVWFGEAPYDMDRIL
GAVGRADLFVSVGTSGAVYPAAGFVQYAAGQGARTLELNLVPSEGSHLFDESRHGPASRLVPEWVAEIFDTP

Sequences:

>Translated_232_residues
MVVRIVVLTGAGISAESGLPTFRDADGLWHGHRVEEVATPEAFERVPALVHRFYDERRAALATVRPNAAHEALARLEQAL
GDDLLVVTQNIDDLHERSGSRQVLHMHGRLRSALCGSCAGHFDWVGDLGDAPPCPRCGRRELRPDVVWFGEAPYDMDRIL
GAVGRADLFVSVGTSGAVYPAAGFVQYAAGQGARTLELNLVPSEGSHLFDESRHGPASRLVPEWVAEIFDTP
>Mature_232_residues
MVVRIVVLTGAGISAESGLPTFRDADGLWHGHRVEEVATPEAFERVPALVHRFYDERRAALATVRPNAAHEALARLEQAL
GDDLLVVTQNIDDLHERSGSRQVLHMHGRLRSALCGSCAGHFDWVGDLGDAPPCPRCGRRELRPDVVWFGEAPYDMDRIL
GAVGRADLFVSVGTSGAVYPAAGFVQYAAGQGARTLELNLVPSEGSHLFDESRHGPASRLVPEWVAEIFDTP

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=237, Percent_Identity=38.3966244725738, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI6912664, Length=254, Percent_Identity=35.8267716535433, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI13787215, Length=238, Percent_Identity=36.1344537815126, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI6912662, Length=242, Percent_Identity=28.9256198347107, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI6912660, Length=207, Percent_Identity=33.8164251207729, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7657575, Length=205, Percent_Identity=30.7317073170732, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI63054862, Length=205, Percent_Identity=32.6829268292683, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI308199517, Length=229, Percent_Identity=55.4585152838428, Blast_Score=247, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17541892, Length=195, Percent_Identity=31.2820512820513, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137536, Length=219, Percent_Identity=29.6803652968037, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571445, Length=201, Percent_Identity=31.8407960199005, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25209; Mature: 25209

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVRIVVLTGAGISAESGLPTFRDADGLWHGHRVEEVATPEAFERVPALVHRFYDERRAA
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LATVRPNAAHEALARLEQALGDDLLVVTQNIDDLHERSGSRQVLHMHGRLRSALCGSCAG
HHCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
HFDWVGDLGDAPPCPRCGRRELRPDVVWFGEAPYDMDRILGAVGRADLFVSVGTSGAVYP
CCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCC
AAGFVQYAAGQGARTLELNLVPSEGSHLFDESRHGPASRLVPEWVAEIFDTP
CHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVVRIVVLTGAGISAESGLPTFRDADGLWHGHRVEEVATPEAFERVPALVHRFYDERRAA
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LATVRPNAAHEALARLEQALGDDLLVVTQNIDDLHERSGSRQVLHMHGRLRSALCGSCAG
HHCCCCCHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
HFDWVGDLGDAPPCPRCGRRELRPDVVWFGEAPYDMDRILGAVGRADLFVSVGTSGAVYP
CCCCCCCCCCCCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCC
AAGFVQYAAGQGARTLELNLVPSEGSHLFDESRHGPASRLVPEWVAEIFDTP
CHHHHHHHCCCCCEEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]