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The map label for this gene is hsaC [H]

Identifier: 119714474

GI number: 119714474

Start: 222790

End: 223707

Strand: Direct

Name: hsaC [H]

Synonym: Noca_0207

Alternate gene names: 119714474

Gene position: 222790-223707 (Clockwise)

Preceding gene: 119714473

Following gene: 119714475

Centisome position: 4.47

GC content: 68.63

Gene sequence:

>918_bases
GTGATCACTCAACTCGCCTACCTGGGGATCGCCTCCCCGAACTACCAGCAGTGGCGCGACTACGGCACCCGCCTGCTCGG
CACCCAGCTCGCCGCGGACGGCCCGGACGGCGCGGTGCGCCTGCGGGTCGACGACAAGGGCTACCGGATCGCGGTCCACC
CCGCGGAGCAGGACGAGTTCCGGTACGCCGGCTGGGCCTGCCACAACGAGACCGAGCTGCGCAGCTACGTCGCCGAGCTG
CGCGGCAAGGGCCTCGAGGTGCACGAGGGCACGCCCGAGGAGCTCAAGGAGCGCCAGGTGGCGGAGCTCTACTGGATCCA
GGACCCGTGGGGGAACCGGCACGAGCTGGTCTGGGGCCAGTTCTCCATGCCGAACTCGTTCTGGCCCGCCCGGAAGATGA
ACGGCTTCGTCACCGGCGACCTCGGTCTGGGCCACATCGTGATGATCGTCCCCGACCTCCAGGCCGCGGACGCGTTCTAC
GCCGAGACGCTGGGCTTCCGGCTCTCCGACCGCGTGGTCAGCGACATCTTCAACCTGCGCTTCTACCACTGCAACGGCCG
GCACCACTCGCTCGCCGTCGCCGAGATCCCGGGCATGACCGGCATCAACCACCTGATGCTCGAGGTCGAGAACATGGACG
ACCTCGGCTCCGCGATCGACCTGTTCACCGCGGACCAGGAGCGCGAGATCCTGCTCTCCCTCGGCCGGCACACCAACGAC
CTGATGACCTCGATCTACGTGCAGACCCCGTCGAGCATGCAGATCGAGTACGGCTTCGGCGGCATCGCCGTCGACGACCT
CACCTGGGTCGCCGGTACCCACGACGTGCCGAGCATCTGGGGCCACCACCGCTCGCAGGCCTACCTCGACGGCCCTCCCG
GAATCTTCCAGATGCTCGACGCGGAGGCCCCGGCGTGA

Upstream 100 bases:

>100_bases
ACGTCACGGCCGAGCTCGGCCACGCGTTCCTGGTCTCCGACGGCGTCGGCCAGTACTACGGCGCCTCCCTTCTCGACTCG
TCCGCTCCGGAGGTCATGCT

Downstream 100 bases:

>100_bases
CCGCAGTCGCCCCGGCACCGGTGGAGCGCTCCGGGATCCGCGAGTCCGACGTCGCGATCGCCGGCGGCCGGCACCTGCGG
GTGCTGGAGGCCGGCGAGCC

Product: glyoxalase/bleomycin resistance protein/dioxygenase

Products: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate; H2O

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MITQLAYLGIASPNYQQWRDYGTRLLGTQLAADGPDGAVRLRVDDKGYRIAVHPAEQDEFRYAGWACHNETELRSYVAEL
RGKGLEVHEGTPEELKERQVAELYWIQDPWGNRHELVWGQFSMPNSFWPARKMNGFVTGDLGLGHIVMIVPDLQAADAFY
AETLGFRLSDRVVSDIFNLRFYHCNGRHHSLAVAEIPGMTGINHLMLEVENMDDLGSAIDLFTADQEREILLSLGRHTND
LMTSIYVQTPSSMQIEYGFGGIAVDDLTWVAGTHDVPSIWGHHRSQAYLDGPPGIFQMLDAEAPA

Sequences:

>Translated_305_residues
MITQLAYLGIASPNYQQWRDYGTRLLGTQLAADGPDGAVRLRVDDKGYRIAVHPAEQDEFRYAGWACHNETELRSYVAEL
RGKGLEVHEGTPEELKERQVAELYWIQDPWGNRHELVWGQFSMPNSFWPARKMNGFVTGDLGLGHIVMIVPDLQAADAFY
AETLGFRLSDRVVSDIFNLRFYHCNGRHHSLAVAEIPGMTGINHLMLEVENMDDLGSAIDLFTADQEREILLSLGRHTND
LMTSIYVQTPSSMQIEYGFGGIAVDDLTWVAGTHDVPSIWGHHRSQAYLDGPPGIFQMLDAEAPA
>Mature_305_residues
MITQLAYLGIASPNYQQWRDYGTRLLGTQLAADGPDGAVRLRVDDKGYRIAVHPAEQDEFRYAGWACHNETELRSYVAEL
RGKGLEVHEGTPEELKERQVAELYWIQDPWGNRHELVWGQFSMPNSFWPARKMNGFVTGDLGLGHIVMIVPDLQAADAFY
AETLGFRLSDRVVSDIFNLRFYHCNGRHHSLAVAEIPGMTGINHLMLEVENMDDLGSAIDLFTADQEREILLSLGRHTND
LMTSIYVQTPSSMQIEYGFGGIAVDDLTWVAGTHDVPSIWGHHRSQAYLDGPPGIFQMLDAEAPA

Specific function: Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4- oic acid (4,9-DSHA). Also involved in biphenyl and polychlorinated biphenyls

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the extradiol ring-cleavage dioxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR000486 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.39

Molecular weight: Translated: 34246; Mature: 34246

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITQLAYLGIASPNYQQWRDYGTRLLGTQLAADGPDGAVRLRVDDKGYRIAVHPAEQDEF
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCC
RYAGWACHNETELRSYVAELRGKGLEVHEGTPEELKERQVAELYWIQDPWGNRHELVWGQ
EEEEEEECCHHHHHHHHHHHCCCCEEECCCCHHHHHHCCEEEEEEEECCCCCCCEEEEEE
FSMPNSFWPARKMNGFVTGDLGLGHIVMIVPDLQAADAFYAETLGFRLSDRVVSDIFNLR
ECCCCCCCCHHHCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHEE
FYHCNGRHHSLAVAEIPGMTGINHLMLEVENMDDLGSAIDLFTADQEREILLSLGRHTND
EEEECCCCCEEEEEECCCCCCCCEEEEEECCCHHHCCHHEEEECCCHHHHHHHHCCCCCC
LMTSIYVQTPSSMQIEYGFGGIAVDDLTWVAGTHDVPSIWGHHRSQAYLDGPPGIFQMLD
CEEEEEEECCCCEEEEECCCCEEECCEEEECCCCCCHHHHCCCCCCEEECCCCHHHHHHC
AEAPA
CCCCC
>Mature Secondary Structure
MITQLAYLGIASPNYQQWRDYGTRLLGTQLAADGPDGAVRLRVDDKGYRIAVHPAEQDEF
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCC
RYAGWACHNETELRSYVAELRGKGLEVHEGTPEELKERQVAELYWIQDPWGNRHELVWGQ
EEEEEEECCHHHHHHHHHHHCCCCEEECCCCHHHHHHCCEEEEEEEECCCCCCCEEEEEE
FSMPNSFWPARKMNGFVTGDLGLGHIVMIVPDLQAADAFYAETLGFRLSDRVVSDIFNLR
ECCCCCCCCHHHCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHEE
FYHCNGRHHSLAVAEIPGMTGINHLMLEVENMDDLGSAIDLFTADQEREILLSLGRHTND
EEEECCCCCEEEEEECCCCCCCCEEEEEECCCHHHCCHHEEEECCCHHHHHHHHCCCCCC
LMTSIYVQTPSSMQIEYGFGGIAVDDLTWVAGTHDVPSIWGHHRSQAYLDGPPGIFQMLD
CEEEEEEECCCCEEEEECCCCEEECCEEEECCCCCCHHHHCCCCCCEEECCCCHHHHHHC
AEAPA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: biphenyl-2,3-diol; O2

Specific reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA