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The map label for this gene is serS

Identifier: 119714441

GI number: 119714441

Start: 187506

End: 188780

Strand: Direct

Name: serS

Synonym: Noca_0174

Alternate gene names: 119714441

Gene position: 187506-188780 (Clockwise)

Preceding gene: 119714439

Following gene: 119714442

Centisome position: 3.76

GC content: 71.14

Gene sequence:

>1275_bases
ATGATCGATCCCCGTGTCCTCCGGGACGAGCCCGACCGCGTGCGCGCCGCCCAGGTCAAGCGCGGTCTGTCCGACGAGGT
CGTGGACCACGCGCTGTCCGCGGACGGCGAGCGTCGCCGGGCGATCGCCGCGTTCGAGGCCAAGCGGGCCGAGCAGAAGC
AGCTCGGCAAGCTGATCCCGCAGGCCCAGGGTGAGGAGAAGCAGGCGCTGCTGGCGCAGACCAAGACCCTCGCTGCCGAG
GTCAAGCAGGCCGAGGCGGCCCAGGCCGTGGCCGAGGAGGCCTGGCAGGCGGCCCTGATGAGCATCCCGAACCTCGCGGC
CGACGAGGCGCCCGCCGGCGGCGAGGACGACTACGTCGTGCTCGAGGAGATCGGCACCCCCCGCGACTTCGCGGCCGACG
GCTTCGAGCCGCGCGACCACATCGAGCTGGGCCGGATGCTCGGCGCGATCGACCTCGACCGGGGCGCCAAGGTGTCCGGG
TCGCGGTTCTACTTCCTCACCGGCGCCGGGGCCGAGCTCGAGCTGGCGCTGGTCAACCTGGCCATGCAGCAGGCCCGCGA
GTCCGGCTTCACCCCGGTCATCGCCCCCTCGATGGTCAAGCCGCGCGCGATGGACGGCACCGGGTTCCTCGGCCAGGCGG
CCGACGACGTCTACCGGATCGAGGGCCAGGACATGTACCTCGTCGGGACGTCCGAGGTCCCGATGGCGGCGTACCACTCC
GACGAGATCCTCGACGGCGGCGCGCTGCCGCTGCGCTACGCCGCGTTCAGCCCGTGCTTCCGCAAGGAGGCCGGCTCGCA
CGGCAAGGACACCAAGGGCATCATCCGGGTGCACTGGTTCGACAAGGTCGAGATGTTCGTCTACACCACGACCGAGGAGT
CGTACGCCGAGCACCAGCGGCTGCTGGCGTGGGAGAAGGAGTTCCTCGAGAAGCTCGAGCTCGCCTACCGGGTGATCGAC
GTCGCCGCCGGTGACTTGGGCCTGTCCGCGCAGCGGAAGTTCGACTGCGAGGCCTGGATCCCCACCCAGGGCCGCTACCG
CGAGCTCACCTCGACGTCGAACTGCACCGAGTTCCAGACCCGCCGCCTCGACACCCGCGGCCGGTTCGGGTCGGAGATCA
GGCCGATCTCGACCCTCAACGGCACCCTGTGCGCGATCACCCGCACGATCGTGGCGGTGCTCGAGACCCACCAGCAGGCC
GACGGCTCGGTCCGGGTGCCGAAGGCGCTCCAGCCCTGGCTGGGCCGCGAGGTCCTGGAGCCGGTCACCACGTGA

Upstream 100 bases:

>100_bases
AATCGGTGCGACTCGTCCTGCGGGGCCCGGATAGCCTTGTCGACATGACCTCACCCCACGAAGTCGCTCGTTGCGCTCCC
GACTCCGCGGGGACCCCGAG

Downstream 100 bases:

>100_bases
GCGGACCCGTGAGCGGCTGGCGGCCCCGGCTCGTCGCCCTCGACATCGACGGCACGATCCTGAAGTGGGTGGAGGGGTCG
GGCACCACCCGCGAGGAGAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIDPRVLRDEPDRVRAAQVKRGLSDEVVDHALSADGERRRAIAAFEAKRAEQKQLGKLIPQAQGEEKQALLAQTKTLAAE
VKQAEAAQAVAEEAWQAALMSIPNLAADEAPAGGEDDYVVLEEIGTPRDFAADGFEPRDHIELGRMLGAIDLDRGAKVSG
SRFYFLTGAGAELELALVNLAMQQARESGFTPVIAPSMVKPRAMDGTGFLGQAADDVYRIEGQDMYLVGTSEVPMAAYHS
DEILDGGALPLRYAAFSPCFRKEAGSHGKDTKGIIRVHWFDKVEMFVYTTTEESYAEHQRLLAWEKEFLEKLELAYRVID
VAAGDLGLSAQRKFDCEAWIPTQGRYRELTSTSNCTEFQTRRLDTRGRFGSEIRPISTLNGTLCAITRTIVAVLETHQQA
DGSVRVPKALQPWLGREVLEPVTT

Sequences:

>Translated_424_residues
MIDPRVLRDEPDRVRAAQVKRGLSDEVVDHALSADGERRRAIAAFEAKRAEQKQLGKLIPQAQGEEKQALLAQTKTLAAE
VKQAEAAQAVAEEAWQAALMSIPNLAADEAPAGGEDDYVVLEEIGTPRDFAADGFEPRDHIELGRMLGAIDLDRGAKVSG
SRFYFLTGAGAELELALVNLAMQQARESGFTPVIAPSMVKPRAMDGTGFLGQAADDVYRIEGQDMYLVGTSEVPMAAYHS
DEILDGGALPLRYAAFSPCFRKEAGSHGKDTKGIIRVHWFDKVEMFVYTTTEESYAEHQRLLAWEKEFLEKLELAYRVID
VAAGDLGLSAQRKFDCEAWIPTQGRYRELTSTSNCTEFQTRRLDTRGRFGSEIRPISTLNGTLCAITRTIVAVLETHQQA
DGSVRVPKALQPWLGREVLEPVTT
>Mature_424_residues
MIDPRVLRDEPDRVRAAQVKRGLSDEVVDHALSADGERRRAIAAFEAKRAEQKQLGKLIPQAQGEEKQALLAQTKTLAAE
VKQAEAAQAVAEEAWQAALMSIPNLAADEAPAGGEDDYVVLEEIGTPRDFAADGFEPRDHIELGRMLGAIDLDRGAKVSG
SRFYFLTGAGAELELALVNLAMQQARESGFTPVIAPSMVKPRAMDGTGFLGQAADDVYRIEGQDMYLVGTSEVPMAAYHS
DEILDGGALPLRYAAFSPCFRKEAGSHGKDTKGIIRVHWFDKVEMFVYTTTEESYAEHQRLLAWEKEFLEKLELAYRVID
VAAGDLGLSAQRKFDCEAWIPTQGRYRELTSTSNCTEFQTRRLDTRGRFGSEIRPISTLNGTLCAITRTIVAVLETHQQA
DGSVRVPKALQPWLGREVLEPVTT

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=360, Percent_Identity=38.0555555555556, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI225579074, Length=336, Percent_Identity=39.2857142857143, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI16306548, Length=294, Percent_Identity=37.7551020408163, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=37.2960372960373, Blast_Score=271, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI17539260, Length=366, Percent_Identity=34.1530054644809, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17542084, Length=312, Percent_Identity=33.6538461538462, Blast_Score=160, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6320226, Length=422, Percent_Identity=33.175355450237, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6321799, Length=288, Percent_Identity=34.7222222222222, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24581334, Length=451, Percent_Identity=32.3725055432373, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17737985, Length=281, Percent_Identity=35.5871886120996, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_NOCSJ (A1SD34)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921406.1
- ProteinModelPortal:   A1SD34
- SMR:   A1SD34
- STRING:   A1SD34
- GeneID:   4598950
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0174
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- PhylomeDB:   A1SD34
- ProtClustDB:   PRK05431
- BioCyc:   NSP35761:NOCA_0174-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46697; Mature: 46697

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 277-277 BINDING 284-284 BINDING 382-382

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPRVLRDEPDRVRAAQVKRGLSDEVVDHALSADGERRRAIAAFEAKRAEQKQLGKLIP
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QAQGEEKQALLAQTKTLAAEVKQAEAAQAVAEEAWQAALMSIPNLAADEAPAGGEDDYVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
LEEIGTPRDFAADGFEPRDHIELGRMLGAIDLDRGAKVSGSRFYFLTGAGAELELALVNL
EECCCCCCCCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCHHHHHHH
AMQQARESGFTPVIAPSMVKPRAMDGTGFLGQAADDVYRIEGQDMYLVGTSEVPMAAYHS
HHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCEEECCC
DEILDGGALPLRYAAFSPCFRKEAGSHGKDTKGIIRVHWFDKVEMFVYTTTEESYAEHQR
CHHCCCCCCCCHHHHCCHHHHHHCCCCCCCCCCEEEEEEECCEEEEEEECCHHHHHHHHH
LLAWEKEFLEKLELAYRVIDVAAGDLGLSAQRKFDCEAWIPTQGRYRELTSTSNCTEFQT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCHHHHCCCCCCHHHHH
RRLDTRGRFGSEIRPISTLNGTLCAITRTIVAVLETHQQADGSVRVPKALQPWLGREVLE
HHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHH
PVTT
HCCC
>Mature Secondary Structure
MIDPRVLRDEPDRVRAAQVKRGLSDEVVDHALSADGERRRAIAAFEAKRAEQKQLGKLIP
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
QAQGEEKQALLAQTKTLAAEVKQAEAAQAVAEEAWQAALMSIPNLAADEAPAGGEDDYVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
LEEIGTPRDFAADGFEPRDHIELGRMLGAIDLDRGAKVSGSRFYFLTGAGAELELALVNL
EECCCCCCCCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCHHHHHHH
AMQQARESGFTPVIAPSMVKPRAMDGTGFLGQAADDVYRIEGQDMYLVGTSEVPMAAYHS
HHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCEEECCC
DEILDGGALPLRYAAFSPCFRKEAGSHGKDTKGIIRVHWFDKVEMFVYTTTEESYAEHQR
CHHCCCCCCCCHHHHCCHHHHHHCCCCCCCCCCEEEEEEECCEEEEEEECCHHHHHHHHH
LLAWEKEFLEKLELAYRVIDVAAGDLGLSAQRKFDCEAWIPTQGRYRELTSTSNCTEFQT
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCHHHHCCCCCCHHHHH
RRLDTRGRFGSEIRPISTLNGTLCAITRTIVAVLETHQQADGSVRVPKALQPWLGREVLE
HHCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHH
PVTT
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA