Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 119714424

GI number: 119714424

Start: 172231

End: 173097

Strand: Reverse

Name: mutM [H]

Synonym: Noca_0157

Alternate gene names: 119714424

Gene position: 173097-172231 (Counterclockwise)

Preceding gene: 119714430

Following gene: 119714423

Centisome position: 3.47

GC content: 72.32

Gene sequence:

>867_bases
GTGCCCGAGCTGCCCGAGGTGGAAGCCCTGGCCCTCGACCTGCGGGGCCGGCTGGACGGCCATGCCATCGCGAAGATCCA
CGTCGCCGCGTTCAGCGCGCTCAAGACCTTCGACCCGCCGCTGTCCGCGCTCGAGGGGACCCTCGTCGACGACGTGACCC
GGCACGGGAAGTTCCTCGACATCGAGGCCTCCGGCCTGCACCTGGTGCTGCACCTGGCGCGCGCCGGGTGGGTCCGTTGG
CGCGACGAGGTCCCCACGATCCCGCCCAAGCCGAGCACGAAGTCCACCCTCGCGGTCCGCATCGTCCTCGACGACCAGTC
CGGGCTCGACGTCACCGAGGCCGGCACCCGCAAGAGCCTGGCGATGTACGTCGTCCGTGACCCGCACGACGTCCCCGGCA
TCGCCAGCCTCGGGCCGGACCCGCTGACCGACGAGTTCACCATCGACCGGCTGCGCGAGATCCTCGAGCGCGAGGGCCGC
AAGCAGCTCAAGGGCGTGCTGCGCCACCAGGGCACCATCGCCGGCATCGGCAACGCCTACTCCGACGAGATCCTGCACGC
CGCCCGGATGTCGCCGTTCAAGGCGGCGGGCACGCTCACCGACGACGAGCTGCAGGTCCTGTACGACGCCCTCCGCGGCA
CCCTCGGCGACGCGGTCGGGCGCTCCCGCGGGCTGGCGGCGAGCGAGCTGAAGGGCGAGAAGAAGTCCCACCTCGCGGTG
CACGGGCGCGCCGGGCAGGCCTGCCCGGTGTGCGGCGACACGGTCCGCGAGGTGTCCTTCGCCGACTCCAGCCTGCAGTA
CTGCCCGACCTGCCAGACCGGCGGCAAGCCGCTCGCCGACCGACGGCTCAGCAAGCTGCTGAAGTAG

Upstream 100 bases:

>100_bases
GGTCGCCCTCACCCTGGGCCTGGTCGGGCTGGTCGCGCTCACGGCGCTGAGCATCGCGCTGGCCTGATCCCCGTGGGGGC
GCGGCTCTAGACTCGTCCGC

Downstream 100 bases:

>100_bases
CACCGAGCCGAACCCGAGCCGAGGGAGCACGATGACCCAGGTCCCGACCGTCCCGATCGAGGGCGTGCCGCACCCGCTGC
CCGACGGGCTGGTGGTGCTC

Product: DNA-(apurinic or apyrimidinic site) lyase / formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MPELPEVEALALDLRGRLDGHAIAKIHVAAFSALKTFDPPLSALEGTLVDDVTRHGKFLDIEASGLHLVLHLARAGWVRW
RDEVPTIPPKPSTKSTLAVRIVLDDQSGLDVTEAGTRKSLAMYVVRDPHDVPGIASLGPDPLTDEFTIDRLREILEREGR
KQLKGVLRHQGTIAGIGNAYSDEILHAARMSPFKAAGTLTDDELQVLYDALRGTLGDAVGRSRGLAASELKGEKKSHLAV
HGRAGQACPVCGDTVREVSFADSSLQYCPTCQTGGKPLADRRLSKLLK

Sequences:

>Translated_288_residues
MPELPEVEALALDLRGRLDGHAIAKIHVAAFSALKTFDPPLSALEGTLVDDVTRHGKFLDIEASGLHLVLHLARAGWVRW
RDEVPTIPPKPSTKSTLAVRIVLDDQSGLDVTEAGTRKSLAMYVVRDPHDVPGIASLGPDPLTDEFTIDRLREILEREGR
KQLKGVLRHQGTIAGIGNAYSDEILHAARMSPFKAAGTLTDDELQVLYDALRGTLGDAVGRSRGLAASELKGEKKSHLAV
HGRAGQACPVCGDTVREVSFADSSLQYCPTCQTGGKPLADRRLSKLLK
>Mature_287_residues
PELPEVEALALDLRGRLDGHAIAKIHVAAFSALKTFDPPLSALEGTLVDDVTRHGKFLDIEASGLHLVLHLARAGWVRWR
DEVPTIPPKPSTKSTLAVRIVLDDQSGLDVTEAGTRKSLAMYVVRDPHDVPGIASLGPDPLTDEFTIDRLREILEREGRK
QLKGVLRHQGTIAGIGNAYSDEILHAARMSPFKAAGTLTDDELQVLYDALRGTLGDAVGRSRGLAASELKGEKKSHLAVH
GRAGQACPVCGDTVREVSFADSSLQYCPTCQTGGKPLADRRLSKLLK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=277, Percent_Identity=25.9927797833935, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31083; Mature: 30952

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEALALDLRGRLDGHAIAKIHVAAFSALKTFDPPLSALEGTLVDDVTRHGKFLD
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCEEE
IEASGLHLVLHLARAGWVRWRDEVPTIPPKPSTKSTLAVRIVLDDQSGLDVTEAGTRKSL
EECCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHCCCCCCCE
AMYVVRDPHDVPGIASLGPDPLTDEFTIDRLREILEREGRKQLKGVLRHQGTIAGIGNAY
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHH
SDEILHAARMSPFKAAGTLTDDELQVLYDALRGTLGDAVGRSRGLAASELKGEKKSHLAV
HHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEE
HGRAGQACPVCGDTVREVSFADSSLQYCPTCQTGGKPLADRRLSKLLK
ECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PELPEVEALALDLRGRLDGHAIAKIHVAAFSALKTFDPPLSALEGTLVDDVTRHGKFLD
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHCCCEEE
IEASGLHLVLHLARAGWVRWRDEVPTIPPKPSTKSTLAVRIVLDDQSGLDVTEAGTRKSL
EECCCHHHHHHHHHHCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHCCCCCCCE
AMYVVRDPHDVPGIASLGPDPLTDEFTIDRLREILEREGRKQLKGVLRHQGTIAGIGNAY
EEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHH
SDEILHAARMSPFKAAGTLTDDELQVLYDALRGTLGDAVGRSRGLAASELKGEKKSHLAV
HHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEE
HGRAGQACPVCGDTVREVSFADSSLQYCPTCQTGGKPLADRRLSKLLK
ECCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA