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The map label for this gene is maeB [C]

Identifier: 119714380

GI number: 119714380

Start: 126048

End: 127421

Strand: Direct

Name: maeB [C]

Synonym: Noca_0113

Alternate gene names: 119714380

Gene position: 126048-127421 (Clockwise)

Preceding gene: 119714379

Following gene: 119714382

Centisome position: 2.53

GC content: 72.27

Gene sequence:

>1374_bases
ATGGCCGCCACCGCGTCGTCGTACTCGATCACCATGCGCCTGCACACGGCGCCCGACCACGGCGTCGTGGGCGCCGTCGC
CACCGCGATCTCGGCGGCCGGCGGCATCGTCACCGCGATCGACGTCGCCGACTCCAGCCACGCCCGCCTGGTCGTGGACG
TGACCTGCTCGGCCAGCGACGCCGAGCACGCCGAGCGGCTCCACGCGGCCGCCGAGTCGGTCGAGGGCGTGGCGGTGCAC
CGGGTCAGCGACCGGACCTTCCTGCTGCACATCGGCGGCAAGATCGAGGTCACCTCCAAGGTGCCGCTGCGCAACCGCGA
CGACCTCTCGATGGCCTACACCCCCGGCGTCGGCCGGGTCAGCATGGCGCTGGCGGAGAGCCCGGGGGACGTCCCCCGGC
TGACCGTGAAGGGCAACTCGGTCGCGGTGGTCACCGACGGCTCGGCCGTGCTCGGACTCGGCAACATCGGGCCCGGTGCC
GCGCTGCCGGTGATGGAGGGCAAGGCCGCGCTGTTCAAGCGGTTCGCGGACATCGACGCCTGGCCGATCTGCCTGGCCTC
CCAGGACACCGACGAGATCGTGCGCGCGGTCGAGATGATCGCACCGGGCTTCGGCGGCATCAACCTCGAGGACATCGCCG
CGCCCCGCTGCTTCGAGATCGAACGGCGGCTGCGCGAGAGCCTGGACATCCCGGTCTTCCACGACGACCAGCACGGCACC
GCGATCGTGGTGCTGGCCGCCCTCACCAACGCGCTGCGGGTGGTGAAGAAGGACATCACCGACGTGCGCATCGTCGTGTC
GGGCGGCGGCGCCGCAGGCACCGCCATCGTCACGCTGCTGCTCGCCGCCGGCGCGCCGGACATCGTGGTGTGGGACCGCG
AGGGCTGCCTCTCGCGCGACGACGACACGCTGCCCCCGGCGAAGCGGCAGCTCGCGGAGATGACCAACCCGCGCCTCGTC
CGGGGTGACCTCCGCGCCGGGCTCGACGGCGCCGACGTCTTCATCGGGGTCAGCGGCCCCGGGGTGCTCGATGCCGAGTG
GATCAAGGACATGGCCCCGGACCCGGTGGTGTTCGCGCTCGCGAACCCCGACCCCGAGGTCGACCCGGCGGAGGCGGAGA
AGTACGCCGCGGTCGTGGCCAGCGGCCGGTCCGACTACCCGAACCAGATCAACAACGTGCTCGCCTTCCCCGGGGTGTTC
CGCGGGCTGCTCGACGCCCGGGCCAGCGAGATCACCCTCGACATGTTGCTGCGGGCGGCCGAGGCGATCGCGCTGGTCGT
CAAGGACGAGGAGCTCAACCCGGCGTTCATCATCCCGACCGTCTTCCACCCCGACGTGCAGCGCAAGGTCGCGGCCGCGG
TCCGCGGCGTCTGA

Upstream 100 bases:

>100_bases
CCCGAGCCGCCGGACCCCGGGGCGGACCCCTGATGGCCGCGGCTGCACCCGGCTGCGTCCGACTTGCCGGTAACCGCGCG
GGGGGAGAAGGGTGCGGGTC

Downstream 100 bases:

>100_bases
ACGGACCGGCCGGGCGACCCGGTCAGGCGACCCGGCGCGGCCACCAGAACCGGTCGCCGAGGACCAGGGCGAGCGCCGGC
ACCACCAGGGTGCGGACCAG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MAATASSYSITMRLHTAPDHGVVGAVATAISAAGGIVTAIDVADSSHARLVVDVTCSASDAEHAERLHAAAESVEGVAVH
RVSDRTFLLHIGGKIEVTSKVPLRNRDDLSMAYTPGVGRVSMALAESPGDVPRLTVKGNSVAVVTDGSAVLGLGNIGPGA
ALPVMEGKAALFKRFADIDAWPICLASQDTDEIVRAVEMIAPGFGGINLEDIAAPRCFEIERRLRESLDIPVFHDDQHGT
AIVVLAALTNALRVVKKDITDVRIVVSGGGAAGTAIVTLLLAAGAPDIVVWDREGCLSRDDDTLPPAKRQLAEMTNPRLV
RGDLRAGLDGADVFIGVSGPGVLDAEWIKDMAPDPVVFALANPDPEVDPAEAEKYAAVVASGRSDYPNQINNVLAFPGVF
RGLLDARASEITLDMLLRAAEAIALVVKDEELNPAFIIPTVFHPDVQRKVAAAVRGV

Sequences:

>Translated_457_residues
MAATASSYSITMRLHTAPDHGVVGAVATAISAAGGIVTAIDVADSSHARLVVDVTCSASDAEHAERLHAAAESVEGVAVH
RVSDRTFLLHIGGKIEVTSKVPLRNRDDLSMAYTPGVGRVSMALAESPGDVPRLTVKGNSVAVVTDGSAVLGLGNIGPGA
ALPVMEGKAALFKRFADIDAWPICLASQDTDEIVRAVEMIAPGFGGINLEDIAAPRCFEIERRLRESLDIPVFHDDQHGT
AIVVLAALTNALRVVKKDITDVRIVVSGGGAAGTAIVTLLLAAGAPDIVVWDREGCLSRDDDTLPPAKRQLAEMTNPRLV
RGDLRAGLDGADVFIGVSGPGVLDAEWIKDMAPDPVVFALANPDPEVDPAEAEKYAAVVASGRSDYPNQINNVLAFPGVF
RGLLDARASEITLDMLLRAAEAIALVVKDEELNPAFIIPTVFHPDVQRKVAAAVRGV
>Mature_456_residues
AATASSYSITMRLHTAPDHGVVGAVATAISAAGGIVTAIDVADSSHARLVVDVTCSASDAEHAERLHAAAESVEGVAVHR
VSDRTFLLHIGGKIEVTSKVPLRNRDDLSMAYTPGVGRVSMALAESPGDVPRLTVKGNSVAVVTDGSAVLGLGNIGPGAA
LPVMEGKAALFKRFADIDAWPICLASQDTDEIVRAVEMIAPGFGGINLEDIAAPRCFEIERRLRESLDIPVFHDDQHGTA
IVVLAALTNALRVVKKDITDVRIVVSGGGAAGTAIVTLLLAAGAPDIVVWDREGCLSRDDDTLPPAKRQLAEMTNPRLVR
GDLRAGLDGADVFIGVSGPGVLDAEWIKDMAPDPVVFALANPDPEVDPAEAEKYAAVVASGRSDYPNQINNVLAFPGVFR
GLLDARASEITLDMLLRAAEAIALVVKDEELNPAFIIPTVFHPDVQRKVAAAVRGV

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=387, Percent_Identity=27.390180878553, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI62420882, Length=358, Percent_Identity=25.6983240223464, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI62420880, Length=358, Percent_Identity=25.6983240223464, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI239049447, Length=358, Percent_Identity=25.6983240223464, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788806, Length=384, Percent_Identity=46.3541666666667, Blast_Score=317, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6322823, Length=277, Percent_Identity=26.3537906137184, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646386, Length=414, Percent_Identity=27.536231884058, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646388, Length=414, Percent_Identity=27.536231884058, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI78707240, Length=370, Percent_Identity=25.9459459459459, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI78707242, Length=370, Percent_Identity=25.9459459459459, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78707238, Length=370, Percent_Identity=25.9459459459459, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362672, Length=359, Percent_Identity=26.7409470752089, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281362674, Length=359, Percent_Identity=26.7409470752089, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356279, Length=359, Percent_Identity=26.7409470752089, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI78707232, Length=442, Percent_Identity=23.7556561085973, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281363503, Length=442, Percent_Identity=23.7556561085973, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281363505, Length=442, Percent_Identity=23.7556561085973, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI78707236, Length=442, Percent_Identity=23.7556561085973, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 47842; Mature: 47711

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATASSYSITMRLHTAPDHGVVGAVATAISAAGGIVTAIDVADSSHARLVVDVTCSASD
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEEECCCC
AEHAERLHAAAESVEGVAVHRVSDRTFLLHIGGKIEVTSKVPLRNRDDLSMAYTPGVGRV
HHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCEEEEEEECCCCCCCCCEEEECCCCCCE
SMALAESPGDVPRLTVKGNSVAVVTDGSAVLGLGNIGPGAALPVMEGKAALFKRFADIDA
EEEECCCCCCCCEEEECCCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCC
WPICLASQDTDEIVRAVEMIAPGFGGINLEDIAAPRCFEIERRLRESLDIPVFHDDQHGT
CEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCC
AIVVLAALTNALRVVKKDITDVRIVVSGGGAAGTAIVTLLLAAGAPDIVVWDREGCLSRD
EEEEHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCC
DDTLPPAKRQLAEMTNPRLVRGDLRAGLDGADVFIGVSGPGVLDAEWIKDMAPDPVVFAL
CCCCCHHHHHHHHCCCCEEEECHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCCCEEEEE
ANPDPEVDPAEAEKYAAVVASGRSDYPNQINNVLAFPGVFRGLLDARASEITLDMLLRAA
ECCCCCCCCHHHHHHHHHEECCCCCCCHHHHHHEECHHHHHHHHHCCHHHHHHHHHHHHH
EAIALVVKDEELNPAFIIPTVFHPDVQRKVAAAVRGV
HHEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AATASSYSITMRLHTAPDHGVVGAVATAISAAGGIVTAIDVADSSHARLVVDVTCSASD
CCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEEEECCCC
AEHAERLHAAAESVEGVAVHRVSDRTFLLHIGGKIEVTSKVPLRNRDDLSMAYTPGVGRV
HHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCEEEEEEECCCCCCCCCEEEECCCCCCE
SMALAESPGDVPRLTVKGNSVAVVTDGSAVLGLGNIGPGAALPVMEGKAALFKRFADIDA
EEEECCCCCCCCEEEECCCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCC
WPICLASQDTDEIVRAVEMIAPGFGGINLEDIAAPRCFEIERRLRESLDIPVFHDDQHGT
CEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCC
AIVVLAALTNALRVVKKDITDVRIVVSGGGAAGTAIVTLLLAAGAPDIVVWDREGCLSRD
EEEEHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCC
DDTLPPAKRQLAEMTNPRLVRGDLRAGLDGADVFIGVSGPGVLDAEWIKDMAPDPVVFAL
CCCCCHHHHHHHHCCCCEEEECHHHCCCCCCEEEEECCCCCCCCHHHHHHCCCCCEEEEE
ANPDPEVDPAEAEKYAAVVASGRSDYPNQINNVLAFPGVFRGLLDARASEITLDMLLRAA
ECCCCCCCCHHHHHHHHHEECCCCCCCHHHHHHEECHHHHHHHHHCCHHHHHHHHHHHHH
EAIALVVKDEELNPAFIIPTVFHPDVQRKVAAAVRGV
HHEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]