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The map label for this gene is pbpA [H]

Identifier: 119714296

GI number: 119714296

Start: 26896

End: 28368

Strand: Reverse

Name: pbpA [H]

Synonym: Noca_0024

Alternate gene names: 119714296

Gene position: 28368-26896 (Counterclockwise)

Preceding gene: 119714297

Following gene: 119714295

Centisome position: 0.57

GC content: 69.04

Gene sequence:

>1473_bases
GTGAACAAGCCGATCCGGACGATCTCGATGTTCTGCCTGCTGCTGTTCCTGGCGCTGATGCTGAACGCGACCTACCTGCA
GTACTGGAAGGCCGGCCGGCTCAACGACGACCCGCAGAACCGACGGGTGCTGGTGGAGTCGTACTCCCGCGAGCGCGGCG
CGATCCTGGTCGGCAACAAGCCGGTGGCCGAGAGCGTCGAGTCCGACGACCAGTACGAGTTCCAGCGCACCTACCCCAAG
CCGCTGGAGTACGCACCGCTCACCGGCTGGTTCAGCTACTACAGCGCGACCGGGATCGAGCAGACCCGCAACGCGATCCT
CTCCGGCGACGACTCGCGGCTGTTCGTGACCAAGCTGGTCGACCTGCTGAGCAACGACTCGACCAAGGGCGGCAACGTCG
CGCTGACCATCGACTCGAAGGCCCAGGACGCGGCGTACAACGGGCTCAAGGCGCTCGGCCCCAACGTGCAGGGCTCCGTG
GTCGCGCTCCAGCCCAGCACCGGCAAGGTCCTGGCGATGGTCTCGCTGCCGACCTACGACCCGAACAAGCTCGCCTCCCA
CGACCTCGGCTCGGTGCAGGACACCTTCGACCGCCTCGACGCCGACCCGACCCAGCCGCTGCTCAACCGGGCCATCCAGA
CCCGGCTGCCGCCCGGCTCGACGTTCAAGATCCTCACCGCGGCCGCGGCCATCGACAACGGTCTCTACAAGGCGGACGAC
CCGGTGCCCGGCGGCGCCACCTTCCAGCTGCCGCAGACCAGCGGGCCCACCGGCGAGATCGACAACGAGGGCCGCTCGTG
CGGCGCCAACAACGCCCGGATCCCGTTCACCCAGGCGCTCGCCCAGTCCTGCAACACCTCCTTCGCCCAGATCGCGATCG
AGGTCGGCGCCGAGGACATGGCCAAGACCGCGGAGGGCTTCGGCTTCAACAGCCACTACTTCGACGACCTGGCGCCGCAG
GCGGAGTCGGTGTTCCCGACCGACGCGAGCGAGCCGGAGATCGGTCAGTCCGGCATCGGACAGTTCGAGGTCGCCGCCAC
GCCGCTGCAGATGGCGATGGTCACCGCCGGCATCGCCAACGGCGGCACCGTGATGCGGCCCTACCTGGTCGACGAGGAGC
AGTCCGCCGACCTCGACGTGATCCAGAAGACCGAGCCGCAGAAGCTCTCCCAGGCGGTCTCGTCCTCGACGGCGAGCGAG
GTGACCAAGCTGATGGTCGCGACGGTGAACGAGGGCACCGCGAGCCCGGCGGCGATGGACGGCTTCCAGGTGGCCGGCAA
GACCGGTACCGCGCAGAGCGGCCAGCCGGACAAGCCGCCGTACGCCTGGTTCGTCTCGTTCGCGCCCGCCGAGAACCCGC
AGGTAGCGGTCGCGGTGATGATCCAGGCCGCCGACATCCCCCGCGGCGAGATCGCGGGCGGCACCTACGGCGGCCCGATC
GCCAAGGCCGTGATGGAGGCGGTGATCAAGTGA

Upstream 100 bases:

>100_bases
TCCTGCTGCGGATCTCCGACCAGGCCCGCCGCCCCACACCGCAGCTCTCCGACGACACCGCCGCGATCGGCGACGACGCC
ACCCAGGTGGTGCGCCTGTC

Downstream 100 bases:

>100_bases
CCTCGACACCGGACCAGGGCCACGGCTTCGCCGACGCCGAGCACCGCTACCGCCTCGACTCCCGGATCGCCACCGGCGGC
ATGGGCGAGGTCTGGCGCGG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNKPIRTISMFCLLLFLALMLNATYLQYWKAGRLNDDPQNRRVLVESYSRERGAILVGNKPVAESVESDDQYEFQRTYPK
PLEYAPLTGWFSYYSATGIEQTRNAILSGDDSRLFVTKLVDLLSNDSTKGGNVALTIDSKAQDAAYNGLKALGPNVQGSV
VALQPSTGKVLAMVSLPTYDPNKLASHDLGSVQDTFDRLDADPTQPLLNRAIQTRLPPGSTFKILTAAAAIDNGLYKADD
PVPGGATFQLPQTSGPTGEIDNEGRSCGANNARIPFTQALAQSCNTSFAQIAIEVGAEDMAKTAEGFGFNSHYFDDLAPQ
AESVFPTDASEPEIGQSGIGQFEVAATPLQMAMVTAGIANGGTVMRPYLVDEEQSADLDVIQKTEPQKLSQAVSSSTASE
VTKLMVATVNEGTASPAAMDGFQVAGKTGTAQSGQPDKPPYAWFVSFAPAENPQVAVAVMIQAADIPRGEIAGGTYGGPI
AKAVMEAVIK

Sequences:

>Translated_490_residues
MNKPIRTISMFCLLLFLALMLNATYLQYWKAGRLNDDPQNRRVLVESYSRERGAILVGNKPVAESVESDDQYEFQRTYPK
PLEYAPLTGWFSYYSATGIEQTRNAILSGDDSRLFVTKLVDLLSNDSTKGGNVALTIDSKAQDAAYNGLKALGPNVQGSV
VALQPSTGKVLAMVSLPTYDPNKLASHDLGSVQDTFDRLDADPTQPLLNRAIQTRLPPGSTFKILTAAAAIDNGLYKADD
PVPGGATFQLPQTSGPTGEIDNEGRSCGANNARIPFTQALAQSCNTSFAQIAIEVGAEDMAKTAEGFGFNSHYFDDLAPQ
AESVFPTDASEPEIGQSGIGQFEVAATPLQMAMVTAGIANGGTVMRPYLVDEEQSADLDVIQKTEPQKLSQAVSSSTASE
VTKLMVATVNEGTASPAAMDGFQVAGKTGTAQSGQPDKPPYAWFVSFAPAENPQVAVAVMIQAADIPRGEIAGGTYGGPI
AKAVMEAVIK
>Mature_490_residues
MNKPIRTISMFCLLLFLALMLNATYLQYWKAGRLNDDPQNRRVLVESYSRERGAILVGNKPVAESVESDDQYEFQRTYPK
PLEYAPLTGWFSYYSATGIEQTRNAILSGDDSRLFVTKLVDLLSNDSTKGGNVALTIDSKAQDAAYNGLKALGPNVQGSV
VALQPSTGKVLAMVSLPTYDPNKLASHDLGSVQDTFDRLDADPTQPLLNRAIQTRLPPGSTFKILTAAAAIDNGLYKADD
PVPGGATFQLPQTSGPTGEIDNEGRSCGANNARIPFTQALAQSCNTSFAQIAIEVGAEDMAKTAEGFGFNSHYFDDLAPQ
AESVFPTDASEPEIGQSGIGQFEVAATPLQMAMVTAGIANGGTVMRPYLVDEEQSADLDVIQKTEPQKLSQAVSSSTASE
VTKLMVATVNEGTASPAAMDGFQVAGKTGTAQSGQPDKPPYAWFVSFAPAENPQVAVAVMIQAADIPRGEIAGGTYGGPI
AKAVMEAVIK

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=359, Percent_Identity=28.4122562674095, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786272, Length=435, Percent_Identity=25.2873563218391, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 52040; Mature: 52040

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPIRTISMFCLLLFLALMLNATYLQYWKAGRLNDDPQNRRVLVESYSRERGAILVGNK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEECCC
PVAESVESDDQYEFQRTYPKPLEYAPLTGWFSYYSATGIEQTRNAILSGDDSRLFVTKLV
CHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHHHH
DLLSNDSTKGGNVALTIDSKAQDAAYNGLKALGPNVQGSVVALQPSTGKVLAMVSLPTYD
HHHCCCCCCCCEEEEEECCCCHHHHHCCHHHCCCCCCCCEEEEECCCCCEEEEEECCCCC
PNKLASHDLGSVQDTFDRLDADPTQPLLNRAIQTRLPPGSTFKILTAAAAIDNGLYKADD
CHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
PVPGGATFQLPQTSGPTGEIDNEGRSCGANNARIPFTQALAQSCNTSFAQIAIEVGAEDM
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHEEEEECCHHHH
AKTAEGFGFNSHYFDDLAPQAESVFPTDASEPEIGQSGIGQFEVAATPLQMAMVTAGIAN
HHHHHCCCCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCC
GGTVMRPYLVDEEQSADLDVIQKTEPQKLSQAVSSSTASEVTKLMVATVNEGTASPAAMD
CCCEEECEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
GFQVAGKTGTAQSGQPDKPPYAWFVSFAPAENPQVAVAVMIQAADIPRGEIAGGTYGGPI
CEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHH
AKAVMEAVIK
HHHHHHHHCC
>Mature Secondary Structure
MNKPIRTISMFCLLLFLALMLNATYLQYWKAGRLNDDPQNRRVLVESYSRERGAILVGNK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCEEEECCC
PVAESVESDDQYEFQRTYPKPLEYAPLTGWFSYYSATGIEQTRNAILSGDDSRLFVTKLV
CHHHHCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHHHH
DLLSNDSTKGGNVALTIDSKAQDAAYNGLKALGPNVQGSVVALQPSTGKVLAMVSLPTYD
HHHCCCCCCCCEEEEEECCCCHHHHHCCHHHCCCCCCCCEEEEECCCCCEEEEEECCCCC
PNKLASHDLGSVQDTFDRLDADPTQPLLNRAIQTRLPPGSTFKILTAAAAIDNGLYKADD
CHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
PVPGGATFQLPQTSGPTGEIDNEGRSCGANNARIPFTQALAQSCNTSFAQIAIEVGAEDM
CCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHEEEEECCHHHH
AKTAEGFGFNSHYFDDLAPQAESVFPTDASEPEIGQSGIGQFEVAATPLQMAMVTAGIAN
HHHHHCCCCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCC
GGTVMRPYLVDEEQSADLDVIQKTEPQKLSQAVSSSTASEVTKLMVATVNEGTASPAAMD
CCCEEECEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
GFQVAGKTGTAQSGQPDKPPYAWFVSFAPAENPQVAVAVMIQAADIPRGEIAGGTYGGPI
CEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHH
AKAVMEAVIK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA