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The map label for this gene is fadR [C]

Identifier: 119714283

GI number: 119714283

Start: 14712

End: 15461

Strand: Reverse

Name: fadR [C]

Synonym: Noca_0011

Alternate gene names: 119714283

Gene position: 15461-14712 (Counterclockwise)

Preceding gene: 119714288

Following gene: 119714282

Centisome position: 0.31

GC content: 76.27

Gene sequence:

>750_bases
GTGCCTACGCTGCCCGGGATGCCCCTGCAACCCGTGAACCGCCGCTCGGTTCCCGACGAGGTCTTCGACCAGGTCCTCTC
CGAGGTGGTCGACGGCGGCATCGGCGCGGGTGAGGCGCTGCCCAGCGAGCGCCGCCTCGCGGAGGTGCTCGGCGTCTCCC
GGCCCGCGGTCCGCGAGGCGCTGCAGCGGATGGCGCAGACCCGGTTGCTCGACGTGCGCCACGGCGGCGCGACGACGGTG
CGCGACTTCCGGCGGTACGGCGGCCTCGACCTGCTCCCCCGTCTCCTGGTGCGCCGCGGCGAGCTCGACCCGGCCGTGGC
GCGCAGCATCCTCGAGGCCCGGCTGGTGGTCGGCCCCGGGGTGGCCGCCCTGGCGGCCGAGCGCGGCGGGCCCGCCCTCG
AGCCGGTGCTCGCCGAGACGGTCGCTGCGCTCGAAGGCACCGAGGACGGCATCGAGCGGCAGCGGCACGCCCTGGCGTTC
TGGGACCTGGTCGTCGACGCCGCCGACTCGATGGTGTTCCGGCTGATGTTCAACAGCCTGCGGGCGGCCTACGAGCCGGC
CCTCGAGGCGCTGGCCGCGCTGATGGCCGAGGAGGTCGGCCAGGTCGGGGCCTACCGGCTGCTGACGGCCGCGATCGGGG
CCGGCGATCCCGAGACGGCGCGGGCGGCGGCCGACCGGGTGCTGCGCCCGGCCACCACCAGCCTGCTCACCGCCCTCGCC
GCACTGGACTCGGACCAGGAGGACTCATGA

Upstream 100 bases:

>100_bases
CGTCCGGGGCACGACGCCAGCGTACGCAGCGGGCCACCCCACGCGACCGCCGGCCGGCATTGGTCAATCTGGTCTGACCA
CTTGACCACCGGCCACCCCC

Downstream 100 bases:

>100_bases
CGAAGTCGCAGAGCCCGATTGCCTCGGGGGAGGTCGAGCGGCTCGCCGCCCAGCGGGTGGCCGCCGACGAGCAGCGGATC
ACCGGCTCCCGGCGGACGAA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MPTLPGMPLQPVNRRSVPDEVFDQVLSEVVDGGIGAGEALPSERRLAEVLGVSRPAVREALQRMAQTRLLDVRHGGATTV
RDFRRYGGLDLLPRLLVRRGELDPAVARSILEARLVVGPGVAALAAERGGPALEPVLAETVAALEGTEDGIERQRHALAF
WDLVVDAADSMVFRLMFNSLRAAYEPALEALAALMAEEVGQVGAYRLLTAAIGAGDPETARAAADRVLRPATTSLLTALA
ALDSDQEDS

Sequences:

>Translated_249_residues
MPTLPGMPLQPVNRRSVPDEVFDQVLSEVVDGGIGAGEALPSERRLAEVLGVSRPAVREALQRMAQTRLLDVRHGGATTV
RDFRRYGGLDLLPRLLVRRGELDPAVARSILEARLVVGPGVAALAAERGGPALEPVLAETVAALEGTEDGIERQRHALAF
WDLVVDAADSMVFRLMFNSLRAAYEPALEALAALMAEEVGQVGAYRLLTAAIGAGDPETARAAADRVLRPATTSLLTALA
ALDSDQEDS
>Mature_248_residues
PTLPGMPLQPVNRRSVPDEVFDQVLSEVVDGGIGAGEALPSERRLAEVLGVSRPAVREALQRMAQTRLLDVRHGGATTVR
DFRRYGGLDLLPRLLVRRGELDPAVARSILEARLVVGPGVAALAAERGGPALEPVLAETVAALEGTEDGIERQRHALAFW
DLVVDAADSMVFRLMFNSLRAAYEPALEALAALMAEEVGQVGAYRLLTAAIGAGDPETARAAADRVLRPATTSLLTALAA
LDSDQEDS

Specific function: Multifunctional Regulator Of Fatty Acid Metabolism. Represses Transcription Of At Least Eight Genes Required For Fatty Acid Transport And Beta-Oxidation Among Which Fada, Fadb, Fadd, Fadl And Fade. Activates Transcription Of At Least Three Genes Required

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26446; Mature: 26314

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLPGMPLQPVNRRSVPDEVFDQVLSEVVDGGIGAGEALPSERRLAEVLGVSRPAVREA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
LQRMAQTRLLDVRHGGATTVRDFRRYGGLDLLPRLLVRRGELDPAVARSILEARLVVGPG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
VAALAAERGGPALEPVLAETVAALEGTEDGIERQRHALAFWDLVVDAADSMVFRLMFNSL
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAYEPALEALAALMAEEVGQVGAYRLLTAAIGAGDPETARAAADRVLRPATTSLLTALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALDSDQEDS
HHCCCCCCC
>Mature Secondary Structure 
PTLPGMPLQPVNRRSVPDEVFDQVLSEVVDGGIGAGEALPSERRLAEVLGVSRPAVREA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
LQRMAQTRLLDVRHGGATTVRDFRRYGGLDLLPRLLVRRGELDPAVARSILEARLVVGPG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
VAALAAERGGPALEPVLAETVAALEGTEDGIERQRHALAFWDLVVDAADSMVFRLMFNSL
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAYEPALEALAALMAEEVGQVGAYRLLTAAIGAGDPETARAAADRVLRPATTSLLTALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALDSDQEDS
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]