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The map label for this gene is yqeC [H]

Identifier: 119714275

GI number: 119714275

Start: 3332

End: 4237

Strand: Direct

Name: yqeC [H]

Synonym: Noca_0003

Alternate gene names: 119714275

Gene position: 3332-4237 (Clockwise)

Preceding gene: 119714274

Following gene: 119714276

Centisome position: 0.07

GC content: 69.54

Gene sequence:

>906_bases
ATGCACATCGGACTCGTCGGCCTCGGCAAGATGGGCGGCAACATGCGCACCCGGCTGCGCGATGCCGGCCACACGGTGGT
GGGCTTCGACCGCAACCCCGATCTCGCCGACGTCGACAGCCTCGAGGCGATGGTCGAACAGCTGCCCTCCCCCAAGGTGG
TCTGGGTGATGGTTCCCGCCGGCGACCCGACACGGGAGACGATCCGCCGGCTGGGCGAGCTGCTCGACGAGGGTGACCTG
GTCGTCGACGGCGGCAACAGCAAGTGGACCGACGACCAGGAGAACGCCGACCTCCTCGCCCAGCGGGGCGTCGGCTTCGT
CGACTGCGGAGTCTCGGGCGGCGTGTGGGGCGCGAAGTTCGGCTACGCCCTGATGTGCGGCGGCTCCGACGAGGACGTCG
CGAAGGTGCAGCCCGCGTTCGACGCGCTCAAGCCGGACGAGGGCGGCTTCGTGCACGCAGGCAAGAAGGTCGGCGCGGGC
CACTTCGCGAAGATGGTCCACAACGGCATCGAGTACGCCATGATGCAGAGCTACGCCGAGGGCTGGGAGCTGCTGGAGAA
GGTCGACCTGGTCGACAACGTGACCGAGGTGTTCGACTCCTGGCGCTCCGGTACCGTCATCCGGTCCTGGCTCCTCGACC
TCCTGGTCACCGCCCTCGAGGAGGACGGGCACCTCGACCAGATCACCGGCTACGCCGACGACTCGGGTGAGGGCAGGTGG
ACGGTGCAGGCCGCGATCGACAACGCGGTCCCGATGCACGTGATCGCTGCGTCCCTCTTCGCCCGCTTCACCTCCCGCCA
GGACGACAGCCCGGCGATGAAGGCGGTCGCCGCGATGCGCAACCAGTTCGGCGGGCACGCCGTACACACGGAGCCGCCGG
TCGGCGGCGACGCCAACCCCGGCTAG

Upstream 100 bases:

>100_bases
ATGCCGCGCCGCCTGCTCTCCTAGGGCCACGCGCTCGCTGGGCCGTTCGGGTACGGGCCCTAGGCTGGGGCCGACCGCGC
CACGGCAGGGAGGAACTGCG

Downstream 100 bases:

>100_bases
GCCGACCGAGCCACCTGTGTACGTCGCGCACCTCTCGCTCCACGACTTCCGGTCCTACGCCACGGCCGAGGTCGAGCTGT
CCCCGGGCGTCACGGCGTTC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MHIGLVGLGKMGGNMRTRLRDAGHTVVGFDRNPDLADVDSLEAMVEQLPSPKVVWVMVPAGDPTRETIRRLGELLDEGDL
VVDGGNSKWTDDQENADLLAQRGVGFVDCGVSGGVWGAKFGYALMCGGSDEDVAKVQPAFDALKPDEGGFVHAGKKVGAG
HFAKMVHNGIEYAMMQSYAEGWELLEKVDLVDNVTEVFDSWRSGTVIRSWLLDLLVTALEEDGHLDQITGYADDSGEGRW
TVQAAIDNAVPMHVIAASLFARFTSRQDDSPAMKAVAAMRNQFGGHAVHTEPPVGGDANPG

Sequences:

>Translated_301_residues
MHIGLVGLGKMGGNMRTRLRDAGHTVVGFDRNPDLADVDSLEAMVEQLPSPKVVWVMVPAGDPTRETIRRLGELLDEGDL
VVDGGNSKWTDDQENADLLAQRGVGFVDCGVSGGVWGAKFGYALMCGGSDEDVAKVQPAFDALKPDEGGFVHAGKKVGAG
HFAKMVHNGIEYAMMQSYAEGWELLEKVDLVDNVTEVFDSWRSGTVIRSWLLDLLVTALEEDGHLDQITGYADDSGEGRW
TVQAAIDNAVPMHVIAASLFARFTSRQDDSPAMKAVAAMRNQFGGHAVHTEPPVGGDANPG
>Mature_301_residues
MHIGLVGLGKMGGNMRTRLRDAGHTVVGFDRNPDLADVDSLEAMVEQLPSPKVVWVMVPAGDPTRETIRRLGELLDEGDL
VVDGGNSKWTDDQENADLLAQRGVGFVDCGVSGGVWGAKFGYALMCGGSDEDVAKVQPAFDALKPDEGGFVHAGKKVGAG
HFAKMVHNGIEYAMMQSYAEGWELLEKVDLVDNVTEVFDSWRSGTVIRSWLLDLLVTALEEDGHLDQITGYADDSGEGRW
TVQAAIDNAVPMHVIAASLFARFTSRQDDSPAMKAVAAMRNQFGGHAVHTEPPVGGDANPG

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=291, Percent_Identity=34.020618556701, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1788341, Length=292, Percent_Identity=34.9315068493151, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI145693186, Length=219, Percent_Identity=29.2237442922374, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=35.8620689655172, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6321695, Length=290, Percent_Identity=33.448275862069, Blast_Score=155, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321977, Length=286, Percent_Identity=32.8671328671329, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24639279, Length=312, Percent_Identity=34.2948717948718, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32262; Mature: 32262

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGLVGLGKMGGNMRTRLRDAGHTVVGFDRNPDLADVDSLEAMVEQLPSPKVVWVMVPA
CEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
GDPTRETIRRLGELLDEGDLVVDGGNSKWTDDQENADLLAQRGVGFVDCGVSGGVWGAKF
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCCCEEECCCCCCCCHHCC
GYALMCGGSDEDVAKVQPAFDALKPDEGGFVHAGKKVGAGHFAKMVHNGIEYAMMQSYAE
CEEEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
GWELLEKVDLVDNVTEVFDSWRSGTVIRSWLLDLLVTALEEDGHLDQITGYADDSGEGRW
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCE
TVQAAIDNAVPMHVIAASLFARFTSRQDDSPAMKAVAAMRNQFGGHAVHTEPPVGGDANP
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MHIGLVGLGKMGGNMRTRLRDAGHTVVGFDRNPDLADVDSLEAMVEQLPSPKVVWVMVPA
CEEEEEECCCCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
GDPTRETIRRLGELLDEGDLVVDGGNSKWTDDQENADLLAQRGVGFVDCGVSGGVWGAKF
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCCCEEECCCCCCCCHHCC
GYALMCGGSDEDVAKVQPAFDALKPDEGGFVHAGKKVGAGHFAKMVHNGIEYAMMQSYAE
CEEEEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
GWELLEKVDLVDNVTEVFDSWRSGTVIRSWLLDLLVTALEEDGHLDQITGYADDSGEGRW
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCE
TVQAAIDNAVPMHVIAASLFARFTSRQDDSPAMKAVAAMRNQFGGHAVHTEPPVGGDANP
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]