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The map label for this gene is rpfC [H]

Identifier: 119387053

GI number: 119387053

Start: 1533474

End: 1535159

Strand: Direct

Name: rpfC [H]

Synonym: Pden_4348

Alternate gene names: 119387053

Gene position: 1533474-1535159 (Clockwise)

Preceding gene: 119387052

Following gene: 119387060

Centisome position: 88.64

GC content: 69.93

Gene sequence:

>1686_bases
ATGGGGATGCTGACGGCTGCACGCCTGCGCCGCGCCATATCCGGCACCCGCCGGCCCGACAGCAGCTACGACGCCGAGGC
CGGGCAATCGCTGGTCCGGGTGGTGCTGACCGTCGTGGTCGCGGCCTATGCCATGATCGGCAACCTGCTGGAACTGGTGG
ACGAAAGCGCCGACCTGGTCTTTCAGATCTACATGCCGGTCTTCATGACCGTCACCTGCCTGATGTTCGCCGCGATCCGC
CTGTGGCCCGGCGTCTATCACTGGCGCCGGATCTTCTGCATGGTGCTGGACTTCGGTACGCTGACGCTGCTGATGACGCT
GGGCGGGCCGTTCATGGCGCCGATGGCCTCGCTGCTGCTTTGGGTGACGGTGGGCTTCGGCATGCGCTACGGCACGCGCT
ATCTGGTCGGCGCGACCGTCGCGGCGCTGGTCAGCCTGATGCTGATCGCCGTCTTCAGCCCGTTCTGGCGCGCCCAGCCC
TATCTGGTGGCGACCTTCGTGCTGACCTCGCTGATCGTGCCCTTCTATGCCAACCTGCTGCTGGCCGACACGCGCGAGGC
CTATCGCTCGGCCGATGCCGCCAACCTGGCCAAGTCGCGCTTTCTGGCCCAGGCCAGCCACGACCTGCGCCAGCCGATCC
ACGCCATCAGCCTGTTCACCAATTGCCTGCGCGAGGCGGGGCTGGCGCCGTCCGAACGGCAGATGGTCGAGAATATCGAG
CATTCGCTGCAAAGCGTCCGGCGCATGTTCCGCTCGCTTCTGGACATCGCGACGCTGGACAGCGGCGGCGTCGTGCCGCG
CATGCAGCCGGTGCCGCTGGGCGCGATCCTGCGCGACGTCGTCACCCAGCACCAGGAGGCCGCACGCCGTGCCGGGGTCG
AGCTGCGGCTGGTCGAAACCGGGCTGACGGTGGAAAGCGATCCGGGCCTGCTGACGGTGATGCTGCAAAACCTGGTCTCG
AACGCGGTGAAATACGCGCCCGGCGCGCGGGTGCTGATCGGCTGCCGCAGGCACGGGTCAGGGGTCGACGTGCTGGTGAT
CGACCGCGGCATCGGCGTCGCGCCCGAGCACCAGCCGCATCTGTTCGAGGAGTTCTATCGCGTCCAGCCGCCCGGCCGCG
ATGTCGAGGGCGTGGGGCTGGGCCTTGCCATCGTGCAACGCATGGCGCAGCTGATCGGCGCGGGGGTCGAGCTGCGCTCG
ATCCCCGGACGCGGGACCACGGTGGCGCTGACCGGGCTGCGCGCGACCGAACCGCCGCCCGCGCCGCCCCACCCCGACGG
CCACCCCGACGACCGCCCGCGCAGCAGCCCGCCGCAAAGCCTGCTGCAGGGGCTTCGCGTCCTGCTGATCGAGGACGATC
CGGCCGTGCTTCTGTCCACGCAGATGCTGATGGAACGCTGGGGCTGCACGGTCCACGCCCATGAGCAGCCGCCCCGCGAT
GTGCCGCCCTGCGACATGATCGTCGCCGATTTCGACCTGAACGGCCCGCTGACCGGCGGCGATGCCATCGCCATCGCGCG
CGCCGCCCTTGGCGCGCCGATCCCCGCCATCGTCATCACCGCCCATGACGAGGCCCGCGTGCGCGAACGGTTGGGCGAGG
CCGGCCTGCCGATCCTGCCCAAGCCGATGCGGCCGGCCGAGTTGCGCGCGCTGATGCTGTCGCTGCGGCTGGAGCGCGGC
GGCTAA

Upstream 100 bases:

>100_bases
GCCCCTGCGCGCCTGATCGCGCATGAGCGGCCGCCGCATTGCCCTTGCACCGCAGGGGCGACTAGGCTGGATGTCGTGGA
CAATGGCGGGGACAAGGCGA

Downstream 100 bases:

>100_bases
AGCGCGCCCTGCCCTGCCCGCGCCGCCGCGGCCGCGCGGGTCGGCACCTCCAGCACCCGCAGGATGGCCGAGACATGGAT
GCGCACCGTGAAGGGCGAAA

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MGMLTAARLRRAISGTRRPDSSYDAEAGQSLVRVVLTVVVAAYAMIGNLLELVDESADLVFQIYMPVFMTVTCLMFAAIR
LWPGVYHWRRIFCMVLDFGTLTLLMTLGGPFMAPMASLLLWVTVGFGMRYGTRYLVGATVAALVSLMLIAVFSPFWRAQP
YLVATFVLTSLIVPFYANLLLADTREAYRSADAANLAKSRFLAQASHDLRQPIHAISLFTNCLREAGLAPSERQMVENIE
HSLQSVRRMFRSLLDIATLDSGGVVPRMQPVPLGAILRDVVTQHQEAARRAGVELRLVETGLTVESDPGLLTVMLQNLVS
NAVKYAPGARVLIGCRRHGSGVDVLVIDRGIGVAPEHQPHLFEEFYRVQPPGRDVEGVGLGLAIVQRMAQLIGAGVELRS
IPGRGTTVALTGLRATEPPPAPPHPDGHPDDRPRSSPPQSLLQGLRVLLIEDDPAVLLSTQMLMERWGCTVHAHEQPPRD
VPPCDMIVADFDLNGPLTGGDAIAIARAALGAPIPAIVITAHDEARVRERLGEAGLPILPKPMRPAELRALMLSLRLERG
G

Sequences:

>Translated_561_residues
MGMLTAARLRRAISGTRRPDSSYDAEAGQSLVRVVLTVVVAAYAMIGNLLELVDESADLVFQIYMPVFMTVTCLMFAAIR
LWPGVYHWRRIFCMVLDFGTLTLLMTLGGPFMAPMASLLLWVTVGFGMRYGTRYLVGATVAALVSLMLIAVFSPFWRAQP
YLVATFVLTSLIVPFYANLLLADTREAYRSADAANLAKSRFLAQASHDLRQPIHAISLFTNCLREAGLAPSERQMVENIE
HSLQSVRRMFRSLLDIATLDSGGVVPRMQPVPLGAILRDVVTQHQEAARRAGVELRLVETGLTVESDPGLLTVMLQNLVS
NAVKYAPGARVLIGCRRHGSGVDVLVIDRGIGVAPEHQPHLFEEFYRVQPPGRDVEGVGLGLAIVQRMAQLIGAGVELRS
IPGRGTTVALTGLRATEPPPAPPHPDGHPDDRPRSSPPQSLLQGLRVLLIEDDPAVLLSTQMLMERWGCTVHAHEQPPRD
VPPCDMIVADFDLNGPLTGGDAIAIARAALGAPIPAIVITAHDEARVRERLGEAGLPILPKPMRPAELRALMLSLRLERG
G
>Mature_560_residues
GMLTAARLRRAISGTRRPDSSYDAEAGQSLVRVVLTVVVAAYAMIGNLLELVDESADLVFQIYMPVFMTVTCLMFAAIRL
WPGVYHWRRIFCMVLDFGTLTLLMTLGGPFMAPMASLLLWVTVGFGMRYGTRYLVGATVAALVSLMLIAVFSPFWRAQPY
LVATFVLTSLIVPFYANLLLADTREAYRSADAANLAKSRFLAQASHDLRQPIHAISLFTNCLREAGLAPSERQMVENIEH
SLQSVRRMFRSLLDIATLDSGGVVPRMQPVPLGAILRDVVTQHQEAARRAGVELRLVETGLTVESDPGLLTVMLQNLVSN
AVKYAPGARVLIGCRRHGSGVDVLVIDRGIGVAPEHQPHLFEEFYRVQPPGRDVEGVGLGLAIVQRMAQLIGAGVELRSI
PGRGTTVALTGLRATEPPPAPPHPDGHPDDRPRSSPPQSLLQGLRVLLIEDDPAVLLSTQMLMERWGCTVHAHEQPPRDV
PPCDMIVADFDLNGPLTGGDAIAIARAALGAPIPAIVITAHDEARVRERLGEAGLPILPKPMRPAELRALMLSLRLERGG

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=30.4347826086957, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=32.7354260089686, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI48994928, Length=299, Percent_Identity=27.7591973244147, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=28.110599078341, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788713, Length=370, Percent_Identity=25.9459459459459, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI87081816, Length=381, Percent_Identity=27.2965879265092, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789403, Length=236, Percent_Identity=31.3559322033898, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=274, Percent_Identity=30.6569343065693, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693157, Length=337, Percent_Identity=21.9584569732938, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=208, Percent_Identity=30.2884615384615, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789808, Length=214, Percent_Identity=29.9065420560748, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=192, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790861, Length=217, Percent_Identity=26.2672811059908, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790436, Length=276, Percent_Identity=24.2753623188406, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=25.1046025104602, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61017; Mature: 60886

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GMLTAARLRRAISGTRRPDSSYDAEAGQSLVRVVLTVVVAAYAMIGNLLELVDESADLV
CCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FQIYMPVFMTVTCLMFAAIRLWPGVYHWRRIFCMVLDFGTLTLLMTLGGPFMAPMASLLL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
WVTVGFGMRYGTRYLVGATVAALVSLMLIAVFSPFWRAQPYLVATFVLTSLIVPFYANLL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LADTREAYRSADAANLAKSRFLAQASHDLRQPIHAISLFTNCLREAGLAPSERQMVENIE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
HSLQSVRRMFRSLLDIATLDSGGVVPRMQPVPLGAILRDVVTQHQEAARRAGVELRLVET
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GLTVESDPGLLTVMLQNLVSNAVKYAPGARVLIGCRRHGSGVDVLVIDRGIGVAPEHQPH
CCEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCH
LFEEFYRVQPPGRDVEGVGLGLAIVQRMAQLIGAGVELRSIPGRGTTVALTGLRATEPPP
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEECCCCCCCCC
APPHPDGHPDDRPRSSPPQSLLQGLRVLLIEDDPAVLLSTQMLMERWGCTVHAHEQPPRD
CCCCCCCCCCCCCCCCCHHHHHHHCEEEEECCCCHHHHHHHHHHHHHCCEEEECCCCCCC
VPPCDMIVADFDLNGPLTGGDAIAIARAALGAPIPAIVITAHDEARVRERLGEAGLPILP
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCCC
KPMRPAELRALMLSLRLERGG
CCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]