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The map label for this gene is alsR [H]

Identifier: 119387060

GI number: 119387060

Start: 1544204

End: 1545109

Strand: Direct

Name: alsR [H]

Synonym: Pden_4355

Alternate gene names: 119387060

Gene position: 1544204-1545109 (Clockwise)

Preceding gene: 119387053

Following gene: 119387062

Centisome position: 89.26

GC content: 65.23

Gene sequence:

>906_bases
TTGACGCGTGATCTTACCGGCATCGAGAATGTCCATTCCTTCGTCACGCTTGCCGAGGAACTGAGCTTTCGCCGAACGGC
CGAGCGGCTGAACTTGGATCAATCAGCGCTCAGCCGGCGAATCCAGAAGCTGGAGGCCAGCCTGGGATTCCGCCTGCTGG
AGCGCACGACCCGCGCGGTCTCGCTGACCCAGGCCGGCCGCAGCTTCTATGAGGAGAACGCCCATCTGCTGCGCCGATAC
GAAGCGTCGGTGCGGCTGGCGCGCCGCGTCGCGGATGGAAAGCTGGGCGCGCTGACCATCGGCTACATGGCCTTCGCGGC
GACCGAGCTGATGCCTTCGGCGGTCGCGCGCTTTCGGCAGCTTCATCCGCATGTCGACCTGAAGATCCGCTATATCCGCA
CCCAGGGCCAGAAGATCGCGCTGGCCCATGACGAAATCGACGCGGGCTACATGATCGGCCCCTTCGATCACGCCGACTAC
CACACGCTGCCGCTGTCGGACGATCCGCTTTACGTCGTGACGCCGCGCGGCCATGCGCTGCAGCGGGTCCCGGTCCTGAC
CCCGGCTGATCTGGCCGGGCAAAACCTGATCCTGGGCGACACGTCGGAATGGGACGAATACCGCTGGCGGCTGGACAGCC
TGTTCAGCGCCGAGGGGGTGGCGCTTGACGTCACGCTGGAGGCTTCGAACACGCTCGCGCTGATCGGCCTGGTCGCGGCG
GGACTGGGGGTCACGATATATCCCGAAAGCCTGATCGGGTTTCTGGGCCGCAACGTCGAGGTCCGGCAGATCACGCATCC
GGCCTTTCGCAGCTGCACGGTTCTGGCGTGGAAAAGGTCGAACCGATCGCGGCAGATCCGCGATTTCATCGAGGTCGCAA
AGATGACGGCCGCCCCGGCAGGGTAG

Upstream 100 bases:

>100_bases
TCTGCCGCTCTGAAAGGCATGTTCCGCTTTTGCTTGACAGCAGTGAATTGGTATAACAGCAATTGTTCATGCAGCATTTG
CATCAATCAGGACCGCCCCC

Downstream 100 bases:

>100_bases
ACCGGGCAAGGTTCGGGCATCGCTGGGGCAGCGCCTGACATGGCCGCCGGCATGGGGACAGAACGCGCCACGGCTCGGCC
ACCCGGCCGCCGCCGGCCGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTRDLTGIENVHSFVTLAEELSFRRTAERLNLDQSALSRRIQKLEASLGFRLLERTTRAVSLTQAGRSFYEENAHLLRRY
EASVRLARRVADGKLGALTIGYMAFAATELMPSAVARFRQLHPHVDLKIRYIRTQGQKIALAHDEIDAGYMIGPFDHADY
HTLPLSDDPLYVVTPRGHALQRVPVLTPADLAGQNLILGDTSEWDEYRWRLDSLFSAEGVALDVTLEASNTLALIGLVAA
GLGVTIYPESLIGFLGRNVEVRQITHPAFRSCTVLAWKRSNRSRQIRDFIEVAKMTAAPAG

Sequences:

>Translated_301_residues
MTRDLTGIENVHSFVTLAEELSFRRTAERLNLDQSALSRRIQKLEASLGFRLLERTTRAVSLTQAGRSFYEENAHLLRRY
EASVRLARRVADGKLGALTIGYMAFAATELMPSAVARFRQLHPHVDLKIRYIRTQGQKIALAHDEIDAGYMIGPFDHADY
HTLPLSDDPLYVVTPRGHALQRVPVLTPADLAGQNLILGDTSEWDEYRWRLDSLFSAEGVALDVTLEASNTLALIGLVAA
GLGVTIYPESLIGFLGRNVEVRQITHPAFRSCTVLAWKRSNRSRQIRDFIEVAKMTAAPAG
>Mature_300_residues
TRDLTGIENVHSFVTLAEELSFRRTAERLNLDQSALSRRIQKLEASLGFRLLERTTRAVSLTQAGRSFYEENAHLLRRYE
ASVRLARRVADGKLGALTIGYMAFAATELMPSAVARFRQLHPHVDLKIRYIRTQGQKIALAHDEIDAGYMIGPFDHADYH
TLPLSDDPLYVVTPRGHALQRVPVLTPADLAGQNLILGDTSEWDEYRWRLDSLFSAEGVALDVTLEASNTLALIGLVAAG
LGVTIYPESLIGFLGRNVEVRQITHPAFRSCTVLAWKRSNRSRQIRDFIEVAKMTAAPAG

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=281, Percent_Identity=30.9608540925267, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=32.6612903225806, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=28.2157676348548, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788748, Length=277, Percent_Identity=27.0758122743682, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787806, Length=293, Percent_Identity=25.2559726962457, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=28.2786885245902, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787601, Length=157, Percent_Identity=33.7579617834395, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI2367136, Length=248, Percent_Identity=27.0161290322581, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI157672245, Length=229, Percent_Identity=27.0742358078603, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789173, Length=220, Percent_Identity=30.4545454545455, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787589, Length=208, Percent_Identity=29.8076923076923, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789204, Length=263, Percent_Identity=25.0950570342205, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788297, Length=238, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693193, Length=141, Percent_Identity=31.2056737588652, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789639, Length=248, Percent_Identity=22.9838709677419, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081904, Length=142, Percent_Identity=28.8732394366197, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=27.5720164609054, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786401, Length=157, Percent_Identity=29.2993630573248, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33582; Mature: 33451

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRDLTGIENVHSFVTLAEELSFRRTAERLNLDQSALSRRIQKLEASLGFRLLERTTRAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTQAGRSFYEENAHLLRRYEASVRLARRVADGKLGALTIGYMAFAATELMPSAVARFRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LHPHVDLKIRYIRTQGQKIALAHDEIDAGYMIGPFDHADYHTLPLSDDPLYVVTPRGHAL
HCCCCCEEEEEEECCCCEEEEEECCCCCCEEECCCCCCCCEEECCCCCCEEEECCCCCCC
QRVPVLTPADLAGQNLILGDTSEWDEYRWRLDSLFSAEGVALDVTLEASNTLALIGLVAA
EECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHH
GLGVTIYPESLIGFLGRNVEVRQITHPAFRSCTVLAWKRSNRSRQIRDFIEVAKMTAAPA
CCCEEECHHHHHHHHCCCCEEEEECCHHHHCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
G
C
>Mature Secondary Structure 
TRDLTGIENVHSFVTLAEELSFRRTAERLNLDQSALSRRIQKLEASLGFRLLERTTRAV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLTQAGRSFYEENAHLLRRYEASVRLARRVADGKLGALTIGYMAFAATELMPSAVARFRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LHPHVDLKIRYIRTQGQKIALAHDEIDAGYMIGPFDHADYHTLPLSDDPLYVVTPRGHAL
HCCCCCEEEEEEECCCCEEEEEECCCCCCEEECCCCCCCCEEECCCCCCEEEECCCCCCC
QRVPVLTPADLAGQNLILGDTSEWDEYRWRLDSLFSAEGVALDVTLEASNTLALIGLVAA
EECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHH
GLGVTIYPESLIGFLGRNVEVRQITHPAFRSCTVLAWKRSNRSRQIRDFIEVAKMTAAPA
CCCEEECHHHHHHHHCCCCEEEEECCHHHHCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]