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The map label for this gene is xdhA [H]

Identifier: 119386963

GI number: 119386963

Start: 1424499

End: 1426811

Strand: Direct

Name: xdhA [H]

Synonym: Pden_4258

Alternate gene names: 119386963

Gene position: 1424499-1426811 (Clockwise)

Preceding gene: 119386962

Following gene: 119386964

Centisome position: 82.34

GC content: 66.32

Gene sequence:

>2313_bases
ATGAAACAGGACGTTTTCGTCAAGGGCGCCGCCCATACGCCCATCATCCACGATTCGGCCGTGAAACATGTCACCGGCCT
GGCCGACTATACCGACGACCTGCTGGAGCCGGTCGGCACGCTGCACGCCTATCTGGGGCTTTCGACCGTGGCGCATGGCC
GCATCGTCGGGATGGACCTCGACGCGGTGCGCAAGGCCCCCGGCGTGCATCTGGTGCTGACCGCCGCGGACATTCCCGGC
CATAACGACATCTCGCCCACCGGACTGCACGACGAGCCGCTGCTGGCCCAGGACGAGGTGCAGTTCCACGGCCAGCCGAT
CTTTGCCGTGGTGGCCGAGACCCGCGACCAGGCCCGCCGCGCCTGCCAGCTGGCCCGCGTGGAATACGAGGAACTGCCCT
TTGCCATCGATGCAATCTCGGCCCGCGACGCCGGCATGGGCTATGTGACGAAGCCCCTGAAGCTCAAGCGCGGCGACATG
GCTGAAATGGACCGCGCGCCCCGGCGCATCGAAGGCCGGCTGACCGTCGGCGGGCAGGAACATTTCTACCTGGAAAGCCA
GATCGCCTTCTCGATCCCGGGCGAGGACGACGAGGTCGTCGTCAACGTCTCGACCCAGCATCCCAGCGAAGTGCAGCACA
TGGTCGCCCATGTGCTGGGCGTGCCCTCGAACGCCGTGGTGGTGAACGTGCGGCGCATGGGCGGCGGCTTCGGCGGCAAG
GAATCGCAGATGAACCCGTTCGCCTGCATCTCGGCGCTGGCGGCCAAGAAGCTCAAGCGCGCCGTCAAGCTGCGCCCCGA
CCGCGACGACGATTTCTCGATCACCGGCAAGCGCCACGACTTCGTCATCGACTATCGGGCGGGCTATGACGAAACCGGCA
AGATCCACGCCGTCGATGCCGATTTCTATGCCCGCTGCGGCTTTTCCTCGGATCTCTCGGGCCCGGTGACGGATCGGGCG
CTGTTCCACGCCGACAATGCCTATTACTACCCGGCGGTCGAGCTGCGCAGCCATCCGATGAAGACCAACACCTGCTCGAA
TACCGCCTTCCGCGGCTTCGGCGGCCCGCAGGGCGTGGTCATGGCCGAGCGCATCGTCGAGGACATCGCCTATGCCCTTG
GCCGCGACCCGCTGGAGATCCGCAAGCTGAACCTTTACGAAAACGGCCAGCTCACCCCCTATCACCAGGAGGTCGAGGAC
CAGATCCTGCCCCGCATCTTCGAGGAGCTGGAGGCCAGCAGCGACTACCACGCCCGCCGCCAGGCCGTGCTGGACTGGAA
CGCCCGTGCGAAGGAACAGGGCGGCGCGATCCGCAAGGGCATCGCGCTTACCCCAGTCAAGTTCGGCATCAGCTTTACCG
CGACCTGGTACAACCAGGCCGGTGCGCTGATCCACATCTATTCGGACGGCTCGATCCACCTGAACCACGGCGGCACCGAG
ATGGGCCAGGGCCTGAACACCAAGGTCGCGCAAGTGGTGGCCGAGGCGCTGGGGGTCAGCATCGACCGCATCAAGATCAC
CAAGACCACGACCGAGAAGGTGCCGAACACCTCGGCCACCGCGGCCTCGTCGGGCTCGGACCTGAACGGCATGGCGGCGC
TGGACGCCTGCCGGCAATTGATCGAGCGGCTGACCGCATTCGCCGCAGAAGCCAGGGGCGTGCCGCCGGAACTGGTCAAC
ATCGGCGAGACGGTGCAGATCGGCACCGAGGAAATGCCCTTCGAGGATTTCGTCAAGACCGCCTATCTGGCACGCATCCA
GCTGTCGGCCGCCGGCTTCTACAAGACGCCCAAGATCCACTGGAACCGCGATACCGGGCAGGGCCGGCCGTTCTATTACT
TCGCCTATGGCGCCGCCTGCTCCGAGGTCTCGGTCGACACGCTGACCGGCGAATATGTCATCGAGCGCGCCGACGTGCTG
CATGACGTGGGCCGCAGCCTGAACCCGGCGCTGGACAAGGGCCAGGTCGAGGGCGCCTTCGTGCAGGGCACCGGCTGGCT
GACCAGCGAGGAACTGTGGTGGGACGACAAGGGCCGGCTGCGCACCCATGCGCCCTCGACCTACAAGATCCCGCTGGCCT
CCGACCGGCCCAAGGTCTTCAACGTCGACCTGGCCGACTGGTCGGTGAACCGCGAGGCGACGATCAAGCGCTCCAAGGCC
GTGGGCGAGCCGCCCTTCATGCTGGGCATCTCGGTCTTCCAGGCGCTGAACATGGCCGTCGCGTCGTTCAACGGCTATGC
CGAGAACCCGCGCATCGACGCGCCCGCCACACCCGAGCGCGTGCTGATGGCCATCGAGCGGCTGCGGCCATGA

Upstream 100 bases:

>100_bases
GGCGGGCCAGCAAGGAATATCGCCAGCAACTCGCCGCCAACTTCTTCCGCCGCTTCTGGCTTGAACAGCAGGGCGCAGAC
CACCGCCTGAGGAGGGTCGA

Downstream 100 bases:

>100_bases
TCCGGGTCGAGATCACCCGCACGCGCGGCTCCTCCCCGCGCGAAAAGGGGGCGGCGATGTTCGTCGCCCCCGAGGGGCTC
AGCGGCACCATCGGCGGCGG

Product: aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MKQDVFVKGAAHTPIIHDSAVKHVTGLADYTDDLLEPVGTLHAYLGLSTVAHGRIVGMDLDAVRKAPGVHLVLTAADIPG
HNDISPTGLHDEPLLAQDEVQFHGQPIFAVVAETRDQARRACQLARVEYEELPFAIDAISARDAGMGYVTKPLKLKRGDM
AEMDRAPRRIEGRLTVGGQEHFYLESQIAFSIPGEDDEVVVNVSTQHPSEVQHMVAHVLGVPSNAVVVNVRRMGGGFGGK
ESQMNPFACISALAAKKLKRAVKLRPDRDDDFSITGKRHDFVIDYRAGYDETGKIHAVDADFYARCGFSSDLSGPVTDRA
LFHADNAYYYPAVELRSHPMKTNTCSNTAFRGFGGPQGVVMAERIVEDIAYALGRDPLEIRKLNLYENGQLTPYHQEVED
QILPRIFEELEASSDYHARRQAVLDWNARAKEQGGAIRKGIALTPVKFGISFTATWYNQAGALIHIYSDGSIHLNHGGTE
MGQGLNTKVAQVVAEALGVSIDRIKITKTTTEKVPNTSATAASSGSDLNGMAALDACRQLIERLTAFAAEARGVPPELVN
IGETVQIGTEEMPFEDFVKTAYLARIQLSAAGFYKTPKIHWNRDTGQGRPFYYFAYGAACSEVSVDTLTGEYVIERADVL
HDVGRSLNPALDKGQVEGAFVQGTGWLTSEELWWDDKGRLRTHAPSTYKIPLASDRPKVFNVDLADWSVNREATIKRSKA
VGEPPFMLGISVFQALNMAVASFNGYAENPRIDAPATPERVLMAIERLRP

Sequences:

>Translated_770_residues
MKQDVFVKGAAHTPIIHDSAVKHVTGLADYTDDLLEPVGTLHAYLGLSTVAHGRIVGMDLDAVRKAPGVHLVLTAADIPG
HNDISPTGLHDEPLLAQDEVQFHGQPIFAVVAETRDQARRACQLARVEYEELPFAIDAISARDAGMGYVTKPLKLKRGDM
AEMDRAPRRIEGRLTVGGQEHFYLESQIAFSIPGEDDEVVVNVSTQHPSEVQHMVAHVLGVPSNAVVVNVRRMGGGFGGK
ESQMNPFACISALAAKKLKRAVKLRPDRDDDFSITGKRHDFVIDYRAGYDETGKIHAVDADFYARCGFSSDLSGPVTDRA
LFHADNAYYYPAVELRSHPMKTNTCSNTAFRGFGGPQGVVMAERIVEDIAYALGRDPLEIRKLNLYENGQLTPYHQEVED
QILPRIFEELEASSDYHARRQAVLDWNARAKEQGGAIRKGIALTPVKFGISFTATWYNQAGALIHIYSDGSIHLNHGGTE
MGQGLNTKVAQVVAEALGVSIDRIKITKTTTEKVPNTSATAASSGSDLNGMAALDACRQLIERLTAFAAEARGVPPELVN
IGETVQIGTEEMPFEDFVKTAYLARIQLSAAGFYKTPKIHWNRDTGQGRPFYYFAYGAACSEVSVDTLTGEYVIERADVL
HDVGRSLNPALDKGQVEGAFVQGTGWLTSEELWWDDKGRLRTHAPSTYKIPLASDRPKVFNVDLADWSVNREATIKRSKA
VGEPPFMLGISVFQALNMAVASFNGYAENPRIDAPATPERVLMAIERLRP
>Mature_770_residues
MKQDVFVKGAAHTPIIHDSAVKHVTGLADYTDDLLEPVGTLHAYLGLSTVAHGRIVGMDLDAVRKAPGVHLVLTAADIPG
HNDISPTGLHDEPLLAQDEVQFHGQPIFAVVAETRDQARRACQLARVEYEELPFAIDAISARDAGMGYVTKPLKLKRGDM
AEMDRAPRRIEGRLTVGGQEHFYLESQIAFSIPGEDDEVVVNVSTQHPSEVQHMVAHVLGVPSNAVVVNVRRMGGGFGGK
ESQMNPFACISALAAKKLKRAVKLRPDRDDDFSITGKRHDFVIDYRAGYDETGKIHAVDADFYARCGFSSDLSGPVTDRA
LFHADNAYYYPAVELRSHPMKTNTCSNTAFRGFGGPQGVVMAERIVEDIAYALGRDPLEIRKLNLYENGQLTPYHQEVED
QILPRIFEELEASSDYHARRQAVLDWNARAKEQGGAIRKGIALTPVKFGISFTATWYNQAGALIHIYSDGSIHLNHGGTE
MGQGLNTKVAQVVAEALGVSIDRIKITKTTTEKVPNTSATAASSGSDLNGMAALDACRQLIERLTAFAAEARGVPPELVN
IGETVQIGTEEMPFEDFVKTAYLARIQLSAAGFYKTPKIHWNRDTGQGRPFYYFAYGAACSEVSVDTLTGEYVIERADVL
HDVGRSLNPALDKGQVEGAFVQGTGWLTSEELWWDDKGRLRTHAPSTYKIPLASDRPKVFNVDLADWSVNREATIKRSKA
VGEPPFMLGISVFQALNMAVASFNGYAENPRIDAPATPERVLMAIERLRP

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=757, Percent_Identity=43.1968295904888, Blast_Score=593, Evalue=1e-169,
Organism=Homo sapiens, GI71773480, Length=758, Percent_Identity=38.6543535620053, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1789230, Length=774, Percent_Identity=29.328165374677, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789246, Length=718, Percent_Identity=26.0445682451253, Blast_Score=176, Evalue=7e-45,
Organism=Escherichia coli, GI1786478, Length=749, Percent_Identity=25.1001335113485, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540638, Length=776, Percent_Identity=40.8505154639175, Blast_Score=524, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI32566215, Length=758, Percent_Identity=31.9261213720317, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17539860, Length=727, Percent_Identity=32.1870701513067, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI17737937, Length=760, Percent_Identity=41.0526315789474, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24647199, Length=758, Percent_Identity=31.2664907651715, Blast_Score=319, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24647193, Length=788, Percent_Identity=31.2182741116751, Blast_Score=318, Evalue=9e-87,
Organism=Drosophila melanogaster, GI24647201, Length=759, Percent_Identity=31.4888010540184, Blast_Score=308, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24647195, Length=777, Percent_Identity=29.3436293436293, Blast_Score=275, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24647197, Length=769, Percent_Identity=29.6488946684005, Blast_Score=274, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84351; Mature: 84351

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDVFVKGAAHTPIIHDSAVKHVTGLADYTDDLLEPVGTLHAYLGLSTVAHGRIVGMDL
CCCCEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCH
DAVRKAPGVHLVLTAADIPGHNDISPTGLHDEPLLAQDEVQFHGQPIFAVVAETRDQARR
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEHHHHHHHHH
ACQLARVEYEELPFAIDAISARDAGMGYVTKPLKLKRGDMAEMDRAPRRIEGRLTVGGQE
HHHHHHHHHHHCCEEEEECCCCCCCCCEECCCCEECCCCHHHHHCCCCCCCCEEEECCCC
HFYLESQIAFSIPGEDDEVVVNVSTQHPSEVQHMVAHVLGVPSNAVVVNVRRMGGGFGGK
EEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
ESQMNPFACISALAAKKLKRAVKLRPDRDDDFSITGKRHDFVIDYRAGYDETGKIHAVDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEECC
DFYARCGFSSDLSGPVTDRALFHADNAYYYPAVELRSHPMKTNTCSNTAFRGFGGPQGVV
CHHHCCCCCCCCCCCCCCCEEEECCCCEEECCHHHCCCCCCCCCCCCCCCCCCCCCCCHH
MAERIVEDIAYALGRDPLEIRKLNLYENGQLTPYHQEVEDQILPRIFEELEASSDYHARR
HHHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
QAVLDWNARAKEQGGAIRKGIALTPVKFGISFTATWYNQAGALIHIYSDGSIHLNHGGTE
HHEECCCCCCHHCCCCHHCCEEECEEEECEEEEEEEECCCCCEEEEEECCEEEEECCCHH
MGQGLNTKVAQVVAEALGVSIDRIKITKTTTEKVPNTSATAASSGSDLNGMAALDACRQL
HCCCCCHHHHHHHHHHHCCEEEEEEEEECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
IERLTAFAAEARGVPPELVNIGETVQIGTEEMPFEDFVKTAYLARIQLSAAGFYKTPKIH
HHHHHHHHHHHCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEE
WNRDTGQGRPFYYFAYGAACSEVSVDTLTGEYVIERADVLHDVGRSLNPALDKGQVEGAF
ECCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VQGTGWLTSEELWWDDKGRLRTHAPSTYKIPLASDRPKVFNVDLADWSVNREATIKRSKA
EECCCCEECCCEEECCCCCEEECCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHC
VGEPPFMLGISVFQALNMAVASFNGYAENPRIDAPATPERVLMAIERLRP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKQDVFVKGAAHTPIIHDSAVKHVTGLADYTDDLLEPVGTLHAYLGLSTVAHGRIVGMDL
CCCCEEEECCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCH
DAVRKAPGVHLVLTAADIPGHNDISPTGLHDEPLLAQDEVQFHGQPIFAVVAETRDQARR
HHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEEEHHHHHHHHH
ACQLARVEYEELPFAIDAISARDAGMGYVTKPLKLKRGDMAEMDRAPRRIEGRLTVGGQE
HHHHHHHHHHHCCEEEEECCCCCCCCCEECCCCEECCCCHHHHHCCCCCCCCEEEECCCC
HFYLESQIAFSIPGEDDEVVVNVSTQHPSEVQHMVAHVLGVPSNAVVVNVRRMGGGFGGK
EEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCC
ESQMNPFACISALAAKKLKRAVKLRPDRDDDFSITGKRHDFVIDYRAGYDETGKIHAVDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEECC
DFYARCGFSSDLSGPVTDRALFHADNAYYYPAVELRSHPMKTNTCSNTAFRGFGGPQGVV
CHHHCCCCCCCCCCCCCCCEEEECCCCEEECCHHHCCCCCCCCCCCCCCCCCCCCCCCHH
MAERIVEDIAYALGRDPLEIRKLNLYENGQLTPYHQEVEDQILPRIFEELEASSDYHARR
HHHHHHHHHHHHHCCCCHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
QAVLDWNARAKEQGGAIRKGIALTPVKFGISFTATWYNQAGALIHIYSDGSIHLNHGGTE
HHEECCCCCCHHCCCCHHCCEEECEEEECEEEEEEEECCCCCEEEEEECCEEEEECCCHH
MGQGLNTKVAQVVAEALGVSIDRIKITKTTTEKVPNTSATAASSGSDLNGMAALDACRQL
HCCCCCHHHHHHHHHHHCCEEEEEEEEECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
IERLTAFAAEARGVPPELVNIGETVQIGTEEMPFEDFVKTAYLARIQLSAAGFYKTPKIH
HHHHHHHHHHHCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHEEEEECCCCCCCCEEE
WNRDTGQGRPFYYFAYGAACSEVSVDTLTGEYVIERADVLHDVGRSLNPALDKGQVEGAF
ECCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VQGTGWLTSEELWWDDKGRLRTHAPSTYKIPLASDRPKVFNVDLADWSVNREATIKRSKA
EECCCCEECCCEEECCCCCEEECCCCEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHC
VGEPPFMLGISVFQALNMAVASFNGYAENPRIDAPATPERVLMAIERLRP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]