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The map label for this gene is xdhB [H]

Identifier: 119386962

GI number: 119386962

Start: 1423057

End: 1424502

Strand: Direct

Name: xdhB [H]

Synonym: Pden_4257

Alternate gene names: 119386962

Gene position: 1423057-1424502 (Clockwise)

Preceding gene: 119386960

Following gene: 119386963

Centisome position: 82.25

GC content: 68.33

Gene sequence:

>1446_bases
ATGGGCCACGAATTGCGCTTTCTTCTGAACGACACCGAGATCAGCCTGACCGAGGCGGGCTCGCGCGACACACTTCTGGA
CTTCCTGCGGCTCAATCGCCGCCTGACCGGCACCAAGGAGGGCTGCGCCGAGGGCGATTGCGGCGCCTGCACCGTGCTGG
TCGGCCGGTTGCACCAGGGCCGGCTGCATTACGAGCCGATCAACGCCTGCATCCGCTTCCTGGCCTCGTGCCACGGCTGC
CATGTCGTCACCGTCGAGCATCTGCGCGGCGCTGATGGCGGGCTGCACCCGGTCCAGGCCGCCATGGTCGAGCATCACGG
CAGCCAGTGCGGCTTTTGCACGCCGGGCTTCGTCATGGCGCTTTACGGGCTGTGGATGTCCGATCCGCATCCCGACATGC
TGGCGATCGAGACCGCGCTGCAAGGCAACCTGTGCCGCTGCACCGGCTACGAGCCGATCGTGAAGGCGGCCTTCGCGGCC
AGCGAGGCGGGCGGGCAACACATGGATGCGCTGACGGTCGAGCGCGACCGCATCACCGCCGCGCTCGATGCCATTCCGCG
CGAACGCGTCGAGGTGGCGCGCGGCGAGGATCGTGCCATCCTGCCGGCCGATGCCGCCGACCTGGCGCAGGTCCTGGCCG
AGAACCCCAAGGCCACCATCGTCGCGGGCGCGACCGACGTGGGCCTGTGGGTGACGAAATTCCTGCGCAACATCTCTCCG
GCCGTGTTCATCGGCCATCTGCAGGATCTCAAGAGGATCGAGATCGCCCCCGGCCACATCACCATCGGCGCCGGCGTGAC
CTATTCCGAGTTCGAGCCCTTCCTGCGCGAGCATTTCCCCGAGGCGGTGGATTACTGGCTGCGCATCGGCGGCTGGCAGG
TCAGGAACGCCGGCACCATCGGCGGCAACGTGGCGAACGGCTCGCCCATCGGCGAGACCCCGCCGCTGCTGATCGCGCTT
GGCGCGAGCCTGCGGCTGCGCAGCGCCGAGGGCGCACGCGAACTGCCCATCGAGGACTACTTCATCGAATACGGCAAGCA
GGACCGCCGCCCCGGCGAGTTCGTGGAATCGATCACCGTGCCGCTGAAAGGCGAGGCCAGGATCGCCGCCTACAAGGTCT
CCAAGCGCCATCACGCCGATATCACCGCCTCGGCCGCCGCCTTCCGGGTGGAAACCGACGGCGCCACGATCATCGACGCG
CGCGTGGCATTCGGCGGCATGGCCGCGACACCGAAACGCGCCACCCAGGCCGAGGCGGCGCTGAAGGGCCAGCCCTTCAC
CGCCGAGACCTTCGAGGCCGCCGCGCGTGCGGTCGCAAACGACTTCCAGCCGCTCAGCGACTGGCGGGCCAGCAAGGAAT
ATCGCCAGCAACTCGCCGCCAACTTCTTCCGCCGCTTCTGGCTTGAACAGCAGGGCGCAGACCACCGCCTGAGGAGGGTC
GAATGA

Upstream 100 bases:

>100_bases
TTCAAGGAATCGCTGAAAGTCTTATGCTCAATCCGAGATTTCGCAAAGAGCAATTCGCATCTAGGCTTTTCCCATACCCA
GCCATGCGAGCGAGGACCGA

Downstream 100 bases:

>100_bases
AACAGGACGTTTTCGTCAAGGGCGCCGCCCATACGCCCATCATCCACGATTCGGCCGTGAAACATGTCACCGGCCTGGCC
GACTATACCGACGACCTGCT

Product: molybdopterin dehydrogenase, FAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MGHELRFLLNDTEISLTEAGSRDTLLDFLRLNRRLTGTKEGCAEGDCGACTVLVGRLHQGRLHYEPINACIRFLASCHGC
HVVTVEHLRGADGGLHPVQAAMVEHHGSQCGFCTPGFVMALYGLWMSDPHPDMLAIETALQGNLCRCTGYEPIVKAAFAA
SEAGGQHMDALTVERDRITAALDAIPRERVEVARGEDRAILPADAADLAQVLAENPKATIVAGATDVGLWVTKFLRNISP
AVFIGHLQDLKRIEIAPGHITIGAGVTYSEFEPFLREHFPEAVDYWLRIGGWQVRNAGTIGGNVANGSPIGETPPLLIAL
GASLRLRSAEGARELPIEDYFIEYGKQDRRPGEFVESITVPLKGEARIAAYKVSKRHHADITASAAAFRVETDGATIIDA
RVAFGGMAATPKRATQAEAALKGQPFTAETFEAAARAVANDFQPLSDWRASKEYRQQLAANFFRRFWLEQQGADHRLRRV
E

Sequences:

>Translated_481_residues
MGHELRFLLNDTEISLTEAGSRDTLLDFLRLNRRLTGTKEGCAEGDCGACTVLVGRLHQGRLHYEPINACIRFLASCHGC
HVVTVEHLRGADGGLHPVQAAMVEHHGSQCGFCTPGFVMALYGLWMSDPHPDMLAIETALQGNLCRCTGYEPIVKAAFAA
SEAGGQHMDALTVERDRITAALDAIPRERVEVARGEDRAILPADAADLAQVLAENPKATIVAGATDVGLWVTKFLRNISP
AVFIGHLQDLKRIEIAPGHITIGAGVTYSEFEPFLREHFPEAVDYWLRIGGWQVRNAGTIGGNVANGSPIGETPPLLIAL
GASLRLRSAEGARELPIEDYFIEYGKQDRRPGEFVESITVPLKGEARIAAYKVSKRHHADITASAAAFRVETDGATIIDA
RVAFGGMAATPKRATQAEAALKGQPFTAETFEAAARAVANDFQPLSDWRASKEYRQQLAANFFRRFWLEQQGADHRLRRV
E
>Mature_480_residues
GHELRFLLNDTEISLTEAGSRDTLLDFLRLNRRLTGTKEGCAEGDCGACTVLVGRLHQGRLHYEPINACIRFLASCHGCH
VVTVEHLRGADGGLHPVQAAMVEHHGSQCGFCTPGFVMALYGLWMSDPHPDMLAIETALQGNLCRCTGYEPIVKAAFAAS
EAGGQHMDALTVERDRITAALDAIPRERVEVARGEDRAILPADAADLAQVLAENPKATIVAGATDVGLWVTKFLRNISPA
VFIGHLQDLKRIEIAPGHITIGAGVTYSEFEPFLREHFPEAVDYWLRIGGWQVRNAGTIGGNVANGSPIGETPPLLIALG
ASLRLRSAEGARELPIEDYFIEYGKQDRRPGEFVESITVPLKGEARIAAYKVSKRHHADITASAAAFRVETDGATIIDAR
VAFGGMAATPKRATQAEAALKGQPFTAETFEAAARAVANDFQPLSDWRASKEYRQQLAANFFRRFWLEQQGADHRLRRVE

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=519, Percent_Identity=28.9017341040462, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI71773480, Length=526, Percent_Identity=27.9467680608365, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1789231, Length=272, Percent_Identity=30.8823529411765, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1786480, Length=154, Percent_Identity=38.3116883116883, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789232, Length=123, Percent_Identity=39.8373983739837, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=548, Percent_Identity=27.7372262773723, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32566215, Length=162, Percent_Identity=41.9753086419753, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=41.2903225806452, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737937, Length=523, Percent_Identity=32.3135755258126, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24647201, Length=492, Percent_Identity=25.4065040650407, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24647199, Length=502, Percent_Identity=26.0956175298805, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24647193, Length=509, Percent_Identity=27.3084479371316, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24647197, Length=482, Percent_Identity=26.5560165975104, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24647195, Length=477, Percent_Identity=25.5765199161426, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 52437; Mature: 52306

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHELRFLLNDTEISLTEAGSRDTLLDFLRLNRRLTGTKEGCAEGDCGACTVLVGRLHQG
CCCCEEEEEECCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
RLHYEPINACIRFLASCHGCHVVTVEHLRGADGGLHPVQAAMVEHHGSQCGFCTPGFVMA
CCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
LYGLWMSDPHPDMLAIETALQGNLCRCTGYEPIVKAAFAASEAGGQHMDALTVERDRITA
HHHHHCCCCCCCCEEEHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCHHEEEHHHHHHH
ALDAIPRERVEVARGEDRAILPADAADLAQVLAENPKATIVAGATDVGLWVTKFLRNISP
HHHHCCHHHHHHHCCCCCEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCH
AVFIGHLQDLKRIEIAPGHITIGAGVTYSEFEPFLREHFPEAVDYWLRIGGWQVRNAGTI
HEEHHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHHCHHHHHHHHHCCCEEEECCCCC
GGNVANGSPIGETPPLLIALGASLRLRSAEGARELPIEDYFIEYGKQDRRPGEFVESITV
CCCCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHCC
PLKGEARIAAYKVSKRHHADITASAAAFRVETDGATIIDARVAFGGMAATPKRATQAEAA
CCCCCCEEEEEEECCHHCCCEEECCEEEEEECCCCEEEEEHHHHCCCCCCCCHHHHHHHH
LKGQPFTAETFEAAARAVANDFQPLSDWRASKEYRQQLAANFFRRFWLEQQGADHRLRRV
HCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCC
E
C
>Mature Secondary Structure 
GHELRFLLNDTEISLTEAGSRDTLLDFLRLNRRLTGTKEGCAEGDCGACTVLVGRLHQG
CCCEEEEEECCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
RLHYEPINACIRFLASCHGCHVVTVEHLRGADGGLHPVQAAMVEHHGSQCGFCTPGFVMA
CCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHH
LYGLWMSDPHPDMLAIETALQGNLCRCTGYEPIVKAAFAASEAGGQHMDALTVERDRITA
HHHHHCCCCCCCCEEEHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCHHEEEHHHHHHH
ALDAIPRERVEVARGEDRAILPADAADLAQVLAENPKATIVAGATDVGLWVTKFLRNISP
HHHHCCHHHHHHHCCCCCEECCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCH
AVFIGHLQDLKRIEIAPGHITIGAGVTYSEFEPFLREHFPEAVDYWLRIGGWQVRNAGTI
HEEHHHHHHHHHEEECCCEEEEECCCCHHHHHHHHHHHCHHHHHHHHHCCCEEEECCCCC
GGNVANGSPIGETPPLLIALGASLRLRSAEGARELPIEDYFIEYGKQDRRPGEFVESITV
CCCCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHCC
PLKGEARIAAYKVSKRHHADITASAAAFRVETDGATIIDARVAFGGMAATPKRATQAEAA
CCCCCCEEEEEEECCHHCCCEEECCEEEEEECCCCEEEEEHHHHCCCCCCCCHHHHHHHH
LKGQPFTAETFEAAARAVANDFQPLSDWRASKEYRQQLAANFFRRFWLEQQGADHRLRRV
HCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]