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The map label for this gene is gppA [H]

Identifier: 119386696

GI number: 119386696

Start: 1128237

End: 1129361

Strand: Direct

Name: gppA [H]

Synonym: Pden_3989

Alternate gene names: 119386696

Gene position: 1128237-1129361 (Clockwise)

Preceding gene: 119386690

Following gene: 119386697

Centisome position: 65.21

GC content: 69.16

Gene sequence:

>1125_bases
ATGGCGCCCAGGCGTCCTGCGGGTGCGGACGCGTTCCCGAGAAAAACGGTCGAGCCTTTCGCCACCCGCCCGGCCGAGGA
CGGGCCGCTCTATGCGGCTTTGGATCTTGGCACGAACAGCTGCCGGATGCTGATTGCCCGCCCCGCGGGCAGCCAGTTCC
AGGTGGTCGACAGTTTCTCGAAGCCGGTCCAGCTGGGCCACGGCCTCGAGGCATCAGGCAGGCTGTCGCGTCCCTCGATG
GCGCGGACGGTGCATGCCTTGCAGGTGTGCCGGCGCAAGCTCGAGGCACATCAGGTCACGCGCATGCGCCTGGTCGCGAC
CGAGGCCTGCCGGCGGGCGAGGAACAGCCGCGATTTCCTGCGCATGATCCGGCGCGAGACCGGCCTGCCGGTCGAGATCA
TCGATGCCGAGGAAGAGGCGCGGCTGGCCGTGATCTCCTGCGCGCCGCTGGTCAGCCAGCGGACCGAGCAATTGCTGGTC
GTCGATATCGGCGGCGGCTCGACCGAGCTGGTCTGGATCGACCTGGAGGATGTCGAGCCCAAGGAACGGTCGCGCGCCAT
CATGCGGCTGGGCGACGGCTTTCGCGATCCGCTGCCGGGCGGCGCCCGGGTGGTGGACTGGATCAGCGTGCCGCTGGGCG
TCGCGACGCTGCGCGACCAGTTCGAGGATGTCGAGGACGACCAGGGCCGCTTCGCGCTGATGTCCTGGCATTTCGAGGAG
ATGCTGGCGGATTTCGCCCCCTATGCCCTGGCGCAGACCATGGAGGAGGGGTTCCAGATCATCGGCACCTCGGGCACGGT
GACGACCGTGGCGGCCAGCCATCTGGGCCTGCGCCGCTATGACCGAACCAAGGTGGACGGGCTGATCATGAGCTCGGCCC
AGATCGACCGGGTGATCCGCGACTACCTGTCGCTGGGGCCCGAGGGGCGGCGCGCCGACCCCCGCATCGGGCGCGAGCGG
CATGCGCTGATCATGTCGGGCGCCGCGATCCTGCAGACGCTGATGCGGGTCTGGCCGACGACGCGGCTGTCGGTCGCCGA
TCGCGGCCTGCGCGAGGGGTTGCTTTATGCGCAGATGGTCAAGGACGGGGTGCTGGCCCCGGATGGAATGAACGGGGTGG
CATGA

Upstream 100 bases:

>100_bases
CCCGCGGCCCTGTCGAGAGGCACGCCCCCTGAACGCCCCCCTTGAAGGCGTGGCGGGCGCAGGTTATTTTCGGACCAACT
TGTTATCGGAGGGCGTGACC

Downstream 100 bases:

>100_bases
GATGAGCGAAGGCAAGAAGCCGGGCTCCGGGCGCAAGAGCTCGGGCCGCGGCCAGCGCGACCTGCGGGTGCGGGTCAAAT
CGGCCAAGGGACGCAAGCTT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MAPRRPAGADAFPRKTVEPFATRPAEDGPLYAALDLGTNSCRMLIARPAGSQFQVVDSFSKPVQLGHGLEASGRLSRPSM
ARTVHALQVCRRKLEAHQVTRMRLVATEACRRARNSRDFLRMIRRETGLPVEIIDAEEEARLAVISCAPLVSQRTEQLLV
VDIGGGSTELVWIDLEDVEPKERSRAIMRLGDGFRDPLPGGARVVDWISVPLGVATLRDQFEDVEDDQGRFALMSWHFEE
MLADFAPYALAQTMEEGFQIIGTSGTVTTVAASHLGLRRYDRTKVDGLIMSSAQIDRVIRDYLSLGPEGRRADPRIGRER
HALIMSGAAILQTLMRVWPTTRLSVADRGLREGLLYAQMVKDGVLAPDGMNGVA

Sequences:

>Translated_374_residues
MAPRRPAGADAFPRKTVEPFATRPAEDGPLYAALDLGTNSCRMLIARPAGSQFQVVDSFSKPVQLGHGLEASGRLSRPSM
ARTVHALQVCRRKLEAHQVTRMRLVATEACRRARNSRDFLRMIRRETGLPVEIIDAEEEARLAVISCAPLVSQRTEQLLV
VDIGGGSTELVWIDLEDVEPKERSRAIMRLGDGFRDPLPGGARVVDWISVPLGVATLRDQFEDVEDDQGRFALMSWHFEE
MLADFAPYALAQTMEEGFQIIGTSGTVTTVAASHLGLRRYDRTKVDGLIMSSAQIDRVIRDYLSLGPEGRRADPRIGRER
HALIMSGAAILQTLMRVWPTTRLSVADRGLREGLLYAQMVKDGVLAPDGMNGVA
>Mature_373_residues
APRRPAGADAFPRKTVEPFATRPAEDGPLYAALDLGTNSCRMLIARPAGSQFQVVDSFSKPVQLGHGLEASGRLSRPSMA
RTVHALQVCRRKLEAHQVTRMRLVATEACRRARNSRDFLRMIRRETGLPVEIIDAEEEARLAVISCAPLVSQRTEQLLVV
DIGGGSTELVWIDLEDVEPKERSRAIMRLGDGFRDPLPGGARVVDWISVPLGVATLRDQFEDVEDDQGRFALMSWHFEEM
LADFAPYALAQTMEEGFQIIGTSGTVTTVAASHLGLRRYDRTKVDGLIMSSAQIDRVIRDYLSLGPEGRRADPRIGRERH
ALIMSGAAILQTLMRVWPTTRLSVADRGLREGLLYAQMVKDGVLAPDGMNGVA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=341, Percent_Identity=26.9794721407625, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI48994966, Length=341, Percent_Identity=28.1524926686217, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 41270; Mature: 41139

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRRPAGADAFPRKTVEPFATRPAEDGPLYAALDLGTNSCRMLIARPAGSQFQVVDSFS
CCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHC
KPVQLGHGLEASGRLSRPSMARTVHALQVCRRKLEAHQVTRMRLVATEACRRARNSRDFL
CHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RMIRRETGLPVEIIDAEEEARLAVISCAPLVSQRTEQLLVVDIGGGSTELVWIDLEDVEP
HHHHHHCCCCEEEECCCCCCCEEEEEHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCC
KERSRAIMRLGDGFRDPLPGGARVVDWISVPLGVATLRDQFEDVEDDQGRFALMSWHFEE
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHH
MLADFAPYALAQTMEEGFQIIGTSGTVTTVAASHLGLRRYDRTKVDGLIMSSAQIDRVIR
HHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DYLSLGPEGRRADPRIGRERHALIMSGAAILQTLMRVWPTTRLSVADRGLREGLLYAQMV
HHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
KDGVLAPDGMNGVA
HCCCCCCCCCCCCC
>Mature Secondary Structure 
APRRPAGADAFPRKTVEPFATRPAEDGPLYAALDLGTNSCRMLIARPAGSQFQVVDSFS
CCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHC
KPVQLGHGLEASGRLSRPSMARTVHALQVCRRKLEAHQVTRMRLVATEACRRARNSRDFL
CHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RMIRRETGLPVEIIDAEEEARLAVISCAPLVSQRTEQLLVVDIGGGSTELVWIDLEDVEP
HHHHHHCCCCEEEECCCCCCCEEEEEHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCC
KERSRAIMRLGDGFRDPLPGGARVVDWISVPLGVATLRDQFEDVEDDQGRFALMSWHFEE
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHH
MLADFAPYALAQTMEEGFQIIGTSGTVTTVAASHLGLRRYDRTKVDGLIMSSAQIDRVIR
HHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DYLSLGPEGRRADPRIGRERHALIMSGAAILQTLMRVWPTTRLSVADRGLREGLLYAQMV
HHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
KDGVLAPDGMNGVA
HCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA