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The map label for this gene is purM [H]

Identifier: 119386633

GI number: 119386633

Start: 1062638

End: 1063684

Strand: Direct

Name: purM [H]

Synonym: Pden_3926

Alternate gene names: 119386633

Gene position: 1062638-1063684 (Clockwise)

Preceding gene: 119386631

Following gene: 119386634

Centisome position: 61.42

GC content: 70.77

Gene sequence:

>1047_bases
ATGACCGAGCGCAAGAGCGGCCTGTCCTATGCCGAGGCCGGAGTGGATATCGACGCGGGCAATGCGCTGGTCGAGCGGAT
CAAGCCCGCCGCCGCCGCCACCCGCCGCCCGGGCGTGATGGAGGGGCTCGGCGGTTTCGGCGCGCTGTTCGATCCGCGGG
CCGCGGGTTACCGCGATCCGGTGCTGGTGGCCGCGACCGACGGTGTCGGCACCAAGCTGCGCATCGGCATCGATACGGGC
GAGCTTGACGGGCTGGGCATCGACCTTGTCGCCATGTGCGTGAACGACCTGGTCTGCCAGGGCGCCGAGCCCCTGTTCTT
CCTCGACTATTTCGCCACCGGCAAGCTGTCGGTCGATGAGGCGGCGCGAGTCATCAACGGCATTGCCGAAGGCTGCCACC
GTTCCGGTTGCGCACTGATCGGCGGCGAGACGGCCGAGATGCCCGGCATGTATGCCCGCGGCGACTTCGACCTTGCCGGC
TTTGCCGTCGGCGCGATGGAGCGCGGCACGGCCCTGCCGGCGGGCGTCGCGGACGGCGACGTCCTGCTGGGCCTTGCCTC
GGACGGGGTGCATTCCAACGGATTCTCGCTGGTGCGCAGGGTGGCCGACCATGCCGGGCTCGACTGGAACGCGCCTGCGC
CCTTCGGCATGGGCACGCTGGGCCAGGCGCTTCTGGTCCCGACCCGGCTTTATGTGCGTCCGGTGCTGGCTGCGATCCGT
GCCGGCGGCGTGCATGCGGCGGCCCATATCACCGGCGGCGGCATCACGGAAAACCTGCCGCGCGTCCTGCCCGAGGGGCT
GGGGGCCCAGGTCGACCTCGACAGCTTCAGCCTGCCACCGGTATTCGACTGGCTGGCCGAGGCCGGCGGGATCGCCGAGG
CCGAGATGCTCAAGACCTTCAACTGCGGCATCGGCATGATCCTGGCCGTCGCCGCCGATCGTGCCGCCGCAATCGAGGCG
CTGCTGAAGGCCGAGGGCGAGACCGTGTTCCGCCTCGGCCAGGTCAGCCCCGGCGCAGGCGTGGGCTACAGCGGCCGGCT
GCGGTGA

Upstream 100 bases:

>100_bases
GGTGCTGGAGCGGCTGGAATCGGATCCCGCCTGCAGCCGATACATTGCCTGCGCGCCGCGCCTGCGCTATCGGAGCGTCA
AAGCAAAGGGGATCCCGAAG

Downstream 100 bases:

>100_bases
AACGCGTCGCCATCCTGATCTCGGGCGGCGGCTCGAACATGGTCAAGCTGGTCGAATCCATGACCGGCACGCATCCCGCG
CGGCCGGTCGTCGTCGGCTC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTERKSGLSYAEAGVDIDAGNALVERIKPAAAATRRPGVMEGLGGFGALFDPRAAGYRDPVLVAATDGVGTKLRIGIDTG
ELDGLGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLSVDEAARVINGIAEGCHRSGCALIGGETAEMPGMYARGDFDLAG
FAVGAMERGTALPAGVADGDVLLGLASDGVHSNGFSLVRRVADHAGLDWNAPAPFGMGTLGQALLVPTRLYVRPVLAAIR
AGGVHAAAHITGGGITENLPRVLPEGLGAQVDLDSFSLPPVFDWLAEAGGIAEAEMLKTFNCGIGMILAVAADRAAAIEA
LLKAEGETVFRLGQVSPGAGVGYSGRLR

Sequences:

>Translated_348_residues
MTERKSGLSYAEAGVDIDAGNALVERIKPAAAATRRPGVMEGLGGFGALFDPRAAGYRDPVLVAATDGVGTKLRIGIDTG
ELDGLGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLSVDEAARVINGIAEGCHRSGCALIGGETAEMPGMYARGDFDLAG
FAVGAMERGTALPAGVADGDVLLGLASDGVHSNGFSLVRRVADHAGLDWNAPAPFGMGTLGQALLVPTRLYVRPVLAAIR
AGGVHAAAHITGGGITENLPRVLPEGLGAQVDLDSFSLPPVFDWLAEAGGIAEAEMLKTFNCGIGMILAVAADRAAAIEA
LLKAEGETVFRLGQVSPGAGVGYSGRLR
>Mature_347_residues
TERKSGLSYAEAGVDIDAGNALVERIKPAAAATRRPGVMEGLGGFGALFDPRAAGYRDPVLVAATDGVGTKLRIGIDTGE
LDGLGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLSVDEAARVINGIAEGCHRSGCALIGGETAEMPGMYARGDFDLAGF
AVGAMERGTALPAGVADGDVLLGLASDGVHSNGFSLVRRVADHAGLDWNAPAPFGMGTLGQALLVPTRLYVRPVLAAIRA
GGVHAAAHITGGGITENLPRVLPEGLGAQVDLDSFSLPPVFDWLAEAGGIAEAEMLKTFNCGIGMILAVAADRAAAIEAL
LKAEGETVFRLGQVSPGAGVGYSGRLR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=52.2255192878338, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=52.2255192878338, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=52.2255192878338, Blast_Score=361, Evalue=1e-100,
Organism=Escherichia coli, GI1788845, Length=337, Percent_Identity=56.6765578635015, Blast_Score=363, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=44.6428571428571, Blast_Score=286, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=52.0710059171598, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24582400, Length=271, Percent_Identity=47.6014760147601, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35573; Mature: 35442

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERKSGLSYAEAGVDIDAGNALVERIKPAAAATRRPGVMEGLGGFGALFDPRAAGYRDP
CCCCCCCCCHHHCCCEECCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCC
VLVAATDGVGTKLRIGIDTGELDGLGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLSVDE
EEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
AARVINGIAEGCHRSGCALIGGETAEMPGMYARGDFDLAGFAVGAMERGTALPAGVADGD
HHHHHHHHHHHHHHCCCEEECCCCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
VLLGLASDGVHSNGFSLVRRVADHAGLDWNAPAPFGMGTLGQALLVPTRLYVRPVLAAIR
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AGGVHAAAHITGGGITENLPRVLPEGLGAQVDLDSFSLPPVFDWLAEAGGIAEAEMLKTF
CCCCEEEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCHHHHHHHH
NCGIGMILAVAADRAAAIEALLKAEGETVFRLGQVSPGAGVGYSGRLR
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TERKSGLSYAEAGVDIDAGNALVERIKPAAAATRRPGVMEGLGGFGALFDPRAAGYRDP
CCCCCCCCHHHCCCEECCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCC
VLVAATDGVGTKLRIGIDTGELDGLGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLSVDE
EEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHH
AARVINGIAEGCHRSGCALIGGETAEMPGMYARGDFDLAGFAVGAMERGTALPAGVADGD
HHHHHHHHHHHHHHCCCEEECCCCCCCCCCEECCCCCHHHHHHHHHHCCCCCCCCCCCCC
VLLGLASDGVHSNGFSLVRRVADHAGLDWNAPAPFGMGTLGQALLVPTRLYVRPVLAAIR
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AGGVHAAAHITGGGITENLPRVLPEGLGAQVDLDSFSLPPVFDWLAEAGGIAEAEMLKTF
CCCCEEEEEECCCCHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCHHHHHHHH
NCGIGMILAVAADRAAAIEALLKAEGETVFRLGQVSPGAGVGYSGRLR
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA