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The map label for this gene is nudF [H]

Identifier: 119386567

GI number: 119386567

Start: 992416

End: 993522

Strand: Direct

Name: nudF [H]

Synonym: Pden_3860

Alternate gene names: 119386567

Gene position: 992416-993522 (Clockwise)

Preceding gene: 119386566

Following gene: 119386568

Centisome position: 57.36

GC content: 71.27

Gene sequence:

>1107_bases
ATGCCGCTGCTGATCGGACCGCTTGCCCATCCGCTTATCCGTGCCCGGCTTGCCCCCCAGGCGACCGAGGCCGGGTCGCT
GCAAGCTGCGCTGATTGGCGGCGGGCTGGCCGGGATCGCGCCCGATGGCTGGCCCCGGCTTGCTGCGGGCGATGATCGCC
TGCCGCTCTGGCAGGCCGACTGGACGCCCGCCCTGCGCCGCTATGCCGAGATCTTCGGGCTCGCCCCGCAGCATCACCAG
GGGCAGGAGTTGCTGGGCCTGGGCGAGCCCGCGAGCGATGCGCCGCAATGGCAGTCGGAACTGGCCGCCGCGATCGCCGA
CCGGTTGCTGGGGCTGCCCGGGAATCGCCCGGCAGAGGCGATCCGCAAGCGCCTGCCGATGATCGCAAGCTGGGTGGCCT
CGCGTCTGCGCGCCGAAATCGAGACGGCAAGCCTGCCGCATGTCGGGCCCGCGGCCATCGACCGGGTCAGGATCGATTCG
GTCGAGGAACCCCATGCCGAGTATTTCTCGGTCGAGGCGATCCGGTTGAGCCAGCACCGCAACGACGGCGGCTGGACCGA
GCCGCTTGCGCGCGCGGTCTTCGTCTCGGGCGACGCGACGGTGGTGCTGCCCTGGGATCCGGTGCGCGACCGGGTGATGC
TGATCGACCAGATGCGGGCCGGGCCGCTGGCGCGCGGCGATGCGCAGCCCTGGCTCTACGAGACCGTGGCCGGCCGCGTC
GATGCCGGCGAAACCCCGGAACAGGCCGCCCGGCGCGAGGCGGTCGAGGAGACGGGCATCGCCCTTTTGCAACTCTTCCC
GGCGCCGCACAACTATCCCAGCCCCGGGGCCGTGGCGGAATACCTCTATCTTTATGTCGGCATCGCCGACCTGCCGGACG
ACAGCGCCGGGCTTGGCGGGCTTGCGACCGAGGACGAGGACATCCGCTCGCATCTGGTCCCGCGGGCCGAACTGACCCGC
ATGGCGCTGGCGGGCGAGATCCGCAACGGGCCGCTTCTGAATCTCGCGCTGTGGCTGGAATTGCGCCACCACGAAATCCG
CCGCGAACTGGGGCAGGGGACCGAGACCGCCCTGGCGGGGTTGCCGCCATCGGTCGGCGGCGTGTAA

Upstream 100 bases:

>100_bases
AGGGGCTTCGCGCCAAAACCGCGAAAAATTTCTCTTACGGGTGAATCATGGTCAGAAGACGCAGCACCAGCCGGATCGCG
AACTCCAGGAGGCTGCAACC

Downstream 100 bases:

>100_bases
ACCGGGCGGGAACATCCTGCGAAAGGCCAAGCCCATGCGCATCTGCCCCGACCTCGCCTCTGCCATCGGCAATACCCCCC
TGATCCGGCTGCGCCGCGCC

Product: NUDIX hydrolase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MPLLIGPLAHPLIRARLAPQATEAGSLQAALIGGGLAGIAPDGWPRLAAGDDRLPLWQADWTPALRRYAEIFGLAPQHHQ
GQELLGLGEPASDAPQWQSELAAAIADRLLGLPGNRPAEAIRKRLPMIASWVASRLRAEIETASLPHVGPAAIDRVRIDS
VEEPHAEYFSVEAIRLSQHRNDGGWTEPLARAVFVSGDATVVLPWDPVRDRVMLIDQMRAGPLARGDAQPWLYETVAGRV
DAGETPEQAARREAVEETGIALLQLFPAPHNYPSPGAVAEYLYLYVGIADLPDDSAGLGGLATEDEDIRSHLVPRAELTR
MALAGEIRNGPLLNLALWLELRHHEIRRELGQGTETALAGLPPSVGGV

Sequences:

>Translated_368_residues
MPLLIGPLAHPLIRARLAPQATEAGSLQAALIGGGLAGIAPDGWPRLAAGDDRLPLWQADWTPALRRYAEIFGLAPQHHQ
GQELLGLGEPASDAPQWQSELAAAIADRLLGLPGNRPAEAIRKRLPMIASWVASRLRAEIETASLPHVGPAAIDRVRIDS
VEEPHAEYFSVEAIRLSQHRNDGGWTEPLARAVFVSGDATVVLPWDPVRDRVMLIDQMRAGPLARGDAQPWLYETVAGRV
DAGETPEQAARREAVEETGIALLQLFPAPHNYPSPGAVAEYLYLYVGIADLPDDSAGLGGLATEDEDIRSHLVPRAELTR
MALAGEIRNGPLLNLALWLELRHHEIRRELGQGTETALAGLPPSVGGV
>Mature_367_residues
PLLIGPLAHPLIRARLAPQATEAGSLQAALIGGGLAGIAPDGWPRLAAGDDRLPLWQADWTPALRRYAEIFGLAPQHHQG
QELLGLGEPASDAPQWQSELAAAIADRLLGLPGNRPAEAIRKRLPMIASWVASRLRAEIETASLPHVGPAAIDRVRIDSV
EEPHAEYFSVEAIRLSQHRNDGGWTEPLARAVFVSGDATVVLPWDPVRDRVMLIDQMRAGPLARGDAQPWLYETVAGRVD
AGETPEQAARREAVEETGIALLQLFPAPHNYPSPGAVAEYLYLYVGIADLPDDSAGLGGLATEDEDIRSHLVPRAELTRM
ALAGEIRNGPLLNLALWLELRHHEIRRELGQGTETALAGLPPSVGGV

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789412, Length=194, Percent_Identity=36.0824742268041, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788810, Length=176, Percent_Identity=31.8181818181818, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 39615; Mature: 39484

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLIGPLAHPLIRARLAPQATEAGSLQAALIGGGLAGIAPDGWPRLAAGDDRLPLWQAD
CCEEECHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEECCC
WTPALRRYAEIFGLAPQHHQGQELLGLGEPASDAPQWQSELAAAIADRLLGLPGNRPAEA
CCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
IRKRLPMIASWVASRLRAEIETASLPHVGPAAIDRVRIDSVEEPHAEYFSVEAIRLSQHR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHEEEECCCC
NDGGWTEPLARAVFVSGDATVVLPWDPVRDRVMLIDQMRAGPLARGDAQPWLYETVAGRV
CCCCHHHHHHHEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
DAGETPEQAARREAVEETGIALLQLFPAPHNYPSPGAVAEYLYLYVGIADLPDDSAGLGG
CCCCCHHHHHHHHHHHHHCCEEEHEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
LATEDEDIRSHLVPRAELTRMALAGEIRNGPLLNLALWLELRHHEIRRELGQGTETALAG
CCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHC
LPPSVGGV
CCCCCCCC
>Mature Secondary Structure 
PLLIGPLAHPLIRARLAPQATEAGSLQAALIGGGLAGIAPDGWPRLAAGDDRLPLWQAD
CEEECHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEECCC
WTPALRRYAEIFGLAPQHHQGQELLGLGEPASDAPQWQSELAAAIADRLLGLPGNRPAEA
CCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
IRKRLPMIASWVASRLRAEIETASLPHVGPAAIDRVRIDSVEEPHAEYFSVEAIRLSQHR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHEEEECCCC
NDGGWTEPLARAVFVSGDATVVLPWDPVRDRVMLIDQMRAGPLARGDAQPWLYETVAGRV
CCCCHHHHHHHEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
DAGETPEQAARREAVEETGIALLQLFPAPHNYPSPGAVAEYLYLYVGIADLPDDSAGLGG
CCCCCHHHHHHHHHHHHHCCEEEHEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
LATEDEDIRSHLVPRAELTRMALAGEIRNGPLLNLALWLELRHHEIRRELGQGTETALAG
CCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHC
LPPSVGGV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]