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The map label for this gene is cysK [H]

Identifier: 119386568

GI number: 119386568

Start: 993557

End: 994588

Strand: Direct

Name: cysK [H]

Synonym: Pden_3861

Alternate gene names: 119386568

Gene position: 993557-994588 (Clockwise)

Preceding gene: 119386567

Following gene: 119386569

Centisome position: 57.43

GC content: 67.05

Gene sequence:

>1032_bases
ATGCGCATCTGCCCCGACCTCGCCTCTGCCATCGGCAATACCCCCCTGATCCGGCTGCGCCGCGCCTCGGAAGAGACCGG
CTGCGAGATCCTGGGCAAGGCCGAGTTCATGAATCCGGGCCAGTCGGTCAAGGATCGCGCCGCGCTCTACATCATCAAGG
ACGCGGTGGCGCGGGGCGAGTTGAAGCCGGGCGGCACAATCGTCGAGGGCACGGCGGGCAATACCGGCATCGGCCTGGCG
CTGGTCGGCGCCTCGATGGGCTTCCGCTCGGTCATCGTCATCCCCGAGACGCAGAGCCAGGAGAAAAAGGACATGCTGCG
CCTCGCGGGGGCCGAACTGGTCGAGGTGCCGGCGCAGCCCTACAAGAACCCCAACAACTATGTGCGCTATTCCGGCCGCC
TGGCCGAGGAACTGGCCAGGACCGAGCCGAACGGCGCCATCTGGGCCAACCAGTTCGACAATGTCGCCAACCGCGAGGCG
CATCTGCACACCACCGGCCCCGAGATCTGGGAACAGACCGGCGGCCGCGTGGACGGCTTCATCTGCGCCGTCGGCTCGGG
CGGGACGCTGGCGGGCGTCGCCATGGCGCTGCAGCCCAAGGGCGTGAAGATGGGGCTGGCCGATCCCGAGGGCGCGGCGC
TTTACAGCTTCTATACCGAAGGCAAGTTCGAATCGCCCGGCTCCTCCATCACCGAGGGCATCGGCCAGGGCCGGATCACC
GCCAACCTGGAAGGCTTCACCCCGGATTTCGCCTATCGCATTTCGGATGCCGAGGCGCTGCCGGTGATCTTCGACCTGCT
GGAATACGAGGGGCTGTGCCTTGGCGGCTCGTCGGGGGTGAACGTCGCCGGCGCGATCCGCATGGCAAGGGACATGGGCC
CCGGTCACACCATCGTGACGGTGCTTTGCGACTATGGCACGCGTTACCAGACCAAGCTCTTCAACCCCGACTTCCTGCGG
GCCAAGGGCCTGCCGGTGCCGGAATGGATGACGCGCAAGCCGGCGGACCTGCCCGAGGTTTACGAGGACTGA

Upstream 100 bases:

>100_bases
CGCGAACTGGGGCAGGGGACCGAGACCGCCCTGGCGGGGTTGCCGCCATCGGTCGGCGGCGTGTAAACCGGGCGGGAACA
TCCTGCGAAAGGCCAAGCCC

Downstream 100 bases:

>100_bases
TCCGAACCATGCCCCGCCTCGCCGCGCTGTCCCGGCTCGCATCGCTGATCCTGGTGCTGTTTCTGGCGCTGAACCTGCCT
GCCCTTGCCCAGCAAGAGCA

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRICPDLASAIGNTPLIRLRRASEETGCEILGKAEFMNPGQSVKDRAALYIIKDAVARGELKPGGTIVEGTAGNTGIGLA
LVGASMGFRSVIVIPETQSQEKKDMLRLAGAELVEVPAQPYKNPNNYVRYSGRLAEELARTEPNGAIWANQFDNVANREA
HLHTTGPEIWEQTGGRVDGFICAVGSGGTLAGVAMALQPKGVKMGLADPEGAALYSFYTEGKFESPGSSITEGIGQGRIT
ANLEGFTPDFAYRISDAEALPVIFDLLEYEGLCLGGSSGVNVAGAIRMARDMGPGHTIVTVLCDYGTRYQTKLFNPDFLR
AKGLPVPEWMTRKPADLPEVYED

Sequences:

>Translated_343_residues
MRICPDLASAIGNTPLIRLRRASEETGCEILGKAEFMNPGQSVKDRAALYIIKDAVARGELKPGGTIVEGTAGNTGIGLA
LVGASMGFRSVIVIPETQSQEKKDMLRLAGAELVEVPAQPYKNPNNYVRYSGRLAEELARTEPNGAIWANQFDNVANREA
HLHTTGPEIWEQTGGRVDGFICAVGSGGTLAGVAMALQPKGVKMGLADPEGAALYSFYTEGKFESPGSSITEGIGQGRIT
ANLEGFTPDFAYRISDAEALPVIFDLLEYEGLCLGGSSGVNVAGAIRMARDMGPGHTIVTVLCDYGTRYQTKLFNPDFLR
AKGLPVPEWMTRKPADLPEVYED
>Mature_343_residues
MRICPDLASAIGNTPLIRLRRASEETGCEILGKAEFMNPGQSVKDRAALYIIKDAVARGELKPGGTIVEGTAGNTGIGLA
LVGASMGFRSVIVIPETQSQEKKDMLRLAGAELVEVPAQPYKNPNNYVRYSGRLAEELARTEPNGAIWANQFDNVANREA
HLHTTGPEIWEQTGGRVDGFICAVGSGGTLAGVAMALQPKGVKMGLADPEGAALYSFYTEGKFESPGSSITEGIGQGRIT
ANLEGFTPDFAYRISDAEALPVIFDLLEYEGLCLGGSSGVNVAGAIRMARDMGPGHTIVTVLCDYGTRYQTKLFNPDFLR
AKGLPVPEWMTRKPADLPEVYED

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=337, Percent_Identity=39.1691394658754, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI295821200, Length=337, Percent_Identity=39.1691394658754, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4557415, Length=337, Percent_Identity=39.1691394658754, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=38.562091503268, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788754, Length=328, Percent_Identity=37.8048780487805, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=37.953795379538, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562970, Length=321, Percent_Identity=35.5140186915888, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI32566674, Length=308, Percent_Identity=36.038961038961, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI115535073, Length=318, Percent_Identity=36.7924528301887, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17561720, Length=326, Percent_Identity=34.3558282208589, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=32.3170731707317, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=331, Percent_Identity=29.9093655589124, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=32.7510917030568, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=38.7692307692308, Blast_Score=188, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6321594, Length=328, Percent_Identity=32.0121951219512, Blast_Score=159, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24643623, Length=331, Percent_Identity=34.441087613293, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI20129101, Length=331, Percent_Identity=34.441087613293, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36687; Mature: 36687

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRICPDLASAIGNTPLIRLRRASEETGCEILGKAEFMNPGQSVKDRAALYIIKDAVARGE
CCCCHHHHHHHCCCCEEEEECCCCCCCCEEEECHHCCCCCCCCHHHHEEEEEEHHHHCCC
LKPGGTIVEGTAGNTGIGLALVGASMGFRSVIVIPETQSQEKKDMLRLAGAELVEVPAQP
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCHHEECCCCC
YKNPNNYVRYSGRLAEELARTEPNGAIWANQFDNVANREAHLHTTGPEIWEQTGGRVDGF
CCCCCCEEEECCHHHHHHHHCCCCCCEECCHHCCCCCCCCEEECCCHHHHHHCCCCCCEE
ICAVGSGGTLAGVAMALQPKGVKMGLADPEGAALYSFYTEGKFESPGSSITEGIGQGRIT
EEEECCCCCHHHEEEEECCCCCEEECCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCEEE
ANLEGFTPDFAYRISDAEALPVIFDLLEYEGLCLGGSSGVNVAGAIRMARDMGPGHTIVT
EEECCCCCCCEEEECCCCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEE
VLCDYGTRYQTKLFNPDFLRAKGLPVPEWMTRKPADLPEVYED
EEECCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCCCCHHHCC
>Mature Secondary Structure
MRICPDLASAIGNTPLIRLRRASEETGCEILGKAEFMNPGQSVKDRAALYIIKDAVARGE
CCCCHHHHHHHCCCCEEEEECCCCCCCCEEEECHHCCCCCCCCHHHHEEEEEEHHHHCCC
LKPGGTIVEGTAGNTGIGLALVGASMGFRSVIVIPETQSQEKKDMLRLAGAELVEVPAQP
CCCCCEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHCCHHEECCCCC
YKNPNNYVRYSGRLAEELARTEPNGAIWANQFDNVANREAHLHTTGPEIWEQTGGRVDGF
CCCCCCEEEECCHHHHHHHHCCCCCCEECCHHCCCCCCCCEEECCCHHHHHHCCCCCCEE
ICAVGSGGTLAGVAMALQPKGVKMGLADPEGAALYSFYTEGKFESPGSSITEGIGQGRIT
EEEECCCCCHHHEEEEECCCCCEEECCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCEEE
ANLEGFTPDFAYRISDAEALPVIFDLLEYEGLCLGGSSGVNVAGAIRMARDMGPGHTIVT
EEECCCCCCCEEEECCCCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEE
VLCDYGTRYQTKLFNPDFLRAKGLPVPEWMTRKPADLPEVYED
EEECCCCCEEEECCCCCHHHCCCCCCCHHHCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA