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The map label for this gene is dctB [H]

Identifier: 119385688

GI number: 119385688

Start: 131915

End: 133708

Strand: Direct

Name: dctB [H]

Synonym: Pden_2963

Alternate gene names: 119385688

Gene position: 131915-133708 (Clockwise)

Preceding gene: 119385687

Following gene: 119385689

Centisome position: 7.62

GC content: 67.73

Gene sequence:

>1794_bases
ATGCAAGAGGAAGACAATTCCATCGGGTTCCCGGAAGGCAGGGCGGGTCTGACCAGCCGCTGGGGCCTGCGCGGTGCGAT
CGCCGTGCTGCTGATCGTGGCTGCGGGCACGGTGTGGTTCACCAATGCCTGGCTGACGGCGCGGTTTTCCGAGACGACGC
GGGTGCGCACCGAGCTGCGCTCGGCGCTTTATACCGGAAACCTTTTGTCGGAATTGCAGCGCACCTCGGTCGTGCCCTTG
CTTCTGGCGCGCGATCCGGCGCTGATCTCGGCGCTGTCGGGCAACGATTTCTCGGGCACCTCGGCGCGGCTGATCTCGGC
CCAGAAGGAGATCGCGGCGGCGTCGATCAAGCTCCTGGATGCCTCGGGGCGGGTCGTGGGCTCGACCGACCGTAACCTGA
TCGGCACCAATTACGTGCAGGAGCCGTTCTTCGTCGAGGCGCTGCGGTCCAAGGATACCGTCTTTACCGTCTCGCCCTCG
CCGCAGGGGGTCTACGAGTTCACCTATTCCCGCACCGTGGTTTCGGATGGGCGCACGCTGGGCGTGGTGGTGGTGGGCGC
CGACCTGACGCGGCTGGTGCGGTCCTGGGCGGGGATCTCGGATGCGATCGCGGTGACGGACAGCGCCGGGCAGATCATCC
TTTCGACCGAGCCGCGCTGGCGCGGGCTGACCCTGCCCGAGGCGCTGGCGGTGCGCTCGGCGCCTTCGGCCATCGCGCGG
GCCTTCCAGGTCACGGCGGATTGGGCGGCGACCCCGGCCGATGCCTATGTGCAGGGCCGCGCCGTGATGCAGTCCGAAAC
CCGCATCCCCTTCCGCGGCTGGAAGATGATCGCCTTCACCACCTATGAATCGGTGCGCGAGCGGGTGAACGCGGTGCTGG
CCATGGTCATCATGGGCTTTGCCATCCTGCTGGCGGCGGTGTTCTATCTGCTGTCGCGCCGGGCGCGGGTGGAATCGGCG
GCCTGGATGCGCGAATCGGCCGACCTGCGGGCGCTGAACATGCGCCTGACCCGCGAGATCGCCGAGCGAGAGCGCATGCA
GAAGGAGCTGCGCGTGGCCGAGCAGACCGTGCAGCAGTCCAGCAAGCTGGCGGCGCTGGGCGAGATGTCGGCGGGCGTCA
GCCATGAGCTGAACCAGCCCCTGGCCGCGATGAAGACCTATCTGGCCGGGGCGCGGCTGCTCTTGCAGCGCGGCCGGGCC
GAGGAGGCGCAGTCCAGTTTCCAGCGCATCGACGACCTGGTCGAGCGCATGGGCGCCATCACCCGGCAGCTGAAATCCTA
TGCCCGCAAGGGCGGCGAGGCCTTCGAGCCGGTCGACCTGCGCGCCGCGCTGTCCAGCGCGCTGGTGATGATGGAGCCGC
AACTGCGGTCCCGCACCATCCGCCTGCAGCGCACCATCCCGCGCTATCCGGTCATGGTCTATTGCGACCGCATCCGGCTG
GAGCAGATCATCATCAACCTGCTGCGCAACGCGGTCGATGCGATCAAGGGGGTCCGCGACCCGGCCATCGAGATCACCGT
CAGCTCGGGCTCTCACGCATTCTTGTCCGTGCGCGACAACGGGCCGGGTGTATCCGACCTTGAAAATCTGTTTGAACCCT
TCTTCACCACGAAGAAACCCGGAGAGGGGACCGGCCTGGGGCTGGCGATCTCATCCGGGATCGCGGCCGATTTCGGGGGG
CGCCTGACGGCGCATAACGCCTTGGACGAGGGGGGCAGGGGCGCCGTATTCGAACTTGAACTGCCGTTGCACGATCCCGG
CCAGAAGGCGGGGCCGCGGCTGGCGGCGGAATGA

Upstream 100 bases:

>100_bases
TGCCTCGCTGGTGCAGGAGCTTGTCGCGGCCTGACTTGAGCGGCGCCCTTTCGCGCACTAGACTGCATCGACCCCCAGTC
GGGGGCGGTGCCGGAGGCTC

Downstream 100 bases:

>100_bases
TGAAAAGAGGTAAGGGCCCATGAGCCGCACTTTGAAGATAGCCGTCGTGGACGACGAACCGGACATGCGCGAATCGATCA
GCCAGTGGCTGGCGCTTTCC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MQEEDNSIGFPEGRAGLTSRWGLRGAIAVLLIVAAGTVWFTNAWLTARFSETTRVRTELRSALYTGNLLSELQRTSVVPL
LLARDPALISALSGNDFSGTSARLISAQKEIAAASIKLLDASGRVVGSTDRNLIGTNYVQEPFFVEALRSKDTVFTVSPS
PQGVYEFTYSRTVVSDGRTLGVVVVGADLTRLVRSWAGISDAIAVTDSAGQIILSTEPRWRGLTLPEALAVRSAPSAIAR
AFQVTADWAATPADAYVQGRAVMQSETRIPFRGWKMIAFTTYESVRERVNAVLAMVIMGFAILLAAVFYLLSRRARVESA
AWMRESADLRALNMRLTREIAERERMQKELRVAEQTVQQSSKLAALGEMSAGVSHELNQPLAAMKTYLAGARLLLQRGRA
EEAQSSFQRIDDLVERMGAITRQLKSYARKGGEAFEPVDLRAALSSALVMMEPQLRSRTIRLQRTIPRYPVMVYCDRIRL
EQIIINLLRNAVDAIKGVRDPAIEITVSSGSHAFLSVRDNGPGVSDLENLFEPFFTTKKPGEGTGLGLAISSGIAADFGG
RLTAHNALDEGGRGAVFELELPLHDPGQKAGPRLAAE

Sequences:

>Translated_597_residues
MQEEDNSIGFPEGRAGLTSRWGLRGAIAVLLIVAAGTVWFTNAWLTARFSETTRVRTELRSALYTGNLLSELQRTSVVPL
LLARDPALISALSGNDFSGTSARLISAQKEIAAASIKLLDASGRVVGSTDRNLIGTNYVQEPFFVEALRSKDTVFTVSPS
PQGVYEFTYSRTVVSDGRTLGVVVVGADLTRLVRSWAGISDAIAVTDSAGQIILSTEPRWRGLTLPEALAVRSAPSAIAR
AFQVTADWAATPADAYVQGRAVMQSETRIPFRGWKMIAFTTYESVRERVNAVLAMVIMGFAILLAAVFYLLSRRARVESA
AWMRESADLRALNMRLTREIAERERMQKELRVAEQTVQQSSKLAALGEMSAGVSHELNQPLAAMKTYLAGARLLLQRGRA
EEAQSSFQRIDDLVERMGAITRQLKSYARKGGEAFEPVDLRAALSSALVMMEPQLRSRTIRLQRTIPRYPVMVYCDRIRL
EQIIINLLRNAVDAIKGVRDPAIEITVSSGSHAFLSVRDNGPGVSDLENLFEPFFTTKKPGEGTGLGLAISSGIAADFGG
RLTAHNALDEGGRGAVFELELPLHDPGQKAGPRLAAE
>Mature_597_residues
MQEEDNSIGFPEGRAGLTSRWGLRGAIAVLLIVAAGTVWFTNAWLTARFSETTRVRTELRSALYTGNLLSELQRTSVVPL
LLARDPALISALSGNDFSGTSARLISAQKEIAAASIKLLDASGRVVGSTDRNLIGTNYVQEPFFVEALRSKDTVFTVSPS
PQGVYEFTYSRTVVSDGRTLGVVVVGADLTRLVRSWAGISDAIAVTDSAGQIILSTEPRWRGLTLPEALAVRSAPSAIAR
AFQVTADWAATPADAYVQGRAVMQSETRIPFRGWKMIAFTTYESVRERVNAVLAMVIMGFAILLAAVFYLLSRRARVESA
AWMRESADLRALNMRLTREIAERERMQKELRVAEQTVQQSSKLAALGEMSAGVSHELNQPLAAMKTYLAGARLLLQRGRA
EEAQSSFQRIDDLVERMGAITRQLKSYARKGGEAFEPVDLRAALSSALVMMEPQLRSRTIRLQRTIPRYPVMVYCDRIRL
EQIIINLLRNAVDAIKGVRDPAIEITVSSGSHAFLSVRDNGPGVSDLENLFEPFFTTKKPGEGTGLGLAISSGIAADFGG
RLTAHNALDEGGRGAVFELELPLHDPGQKAGPRLAAE

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=411, Percent_Identity=28.7104622871046, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081816, Length=224, Percent_Identity=31.6964285714286, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994928, Length=266, Percent_Identity=28.1954887218045, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=31.140350877193, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI145693157, Length=266, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789149, Length=259, Percent_Identity=26.6409266409266, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65026; Mature: 65026

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEEDNSIGFPEGRAGLTSRWGLRGAIAVLLIVAAGTVWFTNAWLTARFSETTRVRTELR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHEEECCEEEEECCHHHHHHHHHH
SALYTGNLLSELQRTSVVPLLLARDPALISALSGNDFSGTSARLISAQKEIAAASIKLLD
HHHHCCHHHHHHHHHCCCEEEEECCCHHEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEE
ASGRVVGSTDRNLIGTNYVQEPFFVEALRSKDTVFTVSPSPQGVYEFTYSRTVVSDGRTL
CCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCEE
GVVVVGADLTRLVRSWAGISDAIAVTDSAGQIILSTEPRWRGLTLPEALAVRSAPSAIAR
EEEEECCHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHH
AFQVTADWAATPADAYVQGRAVMQSETRIPFRGWKMIAFTTYESVRERVNAVLAMVIMGF
HHHHHHCCCCCCHHHHHHCHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
AILLAAVFYLLSRRARVESAAWMRESADLRALNMRLTREIAERERMQKELRVAEQTVQQS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLAALGEMSAGVSHELNQPLAAMKTYLAGARLLLQRGRAEEAQSSFQRIDDLVERMGAI
HHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TRQLKSYARKGGEAFEPVDLRAALSSALVMMEPQLRSRTIRLQRTIPRYPVMVYCDRIRL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHEECCHHHHHHHHHHHCCCCCCEEEHHHHHHH
EQIIINLLRNAVDAIKGVRDPAIEITVSSGSHAFLSVRDNGPGVSDLENLFEPFFTTKKP
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GEGTGLGLAISSGIAADFGGRLTAHNALDEGGRGAVFELELPLHDPGQKAGPRLAAE
CCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQEEDNSIGFPEGRAGLTSRWGLRGAIAVLLIVAAGTVWFTNAWLTARFSETTRVRTELR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHEEECCEEEEECCHHHHHHHHHH
SALYTGNLLSELQRTSVVPLLLARDPALISALSGNDFSGTSARLISAQKEIAAASIKLLD
HHHHCCHHHHHHHHHCCCEEEEECCCHHEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEE
ASGRVVGSTDRNLIGTNYVQEPFFVEALRSKDTVFTVSPSPQGVYEFTYSRTVVSDGRTL
CCCCEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCEE
GVVVVGADLTRLVRSWAGISDAIAVTDSAGQIILSTEPRWRGLTLPEALAVRSAPSAIAR
EEEEECCHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCHHHHHH
AFQVTADWAATPADAYVQGRAVMQSETRIPFRGWKMIAFTTYESVRERVNAVLAMVIMGF
HHHHHHCCCCCCHHHHHHCHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
AILLAAVFYLLSRRARVESAAWMRESADLRALNMRLTREIAERERMQKELRVAEQTVQQS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLAALGEMSAGVSHELNQPLAAMKTYLAGARLLLQRGRAEEAQSSFQRIDDLVERMGAI
HHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TRQLKSYARKGGEAFEPVDLRAALSSALVMMEPQLRSRTIRLQRTIPRYPVMVYCDRIRL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHEECCHHHHHHHHHHHCCCCCCEEEHHHHHHH
EQIIINLLRNAVDAIKGVRDPAIEITVSSGSHAFLSVRDNGPGVSDLENLFEPFFTTKKP
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHCCCCC
GEGTGLGLAISSGIAADFGGRLTAHNALDEGGRGAVFELELPLHDPGQKAGPRLAAE
CCCCCEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]