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The map label for this gene is fcl [H]

Identifier: 119358378

GI number: 119358378

Start: 2995898

End: 2996911

Strand: Reverse

Name: fcl [H]

Synonym: Cpha266_2610

Alternate gene names: 119358378

Gene position: 2996911-2995898 (Counterclockwise)

Preceding gene: 119358379

Following gene: 119358377

Centisome position: 95.63

GC content: 48.52

Gene sequence:

>1014_bases
ATGCATCAAAAAATATATATTGCTGGTCATCGGGGTATGGTTGGTTCGGCCATTGTTCGTAACCTTCTTGCCGGAGGGCT
CAGCTCGGATAATCTTCTTTTCAGAACTCATGTCGAGCTTGATCTTACCTGTCAGGCTGCGGTGCGTTCATTTTTCGAAA
AGGAGATGCCTGATCAGGTTTACCTTGCTGCGGCTAAAGTTGGCGGAATTCATGCCAACAATACGTATCCGGCGGAGTTC
ATCTATCAGAATTTGATGATCGAGGCGAATATTATTCATGAGGCATGGCGAGCGGGTGTTAAGAAATTGTTGTTTCTTGG
TTCCAGTTGTATCTATCCCAAGATGGTGCCGCAGCCGATGAGCGAAAGCGCTTTGCTCACCGGTCCGCTTGAGCCGACCA
ACGAACCCTACGCCATAGCTAAAATTGCCGGCATAAAACTTTGCGAAAGTTATAACCGCCAGTATGGAGAGAGTCATGGC
ACCGACTACCGCAGCGTCATGCCGACCAATCTCTATGGTCCAGGTGACAACTACCACCCGGAAAACAGCCACGTTATCCC
AGCCCTCATCCGCCGCTTCCACGAAGCCAAACTCTCCATGGAATGCACAGCCTACTTTCCACTTTCCAATCCCTATTCCG
TACTTATTTGGGGCACCGGCACGCCAAGACGTGAATTTCTCAACGTTGACGATATGGCAGCAGCCAGCGTTCACGTGATG
AACCTTGATAAAGCGGTATATGAGGCCAATACGCAACCAATGCTCAGCCATATCAACGTCGGTTGTGGCGAGGATATAAC
CATAAAAGAGCTTGCGGAAACAATCGCAAAAGTAGTCGGCTATACCGGTAACATTGATTTCGACCCATCAAAACCAGACG
GCACCCCAAGAAAACTCATGGACAGCACCCGCCTTAACAAGCTCGGTTGGCGGCCAAAAATCGATTTAGTCAGTGGCTTA
AGAGTTGCGTATGATGATTTTTTAAAATCATCATACGCGAGTGCTGAGCAATGA

Upstream 100 bases:

>100_bases
CTGGGGAATAGGTAATGGGAAGTAGGTAGGGGCAGGTGAGGATTGGGAAGTTAGTTCTTTTGAATGGGGTGAAAACGTTG
GATTTATAAGTTCGCTTTAT

Downstream 100 bases:

>100_bases
GTTCTGAGTCCTGAGTCCTGAGTATTTAAGATAGTACACTTCGCTGTTCTTATTCCGCACTCGGAATTCAGAACTTACAT
CCCCGAAAAAATGAAGGTTG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MHQKIYIAGHRGMVGSAIVRNLLAGGLSSDNLLFRTHVELDLTCQAAVRSFFEKEMPDQVYLAAAKVGGIHANNTYPAEF
IYQNLMIEANIIHEAWRAGVKKLLFLGSSCIYPKMVPQPMSESALLTGPLEPTNEPYAIAKIAGIKLCESYNRQYGESHG
TDYRSVMPTNLYGPGDNYHPENSHVIPALIRRFHEAKLSMECTAYFPLSNPYSVLIWGTGTPRREFLNVDDMAAASVHVM
NLDKAVYEANTQPMLSHINVGCGEDITIKELAETIAKVVGYTGNIDFDPSKPDGTPRKLMDSTRLNKLGWRPKIDLVSGL
RVAYDDFLKSSYASAEQ

Sequences:

>Translated_337_residues
MHQKIYIAGHRGMVGSAIVRNLLAGGLSSDNLLFRTHVELDLTCQAAVRSFFEKEMPDQVYLAAAKVGGIHANNTYPAEF
IYQNLMIEANIIHEAWRAGVKKLLFLGSSCIYPKMVPQPMSESALLTGPLEPTNEPYAIAKIAGIKLCESYNRQYGESHG
TDYRSVMPTNLYGPGDNYHPENSHVIPALIRRFHEAKLSMECTAYFPLSNPYSVLIWGTGTPRREFLNVDDMAAASVHVM
NLDKAVYEANTQPMLSHINVGCGEDITIKELAETIAKVVGYTGNIDFDPSKPDGTPRKLMDSTRLNKLGWRPKIDLVSGL
RVAYDDFLKSSYASAEQ
>Mature_337_residues
MHQKIYIAGHRGMVGSAIVRNLLAGGLSSDNLLFRTHVELDLTCQAAVRSFFEKEMPDQVYLAAAKVGGIHANNTYPAEF
IYQNLMIEANIIHEAWRAGVKKLLFLGSSCIYPKMVPQPMSESALLTGPLEPTNEPYAIAKIAGIKLCESYNRQYGESHG
TDYRSVMPTNLYGPGDNYHPENSHVIPALIRRFHEAKLSMECTAYFPLSNPYSVLIWGTGTPRREFLNVDDMAAASVHVM
NLDKAVYEANTQPMLSHINVGCGEDITIKELAETIAKVVGYTGNIDFDPSKPDGTPRKLMDSTRLNKLGWRPKIDLVSGL
RVAYDDFLKSSYASAEQ

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=303, Percent_Identity=32.013201320132, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI7657641, Length=295, Percent_Identity=24.406779661017, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788365, Length=329, Percent_Identity=66.8693009118541, Blast_Score=429, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17554428, Length=307, Percent_Identity=28.9902280130293, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19922778, Length=303, Percent_Identity=32.6732673267327, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 37377; Mature: 37377

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00617 RECF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQKIYIAGHRGMVGSAIVRNLLAGGLSSDNLLFRTHVELDLTCQAAVRSFFEKEMPDQV
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEEEHHHHHHHHHHHCCCCCE
YLAAAKVGGIHANNTYPAEFIYQNLMIEANIIHEAWRAGVKKLLFLGSSCIYPKMVPQPM
EEEHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SESALLTGPLEPTNEPYAIAKIAGIKLCESYNRQYGESHGTDYRSVMPTNLYGPGDNYHP
CCCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCC
ENSHVIPALIRRFHEAKLSMECTAYFPLSNPYSVLIWGTGTPRREFLNVDDMAAASVHVM
CCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECCCCCHHHHCCCCHHHHHEEEEE
NLDKAVYEANTQPMLSHINVGCGEDITIKELAETIAKVVGYTGNIDFDPSKPDGTPRKLM
EHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
DSTRLNKLGWRPKIDLVSGLRVAYDDFLKSSYASAEQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHQKIYIAGHRGMVGSAIVRNLLAGGLSSDNLLFRTHVELDLTCQAAVRSFFEKEMPDQV
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEEEHHHHHHHHHHHCCCCCE
YLAAAKVGGIHANNTYPAEFIYQNLMIEANIIHEAWRAGVKKLLFLGSSCIYPKMVPQPM
EEEHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SESALLTGPLEPTNEPYAIAKIAGIKLCESYNRQYGESHGTDYRSVMPTNLYGPGDNYHP
CCCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCC
ENSHVIPALIRRFHEAKLSMECTAYFPLSNPYSVLIWGTGTPRREFLNVDDMAAASVHVM
CCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECCCCCHHHHCCCCHHHHHEEEEE
NLDKAVYEANTQPMLSHINVGCGEDITIKELAETIAKVVGYTGNIDFDPSKPDGTPRKLM
EHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
DSTRLNKLGWRPKIDLVSGLRVAYDDFLKSSYASAEQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]