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The map label for this gene is etfA [H]

Identifier: 119358288

GI number: 119358288

Start: 2884789

End: 2885703

Strand: Direct

Name: etfA [H]

Synonym: Cpha266_2520

Alternate gene names: 119358288

Gene position: 2884789-2885703 (Clockwise)

Preceding gene: 119358287

Following gene: 119358291

Centisome position: 92.05

GC content: 51.04

Gene sequence:

>915_bases
ATGAAAACATTACTTATCGCCGAAAGCAGAGAAGGCCGGCTTCTCGATACAACTTATGAGCTCTTCGGAGCGGCAGCAAA
ACTGAAAGCCGAAACCGTCCTCTTTCTTGCAGGAACCGAAACCGGACTCCCCTCGTATGCAGGAACGCTCTATCTTGCTG
ATGCAAAAATATATGGCGAATACAACCCTGACCTGCACAAAAACATGATTCTCCAGGTCATCGAAAAAGAAAATCCTGAC
TATGTGGTTTTTCTCCACTCCTCCTACGGCCGGGATCTGGCTCCGCGCATTGCCGCAAGCCTCAGAATTGCCCAGGTATC
CGAAGTCATCGACATTGTTGACGGAACCTTTGAGCTAACCTGCTGCAATGCCAGAATGCATCGAAGCGTTCAAACAACCA
CATCAAAAACAGTACTGACTATCCAGCCGGGAGCCTTTTCGCCAATCCGGCCAGGCGGCGCGCATCTCATACAAGCGATG
CAAACCGATGCCGTTACCTCCATCGAATTCGCTGGATATGAACCAGCCGAACCAGAAGGGATCGATCTGGGAAAGAGCGA
GATCATTATCAGCGCAGGAAGAGGTATCGGCACCAAAGAAAACACGGAGGTCATATGGAATCTCGCCAAAACAGTGGGAG
GAGAGGTGGGAGCAAGCCGCCCTGTTGTTGACGCAGGCTGGATAGAGCACAGCCGTCAGATAGGGAGTACCGGTCAAACC
ATATCGCCAAAACTCTATATAGCCTGCGGCATATCGGGAGCCATACAGCATCTTGCCGGCATAAAAAACTCCGGCTACAT
TGTCGCAATCAACAAAGACAGGGAGGCGCCCATCGGTGAAGTATCTGATGTGCTTGTTGTTGCTGACGTCATGCAGTTTC
TGCCCGCCCTGACCGAAAAACTTGCCGGAAGATAA

Upstream 100 bases:

>100_bases
AACCGGCCTGATTCTCGAAGGCGAAACAGCGAGTCTGGTAAATCAGGTAATCGACCTGTTGAGAAAAAACACGACACTTG
TTCGATAATAAAACACCGCC

Downstream 100 bases:

>100_bases
CGGTGAGCTATCAGTAAAAACCATCCGACAAAACGACCTACTCCCGACACCTACGACTTCCGTGCTGCCGGGGGAGCAAA
CCACTGCTCCCTCGGAACCA

Product: electron transfer flavoprotein, alpha subunit

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKTLLIAESREGRLLDTTYELFGAAAKLKAETVLFLAGTETGLPSYAGTLYLADAKIYGEYNPDLHKNMILQVIEKENPD
YVVFLHSSYGRDLAPRIAASLRIAQVSEVIDIVDGTFELTCCNARMHRSVQTTTSKTVLTIQPGAFSPIRPGGAHLIQAM
QTDAVTSIEFAGYEPAEPEGIDLGKSEIIISAGRGIGTKENTEVIWNLAKTVGGEVGASRPVVDAGWIEHSRQIGSTGQT
ISPKLYIACGISGAIQHLAGIKNSGYIVAINKDREAPIGEVSDVLVVADVMQFLPALTEKLAGR

Sequences:

>Translated_304_residues
MKTLLIAESREGRLLDTTYELFGAAAKLKAETVLFLAGTETGLPSYAGTLYLADAKIYGEYNPDLHKNMILQVIEKENPD
YVVFLHSSYGRDLAPRIAASLRIAQVSEVIDIVDGTFELTCCNARMHRSVQTTTSKTVLTIQPGAFSPIRPGGAHLIQAM
QTDAVTSIEFAGYEPAEPEGIDLGKSEIIISAGRGIGTKENTEVIWNLAKTVGGEVGASRPVVDAGWIEHSRQIGSTGQT
ISPKLYIACGISGAIQHLAGIKNSGYIVAINKDREAPIGEVSDVLVVADVMQFLPALTEKLAGR
>Mature_304_residues
MKTLLIAESREGRLLDTTYELFGAAAKLKAETVLFLAGTETGLPSYAGTLYLADAKIYGEYNPDLHKNMILQVIEKENPD
YVVFLHSSYGRDLAPRIAASLRIAQVSEVIDIVDGTFELTCCNARMHRSVQTTTSKTVLTIQPGAFSPIRPGGAHLIQAM
QTDAVTSIEFAGYEPAEPEGIDLGKSEIIISAGRGIGTKENTEVIWNLAKTVGGEVGASRPVVDAGWIEHSRQIGSTGQT
ISPKLYIACGISGAIQHLAGIKNSGYIVAINKDREAPIGEVSDVLVVADVMQFLPALTEKLAGR

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=312, Percent_Identity=34.2948717948718, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI189181759, Length=258, Percent_Identity=34.8837209302326, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786226, Length=175, Percent_Identity=40.5714285714286, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787990, Length=297, Percent_Identity=27.6094276094276, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082157, Length=242, Percent_Identity=27.6859504132231, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=310, Percent_Identity=34.8387096774194, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325261, Length=248, Percent_Identity=33.8709677419355, Blast_Score=126, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17136898, Length=310, Percent_Identity=34.5161290322581, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24652801, Length=310, Percent_Identity=34.5161290322581, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 32573; Mature: 32573

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLIAESREGRLLDTTYELFGAAAKLKAETVLFLAGTETGLPSYAGTLYLADAKIYGE
CCEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCEEEEEEEEEECC
YNPDLHKNMILQVIEKENPDYVVFLHSSYGRDLAPRIAASLRIAQVSEVIDIVDGTFELT
CCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
CCNARMHRSVQTTTSKTVLTIQPGAFSPIRPGGAHLIQAMQTDAVTSIEFAGYEPAEPEG
EECHHHHCCEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCC
IDLGKSEIIISAGRGIGTKENTEVIWNLAKTVGGEVGASRPVVDAGWIEHSRQIGSTGQT
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHCCCCCCC
ISPKLYIACGISGAIQHLAGIKNSGYIVAINKDREAPIGEVSDVLVVADVMQFLPALTEK
CCCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAGR
HCCC
>Mature Secondary Structure
MKTLLIAESREGRLLDTTYELFGAAAKLKAETVLFLAGTETGLPSYAGTLYLADAKIYGE
CCEEEEEECCCCCEEHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCEEEEEEEEEECC
YNPDLHKNMILQVIEKENPDYVVFLHSSYGRDLAPRIAASLRIAQVSEVIDIVDGTFELT
CCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
CCNARMHRSVQTTTSKTVLTIQPGAFSPIRPGGAHLIQAMQTDAVTSIEFAGYEPAEPEG
EECHHHHCCEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCC
IDLGKSEIIISAGRGIGTKENTEVIWNLAKTVGGEVGASRPVVDAGWIEHSRQIGSTGQT
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHCCCCCCC
ISPKLYIACGISGAIQHLAGIKNSGYIVAINKDREAPIGEVSDVLVVADVMQFLPALTEK
CCCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAGR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]