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The map label for this gene is fabH

Identifier: 119358258

GI number: 119358258

Start: 2857361

End: 2858350

Strand: Direct

Name: fabH

Synonym: Cpha266_2490

Alternate gene names: 119358258

Gene position: 2857361-2858350 (Clockwise)

Preceding gene: 119358257

Following gene: 119358259

Centisome position: 91.18

GC content: 49.8

Gene sequence:

>990_bases
ATGAAAGCTGCAATTACGGCAACCGCCAAATATCTACCGCAAAGCGTTTTAAGCAATCACGATCTCGAGCAGATGCTTGA
AACGAATGACGAATGGATCCGTTCAAGAACAGGAATCGGCGAACGCCGGATCATGAACGATCCGTCAAAAGCAACGGCAT
ACATGTGCGGAGAAGTTGCGCTCCAGCTTCTCGAAGCAAGAAAAATGAAGCCCGAAGAGATTGAGGTGATTATTGTCGCA
ACAATGACGCCAGACATGCTCTTTCCCGCCACGGCATGCTTTGTACAAGGGATCATCGGAGCCACAAATGCATGGGCTTT
TGACATTAATGCTGCATGTTCCGGATTTCTCTTCGCCCTGAGCACAGCATCACGCCTTATTGAGTCGGGGGCCCATAAAA
AGGTTATGGTAATCGGCGGAGACAAAATGTCATCGGTTATCGATTATACCAATCGCTCAACTGCCATTCTTTTTGGCGAC
GGCGCGGCAGGAGTTATCCTTGAGCCTTCGACGAACGACAACTACGGTATTCTCGATGCCAGGCTTTACTCCGATGGAGC
CAGCGGCACCAGCCATCTGCTTATGGCTGCCGGAGGAAGTCTCAACCCTGCAACCCATGAGACCGTTGACAAGCGCATGC
ACTTCCTTCATCAGGATGGAAAGCAGGTATTCAAGTCAGCGGTAACGTCAATGGCGGATGTTGCCGCCGAAATCATGACA
AGAAACAACCTCTCCGCCGAAGATATTTCTTTTCTGGTTCCGCATCAGGCAAATCAGAGAATCATCAATGCCACCGCAGA
AAGAATGGGGCTTGATCAGGAAAAGGTCTATTCCAATGTTGCCCGGTACGGAAACACAACCGCGGGCACCATTCCTATCT
GCCTTGCTGAACTGAACGAACAGGAGCAACTGAAAACCGGCTCCAATCTGGTACTTGTCAGTTTCGGAGCAGGCTATACC
TGGGGCGGCATCTATATAAAATGGCAATAA

Upstream 100 bases:

>100_bases
GAGTGAATAACGTCAAACCTCTTCATAAGGAAAAGTACAGAGAACCGATCCCTGCCATAGCGCAATCAATTATCCAGCAT
GAAATATTAGCAACCCACGC

Downstream 100 bases:

>100_bases
TAACAGGTCACTGTATTTGTTAAAACACTGCATTCATGAAAGCATTTCTATTTCCAGGACAGGGATCTCAATATTGCGGC
ATGGGCAAGGATATTTTCGA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKAAITATAKYLPQSVLSNHDLEQMLETNDEWIRSRTGIGERRIMNDPSKATAYMCGEVALQLLEARKMKPEEIEVIIVA
TMTPDMLFPATACFVQGIIGATNAWAFDINAACSGFLFALSTASRLIESGAHKKVMVIGGDKMSSVIDYTNRSTAILFGD
GAAGVILEPSTNDNYGILDARLYSDGASGTSHLLMAAGGSLNPATHETVDKRMHFLHQDGKQVFKSAVTSMADVAAEIMT
RNNLSAEDISFLVPHQANQRIINATAERMGLDQEKVYSNVARYGNTTAGTIPICLAELNEQEQLKTGSNLVLVSFGAGYT
WGGIYIKWQ

Sequences:

>Translated_329_residues
MKAAITATAKYLPQSVLSNHDLEQMLETNDEWIRSRTGIGERRIMNDPSKATAYMCGEVALQLLEARKMKPEEIEVIIVA
TMTPDMLFPATACFVQGIIGATNAWAFDINAACSGFLFALSTASRLIESGAHKKVMVIGGDKMSSVIDYTNRSTAILFGD
GAAGVILEPSTNDNYGILDARLYSDGASGTSHLLMAAGGSLNPATHETVDKRMHFLHQDGKQVFKSAVTSMADVAAEIMT
RNNLSAEDISFLVPHQANQRIINATAERMGLDQEKVYSNVARYGNTTAGTIPICLAELNEQEQLKTGSNLVLVSFGAGYT
WGGIYIKWQ
>Mature_329_residues
MKAAITATAKYLPQSVLSNHDLEQMLETNDEWIRSRTGIGERRIMNDPSKATAYMCGEVALQLLEARKMKPEEIEVIIVA
TMTPDMLFPATACFVQGIIGATNAWAFDINAACSGFLFALSTASRLIESGAHKKVMVIGGDKMSSVIDYTNRSTAILFGD
GAAGVILEPSTNDNYGILDARLYSDGASGTSHLLMAAGGSLNPATHETVDKRMHFLHQDGKQVFKSAVTSMADVAAEIMT
RNNLSAEDISFLVPHQANQRIINATAERMGLDQEKVYSNVARYGNTTAGTIPICLAELNEQEQLKTGSNLVLVSFGAGYT
WGGIYIKWQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=328, Percent_Identity=38.4146341463415, Blast_Score=236, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CHLPD (A1BJA1)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912902.1
- ProteinModelPortal:   A1BJA1
- SMR:   A1BJA1
- STRING:   A1BJA1
- GeneID:   4568543
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2490
- NMPDR:   fig|290317.7.peg.2606
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   NATAERM
- ProtClustDB:   PRK09352
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 35624; Mature: 35624

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 255-255 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAITATAKYLPQSVLSNHDLEQMLETNDEWIRSRTGIGERRIMNDPSKATAYMCGEVA
CCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHH
LQLLEARKMKPEEIEVIIVATMTPDMLFPATACFVQGIIGATNAWAFDINAACSGFLFAL
HHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
STASRLIESGAHKKVMVIGGDKMSSVIDYTNRSTAILFGDGAAGVILEPSTNDNYGILDA
HHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCEEEEE
RLYSDGASGTSHLLMAAGGSLNPATHETVDKRMHFLHQDGKQVFKSAVTSMADVAAEIMT
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNNLSAEDISFLVPHQANQRIINATAERMGLDQEKVYSNVARYGNTTAGTIPICLAELNE
CCCCCHHHEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCC
QEQLKTGSNLVLVSFGAGYTWGGIYIKWQ
HHHHCCCCCEEEEEECCCCEECEEEEEEC
>Mature Secondary Structure
MKAAITATAKYLPQSVLSNHDLEQMLETNDEWIRSRTGIGERRIMNDPSKATAYMCGEVA
CCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHH
LQLLEARKMKPEEIEVIIVATMTPDMLFPATACFVQGIIGATNAWAFDINAACSGFLFAL
HHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHH
STASRLIESGAHKKVMVIGGDKMSSVIDYTNRSTAILFGDGAAGVILEPSTNDNYGILDA
HHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCEEEEE
RLYSDGASGTSHLLMAAGGSLNPATHETVDKRMHFLHQDGKQVFKSAVTSMADVAAEIMT
EEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNNLSAEDISFLVPHQANQRIINATAERMGLDQEKVYSNVARYGNTTAGTIPICLAELNE
CCCCCHHHEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCC
QEQLKTGSNLVLVSFGAGYTWGGIYIKWQ
HHHHCCCCCEEEEEECCCCEECEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA