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The map label for this gene is proI [H]

Identifier: 119358234

GI number: 119358234

Start: 2838596

End: 2839396

Strand: Direct

Name: proI [H]

Synonym: Cpha266_2466

Alternate gene names: 119358234

Gene position: 2838596-2839396 (Clockwise)

Preceding gene: 119358233

Following gene: 119358235

Centisome position: 90.58

GC content: 53.31

Gene sequence:

>801_bases
ATGAACCAGCTCAGCATCAGCTTTATCGGTACGGGAAGAATTGCCCGTGCGATTATTGCCGGTCTTTCAAACAGAAAAAA
CACGATCATTTCAGGTTTTGACAAGGAGCCGGCGGCCCTGGCCTCCATTGCAGGAACCTATCCGGTCCAACCATGCGCCT
CCATCGAGGAGGCTGCCAGGGAGTCAAGAGTCATTATCCTTGCTGTCAAGCCATACCAGATTGCCGAGGTACTGCAAATA
CTCAAACCAATAGTGACTCAAGATCATCTTCTTATCAGCGTTGCCGCCGGAATCTCATCCGGGTTCATCCGGCAAAACAC
CAGTGAAACCATGCGCGTGATCCGTGTGATGCCCAATACCCCTGCTTTTTCGGGACAGGGAATGACTGCCATCAGTCGCG
GCGCTCATGCAACTGACGAAGATCTCGCTACTGCCGTCGAACTGTTCCAGGCTATCGGTAAAACAGCCATTCTTGACGAA
TCGAAAATGGACGCAGCAACTGCGGTTTCGGGCAGCGGCCCCGCCTATATGTTCCAGGTGCTCGACTCCCTTGCTGAAGG
AGGCGTTCGTTGCGGTCTCACGAGCGAAGAGGCGCTCTTCCTGGCTGCGCAGACCATGCTCGGAGCCGCAACAATGGTAC
TCGGCGGAGAAAAAAGCCCAAAAACACTCATCAGTGAAGTAACAACACCAGGAGGAACAACGGAAGCAGGGCTGAACGTC
ATGAGGGAAAAAAATATCCACCAGACGTTGATCGATACTGTTGCCGCCGCCGCTGCCCGTTCAAGGGAACTCATGCAATA
A

Upstream 100 bases:

>100_bases
GCTACCGATAAAACAGATCCCCTGCTACATACTTGAAAACTCACAAAAAAAGCGTACCTATCTGAAACAGGCGACAGCAA
CAGCAAACCAAACACATGCA

Downstream 100 bases:

>100_bases
ACCCTGTCCCATGAAGAGAACCATTCATCGGGTGAGCTGCCGGATCTTGCTGTGCATCCTGACCATGCTCTCTATCTTCT
TTTTTTCCGGGCATGCCTAC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 2; P5CR 2 [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MNQLSISFIGTGRIARAIIAGLSNRKNTIISGFDKEPAALASIAGTYPVQPCASIEEAARESRVIILAVKPYQIAEVLQI
LKPIVTQDHLLISVAAGISSGFIRQNTSETMRVIRVMPNTPAFSGQGMTAISRGAHATDEDLATAVELFQAIGKTAILDE
SKMDAATAVSGSGPAYMFQVLDSLAEGGVRCGLTSEEALFLAAQTMLGAATMVLGGEKSPKTLISEVTTPGGTTEAGLNV
MREKNIHQTLIDTVAAAAARSRELMQ

Sequences:

>Translated_266_residues
MNQLSISFIGTGRIARAIIAGLSNRKNTIISGFDKEPAALASIAGTYPVQPCASIEEAARESRVIILAVKPYQIAEVLQI
LKPIVTQDHLLISVAAGISSGFIRQNTSETMRVIRVMPNTPAFSGQGMTAISRGAHATDEDLATAVELFQAIGKTAILDE
SKMDAATAVSGSGPAYMFQVLDSLAEGGVRCGLTSEEALFLAAQTMLGAATMVLGGEKSPKTLISEVTTPGGTTEAGLNV
MREKNIHQTLIDTVAAAAARSRELMQ
>Mature_266_residues
MNQLSISFIGTGRIARAIIAGLSNRKNTIISGFDKEPAALASIAGTYPVQPCASIEEAARESRVIILAVKPYQIAEVLQI
LKPIVTQDHLLISVAAGISSGFIRQNTSETMRVIRVMPNTPAFSGQGMTAISRGAHATDEDLATAVELFQAIGKTAILDE
SKMDAATAVSGSGPAYMFQVLDSLAEGGVRCGLTSEEALFLAAQTMLGAATMVLGGEKSPKTLISEVTTPGGTTEAGLNV
MREKNIHQTLIDTVAAAAARSRELMQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=35.6877323420074, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=35.6877323420074, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=34.7014925373134, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=34.0823970037453, Blast_Score=138, Evalue=4e-33,
Organism=Escherichia coli, GI1786585, Length=262, Percent_Identity=30.9160305343511, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=35.361216730038, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=30, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=238, Percent_Identity=37.3949579831933, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=35.7142857142857, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=34.1818181818182, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=39.2857142857143, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27875; Mature: 27875

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLSISFIGTGRIARAIIAGLSNRKNTIISGFDKEPAALASIAGTYPVQPCASIEEAAR
CCCEEEEEEECHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHH
ESRVIILAVKPYQIAEVLQILKPIVTQDHLLISVAAGISSGFIRQNTSETMRVIRVMPNT
CCCEEEEEECCHHHHHHHHHHHHHHCCCHHEEEEHHHHHCCHHHCCHHHHHHHHHCCCCC
PAFSGQGMTAISRGAHATDEDLATAVELFQAIGKTAILDESKMDAATAVSGSGPAYMFQV
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCHHCCCCHHCCHHHCCCCCCHHHHHHH
LDSLAEGGVRCGLTSEEALFLAAQTMLGAATMVLGGEKSPKTLISEVTTPGGTTEAGLNV
HHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCCCCCCHHHHHHH
MREKNIHQTLIDTVAAAAARSRELMQ
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQLSISFIGTGRIARAIIAGLSNRKNTIISGFDKEPAALASIAGTYPVQPCASIEEAAR
CCCEEEEEEECHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHH
ESRVIILAVKPYQIAEVLQILKPIVTQDHLLISVAAGISSGFIRQNTSETMRVIRVMPNT
CCCEEEEEECCHHHHHHHHHHHHHHCCCHHEEEEHHHHHCCHHHCCHHHHHHHHHCCCCC
PAFSGQGMTAISRGAHATDEDLATAVELFQAIGKTAILDESKMDAATAVSGSGPAYMFQV
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCHHCCCCHHCCHHHCCCCCCHHHHHHH
LDSLAEGGVRCGLTSEEALFLAAQTMLGAATMVLGGEKSPKTLISEVTTPGGTTEAGLNV
HHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHCCCCCCHHHHHHH
MREKNIHQTLIDTVAAAAARSRELMQ
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 11418582 [H]