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The map label for this gene is hisG

Identifier: 119358125

GI number: 119358125

Start: 2742398

End: 2743282

Strand: Reverse

Name: hisG

Synonym: Cpha266_2357

Alternate gene names: 119358125

Gene position: 2743282-2742398 (Counterclockwise)

Preceding gene: 119358126

Following gene: 119358124

Centisome position: 87.54

GC content: 48.36

Gene sequence:

>885_bases
ATGGATAATTTGCAGAACGTGCTTAAAATAGGTTTGCCAAAGGGTAGTCTTCAGGACTCAACCCTTGAGTTGTTTGCTAA
TGCGGGATTTCATTTTTCGGTTCAGAGCCGATCCTACTTCCCCTCTATCGAAGATGATGAGCTTGAAGCCATTCTGATTC
GTGCGCAGGAAATGGCTCACTATGTGGAACTTGGCGCTTTTGACGTCGGGTTGACCGGTAAGGACTGGATTATTGAAACC
GATGCCGATGTCGTTGAGGTTGCCGACCTTGTTTATTCAAAGGCCTCCATGAGGCCGGTACGCTGGGTGCTTGCCGTCCC
CGAGAGTTCCGCGATAAAGTCGGTAAAAGATCTTGAAGGTAAGCATATTGCGACAGAAGTGGTCAATATCACCAAAAAGT
ATCTTGCCCGTAACGGAGTCAATGCATCAGTCGAGTTCAGTTGGGGCGCAACAGAGGTCAAGCCTCCCGATCTGGCCGAC
GCTATTGTCGAGGTAACGGAAACAGGTTCGTCGCTCCGGGCAAACAAACTTCGGATCGTTGATACCATCCTTGAATCAAA
TACCAAACTGATAGCCAACAAGGCCTCATGGAACGATTCGTGGAAGCGCGAAAAGATCGAGAATATGGCCATGCTTTTAC
AGGGCGCCATTAACGCCCAGGGGAAAGTCGGCTTGAAAATGAATGCTCCAAAAGCAGCCCTGCAAAACATAGCCGCTATT
ATTCCGGCACTTCGTCAGCCAACTATTTCAAATCTGGCCGATGAAAACTGGGTGGCTCTTGAGGTTATCGTGTCCGAAAA
AACAGTCCGCAAGTTGATTCCTGAACTGAAACGGGCAGGAGCTGAAGGTATTTTCGAGTACAATATCAACAAGCTCATCG
ACTGA

Upstream 100 bases:

>100_bases
GGGAGCTGGATAGACGGAATAAACTCCTACGGAGTTTTTCGCGACGGCGCCTTGTCATTACAAGAGTTGTAACTGTTAAT
TCAATACATTGATTCTCCTT

Downstream 100 bases:

>100_bases
GATCTCCTTTGATGGAATTACTGAACGCAAAGGCTGCCTGATCAACGGCAGCCTTTTTACCTTTGCCATGCTGATATTGA
TCTACCAGATAGTTGTTCTG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MDNLQNVLKIGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIEDDELEAILIRAQEMAHYVELGAFDVGLTGKDWIIET
DADVVEVADLVYSKASMRPVRWVLAVPESSAIKSVKDLEGKHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPDLAD
AIVEVTETGSSLRANKLRIVDTILESNTKLIANKASWNDSWKREKIENMAMLLQGAINAQGKVGLKMNAPKAALQNIAAI
IPALRQPTISNLADENWVALEVIVSEKTVRKLIPELKRAGAEGIFEYNINKLID

Sequences:

>Translated_294_residues
MDNLQNVLKIGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIEDDELEAILIRAQEMAHYVELGAFDVGLTGKDWIIET
DADVVEVADLVYSKASMRPVRWVLAVPESSAIKSVKDLEGKHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPDLAD
AIVEVTETGSSLRANKLRIVDTILESNTKLIANKASWNDSWKREKIENMAMLLQGAINAQGKVGLKMNAPKAALQNIAAI
IPALRQPTISNLADENWVALEVIVSEKTVRKLIPELKRAGAEGIFEYNINKLID
>Mature_294_residues
MDNLQNVLKIGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIEDDELEAILIRAQEMAHYVELGAFDVGLTGKDWIIET
DADVVEVADLVYSKASMRPVRWVLAVPESSAIKSVKDLEGKHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPDLAD
AIVEVTETGSSLRANKLRIVDTILESNTKLIANKASWNDSWKREKIENMAMLLQGAINAQGKVGLKMNAPKAALQNIAAI
IPALRQPTISNLADENWVALEVIVSEKTVRKLIPELKRAGAEGIFEYNINKLID

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320896, Length=298, Percent_Identity=27.5167785234899, Blast_Score=109, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CHLPD (A1BIW8)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912769.1
- ProteinModelPortal:   A1BIW8
- SMR:   A1BIW8
- STRING:   A1BIW8
- GeneID:   4569615
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2357
- NMPDR:   fig|290317.7.peg.2473
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32340; Mature: 32340

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNLQNVLKIGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIEDDELEAILIRAQEMAH
CCCHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
YVELGAFDVGLTGKDWIIETDADVVEVADLVYSKASMRPVRWVLAVPESSAIKSVKDLEG
HHHHCCEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCC
KHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPDLADAIVEVTETGSSLRANKLRIV
CHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCHHHHH
DTILESNTKLIANKASWNDSWKREKIENMAMLLQGAINAQGKVGLKMNAPKAALQNIAAI
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IPALRQPTISNLADENWVALEVIVSEKTVRKLIPELKRAGAEGIFEYNINKLID
HHHHCCCHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCCEEEECHHHHCC
>Mature Secondary Structure
MDNLQNVLKIGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIEDDELEAILIRAQEMAH
CCCHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
YVELGAFDVGLTGKDWIIETDADVVEVADLVYSKASMRPVRWVLAVPESSAIKSVKDLEG
HHHHCCEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCC
KHIATEVVNITKKYLARNGVNASVEFSWGATEVKPPDLADAIVEVTETGSSLRANKLRIV
CHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCHHHHH
DTILESNTKLIANKASWNDSWKREKIENMAMLLQGAINAQGKVGLKMNAPKAALQNIAAI
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHH
IPALRQPTISNLADENWVALEVIVSEKTVRKLIPELKRAGAEGIFEYNINKLID
HHHHCCCHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCCEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA