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The map label for this gene is lpxH [H]

Identifier: 119358126

GI number: 119358126

Start: 2743311

End: 2744063

Strand: Reverse

Name: lpxH [H]

Synonym: Cpha266_2358

Alternate gene names: 119358126

Gene position: 2744063-2743311 (Counterclockwise)

Preceding gene: 119358127

Following gene: 119358125

Centisome position: 87.56

GC content: 45.82

Gene sequence:

>753_bases
ATGCAGATGCCTTTATGTGACATGGGAGCGACATTTTTTATCAGCGATACCCATTTCGGTTTGCAGTCTCAAGAGGATGA
AGATCTCAAGCTTGAAAAACTCGAAACTCTTTTTGCCATCATAAAAGCGGAAGGCGGTTCGCTTTATATGCTCGGCGATA
TTCTTGATTACTGGATGGAGTTTCATCATGTCATACCCAAAGGATTCACCCGTTTTATTTGCCTGCTATCAGATCTTGTT
CGCAGCCATGCAGACGTTTACTACCTCGCCGGAAACCATGACTTTTTTCTTGGCCGTTTTTTCGACGAGGAGCTTGGCGT
CAAAACCCTCTATGGCGTGAACAGTTTTACCCGTGACGGCAAGCAGTTTATCGTTGCTCACGGCGACGGTCTTGGAGAGG
GGGATATCGGCTATAAATTGTTTGCCCGTTTCGTCAGAAACCGATACTTTCTCGGTTTATTTACCGGGTTTCATGCCGAT
CTCGGCGTTGCGCTCATGAGAAAATCTTCCAGATTCAGCCGACATCACAAGCAGGTCAATTATACGATGGAGAAAGATCG
TTTGTTAAACTTTGCCCAATCGCTCGTCACGAAACAGGAATTTGATTACTTTGTGTGCGGTCATAACCATGTTCGGGGAG
AGTATCTGCTGAGCAATGGTTCCAGTCGCTATATTAATCTCGGGAGCTGGATAGACGGAATAAACTCCTACGGAGTTTTT
CGCGACGGCGCCTTGTCATTACAAGAGTTGTAA

Upstream 100 bases:

>100_bases
GCCCTTATTGCCACGGTAGTCGAAGGGATCAGTCCGAAAGAGGTTGACAATATCAGCATTCCGATTGCCGTTATAGGTGC
TGCGCAATTATTGTGAACTG

Downstream 100 bases:

>100_bases
CTGTTAATTCAATACATTGATTCTCCTTATGGATAATTTGCAGAACGTGCTTAAAATAGGTTTGCCAAAGGGTAGTCTTC
AGGACTCAACCCTTGAGTTG

Product: metallophosphoesterase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MQMPLCDMGATFFISDTHFGLQSQEDEDLKLEKLETLFAIIKAEGGSLYMLGDILDYWMEFHHVIPKGFTRFICLLSDLV
RSHADVYYLAGNHDFFLGRFFDEELGVKTLYGVNSFTRDGKQFIVAHGDGLGEGDIGYKLFARFVRNRYFLGLFTGFHAD
LGVALMRKSSRFSRHHKQVNYTMEKDRLLNFAQSLVTKQEFDYFVCGHNHVRGEYLLSNGSSRYINLGSWIDGINSYGVF
RDGALSLQEL

Sequences:

>Translated_250_residues
MQMPLCDMGATFFISDTHFGLQSQEDEDLKLEKLETLFAIIKAEGGSLYMLGDILDYWMEFHHVIPKGFTRFICLLSDLV
RSHADVYYLAGNHDFFLGRFFDEELGVKTLYGVNSFTRDGKQFIVAHGDGLGEGDIGYKLFARFVRNRYFLGLFTGFHAD
LGVALMRKSSRFSRHHKQVNYTMEKDRLLNFAQSLVTKQEFDYFVCGHNHVRGEYLLSNGSSRYINLGSWIDGINSYGVF
RDGALSLQEL
>Mature_250_residues
MQMPLCDMGATFFISDTHFGLQSQEDEDLKLEKLETLFAIIKAEGGSLYMLGDILDYWMEFHHVIPKGFTRFICLLSDLV
RSHADVYYLAGNHDFFLGRFFDEELGVKTLYGVNSFTRDGKQFIVAHGDGLGEGDIGYKLFARFVRNRYFLGLFTGFHAD
LGVALMRKSSRFSRHHKQVNYTMEKDRLLNFAQSLVTKQEFDYFVCGHNHVRGEYLLSNGSSRYINLGSWIDGINSYGVF
RDGALSLQEL

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=228, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 28673; Mature: 28673

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMPLCDMGATFFISDTHFGLQSQEDEDLKLEKLETLFAIIKAEGGSLYMLGDILDYWME
CCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
FHHVIPKGFTRFICLLSDLVRSHADVYYLAGNHDFFLGRFFDEELGVKTLYGVNSFTRDG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHCCCEEEECCCCCCCCC
KQFIVAHGDGLGEGDIGYKLFARFVRNRYFLGLFTGFHADLGVALMRKSSRFSRHHKQVN
CEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
YTMEKDRLLNFAQSLVTKQEFDYFVCGHNHVRGEYLLSNGSSRYINLGSWIDGINSYGVF
CCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCEEECCHHHCCCCCCCCC
RDGALSLQEL
CCCCCHHHCC
>Mature Secondary Structure
MQMPLCDMGATFFISDTHFGLQSQEDEDLKLEKLETLFAIIKAEGGSLYMLGDILDYWME
CCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
FHHVIPKGFTRFICLLSDLVRSHADVYYLAGNHDFFLGRFFDEELGVKTLYGVNSFTRDG
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEHHHHHCCCEEEECCCCCCCCC
KQFIVAHGDGLGEGDIGYKLFARFVRNRYFLGLFTGFHADLGVALMRKSSRFSRHHKQVN
CEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
YTMEKDRLLNFAQSLVTKQEFDYFVCGHNHVRGEYLLSNGSSRYINLGSWIDGINSYGVF
CCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCEEECCHHHCCCCCCCCC
RDGALSLQEL
CCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA