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The map label for this gene is folK [H]

Identifier: 119358067

GI number: 119358067

Start: 2626775

End: 2627332

Strand: Direct

Name: folK [H]

Synonym: Cpha266_2295

Alternate gene names: 119358067

Gene position: 2626775-2627332 (Clockwise)

Preceding gene: 119358066

Following gene: 119358068

Centisome position: 83.82

GC content: 51.79

Gene sequence:

>558_bases
ATGCACCCTCAAACCGTTTTTTTAGGAATAGGCTCCAACATAGGAAATCGCCTGCTGCATCTTGAAGAAGCTGTAAGGCG
GCTTGCAGACATTCCCGATATTGATGTTATTGCTGTCTCAAGAATCTACATGACCGAGCCCGTAGGAATAACGGAGCAGG
ATCGCTTCTATAATGGAGTCGTCAAGCTTGCAACATCGATCCTGCCGGAAGATCTCCGGAAACAATGCAAAACCATAGAG
CAGGAGATCGGAAGACCCGAGAACTACCTGCGCTGGAGCCCGAGAGTGATTGATCTCGACATTCTCCTCTATGGGGACCT
CTGTTGCAACACCGAAACCCTGACCATACCCCATCCAGAACTGCACCGCCGTAAATTCGTAATGGTGCCCCTGCTCGATA
TTGACGATCCTCAACATCCGGTCTTGCGATGCCCGATTTCAGGGCTGCTCAAATCCTGTGAAGACCGCTCGGTCCTTATT
CGCACCATAAACACAATCCCCACACCGCTGCCGCGCCACCCCCATGGACTCAGAGATCCCTCTCTGCGTTCGGGATAA

Upstream 100 bases:

>100_bases
CCTCGAAGAAATAACCGTGAAAGTAAGAAAGCGCAACCCGCCAATCAATGGCATCTGTGATTATGCAGAAGCCGTTTATA
CAGAACGACGCTCCTGATCC

Downstream 100 bases:

>100_bases
CCTCCCCCCCCTCCTGTCATCTCGACCATCGGGAGAGATCTCTCTTCTCTTCCTTCCCCCAACTCAGGACTCATTGCTCA
GCACTCTGCACTCATATCCC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MHPQTVFLGIGSNIGNRLLHLEEAVRRLADIPDIDVIAVSRIYMTEPVGITEQDRFYNGVVKLATSILPEDLRKQCKTIE
QEIGRPENYLRWSPRVIDLDILLYGDLCCNTETLTIPHPELHRRKFVMVPLLDIDDPQHPVLRCPISGLLKSCEDRSVLI
RTINTIPTPLPRHPHGLRDPSLRSG

Sequences:

>Translated_185_residues
MHPQTVFLGIGSNIGNRLLHLEEAVRRLADIPDIDVIAVSRIYMTEPVGITEQDRFYNGVVKLATSILPEDLRKQCKTIE
QEIGRPENYLRWSPRVIDLDILLYGDLCCNTETLTIPHPELHRRKFVMVPLLDIDDPQHPVLRCPISGLLKSCEDRSVLI
RTINTIPTPLPRHPHGLRDPSLRSG
>Mature_185_residues
MHPQTVFLGIGSNIGNRLLHLEEAVRRLADIPDIDVIAVSRIYMTEPVGITEQDRFYNGVVKLATSILPEDLRKQCKTIE
QEIGRPENYLRWSPRVIDLDILLYGDLCCNTETLTIPHPELHRRKFVMVPLLDIDDPQHPVLRCPISGLLKSCEDRSVLI
RTINTIPTPLPRHPHGLRDPSLRSG

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=129, Percent_Identity=39.5348837209302, Blast_Score=109, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324073, Length=157, Percent_Identity=36.3057324840764, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 21050; Mature: 21050

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPQTVFLGIGSNIGNRLLHLEEAVRRLADIPDIDVIAVSRIYMTEPVGITEQDRFYNGV
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEHHEEEECCCCCCCHHHHHHHH
VKLATSILPEDLRKQCKTIEQEIGRPENYLRWSPRVIDLDILLYGDLCCNTETLTIPHPE
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHEECCCEEEEEEEEEECCEECCCCEEECCCCH
LHRRKFVMVPLLDIDDPQHPVLRCPISGLLKSCEDRSVLIRTINTIPTPLPRHPHGLRDP
HHCCEEEEEEEEECCCCCCCEEECCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
SLRSG
CCCCC
>Mature Secondary Structure
MHPQTVFLGIGSNIGNRLLHLEEAVRRLADIPDIDVIAVSRIYMTEPVGITEQDRFYNGV
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEHHEEEECCCCCCCHHHHHHHH
VKLATSILPEDLRKQCKTIEQEIGRPENYLRWSPRVIDLDILLYGDLCCNTETLTIPHPE
HHHHHHHCCHHHHHHHHHHHHHCCCCCHHEECCCEEEEEEEEEECCEECCCCEEECCCCH
LHRRKFVMVPLLDIDDPQHPVLRCPISGLLKSCEDRSVLIRTINTIPTPLPRHPHGLRDP
HHCCEEEEEEEEECCCCCCCEEECCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
SLRSG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]