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The map label for this gene is gltA [H]

Identifier: 119357875

GI number: 119357875

Start: 2415525

End: 2416868

Strand: Reverse

Name: gltA [H]

Synonym: Cpha266_2083

Alternate gene names: 119357875

Gene position: 2416868-2415525 (Counterclockwise)

Preceding gene: 119357876

Following gene: 119357874

Centisome position: 77.12

GC content: 49.4

Gene sequence:

>1344_bases
ATGACCGCCACTGAACAGAGTAATTCCTTGTCGATTACCGATAATCGCACAGGTAAACGTTACGAAGTACCAATTCAAAA
CGGTACCATCAGTACCATGGATCTCCGCCAGATCAGGGTTGATGAGGAGGATTTCGGTCTTTTAGGTTATGATCCCGGTT
TTCTTAATACAGCGTCATGTAAAAGCCGCATTACCTATATCGATGGCGATCAGGGTATTCTCCGGTACAGAGGCTATCCG
ATTGAACAGCTTGCCATGAGCAGCTCCTTTCTTGAAACCTCCTACCTGCTCATCAAGGGAGAGCTTCCGGATAAGGAACG
GCTTGCGGTCTGGACATACAATATCCGCCACCATACCATGACCCATGCCAATATCATCAAGTTCATGGATGGTTTTCGTT
ACGATGCCCATCCAATGGGAATTATGGTCGGGACAGTAGGCGCGCTTTCGACCTTTTACCGCGATGCAAAGGATATCAAC
AGCGAAGAGTCACGTAAACTTCAGGTACGGCGTCTTATCGGGAAGATTCCTACCCTTGCCGCCATGAGTTTTCGACACAG
TCTGGGCTTCCCCTACGTTTTGCCTGACAACGATCTCAGTTATGCCGGTAATTTTCTCTCGATGATGTTCAAGATGACCG
AGCAGCGGTATAAGCCCAATCCGGTGCTTGAACGGGCGCTTGATGTGTTGTTCATTCTCCACGCCGATCACGAGCAGAAC
TGCTCCACCAATGCTGTTCGCGCAGTCGGAAGTTCAGGCGTTGATCCCTATACGGCGATTGCGGCAGGGTGCGCAGCACT
CTACGGTCCGCTGCATGGAGGCGCAAACGAGGCGGTTATTCATATGCTCCTGAAAATCGGCTCCGTCGACAAGGTTCCCG
AGTTTATCAAATCGGTAAAGGATGGCGACGGACGTCTGATGGGGTTTGGCCATCGGGTCTATAAAAATTACGATCCGAGA
GCAAAAATAATCAAGGAAATCGCTTTTCAGGTTTTTGAGGAGACAGGAAAAAACCCTCTGCTTGAAATTGCTCTGGAACT
TGAGCGGATTGCTCTCGAAGATGACTATTTTGTCAGCAGGAAACTCTATCCGAATGTTGATTTTTACTCCGGTTTGATCT
ATCAGGCCATGGGATTTCCCATGGATATGTTCCCGGTCCTTTTTGCCATTGGCAGAATTCCCGGCTGGCTGTCACAGTGG
ATCGAGCATGTCAAGGACGGCGAACAGAAAATTGCACGACCCCGTCAGATTTACCTTGGCGAAGCCGAGCGAGACTATAT
TCCAATGGAGAAACGACCGAAAACCCGTCTTGACGAGCAGAGAGCAGGTATTTGCCGGCTGTGA

Upstream 100 bases:

>100_bases
GATTTGTATTTTCAGGTTTGATTCTGATGCGGCTTTTGCTGCTGAAGGGTATTTCTTGTTGGGGGAATTTTTTTTAACAA
CAACAAGGCAATGATACATC

Downstream 100 bases:

>100_bases
TGACGGATGTTATTTTGCATGAAGCGCAGGAATGAAAAATATTTTTAATCCCAGGTAGAAAGAGTATATGTCCGTTACCA
AAAAAGATGTTGCCTATATA

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTATEQSNSLSITDNRTGKRYEVPIQNGTISTMDLRQIRVDEEDFGLLGYDPGFLNTASCKSRITYIDGDQGILRYRGYP
IEQLAMSSSFLETSYLLIKGELPDKERLAVWTYNIRHHTMTHANIIKFMDGFRYDAHPMGIMVGTVGALSTFYRDAKDIN
SEESRKLQVRRLIGKIPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFKMTEQRYKPNPVLERALDVLFILHADHEQN
CSTNAVRAVGSSGVDPYTAIAAGCAALYGPLHGGANEAVIHMLLKIGSVDKVPEFIKSVKDGDGRLMGFGHRVYKNYDPR
AKIIKEIAFQVFEETGKNPLLEIALELERIALEDDYFVSRKLYPNVDFYSGLIYQAMGFPMDMFPVLFAIGRIPGWLSQW
IEHVKDGEQKIARPRQIYLGEAERDYIPMEKRPKTRLDEQRAGICRL

Sequences:

>Translated_447_residues
MTATEQSNSLSITDNRTGKRYEVPIQNGTISTMDLRQIRVDEEDFGLLGYDPGFLNTASCKSRITYIDGDQGILRYRGYP
IEQLAMSSSFLETSYLLIKGELPDKERLAVWTYNIRHHTMTHANIIKFMDGFRYDAHPMGIMVGTVGALSTFYRDAKDIN
SEESRKLQVRRLIGKIPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFKMTEQRYKPNPVLERALDVLFILHADHEQN
CSTNAVRAVGSSGVDPYTAIAAGCAALYGPLHGGANEAVIHMLLKIGSVDKVPEFIKSVKDGDGRLMGFGHRVYKNYDPR
AKIIKEIAFQVFEETGKNPLLEIALELERIALEDDYFVSRKLYPNVDFYSGLIYQAMGFPMDMFPVLFAIGRIPGWLSQW
IEHVKDGEQKIARPRQIYLGEAERDYIPMEKRPKTRLDEQRAGICRL
>Mature_446_residues
TATEQSNSLSITDNRTGKRYEVPIQNGTISTMDLRQIRVDEEDFGLLGYDPGFLNTASCKSRITYIDGDQGILRYRGYPI
EQLAMSSSFLETSYLLIKGELPDKERLAVWTYNIRHHTMTHANIIKFMDGFRYDAHPMGIMVGTVGALSTFYRDAKDINS
EESRKLQVRRLIGKIPTLAAMSFRHSLGFPYVLPDNDLSYAGNFLSMMFKMTEQRYKPNPVLERALDVLFILHADHEQNC
STNAVRAVGSSGVDPYTAIAAGCAALYGPLHGGANEAVIHMLLKIGSVDKVPEFIKSVKDGDGRLMGFGHRVYKNYDPRA
KIIKEIAFQVFEETGKNPLLEIALELERIALEDDYFVSRKLYPNVDFYSGLIYQAMGFPMDMFPVLFAIGRIPGWLSQWI
EHVKDGEQKIARPRQIYLGEAERDYIPMEKRPKTRLDEQRAGICRL

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=368, Percent_Identity=27.445652173913, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1786939, Length=410, Percent_Identity=51.9512195121951, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1786527, Length=378, Percent_Identity=31.7460317460317, Blast_Score=188, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17555174, Length=374, Percent_Identity=28.6096256684492, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324328, Length=363, Percent_Identity=25.3443526170799, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=340, Percent_Identity=25.8823529411765, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=403, Percent_Identity=25.3101736972705, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640124, Length=370, Percent_Identity=27.5675675675676, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24640126, Length=379, Percent_Identity=27.1767810026385, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21356863, Length=417, Percent_Identity=26.1390887290168, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 50713; Mature: 50582

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATEQSNSLSITDNRTGKRYEVPIQNGTISTMDLRQIRVDEEDFGLLGYDPGFLNTASC
CCCCCCCCCEEEEECCCCCEEEEECCCCCEEEEEHHHEECCCCCCCEEECCCCCCCCHHH
KSRITYIDGDQGILRYRGYPIEQLAMSSSFLETSYLLIKGELPDKERLAVWTYNIRHHTM
HCEEEEEECCCCEEEECCCCHHHHHHHHHHHCEEEEEEECCCCCCCCEEEEEEECCHHHH
THANIIKFMDGFRYDAHPMGIMVGTVGALSTFYRDAKDINSEESRKLQVRRLIGKIPTLA
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHH
AMSFRHSLGFPYVLPDNDLSYAGNFLSMMFKMTEQRYKPNPVLERALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCC
CSTNAVRAVGSSGVDPYTAIAAGCAALYGPLHGGANEAVIHMLLKIGSVDKVPEFIKSVK
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHC
DGDGRLMGFGHRVYKNYDPRAKIIKEIAFQVFEETGKNPLLEIALELERIALEDDYFVSR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECC
KLYPNVDFYSGLIYQAMGFPMDMFPVLFAIGRIPGWLSQWIEHVKDGEQKIARPRQIYLG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCEEEEC
EAERDYIPMEKRPKTRLDEQRAGICRL
CCCCCCCCCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
TATEQSNSLSITDNRTGKRYEVPIQNGTISTMDLRQIRVDEEDFGLLGYDPGFLNTASC
CCCCCCCCEEEEECCCCCEEEEECCCCCEEEEEHHHEECCCCCCCEEECCCCCCCCHHH
KSRITYIDGDQGILRYRGYPIEQLAMSSSFLETSYLLIKGELPDKERLAVWTYNIRHHTM
HCEEEEEECCCCEEEECCCCHHHHHHHHHHHCEEEEEEECCCCCCCCEEEEEEECCHHHH
THANIIKFMDGFRYDAHPMGIMVGTVGALSTFYRDAKDINSEESRKLQVRRLIGKIPTLA
HHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHH
AMSFRHSLGFPYVLPDNDLSYAGNFLSMMFKMTEQRYKPNPVLERALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCC
CSTNAVRAVGSSGVDPYTAIAAGCAALYGPLHGGANEAVIHMLLKIGSVDKVPEFIKSVK
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHC
DGDGRLMGFGHRVYKNYDPRAKIIKEIAFQVFEETGKNPLLEIALELERIALEDDYFVSR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECC
KLYPNVDFYSGLIYQAMGFPMDMFPVLFAIGRIPGWLSQWIEHVKDGEQKIARPRQIYLG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCEEEEC
EAERDYIPMEKRPKTRLDEQRAGICRL
CCCCCCCCCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]