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The map label for this gene is trpA

Identifier: 119357729

GI number: 119357729

Start: 2240876

End: 2241679

Strand: Reverse

Name: trpA

Synonym: Cpha266_1933

Alternate gene names: 119357729

Gene position: 2241679-2240876 (Counterclockwise)

Preceding gene: 119357730

Following gene: 119357728

Centisome position: 71.53

GC content: 51.74

Gene sequence:

>804_bases
ATGCCTGAAAACAGAATCGCCCGTCTTCTGAAGAAGAATAAAAAACTGCTGATAGCCTACTATATGCCTGAATTTCCTGT
GCCTGGAGCGACGCTTCCGGTGCTTGAAGCCCTGCAGAAGAACGGTGCTGATCTGATCGAGCTTGGCATAGCCTATTCAG
ACCCGATCGGCGACGGTCCGGTGATTCAGGATGCCGCTCATACGGCAATCCGTAACGGCATGAGCGTTAAAAAACTGCTT
GATCTGGTCAGGCAGGCCCGCAAAGGAGAGGGGTGCCGAAAGATAACCGCTCCGATACTGTTGATGGGGTACTGTAATCC
GTTGATAGCTTACGGAGGAGACTGTTTTCTGCAGGATGCGGCAAGCGCCGGTGTGGACGGTCTTCTGCTTCCTGATCTTC
CTCCTGAAGAGGCTGATGATTTTCTTGAGCGTGCAAAAGGGTTTGGCCTTACCGTGGTCTTTCTTGTTTCACCCGTTACT
CCGCCCGAAAGAATTGAATATATCGACTCTCTCTCGACGGATTTTTCATACTGTCTTGCCGTAAATGCCACAACCGGAAC
TGCCAAGCTTTCGGATGCAGGCAGTGAAGCGGCTATTGACGAATACCTCAGGAGGGTAAGGCGGCATACCCGTAAAAAAT
TTGTTGTCGGTTTCGGTATCAAGGATAAAGCAAGGGTGGGTCATATGTGGGAACTTGCCGATGGCGCTGTTGTGGGCACA
GCTCTTTTGCAGCATATCGCCGGAGCCGGAACGCCTGAAGAGACCGCCAGACTTGCCGGAGAGTTCTGGCAGACACTACA
GTAA

Upstream 100 bases:

>100_bases
TCTGGGGGAGTGTGCTGGTGCACATGATCACCATGTTGTCCATGATTATCGATATTTTTCTTATTCCACAACTCCTGTTC
TGACCACAAAGGTTTTTCCT

Downstream 100 bases:

>100_bases
TGCGCTTCAGTCATGATTGAACCCGAACGGCTCCGCCCCGCCGTTGACATTATCATTCCCCATTTTCGGGGACTGGAGAT
GCTTGAACGCTCTCTTGAGT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MPENRIARLLKKNKKLLIAYYMPEFPVPGATLPVLEALQKNGADLIELGIAYSDPIGDGPVIQDAAHTAIRNGMSVKKLL
DLVRQARKGEGCRKITAPILLMGYCNPLIAYGGDCFLQDAASAGVDGLLLPDLPPEEADDFLERAKGFGLTVVFLVSPVT
PPERIEYIDSLSTDFSYCLAVNATTGTAKLSDAGSEAAIDEYLRRVRRHTRKKFVVGFGIKDKARVGHMWELADGAVVGT
ALLQHIAGAGTPEETARLAGEFWQTLQ

Sequences:

>Translated_267_residues
MPENRIARLLKKNKKLLIAYYMPEFPVPGATLPVLEALQKNGADLIELGIAYSDPIGDGPVIQDAAHTAIRNGMSVKKLL
DLVRQARKGEGCRKITAPILLMGYCNPLIAYGGDCFLQDAASAGVDGLLLPDLPPEEADDFLERAKGFGLTVVFLVSPVT
PPERIEYIDSLSTDFSYCLAVNATTGTAKLSDAGSEAAIDEYLRRVRRHTRKKFVVGFGIKDKARVGHMWELADGAVVGT
ALLQHIAGAGTPEETARLAGEFWQTLQ
>Mature_266_residues
PENRIARLLKKNKKLLIAYYMPEFPVPGATLPVLEALQKNGADLIELGIAYSDPIGDGPVIQDAAHTAIRNGMSVKKLLD
LVRQARKGEGCRKITAPILLMGYCNPLIAYGGDCFLQDAASAGVDGLLLPDLPPEEADDFLERAKGFGLTVVFLVSPVTP
PERIEYIDSLSTDFSYCLAVNATTGTAKLSDAGSEAAIDEYLRRVRRHTRKKFVVGFGIKDKARVGHMWELADGAVVGTA
LLQHIAGAGTPEETARLAGEFWQTLQ

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=224, Percent_Identity=25.4464285714286, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321412, Length=239, Percent_Identity=38.0753138075314, Blast_Score=171, Evalue=9e-44,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_CHLPD (A1BHS2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912373.1
- ProteinModelPortal:   A1BHS2
- SMR:   A1BHS2
- STRING:   A1BHS2
- GeneID:   4570047
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1933
- NMPDR:   fig|290317.7.peg.2039
- eggNOG:   COG0159
- HOGENOM:   HBG391690
- OMA:   VILMTYY
- ProtClustDB:   PRK13111
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28894; Mature: 28762

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 47-47 ACT_SITE 58-58

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPENRIARLLKKNKKLLIAYYMPEFPVPGATLPVLEALQKNGADLIELGIAYSDPIGDGP
CCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEHCCCCCCCCCCCCC
VIQDAAHTAIRNGMSVKKLLDLVRQARKGEGCRKITAPILLMGYCNPLIAYGGDCFLQDA
CHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ASAGVDGLLLPDLPPEEADDFLERAKGFGLTVVFLVSPVTPPERIEYIDSLSTDFSYCLA
HHCCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEE
VNATTGTAKLSDAGSEAAIDEYLRRVRRHTRKKFVVGFGIKDKARVGHMWELADGAVVGT
EECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHCCHHHHHCCHHHHH
ALLQHIAGAGTPEETARLAGEFWQTLQ
HHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PENRIARLLKKNKKLLIAYYMPEFPVPGATLPVLEALQKNGADLIELGIAYSDPIGDGP
CHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEHCCCCCCCCCCCCC
VIQDAAHTAIRNGMSVKKLLDLVRQARKGEGCRKITAPILLMGYCNPLIAYGGDCFLQDA
CHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ASAGVDGLLLPDLPPEEADDFLERAKGFGLTVVFLVSPVTPPERIEYIDSLSTDFSYCLA
HHCCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEE
VNATTGTAKLSDAGSEAAIDEYLRRVRRHTRKKFVVGFGIKDKARVGHMWELADGAVVGT
EECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHCCHHHHHCCHHHHH
ALLQHIAGAGTPEETARLAGEFWQTLQ
HHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA