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The map label for this gene is hrcA

Identifier: 119357670

GI number: 119357670

Start: 2171348

End: 2172421

Strand: Reverse

Name: hrcA

Synonym: Cpha266_1874

Alternate gene names: 119357670

Gene position: 2172421-2171348 (Counterclockwise)

Preceding gene: 119357671

Following gene: 119357669

Centisome position: 69.32

GC content: 48.14

Gene sequence:

>1074_bases
ATGGAATCGCGTGATCTGAACCTGAGGGAACGACAGGTCCTGGGTATTATTATTCAGGCATATGTGGTATCGGCTGCACC
CGTTGGCTCAAGGTATATAGCCAGAAACTGCAACCTCGGTCTTTCGGATGCGACGATTCGAAACGTTATGGCTGATCTCG
AGGACGAAGGGTATATAAGCCAGCCTCATACATCTGCGGGAAGAACGCCGACCGACAAGGGATATCGGTACTATGTCGAT
CTTATTATGAAGGTGAGGCGAGTCAATGATGAGGAGAAAAAACGTATTGATGCCGATTTCGGACAACTGACTACCGAGCG
AAGAGGAAGCTCTTCAGAAGTGCTTCTTTCGGCAGCCAAGGTTCTTGGCAGTATATCACGACAGTTAAGCGTTGTGCTGT
CGCCTGCGCTTTCAAATGCTGTTTTTGAAAAGCTCGATATGGTGTTGTTGAGTTCGACGCGCATGATGGTTATTCTGTCG
ATCCAGTCTCTCATTGTCAAAACCATTGTTATGGAGCTGGATCTTGCGGTTTCGCGTCAGGAGGTCAGCGGTGTTGTTGA
TCTGCTCAATCAGAGGCTTTCCGGGCTGACTCTTTCGGAGATTCGTAAAACCATCTCGATGCGCCTGAGCGATTGTCTTG
CTGATGCGTCGCTGATTAATTTTGTTGTCCGTTCGGCTGGCCAGCTTTTTGACGAGACCCCGATCATTGAGCGGCTTTAT
ATTTCAGGTGCCGGGTATATCGTCGATCAGCCGGAATTCAAACAACCTGAAAAGGTTCGTGATTTTATTACCATGATTGA
AGATAAATTCAGTGTGGCAAAACTGGTGGAGCGCAACAGGATCTATTCTGAAACGGTCCACCCCTCCCGTATGGAGGTTT
CAATCAGTATCGGCAAGGAGAATCGGGAAAGAAAAGCCGAAGATCTTACCATTGTCTCAACGCCGTATTACGTAGGCGGG
ATGATGGGAAAGCTCGGTATTCTGGGCCCTACAAGAATGGATTACGGTCACGCTGTCAGCGTGCTCAATTATATGGCTGA
CTGTCTGTCGGCAACACTCTCTGAAGTAAACTAA

Upstream 100 bases:

>100_bases
TGGCGGTGAATGATCGGTTTGTTTTTTTTACATTACCCTGTTTTGCCGCATGCCCTGAACAGACGAGAGGGGCTTAATCG
AGGATGATTTTTTGTTATAT

Downstream 100 bases:

>100_bases
ACAGTACATATTTGCCATTATGATTATGAAAAAAGGATCTGCCGATAAAGAAACACCTTTCAATCCTGTTCCTCCTTTTT
CCGGAGCGGGTGAATCGGAA

Product: heat-inducible transcription repressor HrcA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MESRDLNLRERQVLGIIIQAYVVSAAPVGSRYIARNCNLGLSDATIRNVMADLEDEGYISQPHTSAGRTPTDKGYRYYVD
LIMKVRRVNDEEKKRIDADFGQLTTERRGSSSEVLLSAAKVLGSISRQLSVVLSPALSNAVFEKLDMVLLSSTRMMVILS
IQSLIVKTIVMELDLAVSRQEVSGVVDLLNQRLSGLTLSEIRKTISMRLSDCLADASLINFVVRSAGQLFDETPIIERLY
ISGAGYIVDQPEFKQPEKVRDFITMIEDKFSVAKLVERNRIYSETVHPSRMEVSISIGKENRERKAEDLTIVSTPYYVGG
MMGKLGILGPTRMDYGHAVSVLNYMADCLSATLSEVN

Sequences:

>Translated_357_residues
MESRDLNLRERQVLGIIIQAYVVSAAPVGSRYIARNCNLGLSDATIRNVMADLEDEGYISQPHTSAGRTPTDKGYRYYVD
LIMKVRRVNDEEKKRIDADFGQLTTERRGSSSEVLLSAAKVLGSISRQLSVVLSPALSNAVFEKLDMVLLSSTRMMVILS
IQSLIVKTIVMELDLAVSRQEVSGVVDLLNQRLSGLTLSEIRKTISMRLSDCLADASLINFVVRSAGQLFDETPIIERLY
ISGAGYIVDQPEFKQPEKVRDFITMIEDKFSVAKLVERNRIYSETVHPSRMEVSISIGKENRERKAEDLTIVSTPYYVGG
MMGKLGILGPTRMDYGHAVSVLNYMADCLSATLSEVN
>Mature_357_residues
MESRDLNLRERQVLGIIIQAYVVSAAPVGSRYIARNCNLGLSDATIRNVMADLEDEGYISQPHTSAGRTPTDKGYRYYVD
LIMKVRRVNDEEKKRIDADFGQLTTERRGSSSEVLLSAAKVLGSISRQLSVVLSPALSNAVFEKLDMVLLSSTRMMVILS
IQSLIVKTIVMELDLAVSRQEVSGVVDLLNQRLSGLTLSEIRKTISMRLSDCLADASLINFVVRSAGQLFDETPIIERLY
ISGAGYIVDQPEFKQPEKVRDFITMIEDKFSVAKLVERNRIYSETVHPSRMEVSISIGKENRERKAEDLTIVSTPYYVGG
MMGKLGILGPTRMDYGHAVSVLNYMADCLSATLSEVN

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_CHLPD (A1BHL3)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912314.1
- ProteinModelPortal:   A1BHL3
- SMR:   A1BHL3
- STRING:   A1BHL3
- GeneID:   4571216
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1874
- NMPDR:   fig|290317.7.peg.1974
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   CLSK637786
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39717; Mature: 39717

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRDLNLRERQVLGIIIQAYVVSAAPVGSRYIARNCNLGLSDATIRNVMADLEDEGYIS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCC
QPHTSAGRTPTDKGYRYYVDLIMKVRRVNDEEKKRIDADFGQLTTERRGSSSEVLLSAAK
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHH
VLGSISRQLSVVLSPALSNAVFEKLDMVLLSSTRMMVILSIQSLIVKTIVMELDLAVSRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVSGVVDLLNQRLSGLTLSEIRKTISMRLSDCLADASLINFVVRSAGQLFDETPIIERLY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ISGAGYIVDQPEFKQPEKVRDFITMIEDKFSVAKLVERNRIYSETVHPSRMEVSISIGKE
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
NRERKAEDLTIVSTPYYVGGMMGKLGILGPTRMDYGHAVSVLNYMADCLSATLSEVN
CHHHHHHCEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESRDLNLRERQVLGIIIQAYVVSAAPVGSRYIARNCNLGLSDATIRNVMADLEDEGYIS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCC
QPHTSAGRTPTDKGYRYYVDLIMKVRRVNDEEKKRIDADFGQLTTERRGSSSEVLLSAAK
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHH
VLGSISRQLSVVLSPALSNAVFEKLDMVLLSSTRMMVILSIQSLIVKTIVMELDLAVSRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVSGVVDLLNQRLSGLTLSEIRKTISMRLSDCLADASLINFVVRSAGQLFDETPIIERLY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ISGAGYIVDQPEFKQPEKVRDFITMIEDKFSVAKLVERNRIYSETVHPSRMEVSISIGKE
CCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
NRERKAEDLTIVSTPYYVGGMMGKLGILGPTRMDYGHAVSVLNYMADCLSATLSEVN
CHHHHHHCEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA