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The map label for this gene is fmt

Identifier: 119357656

GI number: 119357656

Start: 2155390

End: 2156337

Strand: Reverse

Name: fmt

Synonym: Cpha266_1860

Alternate gene names: 119357656

Gene position: 2156337-2155390 (Counterclockwise)

Preceding gene: 119357657

Following gene: 119357655

Centisome position: 68.81

GC content: 52.43

Gene sequence:

>948_bases
ATGCGTATCGTCTTTATGGGAACTCCGGAATTTGCGGTTCCCTCACTCCGAAGCATTGCTGCCGAGCATAACCATTTTGA
GCTGGTGCTGGTCGTTACCGGCAGCGACAAGCCCCGCAGAGGCCGAAACGCCCCTTCGGAGCCTTCGCCTGTAAAGAGTG
CAGCTCTTGAACTCGGGTTTCAGGTTTACGAAACCGATGATGTCTCCAGTTCCGATTTTCTCTCTGTTGTTGCTGACTCA
GCTCCTGACGTGATTGTCGTTGCGGCTTTCAGGATTCTCCCGCCTGAAGTCTACGGTCAGGCAAAACTCGGAGCTTTCAA
TCTCCATGCATCGCTTCTGCCTGCCTATCGGGGTGCGGCGCCGATCAACTGGGCGATCATCAACGGCGAAAAAGAGAGTG
GTGTCACCACGTTTTTTCTGCAAAAAACCGTTGACACCGGCAATGTTATCATGCAGGAAAAAATTCCCGTTTTGCCCGAT
GATAATGCTTCCATCCTTTCAGTAAAACTTTCACATCTTGGTGCGGAGCTTGTTGTGAAAACATTGCGAAGCATTCAGGC
CGGGACTGTTGAGGTTCAGGCGCAGGATGACGCGTTTTTTTCGCGAGCGCCTAAACTCACAAGGGAGAACACCCGTATCC
GTTGGAATCAGCCTGTGGCAGTTCTGTCGGATTTTATTCGCGGACTGGCGATGAAACCTGCCGCCTGGACAACCGTGCAG
AACAGAACCATGAAGATTTTCCGGGCGATTCCGTTTACAGAAGAGATCACCTCTTCAATAGAGCAGCCTGGCAGCATTCT
TGTGGAAAGGGGACGTTTTCTTGTGCGAGGCAGCGACGGCTGGCTTGAGGTGAAGCAGTTGCAGCCTGAAGGCCGAAAAC
CCATGGAGGGCGCTGAATTCGCAAGAGGGTTCCGCCCTGAAAGCGGCACATCCCTTTTGTTTGAGTAA

Upstream 100 bases:

>100_bases
CTGGCACTGGCAGGTATTGCTCAAAAGGCCTGTGAGGCTTGAAGTCTTTTCTGCCGCTTGATCAAGCGGCATTCAACCCT
GTTTCAACATTCTCAATCTC

Downstream 100 bases:

>100_bases
TGATTGCCCTGCCATTGGTAATATTTTTTATATTCTTCACCTTGACTGCTCCACGAACTTAAAGTGCTGTTTATGGCCTT
GCCTCCTACAGAAGTGCACC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRIVFMGTPEFAVPSLRSIAAEHNHFELVLVVTGSDKPRRGRNAPSEPSPVKSAALELGFQVYETDDVSSSDFLSVVADS
APDVIVVAAFRILPPEVYGQAKLGAFNLHASLLPAYRGAAPINWAIINGEKESGVTTFFLQKTVDTGNVIMQEKIPVLPD
DNASILSVKLSHLGAELVVKTLRSIQAGTVEVQAQDDAFFSRAPKLTRENTRIRWNQPVAVLSDFIRGLAMKPAAWTTVQ
NRTMKIFRAIPFTEEITSSIEQPGSILVERGRFLVRGSDGWLEVKQLQPEGRKPMEGAEFARGFRPESGTSLLFE

Sequences:

>Translated_315_residues
MRIVFMGTPEFAVPSLRSIAAEHNHFELVLVVTGSDKPRRGRNAPSEPSPVKSAALELGFQVYETDDVSSSDFLSVVADS
APDVIVVAAFRILPPEVYGQAKLGAFNLHASLLPAYRGAAPINWAIINGEKESGVTTFFLQKTVDTGNVIMQEKIPVLPD
DNASILSVKLSHLGAELVVKTLRSIQAGTVEVQAQDDAFFSRAPKLTRENTRIRWNQPVAVLSDFIRGLAMKPAAWTTVQ
NRTMKIFRAIPFTEEITSSIEQPGSILVERGRFLVRGSDGWLEVKQLQPEGRKPMEGAEFARGFRPESGTSLLFE
>Mature_315_residues
MRIVFMGTPEFAVPSLRSIAAEHNHFELVLVVTGSDKPRRGRNAPSEPSPVKSAALELGFQVYETDDVSSSDFLSVVADS
APDVIVVAAFRILPPEVYGQAKLGAFNLHASLLPAYRGAAPINWAIINGEKESGVTTFFLQKTVDTGNVIMQEKIPVLPD
DNASILSVKLSHLGAELVVKTLRSIQAGTVEVQAQDDAFFSRAPKLTRENTRIRWNQPVAVLSDFIRGLAMKPAAWTTVQ
NRTMKIFRAIPFTEEITSSIEQPGSILVERGRFLVRGSDGWLEVKQLQPEGRKPMEGAEFARGFRPESGTSLLFE

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=221, Percent_Identity=28.9592760180996, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI164663775, Length=319, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI238814322, Length=221, Percent_Identity=27.6018099547511, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1789683, Length=308, Percent_Identity=33.7662337662338, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788589, Length=291, Percent_Identity=32.6460481099656, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788846, Length=91, Percent_Identity=37.3626373626374, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133930964, Length=207, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550868, Length=313, Percent_Identity=30.0319488817891, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571984, Length=232, Percent_Identity=32.3275862068966, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24582400, Length=89, Percent_Identity=39.3258426966292, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_CHLPD (A1BHJ9)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912300.1
- ProteinModelPortal:   A1BHJ9
- SMR:   A1BHJ9
- STRING:   A1BHJ9
- GeneID:   4571202
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1860
- NMPDR:   fig|290317.7.peg.1957
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- ProtClustDB:   CLSK637772
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34561; Mature: 34561

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVFMGTPEFAVPSLRSIAAEHNHFELVLVVTGSDKPRRGRNAPSEPSPVKSAALELGF
CEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCE
QVYETDDVSSSDFLSVVADSAPDVIVVAAFRILPPEVYGQAKLGAFNLHASLLPAYRGAA
EEEECCCCCCCHHHHHHHCCCCCEEEEEEHHHCCHHHCCCCCCCEEEHHHHHHHHHCCCC
PINWAIINGEKESGVTTFFLQKTVDTGNVIMQEKIPVLPDDNASILSVKLSHLGAELVVK
CEEEEEECCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEEHHHCCHHHHHH
TLRSIQAGTVEVQAQDDAFFSRAPKLTRENTRIRWNQPVAVLSDFIRGLAMKPAAWTTVQ
HHHHCCCCEEEEEECCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEHHH
NRTMKIFRAIPFTEEITSSIEQPGSILVERGRFLVRGSDGWLEVKQLQPEGRKPMEGAEF
HHHEEEHHCCCCHHHHHHHHCCCCHHEEECCEEEEECCCCCEEEEECCCCCCCCCCHHHH
ARGFRPESGTSLLFE
HHCCCCCCCCEECCC
>Mature Secondary Structure
MRIVFMGTPEFAVPSLRSIAAEHNHFELVLVVTGSDKPRRGRNAPSEPSPVKSAALELGF
CEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCE
QVYETDDVSSSDFLSVVADSAPDVIVVAAFRILPPEVYGQAKLGAFNLHASLLPAYRGAA
EEEECCCCCCCHHHHHHHCCCCCEEEEEEHHHCCHHHCCCCCCCEEEHHHHHHHHHCCCC
PINWAIINGEKESGVTTFFLQKTVDTGNVIMQEKIPVLPDDNASILSVKLSHLGAELVVK
CEEEEEECCCCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEEHHHCCHHHHHH
TLRSIQAGTVEVQAQDDAFFSRAPKLTRENTRIRWNQPVAVLSDFIRGLAMKPAAWTTVQ
HHHHCCCCEEEEEECCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEHHH
NRTMKIFRAIPFTEEITSSIEQPGSILVERGRFLVRGSDGWLEVKQLQPEGRKPMEGAEF
HHHEEEHHCCCCHHHHHHHHCCCCHHEEECCEEEEECCCCCEEEEECCCCCCCCCCHHHH
ARGFRPESGTSLLFE
HHCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA